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Q8NKC0 (ASPG3_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable L-asparaginase 3
EC=3.5.1.1
Alternative name(s):
L-asparagine amidohydrolase 3
Gene names
ORF Names:SPBPB21E7.09
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-asparagine + H2O = L-aspartate + NH3.

Subcellular location

Secreted › cell wall By similarity.

Sequence similarities

Belongs to the asparaginase 1 family.

Ontologies

Keywords
   Cellular componentCell wall
Secreted
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processasparagine metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcell surface

Non-traceable author statement. Source: GeneDB_Spombe

cell wall

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionasparaginase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 360344Probable L-asparaginase 3
PRO_0000002365

Regions

Region129 – 1302Substrate binding By similarity

Sites

Active site491O-isoaspartyl threonine intermediate By similarity
Binding site961Substrate By similarity

Amino acid modifications

Glycosylation271N-linked (GlcNAc...) Potential
Glycosylation351N-linked (GlcNAc...) Potential
Glycosylation401N-linked (GlcNAc...) Potential
Glycosylation821N-linked (GlcNAc...) Potential
Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation1441N-linked (GlcNAc...) Potential
Glycosylation1791N-linked (GlcNAc...) Potential
Glycosylation2461N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential
Glycosylation3511N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8NKC0 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: B04A0ABF3E5DFE3B

FASTA36038,597
        10         20         30         40         50         60 
MWSSIISFLF FSVALCQPLL FQKRSSNVSD FISFNASLPN VTIFAMGGTI AGYASSSTET 

        70         80         90        100        110        120 
VDYAAGSVGI ATLVDAVPAI KNFSNIRGVQ VTNVGSEELT PANVLNLTQL ILAEVAKPDV 

       130        140        150        160        170        180 
HGIVVTHGTD SLEETAIFLD MTVNTTKPIV VVGAMRPSTA ISADGPMNLL NAVVVAASNR 

       190        200        210        220        230        240 
SIGRGTMILL NDRIGSAFYT TKTNGNMLDT FKSYEAGFLG MILDQRPHFF YSPATPTGKV 

       250        260        270        280        290        300 
HFDVSNTTEL PAVEILYGYQ GLNPNLAKAA VDLGAKGLVL AGMGAASWTD PGNEVIDGLI 

       310        320        330        340        350        360 
SNQSIPVVYS HRTMDGFSDY YYNGIPAYFQ NPQKARYMLM LSINAGYSIQ NITDIFSLEY

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329671 Genomic DNA. Translation: CAD31749.1.
RefSeqNP_001018773.1. NM_001020948.1.

3D structure databases

ProteinModelPortalQ8NKC0.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8NKC0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBPB21E7.09.1; SPBPB21E7.09.1:pep; SPBPB21E7.09.
GeneID3361173.
KEGGspo:SPBPB21E7.09.

Organism-specific databases

GeneDB_SpombeSPBPB21E7.09.

Phylogenomic databases

eggNOGfuNOG08340.
GeneTreeEFGT00050000004559.
HOGENOMHBG497495.
OMAGEQIANT.
OrthoDBEOG4P5PJT.

Family and domain databases

InterProIPR004550. AsnASE_II.
IPR006034. Asparaginase/glutaminase.
[Graphical view]
KOK01424.
PANTHERPTHR11707. Asp/Glutamnse. 1 hit.
PfamPF00710. Asparaginase. 1 hit.
[Graphical view]
PIRSFPIRSF001220. L-ASNase_gatD. 1 hit.
PRINTSPR00139. ASNGLNASE.
SMARTSM00870. Asparaginase. 1 hit.
[Graphical view]
SUPFAMSSF53774. Asp/Glutamnse. 1 hit.
TIGRFAMsTIGR00520. AsnASE_II. 1 hit.
ProtoNetSearch...

Entry information

Entry nameASPG3_SCHPO
AccessionPrimary (citable) accession number: Q8NKC0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2002
Last modified: December 14, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

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