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Q8NKF9

- EXG_CANOL

UniProt

Q8NKF9 - EXG_CANOL

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Protein
Glucan 1,3-beta-glucosidase
Gene
EXG1
Organism
Candida oleophila (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase By similarity.

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei214 – 2141Proton donor By similarity
Active sitei328 – 3281Nucleophile By similarity

GO - Molecular functioni

  1. glucan exo-1,3-beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation

Protein family/group databases

CAZyiGH5. Glycoside Hydrolase Family 5.
mycoCLAPiEXG5A_CANOL.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucan 1,3-beta-glucosidase (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase
Gene namesi
Name:EXG1
OrganismiCandida oleophila (Yeast)
Taxonomic identifieri45573 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 425408Glucan 1,3-beta-glucosidase
PRO_0000007880Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi301 ↔ 423 By similarity
Disulfide bondi326 ↔ 352 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliQ8NKF9.
SMRiQ8NKF9. Positions 30-425.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NKF9-1 [UniParc]FASTAAdd to Basket

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MLLTFAPIFL LISSIVAAPT LQLQRKGLEW DYQNDKIRGV NLGGWFVLEP    50
YITPSLFSVW SNGEDDLNTP VDEYHYTQKL GKETALSRLE AHWSSWYTEA 100
DFAQMKYLGI NAVRIPIGYW AFQLLDNDPY VQGQVKYLDQ ALEWCRNNGL 150
YAWVDLHGAP GSQNGFDNSG LRDSYKFQDD DDVKVTLEVL KTIGAKYGGS 200
DYEDVVIGIE LLNEPLGPVL DMDGLRQFYQ DGYSEIRNND GVESYNAIII 250
HDAFQQTDHY WDNFMQVSGG YWNVVVDHHH YQVFDQAALE LLIEDHIKTA 300
CNWGTTHKDE AHWNIVGEWS SALTDCAKWL NGVGHGARWS GNYDNCPYID 350
SCLSYTDLSG WTDEYKTNVR KYTEAQLDAW EQVGGWFFWC WKTESAPEWD 400
FQALTNAGLI PQPLNDRQYP NQCGY 425
Length:425
Mass (Da):48,774
Last modified:October 1, 2002 - v1
Checksum:iC374EB3438AD5D1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF393806 Genomic DNA. Translation: AAM21469.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF393806 Genomic DNA. Translation: AAM21469.1 .

3D structure databases

ProteinModelPortali Q8NKF9.
SMRi Q8NKF9. Positions 30-425.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH5. Glycoside Hydrolase Family 5.
mycoCLAPi EXG5A_CANOL.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and analysis of CoEXG1, a secreted 1,3-beta-glucanase of the yeast biocontrol agent Candida oleophila."
    Segal E., Yehuda H., Droby S., Wisniewski M., Goldway M.
    Yeast 19:1171-1182(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
    Strain: ATCC MYA-1208 / I-182 / NRRL Y-18846.

Entry informationi

Entry nameiEXG_CANOL
AccessioniPrimary (citable) accession number: Q8NKF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2002
Last modified: October 16, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi