Q8NKF4 (RL3_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60S ribosomal protein L3

Alternative name(s):
Allergen=Asp f 23

Gene names

Name:	rpl3
ORF Names:	AFUA_2G11850

Organism

Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) [Reference proteome]

Taxonomic identifier

330879 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › Neosartorya fumigata

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The L3 protein is a component of the large subunit of cytoplasmic ribosomes.
Subcellular location	Cytoplasm.
Allergenic properties	Causes an allergic reaction in human. Binds to IgE and IgG. Ref.1
Sequence similarities	Belongs to the ribosomal protein L3P family.

Ontologies

Keywords
Cellular component	Cytoplasm
Disease	Allergen
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: InterPro
Cellular_component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	60S ribosomal protein L3		PRO_0000077244
Experimental info
	Sequence conflict	35	1	D → Y in AAM43909. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8NKF4 [UniParc]. Last modified December 6, 2005. Version 2. Checksum: 0A2D7C976D1023F5	FASTA	392	44,445
	10 20 30 40 50 60 MSHRKYEAPR HGSLAFLPRK RAARHRGKVK SFPKDDPKKP VHLTASMGYK AGMTTVVRDL 70 80 90 100 110 120 DRPGAKMHKK EIVEAVTIIE TPPLVAVGVV GYIETPRGLR SLTTVWAEHL SDEVKRRFYK 130 140 150 160 170 180 NWYKSKKKAF TKYAKKHAEE NGASITRELE RIKKYCTVVR VLAHTQIRKT PLKQKKAHLM 190 200 210 220 230 240 EIQVNGGSVA DKVDFARNLF EKPIEIDSIF EKDEMIDVIA VTKGHGFQGV TSRWGTKKLP 250 260 270 280 290 300 RKTHKGLRKV ACIGAWHPSH VQWTVARAGQ MGYHHRTSCN HKVFRIGKGS DEGNASTDFD 310 320 330 340 350 360 ISKKQITPMG GFVRYGEVKN DYIMVKGSVP GVKKRVMTLR KTLYPQTSRR ATEKVELKWI 370 380 390 DTSSKFGHGA FQTPEEKRAF MGTLKKDLVT SA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning, expression and characterization of an allergenic L3 ribosomal protein of Aspergillus fumigatus." Saxena S., Madan T., Muralidhar K., Sarma P.U. Clin. Exp. Immunol. 134:86-91(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.
[2]	"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF464911 mRNA. Translation: AAM43909.1. AAHF01000001 Genomic DNA. Translation: EAL93479.1.
RefSeq	XP_755517.1. XM_750424.1.
3D structure databases
ProteinModelPortal	Q8NKF4.
SMR	Q8NKF4. Positions 8-343.
ModBase	Search...
Protein family/group databases
Allergome	1183. Asp f 23. 3117. Asp f 23.0101.
Proteomic databases
PRIDE	Q8NKF4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADAFUAT00004608; CADAFUAP00004608; CADAFUAG00004608.
GeneID	3513239.
KEGG	afm:AFUA_2G11850.
Phylogenomic databases
eggNOG	COG0087.
HOGENOM	HOG000107319.
KO	K02925.
OMA	QETHSAM.
OrthoDB	EOG4CG3HR.
Family and domain databases
InterPro	IPR000597. Ribosomal_L3. IPR019926. Ribosomal_L3_CS. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Pfam	PF00297. Ribosomal_L3. 1 hit. [Graphical view]
SUPFAM	SSF50447. Translat_factor. 1 hit.
PROSITE	PS00474. RIBOSOMAL_L3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RL3_ASPFU

Accession

Primary (citable) accession number: Q8NKF4
Secondary accession number(s): Q4X0Y6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	December 6, 2005
Last modified:	May 1, 2013
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program