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Protein

Exotoxin type C

Gene

speC

Organism
Streptococcus pyogenes serotype M18 (strain MGAS8232)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Toxin

Enzyme and pathway databases

BioCyciSPYO186103:GHJG-664-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exotoxin type C
Alternative name(s):
SPE C
Gene namesi
Name:speC
Ordered Locus Names:spyM18_0778
OrganismiStreptococcus pyogenes serotype M18 (strain MGAS8232)
Taxonomic identifieri186103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Protein family/group databases

Allergomei8279. Str py SPEC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 27271 PublicationAdd
BLAST
Chaini28 – 235208Exotoxin type CPRO_0000035598Add
BLAST

Structurei

Secondary structure

1
235
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi33 – 4412Combined sources
Beta strandi49 – 5911Combined sources
Beta strandi61 – 677Combined sources
Helixi69 – 724Combined sources
Beta strandi77 – 815Combined sources
Helixi84 – 874Combined sources
Beta strandi95 – 1006Combined sources
Beta strandi110 – 1145Combined sources
Beta strandi117 – 1193Combined sources
Beta strandi131 – 1355Combined sources
Beta strandi152 – 1554Combined sources
Helixi156 – 17116Combined sources
Beta strandi173 – 1775Combined sources
Beta strandi182 – 1898Combined sources
Beta strandi194 – 2007Combined sources
Helixi208 – 2125Combined sources
Helixi213 – 2175Combined sources
Beta strandi220 – 2223Combined sources
Helixi223 – 2253Combined sources
Beta strandi226 – 2349Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AN8X-ray2.40A28-235[»]
1HQRX-ray3.20D28-235[»]
1KTKX-ray3.00A/B/C/D28-235[»]
ProteinModelPortaliQ8NKX2.
SMRiQ8NKX2. Positions 28-235.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NKX2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000235485.
KOiK11040.
OMAiHIIKIVF.

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NKX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKINIIKIV FIITVILIST ISPIIKSDSK KDISNVKSDL LYAYTITPYD
60 70 80 90 100
YKDCRVNFST THTLNIDTQK YRGKDYYISS EMSYEASQKF KRDDHVDVFG
110 120 130 140 150
LFYILNSHTG EYIYGGITPA QNNKVNHKLL GNLFISGESQ QNLNNKIILE
160 170 180 190 200
KDIVTFQEID FKIRKYLMDN YKIYDATSPY VSGRIEIGTK DGKHEQIDLF
210 220 230
DSPNEGTRSD IFAKYKDNRI INMKNFSHFD IYLEK
Length:235
Mass (Da):27,372
Last modified:October 1, 2002 - v1
Checksum:i53EBD041B958C65B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35514 Genomic DNA. Translation: AAA27017.1. Sequence problems.
M97156 Genomic DNA. Translation: AAB59091.1.
M97157 Genomic DNA. Translation: AAB59092.1.
AE009949 Genomic DNA. Translation: AAL97445.1.
PIRiA30509.
A44799.
RefSeqiWP_002985327.1. NC_003485.1.

Genome annotation databases

EnsemblBacteriaiAAL97445; AAL97445; spyM18_0778.
KEGGispm:spyM18_0778.
PATRICi19748176. VBIStrPyo4396_0679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35514 Genomic DNA. Translation: AAA27017.1. Sequence problems.
M97156 Genomic DNA. Translation: AAB59091.1.
M97157 Genomic DNA. Translation: AAB59092.1.
AE009949 Genomic DNA. Translation: AAL97445.1.
PIRiA30509.
A44799.
RefSeqiWP_002985327.1. NC_003485.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AN8X-ray2.40A28-235[»]
1HQRX-ray3.20D28-235[»]
1KTKX-ray3.00A/B/C/D28-235[»]
ProteinModelPortaliQ8NKX2.
SMRiQ8NKX2. Positions 28-235.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei8279. Str py SPEC.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL97445; AAL97445; spyM18_0778.
KEGGispm:spyM18_0778.
PATRICi19748176. VBIStrPyo4396_0679.

Phylogenomic databases

HOGENOMiHOG000235485.
KOiK11040.
OMAiHIIKIVF.

Enzyme and pathway databases

BioCyciSPYO186103:GHJG-664-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8NKX2.

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPEC_STRP8
AccessioniPrimary (citable) accession number: Q8NKX2
Secondary accession number(s): P13380
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Superantigen that binds to major histocompatibility complex class II beta chain in a zinc-dependent manner, it may activate up to 20% of all T-cells. Superantigens bind simultaneously TCRs and MHC class II molecules resulting in a massive release of pyrogenic and inflammatory cytokines.
This toxin seems to be coded by a bacteriophage.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.