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Q8NKC1

- COMT2_SCHPO

UniProt

Q8NKC1 - COMT2_SCHPO

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Protein

Probable catechol O-methyltransferase 2

Gene

SPBPB21E7.04c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.

Cofactori

Binds 1 magnesium ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei78 – 781S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
Binding sitei100 – 1001S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei108 – 1081S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei127 – 1271S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei128 – 1281S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
Binding sitei156 – 1561S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
Metal bindingi183 – 1831MagnesiumBy similarity
Binding sitei183 – 1831S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei186 – 1861SubstrateBy similarity
Metal bindingi211 – 2111MagnesiumBy similarity
Metal bindingi212 – 2121MagnesiumBy similarity
Binding sitei212 – 2121SubstrateBy similarity

GO - Molecular functioni

  1. catechol O-methyltransferase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. catecholamine metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Catecholamine metabolism

Keywords - Ligandi

Magnesium, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable catechol O-methyltransferase 2 (EC:2.1.1.6)
Gene namesi
ORF Names:SPBPB21E7.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBPB21E7.04c.

Subcellular locationi

Vacuole 1 Publication

GO - Cellular componenti

  1. fungal-type vacuole Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Probable catechol O-methyltransferase 2PRO_0000318149Add
BLAST

Proteomic databases

MaxQBiQ8NKC1.

Interactioni

Protein-protein interaction databases

MINTiMINT-4700849.
STRINGi4896.SPBPB21E7.04c-1.

Structurei

3D structure databases

ProteinModelPortaliQ8NKC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG4122.
HOGENOMiHOG000171638.
InParanoidiQ8NKC1.
KOiK00545.
OMAiFIDHYKP.
OrthoDBiEOG7KM644.
PhylomeDBiQ8NKC1.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025782. Catechol_O-MeTrfase.
IPR002935. O-MeTrfase_3.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10509. PTHR10509. 1 hit.
PfamiPF01596. Methyltransf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51682. SAM_OMT_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NKC1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFAQALHWLT TSKLRYALAL PFLFFILYTK TKKSKEQELE NYIFSLPREK
60 70 80 90 100
LDQIRGKPDE VINVIDEYVE QGHFLMNIGK LKGKIISEKI QQVKPKVMIE
110 120 130 140 150
LGGYVGYSAI LFGKQLTDPS AHYYSLEVNP KFAKIASKII DLAGLSNKVT
160 170 180 190 200
IIVGKATDSL VELRRSLPNV IPSFEYLDFV FIDHWKDLYV PDLRVMETLD
210 220 230 240 250
LIGQGSIIAA DNILRPGVPE YVKYVQGSLD YRKEYDSTVS NVNGPQFIGK
260 270 280
WNIIYKSKTI KVDDGKREKD AVEITEYIEA K
Length:281
Mass (Da):32,123
Last modified:October 1, 2002 - v1
Checksum:i24022103FE9993B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAD31744.1.
RefSeqiNP_001018770.1. NM_001020945.2.

Genome annotation databases

EnsemblFungiiSPBPB21E7.04c.1; SPBPB21E7.04c.1:pep; SPBPB21E7.04c.
GeneIDi3361178.
KEGGispo:SPBPB21E7.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAD31744.1 .
RefSeqi NP_001018770.1. NM_001020945.2.

3D structure databases

ProteinModelPortali Q8NKC1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4700849.
STRINGi 4896.SPBPB21E7.04c-1.

Proteomic databases

MaxQBi Q8NKC1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBPB21E7.04c.1 ; SPBPB21E7.04c.1:pep ; SPBPB21E7.04c .
GeneIDi 3361178.
KEGGi spo:SPBPB21E7.04c.

Organism-specific databases

PomBasei SPBPB21E7.04c.

Phylogenomic databases

eggNOGi COG4122.
HOGENOMi HOG000171638.
InParanoidi Q8NKC1.
KOi K00545.
OMAi FIDHYKP.
OrthoDBi EOG7KM644.
PhylomeDBi Q8NKC1.

Miscellaneous databases

NextBioi 20811292.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR025782. Catechol_O-MeTrfase.
IPR002935. O-MeTrfase_3.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10509. PTHR10509. 1 hit.
Pfami PF01596. Methyltransf_3. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51682. SAM_OMT_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOMT2_SCHPO
AccessioniPrimary (citable) accession number: Q8NKC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3