Reviewed, UniProtKB/Swiss-Prot Q8NJN3 (ACS2_CANAL)

Names and origin

Protein names

Recommended name:
    Acetyl-coenzyme A synthetase 2
    EC=6.2.1.1
Alternative name(s):
    Acetate--CoA ligase 2
    Acyl-activating enzyme 2

Gene names

Name:	ACS2
ORF Names:	CaO19.1064, CaO19.8666

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	671 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 671	671	Acetyl-coenzyme A synthetase 2		PRO_0000208406
Experimental info
	Sequence conflict	388	1	A → V in AAN01233. Ref.2
	Sequence conflict	576 – 581	6	VIAYVA → ALLTLP in AAN01233. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8NJN3-1 [UniParc]. Last modified March 3, 2009. Version 2. Checksum: 16FCB5DCC5922275	FASTA	671	73,862
	10 20 30 40 50 60 MPTEQTHNVV HEANGVKLRE TPKEFFERQP NKGHIHDVNQ YKQMYEQSIK DPQGFFGPLA 70 80 90 100 110 120 KELLSWDHDF HTVKSGTLKN GDAAWFLGGE LNASYNCVDR HAFANPDKPA LICEADDEKD 130 140 150 160 170 180 SHILTYGDLL REVSKVAGVL QSWGIKKGDT VAVYLPMNAQ AIIAMLAIAR LGAAHSVIFA 190 200 210 220 230 240 GFSAGSIKDR VNDASCKALI TCDEGKRGGR TTNIKKLCDE ALVDCPTVEK VLVYKRTNNP 250 260 270 280 290 300 EIHLTEGRDY YWDVETAKFP GYLPPVSVNS EDPLFLLYTS GSTGTPKGVV HSTAGYLLGA 310 320 330 340 350 360 ALSTKYIFDI HPEDILFTAG DVGWITGHTY ALYGPLLLGV PTIIFEGTPA YPDYGRFWQI 370 380 390 400 410 420 VEKHKATHFY VAPTALRLLR KAGEQEIAKY DLSSLRTLGS VGEPISPDIW EWYNEFVGKN 430 440 450 460 470 480 QCHISDTYWQ TESGSHLIAP LAGVVPNKPG SASYPFFGID AALIDPVTGV EIEGNDAEGV 490 500 510 520 530 540 LAIKDHWPSM ARTVYKNHTK YMDTYMNPYP GYYFTGDGAA RDHDGYYWIR GRVDDVVNVS 550 560 570 580 590 600 GHRLSTAEIE AALIEDKKVS EAAVVGIHDD ITGQAVIAYV ALKEGNSDED SEGLRKELVL 610 620 630 640 650 660 QVRKTIGPFA APKSVIIVQD LPKTRSGKIM RRILRKVSSN EADQLGDIST LSNPQSVEGI 670 ISAFGAQFGK K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.
[2]	"Acetyl-CoA synthetase 2 of Candida albicans." Jones P.M., Clarkson J.M., Wheals A.E. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-581.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000121 Genomic DNA. Translation: EAK94564.1. AACQ01000120 Genomic DNA. Translation: EAK94610.1. AF535132 Genomic DNA. Translation: AAN01233.1.
RefSeq	XP_713668.1. XP_713713.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3644652. 3644710.
KEGG	cal:CaO19.1064. cal:CaO19.8666.
Organism-specific databases
CGD	CAL0001207. ACS2.
Phylogenomic databases
OMA	KEFFERQ.
Enzyme and pathway databases
BRENDA	6.2.1.1. 1124.
Family and domain databases
InterPro	IPR011904. Ac_CoA_lig_AcsA. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACS2_CANAL

Accession

Primary (citable) accession number: Q8NJN3
Secondary accession number(s): Q59VM9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	March 3, 2009
Last modified:	November 3, 2009
This is version 29 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)