Reviewed, UniProtKB/Swiss-Prot Q8NKF4 (RL3_ASPFU)

Names and origin

Protein names

Recommended name:
    60S ribosomal protein L3
Alternative name(s):
    Allergen=Asp f 23

Gene names

Name:	rpl3
ORF Names:	AFUA_2G11850

Organism

Aspergillus fumigatus (Sartorya fumigata) [Complete proteome]

Taxonomic identifier

5085 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	The L3 protein is a component of the large subunit of cytoplasmic ribosomes.
Subcellular location	Cytoplasm.
Allergenic properties	Causes an allergic reaction in human. Binds to IgE and IgG. Ref.1
Sequence similarities	Belongs to the ribosomal protein L3P family.

Ontologies

Keywords
Cellular component	Cytoplasm
Disease	Allergen
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: InterPro
Cellular component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	60S ribosomal protein L3		PRO_0000077244
Experimental info
	Sequence conflict	35	1	D → Y in AAM43909. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8NKF4-1 [UniParc]. Last modified December 6, 2005. Version 2. Checksum: 0A2D7C976D1023F5	FASTA	392	44,445
	10 20 30 40 50 60 MSHRKYEAPR HGSLAFLPRK RAARHRGKVK SFPKDDPKKP VHLTASMGYK AGMTTVVRDL 70 80 90 100 110 120 DRPGAKMHKK EIVEAVTIIE TPPLVAVGVV GYIETPRGLR SLTTVWAEHL SDEVKRRFYK 130 140 150 160 170 180 NWYKSKKKAF TKYAKKHAEE NGASITRELE RIKKYCTVVR VLAHTQIRKT PLKQKKAHLM 190 200 210 220 230 240 EIQVNGGSVA DKVDFARNLF EKPIEIDSIF EKDEMIDVIA VTKGHGFQGV TSRWGTKKLP 250 260 270 280 290 300 RKTHKGLRKV ACIGAWHPSH VQWTVARAGQ MGYHHRTSCN HKVFRIGKGS DEGNASTDFD 310 320 330 340 350 360 ISKKQITPMG GFVRYGEVKN DYIMVKGSVP GVKKRVMTLR KTLYPQTSRR ATEKVELKWI 370 380 390 DTSSKFGHGA FQTPEEKRAF MGTLKKDLVT SA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning, expression and characterization of an allergenic L3 ribosomal protein of Aspergillus fumigatus." Saxena S., Madan T., Muralidhar K., Sarma P.U. Clin. Exp. Immunol. 134:86-91(2003) [PubMed: 12974759] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGENICITY.
[2]	"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF464911 mRNA. Translation: AAM43909.1. AAHF01000001 Genomic DNA. Translation: EAL93479.1.
RefSeq	XP_755517.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8NKF4.
Genome annotation databases
GeneID	3513239.
GenomeReviews	Gene locus rpl3 in contig CM000170_GR.
KEGG	afm:AFUA_2G11850.
Phylogenomic databases
HOGENOM	Q8NKF4.
OMA	WGTKKLP
OrthoDB	EOG99S7Q2
Family and domain databases
InterPro	IPR000597. Ribosomal_L3. IPR019926. Ribosomal_L3_CS. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Pfam	PF00297. Ribosomal_L3. 1 hit. [Graphical view]
PROSITE	PS00474. RIBOSOMAL_L3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RL3_ASPFU

Accession

Primary (citable) accession number: Q8NKF4
Secondary accession number(s): Q4X0Y6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	December 6, 2005
Last modified:	November 24, 2009
This is version 41 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)