Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8NJ72 (ACEA_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate lyase

Short name=ICL
Short name=Isocitrase
Short name=Isocitratase
EC=4.1.3.1
Gene names
Name:ICL1
Ordered Locus Names:KLLA0C08107g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length542 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate = succinate + glyoxylate.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.

Subunit structure

Homotetramer By similarity.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentPeroxisome
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate lyase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 542542Isocitrate lyase
PRO_0000068791

Sites

Active site2081 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NJ72 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 0EDA831B7AC0AA90

FASTA54260,382
        10         20         30         40         50         60 
MVSVKASAAE KKEFLQSQID EIEKWWSEPR WKDTKRIYSA YEIAKRRGSV KPNTFPSTVM 

        70         80         90        100        110        120 
SQKLFKILGE HAKNGTVSKT FGALDPVQVT QMSKYLDTIY VSGWQCSSTA STSNEPGPDL 

       130        140        150        160        170        180 
ADYPMDTVPN KVEHLFKAQQ FHDRKQWERI CDGTIEESEI IDYLTPIVAD GDAGHGGLTA 

       190        200        210        220        230        240 
VFKLTKMFIE RGAAGIHIED QTSTNKKCGH MAGRCVIPVQ EHINRLITCR MAADVLGSDL 

       250        260        270        280        290        300 
ILVARTDSEA ATLLSSTADS RDHYFILGAS NPAVKGKPLN DLLNKAILDG ATIDDLQTIE 

       310        320        330        340        350        360 
KEWLAKADVK LFHEVFADAA KAAGKDQSVI DQFNSKVNPL SETSIYEMQA LAKELLGTEL 

       370        380        390        400        410        420 
FFDWDLPRGR EGLYRYQGGT QCSVMRARAF APYADLCWME SNYPDYEQAK EFAEGVTAKF 

       430        440        450        460        470        480 
PGKWMAYNLS PSFNWTKAMS VDEQETFIQR LGDLGYIWQF ITLAGLHTSG LAIEQFSKNF 

       490        500        510        520        530        540 
AKLGMKAYAQ DIQKKELDNG IDMVKHQKWS GAEYIDGLLR LAQGGLAATA AMGQGVTEDQ 


FK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY124768 Genomic DNA. Translation: AAM75421.1.
CR382123 Genomic DNA. Translation: CAH01411.1.
RefSeqXP_452560.1. XM_452560.1.

3D structure databases

ProteinModelPortalQ8NJ72.
SMRQ8NJ72. Positions 10-525.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2892560.
KEGGkla:KLLA0C08107g.

Phylogenomic databases

eggNOGCOG2224.
HOGENOMHOG000238475.
KOK01637.
OMACAINRAI.
OrthoDBEOG73Z331.

Enzyme and pathway databases

UniPathwayUPA00703; UER00719.

Family and domain databases

Gene3D3.20.20.60. 2 hits.
InterProIPR006254. Isocitrate_lyase.
IPR000918. Isocitrate_lyase/Pmutase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamPF00463. ICL. 1 hit.
[Graphical view]
PIRSFPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMSSF51621. SSF51621. 1 hit.
TIGRFAMsTIGR01346. isocit_lyase. 1 hit.
PROSITEPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACEA_KLULA
AccessionPrimary (citable) accession number: Q8NJ72
Secondary accession number(s): Q6CU29
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 1, 2002
Last modified: November 13, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways