UniProtKB - Q8NKC1 (COMT2_SCHPO)
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Protein
Probable catechol O-methyltransferase 2
Gene
SPBPB21E7.04c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Catalytic activityi
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.
Cofactori
Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 78 | S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation | 1 | |
Binding sitei | 100 | S-adenosyl-L-methioninePROSITE-ProRule annotation | 1 | |
Binding sitei | 108 | S-adenosyl-L-methioninePROSITE-ProRule annotation | 1 | |
Binding sitei | 127 | S-adenosyl-L-methioninePROSITE-ProRule annotation | 1 | |
Binding sitei | 128 | S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation | 1 | |
Binding sitei | 156 | S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 183 | MagnesiumBy similarity | 1 | |
Binding sitei | 183 | S-adenosyl-L-methioninePROSITE-ProRule annotation | 1 | |
Binding sitei | 186 | SubstrateBy similarity | 1 | |
Metal bindingi | 211 | MagnesiumBy similarity | 1 | |
Metal bindingi | 212 | MagnesiumBy similarity | 1 | |
Binding sitei | 212 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- O-methyltransferase activity Source: PomBase
GO - Biological processi
- catecholamine metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | Catecholamine metabolism |
Ligand | Magnesium, Metal-binding, S-adenosyl-L-methionine |
Enzyme and pathway databases
Reactomei | R-SPO-156581. Methylation. R-SPO-379397. Enzymatic degradation of dopamine by COMT. R-SPO-379398. Enzymatic degradation of Dopamine by monoamine oxidase. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:SPBPB21E7.04c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:SPBPB21E7.04c. |
PomBasei | SPBPB21E7.04c. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000318149 | 1 – 281 | Probable catechol O-methyltransferase 2Add BLAST | 281 |
Proteomic databases
MaxQBi | Q8NKC1. |
PaxDbi | Q8NKC1. |
PRIDEi | Q8NKC1. |
Interactioni
Protein-protein interaction databases
BioGridi | 280254. 2 interactors. |
STRINGi | 4896.SPBPB21E7.04c.1. |
Structurei
3D structure databases
ProteinModelPortali | Q8NKC1. |
SMRi | Q8NKC1. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.PROSITE-ProRule annotation
Phylogenomic databases
HOGENOMi | HOG000171638. |
InParanoidi | Q8NKC1. |
KOi | K00545. |
OMAi | SRFECTH. |
OrthoDBi | EOG092C4KCD. |
PhylomeDBi | Q8NKC1. |
Family and domain databases
InterProi | View protein in InterPro IPR002935. O-MeTrfase_3. IPR029063. SAM-dependent_MTases. |
Pfami | View protein in Pfam PF01596. Methyltransf_3. 1 hit. |
SUPFAMi | SSF53335. SSF53335. 1 hit. |
PROSITEi | View protein in PROSITE PS51682. SAM_OMT_I. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q8NKC1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFAQALHWLT TSKLRYALAL PFLFFILYTK TKKSKEQELE NYIFSLPREK
60 70 80 90 100
LDQIRGKPDE VINVIDEYVE QGHFLMNIGK LKGKIISEKI QQVKPKVMIE
110 120 130 140 150
LGGYVGYSAI LFGKQLTDPS AHYYSLEVNP KFAKIASKII DLAGLSNKVT
160 170 180 190 200
IIVGKATDSL VELRRSLPNV IPSFEYLDFV FIDHWKDLYV PDLRVMETLD
210 220 230 240 250
LIGQGSIIAA DNILRPGVPE YVKYVQGSLD YRKEYDSTVS NVNGPQFIGK
260 270 280
WNIIYKSKTI KVDDGKREKD AVEITEYIEA K
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA. Translation: CAD31744.1. |
RefSeqi | NP_001018770.1. NM_001020945.2. |
Genome annotation databases
EnsemblFungii | SPBPB21E7.04c.1; SPBPB21E7.04c.1:pep; SPBPB21E7.04c. |
GeneIDi | 3361178. |
KEGGi | spo:SPBPB21E7.04c. |
Similar proteinsi
Entry informationi
Entry namei | COMT2_SCHPO | |
Accessioni | Q8NKC1Primary (citable) accession number: Q8NKC1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | October 1, 2002 | |
Last modified: | March 28, 2018 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |