Reviewed, UniProtKB/Swiss-Prot Q8NI99 (ANGL6_HUMAN)

Names and origin

Protein names

Recommended name:
    Angiopoietin-related protein 6
Alternative name(s):
    Angiopoietin-like 6
    Angiopoietin-related growth factor
    Angiopoietin-related protein 5

Gene names

Name:	ANGPTL6
Synonyms:	AGF, ARP5
ORF Names:	UNQ152/PRO178

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.
Subcellular location	Secreted Probable.
Sequence similarities	Contains 1 fibrinogen C-terminal domain.

Ontologies

Keywords
Biological process	Angiogenesis Differentiation
Cellular component	Secreted
Domain	Coiled coil Signal
Molecular function	Developmental protein
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	angiogenesis Inferred from electronic annotation. Source: UniProtKB-KW cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 470	450	Angiopoietin-related protein 6		PRO_0000009128
Regions
	Domain	251 – 469	219	Fibrinogen C-terminal
	Coiled coil	59 – 116	58	Potential
Amino acid modifications
	Glycosylation	58	1	N-linked (GlcNAc...)
	Glycosylation	145	1	N-linked (GlcNAc...) Ref.4
	Disulfide bond	260 ↔ 287		By similarity
	Disulfide bond	410 ↔ 423		By similarity
Experimental info
	Sequence conflict	92	1	E → K in AAK06404. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8NI99-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: FAD20B1B00965239	FASTA	470	51,694
	10 20 30 40 50 60 MGKPWLRALQ LLLLLGASWA RAGAPRCTYT FVLPPQKFTG AVCWSGPAST RATPEAANAS 70 80 90 100 110 120 ELAALRMRVG RHEELLRELQ RLAAADGAVA GEVRALRKES RGLSARLGQL RAQLQHEAGP 130 140 150 160 170 180 GAGPGADLGA EPAAALALLG ERVLNASAEA QRAAARFHQL DVKFRELAQL VTQQSSLIAR 190 200 210 220 230 240 LERLCPGGAG GQQQVLPPPP LVPVVPVRLV GSTSDTSRML DPAPEPQRDQ TQRQQEPMAS 250 260 270 280 290 300 PMPAGHPAVP TKPVGPWQDC AEARQAGHEQ SGVYELRVGR HVVSVWCEQQ LEGGGWTVIQ 310 320 330 340 350 360 RRQDGSVNFF TTWQHYKAGF GRPDGEYWLG LEPVYQLTSR GDHELLVLLE DWGGRGARAH 370 380 390 400 410 420 YDGFSLEPES DHYRLRLGQY HGDAGDSLSW HNDKPFSTVD RDRDSYSGNC ALYQRGGWWY 430 440 450 460 470 HACAHSNLNG VWHHGGHYRS RYQDGVYWAE FRGGAYSLRK AAMLIRPLKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration." Oike Y., Yasunaga K., Ito Y., Matsumoto S., Maekawa H., Morisada T., Arai F., Nakagata N., Takeya M., Masuho Y., Suda T. Proc. Natl. Acad. Sci. U.S.A. 100:9494-9499(2003) [PubMed: 12871997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning of a novel angiopoietin-related protein." Samal B., Wu C., Dias P., Singh S. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145, MASS SPECTROMETRY. Tissue: Plasma.
[5]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-58 AND ASN-145, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB054064 mRNA. Translation: BAB91248.1. AF230330 mRNA. Translation: AAK06404.1. AY358276 mRNA. Translation: AAQ88643.1.
IPI	IPI00289346.
RefSeq	NP_114123.2.
UniGene	Hs.712850
3D structure databases
HSSP	HSSP built from PDB template 1FZD based on UniProtKB P02671.
ModBase	Search...
Proteomic databases
PRIDE	Q8NI99.
Genome annotation databases
Ensembl	ENSG00000130812. Homo sapiens. [Contig view]
GeneID	83854.
KEGG	hsa:83854.
Organism-specific databases
GeneCards	GC19M010064.
H-InvDB	HIX0039936.
HGNC	HGNC:23140. ANGPTL6.
MIM	609336. gene.
PharmGKB	PA134950669.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8NI99.
HOVERGEN	Q8NI99.
OMA	Q8NI99. RAHYDGF.
Gene expression databases
Bgee	Q8NI99.
CleanEx	HS_ANGPTL6.
GermOnline	ENSG00000130812. Homo sapiens.
Family and domain databases
InterPro	IPR002181. Fibrinogen_a/b/g_C. IPR014716. Fibrinogen_a/b/g_C_1. [Graphical view]
Gene3D	G3DSA:3.90.215.10. Fibrinogen_a/b/g_C_1. 1 hit.
Pfam	PF00147. Fibrinogen_C. 1 hit. [Graphical view]
SMART	SM00186. FBG. 1 hit. [Graphical view]
PROSITE	PS00514. FIBRINOGEN_C_1. 1 hit. PS51406. FIBRINOGEN_C_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	72839.
SOURCE	Search...

Entry information

Entry name

ANGL6_HUMAN

Accession

Primary (citable) accession number: Q8NI99
Secondary accession number(s): Q9BZZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)