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Protein

Probable catechol O-methyltransferase 2

Gene

SPBPB21E7.04c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei78S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei100S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei108S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei127S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei128S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei156S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Metal bindingi183MagnesiumBy similarity1
Binding sitei183S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei186SubstrateBy similarity1
Metal bindingi211MagnesiumBy similarity1
Metal bindingi212MagnesiumBy similarity1
Binding sitei212SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Catecholamine metabolism

Keywords - Ligandi

Magnesium, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-SPO-156581. Methylation.
R-SPO-379397. Enzymatic degradation of dopamine by COMT.
R-SPO-379398. Enzymatic degradation of Dopamine by monoamine oxidase.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable catechol O-methyltransferase 2 (EC:2.1.1.6)
Gene namesi
ORF Names:SPBPB21E7.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBPB21E7.04c.
PomBaseiSPBPB21E7.04c.

Subcellular locationi

GO - Cellular componenti

  • fungal-type vacuole Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003181491 – 281Probable catechol O-methyltransferase 2Add BLAST281

Proteomic databases

MaxQBiQ8NKC1.
PRIDEiQ8NKC1.

Interactioni

Protein-protein interaction databases

BioGridi280254. 1 interactor.
MINTiMINT-4700849.

Structurei

3D structure databases

ProteinModelPortaliQ8NKC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000171638.
InParanoidiQ8NKC1.
KOiK00545.
OMAiITECVEY.
OrthoDBiEOG092C4KCD.
PhylomeDBiQ8NKC1.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002935. O-MeTrfase_3.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01596. Methyltransf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51682. SAM_OMT_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NKC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAQALHWLT TSKLRYALAL PFLFFILYTK TKKSKEQELE NYIFSLPREK
60 70 80 90 100
LDQIRGKPDE VINVIDEYVE QGHFLMNIGK LKGKIISEKI QQVKPKVMIE
110 120 130 140 150
LGGYVGYSAI LFGKQLTDPS AHYYSLEVNP KFAKIASKII DLAGLSNKVT
160 170 180 190 200
IIVGKATDSL VELRRSLPNV IPSFEYLDFV FIDHWKDLYV PDLRVMETLD
210 220 230 240 250
LIGQGSIIAA DNILRPGVPE YVKYVQGSLD YRKEYDSTVS NVNGPQFIGK
260 270 280
WNIIYKSKTI KVDDGKREKD AVEITEYIEA K
Length:281
Mass (Da):32,123
Last modified:October 1, 2002 - v1
Checksum:i24022103FE9993B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAD31744.1.
RefSeqiNP_001018770.1. NM_001020945.2.

Genome annotation databases

EnsemblFungiiSPBPB21E7.04c.1; SPBPB21E7.04c.1:pep; SPBPB21E7.04c.
GeneIDi3361178.
KEGGispo:SPBPB21E7.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAD31744.1.
RefSeqiNP_001018770.1. NM_001020945.2.

3D structure databases

ProteinModelPortaliQ8NKC1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi280254. 1 interactor.
MINTiMINT-4700849.

Proteomic databases

MaxQBiQ8NKC1.
PRIDEiQ8NKC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBPB21E7.04c.1; SPBPB21E7.04c.1:pep; SPBPB21E7.04c.
GeneIDi3361178.
KEGGispo:SPBPB21E7.04c.

Organism-specific databases

EuPathDBiFungiDB:SPBPB21E7.04c.
PomBaseiSPBPB21E7.04c.

Phylogenomic databases

HOGENOMiHOG000171638.
InParanoidiQ8NKC1.
KOiK00545.
OMAiITECVEY.
OrthoDBiEOG092C4KCD.
PhylomeDBiQ8NKC1.

Enzyme and pathway databases

ReactomeiR-SPO-156581. Methylation.
R-SPO-379397. Enzymatic degradation of dopamine by COMT.
R-SPO-379398. Enzymatic degradation of Dopamine by monoamine oxidase.

Miscellaneous databases

PROiQ8NKC1.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002935. O-MeTrfase_3.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01596. Methyltransf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51682. SAM_OMT_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOMT2_SCHPO
AccessioniPrimary (citable) accession number: Q8NKC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2002
Last modified: October 5, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.