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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei653ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTKOD69014:G1G2A-1460-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:TK1461
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001521411 – 967Leucine--tRNA ligaseAdd BLAST967

Interactioni

Protein-protein interaction databases

IntActiQ8NKR7, 119 interactors
MINTiQ8NKR7
STRINGi69014.TK1461

Structurei

3D structure databases

ProteinModelPortaliQ8NKR7
SMRiQ8NKR7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 53"HIGH" regionAdd BLAST11
Motifi650 – 654"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
HOGENOMiHOG000216620
InParanoidiQ8NKR7
KOiK01869
OMAiHVTGTPI
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NKR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELNFKAIE EKWQKRWMEA RVFEPDRKAK PKEKKFYITV AFPYLSGHLH
60 70 80 90 100
VGHARTYTIP DVIARFKRMQ GYNVLFPMGW HITGAPIVGI AERIKNRDPK
110 120 130 140 150
TIHIYRDVYK VPEEILWKFE DPKEIVKYFM KAAKETFIRA GFSVDWTREF
160 170 180 190 200
HTTSLFPPFS KFIEWQFWTL KDMGLVVKGA HRVRWDPVVG TPLGDHDIME
210 220 230 240 250
GEDVQILEYV IIKFILEENG ETIYLPAATL RPETVYGVTN MWLNPEATYV
260 270 280 290 300
KAKVRKGDRE ELWIVSKEAA YKLSFQDREI EVIEEFKGEK LIGKYVKNPV
310 320 330 340 350
TGDEVIILPA EFVDPDNATG VVMSVPAHAP FDHIALEDLK KETEILLKYD
360 370 380 390 400
IDPRVVEEIS YISLISLEGY GEFPAVEEAE RLGVKSQKDK EKLEQATKNI
410 420 430 440 450
YKAEYHKGIF KIEPYAGKPV QEVKELVAKE MMEKGIAEIM YEFADKPVIS
460 470 480 490 500
RFGNQAVIKI IHDQWFIDYG NPEWKAKARE ALANMTIYPE SRRAQFEAVI
510 520 530 540 550
DWLDKKACAR KVGLGTPLPW DPDWVIESLS DSTIYMAYYT ISRHINQLRK
560 570 580 590 600
EGKLDAEKLD REFFDYIFRE PFSEEKERKL SEKTGIPAET IHEMKEEFEY
610 620 630 640 650
WYPLDWRCSA KDLIPNHLTF FIFNHVAIFD KKHWPKGIAV NGFGTLEGQK
660 670 680 690 700
MSKSKGNVLN FIDAIEENGA DVVRLYIMGL AEHDSDFDWR RKEVGKLRKQ
710 720 730 740 750
VERFYELVSE FATYEAKEGV ELKDIDRWML HRLNKAIEGA TKALEEFRTR
760 770 780 790 800
TAVQWAFYTV LNDLRWYLRR TEGRDDDAKR YVLRTLADVW VRLMAPFTPH
810 820 830 840 850
ISEELWEKLG GEGFVSLAPW PEPVPEWWNE TVEAEEDFVK SLIEDIKEII
860 870 880 890 900
TVAKIENPKR AYIYTAPEWK WRVVEVVAEK RDFKAAMAEL MKDPEMRKHG
910 920 930 940 950
KEVSKLIQRL IKERAFEVKR IDEEKALREA KDFIEKELGI EIIINPEEDR
960
GGKKKQAMPL KPAVFVE
Length:967
Mass (Da):113,135
Last modified:March 29, 2005 - v2
Checksum:i13A9161049DC233C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti321V → C in BAC10608 (Ref. 1) Curated1
Sequence conflicti590T → A in BAC10608 (Ref. 1) Curated1
Sequence conflicti654 – 655SK → RQ (Ref. 1) Curated2
Sequence conflicti657N → Q (Ref. 1) Curated1
Sequence conflicti659L → Q (Ref. 1) Curated1
Sequence conflicti663D → Y in BAC10608 (Ref. 1) Curated1
Sequence conflicti822E → D in BAC10608 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB090309 Genomic DNA Translation: BAC10608.1
AP006878 Genomic DNA Translation: BAD85650.1
RefSeqiWP_011250412.1, NC_006624.1

Genome annotation databases

EnsemblBacteriaiBAD85650; BAD85650; TK1461
GeneIDi3234295
KEGGitko:TK1461
PATRICifig|69014.16.peg.1423

Similar proteinsi

Entry informationi

Entry nameiSYL_THEKO
AccessioniPrimary (citable) accession number: Q8NKR7
Secondary accession number(s): Q5JH65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 29, 2005
Last modified: March 28, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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