ID   ANGL6_HUMAN             Reviewed;         470 AA.
AC   Q8NI99; A5PKV7; Q9BZZ0;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   19-JAN-2010, entry version 58.
DE   RecName: Full=Angiopoietin-related protein 6;
DE   AltName: Full=Angiopoietin-like protein 6;
DE   AltName: Full=Angiopoietin-related growth factor;
DE   AltName: Full=Angiopoietin-related protein 5;
DE   Flags: Precursor;
GN   Name=ANGPTL6; Synonyms=AGF, ARP5; ORFNames=UNQ152/PRO178;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=22784673; PubMed=12871997; DOI=10.1073/pnas.1531901100;
RA   Oike Y., Yasunaga K., Ito Y., Matsumoto S., Maekawa H., Morisada T.,
RA   Arai F., Nakagata N., Takeya M., Masuho Y., Suda T.;
RT   "Angiopoietin-related growth factor (AGF) promotes epidermal
RT   proliferation, remodeling, and regeneration.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:9494-9499(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Samal B., Wu C., Dias P., Singh S.;
RT   "Molecular cloning of a novel angiopoietin-related protein.";
RL   Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Plasma;
RX   PubMed=16335952; DOI=10.1021/pr0502065;
RA   Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,
RA   Moore R.J., Smith R.D.;
RT   "Human plasma N-glycoproteome analysis by immunoaffinity subtraction,
RT   hydrazide chemistry, and mass spectrometry.";
RL   J. Proteome Res. 4:2070-2080(2005).
RN   [7]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-58 AND ASN-145, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Liver;
RX   PubMed=19159218; DOI=10.1021/pr8008012;
RA   Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT   "Glycoproteomics analysis of human liver tissue by combination of
RT   multiple enzyme digestion and hydrazide chemistry.";
RL   J. Proteome Res. 8:651-661(2009).
CC   -!- FUNCTION: May play a role in the wound healing process. May
CC       promote epidermal proliferation, remodeling and regeneration. May
CC       promote the chemotactic activity of endothelial cells and induce
CC       neovascularization. May counteract high-fat diet-induced obesity
CC       and related insulin resistance through increased energy
CC       expenditure.
CC   -!- SUBCELLULAR LOCATION: Secreted (Probable).
CC   -!- SIMILARITY: Contains 1 fibrinogen C-terminal domain.
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DR   EMBL; AB054064; BAB91248.1; -; mRNA.
DR   EMBL; AF230330; AAK06404.1; -; mRNA.
DR   EMBL; AY358276; AAQ88643.1; -; mRNA.
DR   EMBL; CH471106; EAW84071.1; -; Genomic_DNA.
DR   EMBL; BC142632; AAI42633.1; -; mRNA.
DR   IPI; IPI00289346; -.
DR   RefSeq; NP_114123.2; -.
DR   UniGene; Hs.712850; -.
DR   SMR; Q8NI99; 255-466.
DR   STRING; Q8NI99; -.
DR   PRIDE; Q8NI99; -.
DR   Ensembl; ENST00000253109; ENSP00000253109; ENSG00000130812; Homo sapiens.
DR   GeneID; 83854; -.
DR   KEGG; hsa:83854; -.
DR   UCSC; uc002mmx.1; human.
DR   CTD; 83854; -.
DR   GeneCards; GC19M010064; -.
DR   H-InvDB; HIX0039936; -.
DR   HGNC; HGNC:23140; ANGPTL6.
DR   MIM; 609336; gene.
DR   PharmGKB; PA134950669; -.
DR   eggNOG; maNOG17602; -.
DR   HOGENOM; HBG446224; -.
DR   HOVERGEN; Q8NI99; -.
DR   InParanoid; Q8NI99; -.
DR   OMA; RAHYDGF; -.
DR   OrthoDB; EOG944P5H; -.
DR   PhylomeDB; Q8NI99; -.
DR   NextBio; 72839; -.
DR   ArrayExpress; Q8NI99; -.
DR   Bgee; Q8NI99; -.
DR   CleanEx; HS_ANGPTL6; -.
DR   Genevestigator; Q8NI99; -.
DR   GermOnline; ENSG00000130812; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005102; F:receptor binding; IEA:InterPro.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C.
DR   InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR   InterPro; IPR020837; Fibrinogen_CS.
DR   Gene3D; G3DSA:3.90.215.10; Fibrinogen_a/b/g_C_1; 1.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   SMART; SM00186; FBG; 1.
DR   PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE   1: Evidence at protein level;
KW   Angiogenesis; Coiled coil; Complete proteome; Developmental protein;
KW   Differentiation; Disulfide bond; Glycoprotein; Secreted; Signal.
FT   SIGNAL        1     20       Potential.
FT   CHAIN        21    470       Angiopoietin-related protein 6.
FT                                /FTId=PRO_0000009128.
FT   DOMAIN      251    469       Fibrinogen C-terminal.
FT   COILED       59    116       Potential.
FT   CARBOHYD     58     58       N-linked (GlcNAc...).
FT   CARBOHYD    145    145       N-linked (GlcNAc...).
FT   DISULFID    260    287       By similarity.
FT   DISULFID    410    423       By similarity.
FT   CONFLICT     92     92       E -> K (in Ref. 2; AAK06404).
SQ   SEQUENCE   470 AA;  51694 MW;  FAD20B1B00965239 CRC64;
     MGKPWLRALQ LLLLLGASWA RAGAPRCTYT FVLPPQKFTG AVCWSGPAST RATPEAANAS
     ELAALRMRVG RHEELLRELQ RLAAADGAVA GEVRALRKES RGLSARLGQL RAQLQHEAGP
     GAGPGADLGA EPAAALALLG ERVLNASAEA QRAAARFHQL DVKFRELAQL VTQQSSLIAR
     LERLCPGGAG GQQQVLPPPP LVPVVPVRLV GSTSDTSRML DPAPEPQRDQ TQRQQEPMAS
     PMPAGHPAVP TKPVGPWQDC AEARQAGHEQ SGVYELRVGR HVVSVWCEQQ LEGGGWTVIQ
     RRQDGSVNFF TTWQHYKAGF GRPDGEYWLG LEPVYQLTSR GDHELLVLLE DWGGRGARAH
     YDGFSLEPES DHYRLRLGQY HGDAGDSLSW HNDKPFSTVD RDRDSYSGNC ALYQRGGWWY
     HACAHSNLNG VWHHGGHYRS RYQDGVYWAE FRGGAYSLRK AAMLIRPLKL
//