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Protein

Angiopoietin-related protein 6

Gene

ANGPTL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-related protein 6
Alternative name(s):
Angiopoietin-like protein 6
Angiopoietin-related growth factor
Angiopoietin-related protein 5
Gene namesi
Name:ANGPTL6
Synonyms:AGF, ARP5
ORF Names:UNQ152/PRO178
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23140. ANGPTL6.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950669.

Polymorphism and mutation databases

BioMutaiANGPTL6.
DMDMi66774050.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 470450Angiopoietin-related protein 6PRO_0000009128Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi58 – 581N-linked (GlcNAc...)1 Publication
Glycosylationi145 – 1451N-linked (GlcNAc...) (complex)3 Publications
Disulfide bondi260 ↔ 287PROSITE-ProRule annotation
Disulfide bondi410 ↔ 423PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8NI99.
PaxDbiQ8NI99.
PeptideAtlasiQ8NI99.
PRIDEiQ8NI99.

PTM databases

iPTMnetiQ8NI99.
PhosphoSiteiQ8NI99.

Expressioni

Gene expression databases

BgeeiQ8NI99.
CleanExiHS_ANGPTL6.
ExpressionAtlasiQ8NI99. baseline and differential.
GenevisibleiQ8NI99. HS.

Organism-specific databases

HPAiHPA041171.

Interactioni

Protein-protein interaction databases

BioGridi123770. 1 interaction.
STRINGi9606.ENSP00000253109.

Structurei

3D structure databases

ProteinModelPortaliQ8NI99.
SMRiQ8NI99. Positions 205-467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini251 – 469219Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili59 – 11658Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037129.
HOVERGENiHBG103336.
InParanoidiQ8NI99.
OMAiAVCWSGP.
PhylomeDBiQ8NI99.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NI99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKPWLRALQ LLLLLGASWA RAGAPRCTYT FVLPPQKFTG AVCWSGPAST
60 70 80 90 100
RATPEAANAS ELAALRMRVG RHEELLRELQ RLAAADGAVA GEVRALRKES
110 120 130 140 150
RGLSARLGQL RAQLQHEAGP GAGPGADLGA EPAAALALLG ERVLNASAEA
160 170 180 190 200
QRAAARFHQL DVKFRELAQL VTQQSSLIAR LERLCPGGAG GQQQVLPPPP
210 220 230 240 250
LVPVVPVRLV GSTSDTSRML DPAPEPQRDQ TQRQQEPMAS PMPAGHPAVP
260 270 280 290 300
TKPVGPWQDC AEARQAGHEQ SGVYELRVGR HVVSVWCEQQ LEGGGWTVIQ
310 320 330 340 350
RRQDGSVNFF TTWQHYKAGF GRPDGEYWLG LEPVYQLTSR GDHELLVLLE
360 370 380 390 400
DWGGRGARAH YDGFSLEPES DHYRLRLGQY HGDAGDSLSW HNDKPFSTVD
410 420 430 440 450
RDRDSYSGNC ALYQRGGWWY HACAHSNLNG VWHHGGHYRS RYQDGVYWAE
460 470
FRGGAYSLRK AAMLIRPLKL
Length:470
Mass (Da):51,694
Last modified:October 1, 2002 - v1
Checksum:iFAD20B1B00965239
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921E → K in AAK06404 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054064 mRNA. Translation: BAB91248.1.
AF230330 mRNA. Translation: AAK06404.1.
AY358276 mRNA. Translation: AAQ88643.1.
CH471106 Genomic DNA. Translation: EAW84071.1.
BC142632 mRNA. Translation: AAI42633.1.
CCDSiCCDS12224.1.
RefSeqiNP_001308340.1. NM_001321411.1.
NP_114123.2. NM_031917.2.
XP_011526649.1. XM_011528347.1.
XP_011526652.1. XM_011528350.1.
UniGeneiHs.712850.

Genome annotation databases

EnsembliENST00000253109; ENSP00000253109; ENSG00000130812.
ENST00000592641; ENSP00000467930; ENSG00000130812.
GeneIDi83854.
KEGGihsa:83854.
UCSCiuc002mmx.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054064 mRNA. Translation: BAB91248.1.
AF230330 mRNA. Translation: AAK06404.1.
AY358276 mRNA. Translation: AAQ88643.1.
CH471106 Genomic DNA. Translation: EAW84071.1.
BC142632 mRNA. Translation: AAI42633.1.
CCDSiCCDS12224.1.
RefSeqiNP_001308340.1. NM_001321411.1.
NP_114123.2. NM_031917.2.
XP_011526649.1. XM_011528347.1.
XP_011526652.1. XM_011528350.1.
UniGeneiHs.712850.

3D structure databases

ProteinModelPortaliQ8NI99.
SMRiQ8NI99. Positions 205-467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123770. 1 interaction.
STRINGi9606.ENSP00000253109.

PTM databases

iPTMnetiQ8NI99.
PhosphoSiteiQ8NI99.

Polymorphism and mutation databases

BioMutaiANGPTL6.
DMDMi66774050.

Proteomic databases

EPDiQ8NI99.
PaxDbiQ8NI99.
PeptideAtlasiQ8NI99.
PRIDEiQ8NI99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253109; ENSP00000253109; ENSG00000130812.
ENST00000592641; ENSP00000467930; ENSG00000130812.
GeneIDi83854.
KEGGihsa:83854.
UCSCiuc002mmx.3. human.

Organism-specific databases

CTDi83854.
GeneCardsiANGPTL6.
H-InvDBHIX0014733.
HGNCiHGNC:23140. ANGPTL6.
HPAiHPA041171.
MIMi609336. gene.
neXtProtiNX_Q8NI99.
PharmGKBiPA134950669.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037129.
HOVERGENiHBG103336.
InParanoidiQ8NI99.
OMAiAVCWSGP.
PhylomeDBiQ8NI99.

Miscellaneous databases

GenomeRNAii83854.
PROiQ8NI99.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NI99.
CleanExiHS_ANGPTL6.
ExpressionAtlasiQ8NI99. baseline and differential.
GenevisibleiQ8NI99. HS.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration."
    Oike Y., Yasunaga K., Ito Y., Matsumoto S., Maekawa H., Morisada T., Arai F., Nakagata N., Takeya M., Masuho Y., Suda T.
    Proc. Natl. Acad. Sci. U.S.A. 100:9494-9499(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of a novel angiopoietin-related protein."
    Samal B., Wu C., Dias P., Singh S.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145.
    Tissue: Plasma.
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-58 AND ASN-145.
    Tissue: Liver.
  8. Cited for: GLYCOSYLATION AT ASN-145.

Entry informationi

Entry nameiANGL6_HUMAN
AccessioniPrimary (citable) accession number: Q8NI99
Secondary accession number(s): A5PKV7, Q9BZZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.