Reviewed, UniProtKB/Swiss-Prot Q8NIL3 (AES1_SCHPO)

Names and origin

Protein names

Recommended name:
    Antisense-enhancing sequence 1
    EC=5.1.-.-
Alternative name(s):
    AES factor 1

Gene names

Name:	aes1
ORF Names:	SPBPB21E7.07

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	May have isomerase activity By similarity. Enhances target gene silencing when coexpressed with antisense RNA.
Sequence similarities	Belongs to the phzF family. UniProtKB P38765

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro chromatin silencing by small RNA Ref.1 Inferred from mutant phenotype. Source: UniProtKB
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_SPombe nucleus Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Antisense-enhancing sequence 1		PRO_0000162386
Sites
	Active site	47	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8NIL3-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 4642DFC53A7B9B91	FASTA	296	32,229
	10 20 30 40 50 60 MTEHSFKQID VFSNKGFRGN PVAVFFDADN LSQKEMQQIA KWTNLSETTF VQKPTIDKAD 70 80 90 100 110 120 YRLRIFTPEC ELSFAGHPTI GSCFAVVESG YCTPKNCKII QECLAGLVEL TIDGEKDEDT 130 140 150 160 170 180 WISFKLPYYK ILQTSETAIS EVENALGIPL NYSSQVSPPV LIDDGPKWLV IQLPNATDVL 190 200 210 220 230 240 NLVPKFQSLS QVCKNNDWIG VTVFGELGKD SFESRSFAPL IHVNEDPACG SGAGAVGVYI 250 260 270 280 290 GSSQKTPTSL SFTISQGTKL SRQAISKVSV DVSSNKSIAV FVGGQAKTCI SGKSFI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Dominant genetic screen for cofactors that enhance antisense RNA-mediated gene silencing in fission yeast." Raponi M., Arndt G.M. Nucleic Acids Res. 30:2546-2554(2002) [PubMed: 12034844] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329671 Genomic DNA. Translation: CAD31747.1.
RefSeq	NP_001018772.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8NIL3.
Genome annotation databases
GeneID	3361177.
GenomeReviews	Gene locus aes1 in contig CU329671_GR.
KEGG	spo:SPBPB21E7.07.
Organism-specific databases
GeneDB_Spombe	SPBPB21E7.07.
Phylogenomic databases
OMA	GARWIVA
OrthoDB	EOG9HB02P
Family and domain databases
InterPro	IPR003719. PhzC_PhzF. [Graphical view]
PANTHER	PTHR13774. PhzC_PhzF. 1 hit.
Pfam	PF02567. PhzC-PhzF. 1 hit. [Graphical view]
PIRSF	PIRSF016184. PhzC_PhzF. 1 hit.
TIGRFAMs	TIGR00654. PhzF_family. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AES1_SCHPO

Accession

Primary (citable) accession number: Q8NIL3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	October 1, 2002
Last modified:	November 24, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)