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Q8NKC1

- COMT2_SCHPO

UniProt

Q8NKC1 - COMT2_SCHPO

Protein

Probable catechol O-methyltransferase 2

Gene

SPBPB21E7.04c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei78 – 781S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
    Binding sitei100 – 1001S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei108 – 1081S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei127 – 1271S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei128 – 1281S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
    Binding sitei156 – 1561S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
    Metal bindingi183 – 1831MagnesiumBy similarity
    Binding sitei183 – 1831S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei186 – 1861SubstrateBy similarity
    Metal bindingi211 – 2111MagnesiumBy similarity
    Metal bindingi212 – 2121MagnesiumBy similarity
    Binding sitei212 – 2121SubstrateBy similarity

    GO - Molecular functioni

    1. catechol O-methyltransferase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. catecholamine metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Catecholamine metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable catechol O-methyltransferase 2 (EC:2.1.1.6)
    Gene namesi
    ORF Names:SPBPB21E7.04c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBPB21E7.04c.

    Subcellular locationi

    Vacuole 1 Publication

    GO - Cellular componenti

    1. fungal-type vacuole Source: PomBase

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 281281Probable catechol O-methyltransferase 2PRO_0000318149Add
    BLAST

    Proteomic databases

    MaxQBiQ8NKC1.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4700849.
    STRINGi4896.SPBPB21E7.04c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NKC1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG4122.
    HOGENOMiHOG000171638.
    KOiK00545.
    OMAiFIDHYKP.
    OrthoDBiEOG7KM644.
    PhylomeDBiQ8NKC1.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR025782. Catechol_O-MeTrfase.
    IPR002935. O-MeTrfase_3.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10509. PTHR10509. 1 hit.
    PfamiPF01596. Methyltransf_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51682. SAM_OMT_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NKC1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFAQALHWLT TSKLRYALAL PFLFFILYTK TKKSKEQELE NYIFSLPREK    50
    LDQIRGKPDE VINVIDEYVE QGHFLMNIGK LKGKIISEKI QQVKPKVMIE 100
    LGGYVGYSAI LFGKQLTDPS AHYYSLEVNP KFAKIASKII DLAGLSNKVT 150
    IIVGKATDSL VELRRSLPNV IPSFEYLDFV FIDHWKDLYV PDLRVMETLD 200
    LIGQGSIIAA DNILRPGVPE YVKYVQGSLD YRKEYDSTVS NVNGPQFIGK 250
    WNIIYKSKTI KVDDGKREKD AVEITEYIEA K 281
    Length:281
    Mass (Da):32,123
    Last modified:October 1, 2002 - v1
    Checksum:i24022103FE9993B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAD31744.1.
    RefSeqiNP_001018770.1. NM_001020945.2.

    Genome annotation databases

    EnsemblFungiiSPBPB21E7.04c.1; SPBPB21E7.04c.1:pep; SPBPB21E7.04c.
    GeneIDi3361178.
    KEGGispo:SPBPB21E7.04c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAD31744.1 .
    RefSeqi NP_001018770.1. NM_001020945.2.

    3D structure databases

    ProteinModelPortali Q8NKC1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4700849.
    STRINGi 4896.SPBPB21E7.04c-1.

    Proteomic databases

    MaxQBi Q8NKC1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBPB21E7.04c.1 ; SPBPB21E7.04c.1:pep ; SPBPB21E7.04c .
    GeneIDi 3361178.
    KEGGi spo:SPBPB21E7.04c.

    Organism-specific databases

    PomBasei SPBPB21E7.04c.

    Phylogenomic databases

    eggNOGi COG4122.
    HOGENOMi HOG000171638.
    KOi K00545.
    OMAi FIDHYKP.
    OrthoDBi EOG7KM644.
    PhylomeDBi Q8NKC1.

    Miscellaneous databases

    NextBioi 20811292.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR025782. Catechol_O-MeTrfase.
    IPR002935. O-MeTrfase_3.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10509. PTHR10509. 1 hit.
    Pfami PF01596. Methyltransf_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51682. SAM_OMT_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOMT2_SCHPO
    AccessioniPrimary (citable) accession number: Q8NKC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3