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Protein

Kinesin-like protein KIF18A

Gene

KIF18A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi113 – 120ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: UniProtKB
  • microtubule binding Source: UniProtKB
  • microtubule plus-end binding Source: UniProtKB
  • tubulin-dependent ATPase activity Source: UniProtKB
  • ubiquitin binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121621-MONOMER.
BRENDAi3.6.4.4. 2681.
ReactomeiR-HSA-2132295. MHC class II antigen presentation.
R-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.
R-HSA-5663220. RHO GTPases Activate Formins.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-68877. Mitotic Prometaphase.
R-HSA-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF18A
Alternative name(s):
Marrow stromal KIF18A
Short name:
MS-KIF18A
Gene namesi
Name:KIF18A
ORF Names:OK/SW-cl.108
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:29441. KIF18A.

Subcellular locationi

GO - Cellular componenti

  • caveola Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • kinesin complex Source: GO_Central
  • kinetochore Source: Ensembl
  • kinetochore microtubule Source: UniProtKB
  • microtubule cytoskeleton Source: LIFEdb
  • microtubule organizing center Source: UniProtKB-SubCell
  • mitotic spindle midzone Source: Ensembl
  • nucleus Source: UniProtKB
  • ruffle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi81930.
OpenTargetsiENSG00000121621.
PharmGKBiPA134951326.

Polymorphism and mutation databases

BioMutaiKIF18A.
DMDMi66774137.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254581 – 898Kinesin-like protein KIF18AAdd BLAST898

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei674PhosphoserineCombined sources1
Modified residuei695PhosphoserineCombined sources1
Modified residuei838PhosphoserineCombined sources1

Post-translational modificationi

Glycosylated.1 Publication
Ubiquitinated.1 Publication

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8NI77.
MaxQBiQ8NI77.
PaxDbiQ8NI77.
PeptideAtlasiQ8NI77.
PRIDEiQ8NI77.

PTM databases

iPTMnetiQ8NI77.
PhosphoSitePlusiQ8NI77.

Expressioni

Inductioni

By estrogen.1 Publication

Gene expression databases

BgeeiENSG00000121621.
CleanExiHS_KIF18A.
GenevisibleiQ8NI77. HS.

Organism-specific databases

HPAiHPA039312.
HPA039484.

Interactioni

Subunit structurei

Interacts with CENPE and ESR1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ANAPC4Q9UJX52EBI-355426,EBI-2554854

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • microtubule binding Source: UniProtKB
  • microtubule plus-end binding Source: UniProtKB
  • ubiquitin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123630. 30 interactors.
IntActiQ8NI77. 27 interactors.
MINTiMINT-1199710.
STRINGi9606.ENSP00000263181.

Structurei

Secondary structure

1898
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 18Combined sources6
Helixi23 – 27Combined sources5
Beta strandi32 – 36Combined sources5
Beta strandi38 – 44Combined sources7
Beta strandi72 – 75Combined sources4
Beta strandi77 – 80Combined sources4
Helixi86 – 91Combined sources6
Helixi94 – 101Combined sources8
Turni102 – 104Combined sources3
Beta strandi107 – 112Combined sources6
Helixi119 – 123Combined sources5
Beta strandi127 – 130Combined sources4
Helixi132 – 146Combined sources15
Turni147 – 150Combined sources4
Beta strandi151 – 163Combined sources13
Beta strandi166 – 172Combined sources7
Beta strandi177 – 181Combined sources5
Beta strandi187 – 190Combined sources4
Helixi200 – 212Combined sources13
Beta strandi229 – 240Combined sources12
Beta strandi252 – 258Combined sources7
Helixi283 – 295Combined sources13
Helixi307 – 309Combined sources3
Helixi311 – 315Combined sources5
Turni316 – 319Combined sources4
Beta strandi324 – 332Combined sources9
Helixi336 – 338Combined sources3
Helixi339 – 351Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LREX-ray2.20A/B1-355[»]
ProteinModelPortaliQ8NI77.
SMRiQ8NI77.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NI77.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 355Kinesin motorPROSITE-ProRule annotationAdd BLAST345

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili368 – 453Sequence analysisAdd BLAST86

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0242. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00860000133670.
HOGENOMiHOG000231436.
HOVERGENiHBG052245.
InParanoidiQ8NI77.
KOiK10401.
OMAiCRKAFQN.
OrthoDBiEOG091G0438.
PhylomeDBiQ8NI77.
TreeFamiTF105231.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NI77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVTEEDLCH HMKVVVRVRP ENTKEKAAGF HKVVHVVDKH ILVFDPKQEE
60 70 80 90 100
VSFFHGKKTT NQNVIKKQNK DLKFVFDAVF DETSTQSEVF EHTTKPILRS
110 120 130 140 150
FLNGYNCTVL AYGATGAGKT HTMLGSADEP GVMYLTMLHL YKCMDEIKEE
160 170 180 190 200
KICSTAVSYL EVYNEQIRDL LVNSGPLAVR EDTQKGVVVH GLTLHQPKSS
210 220 230 240 250
EEILHLLDNG NKNRTQHPTD MNATSSRSHA VFQIYLRQQD KTASINQNVR
260 270 280 290 300
IAKMSLIDLA GSERASTSGA KGTRFVEGTN INRSLLALGN VINALADSKR
310 320 330 340 350
KNQHIPYRNS KLTRLLKDSL GGNCQTIMIA AVSPSSVFYD DTYNTLKYAN
360 370 380 390 400
RAKDIKSSLK SNVLNVNNHI TQYVKICNEQ KAEILLLKEK LKAYEEQKAF
410 420 430 440 450
TNENDQAKLM ISNPQEKEIE RFQEILNCLF QNREEIRQEY LKLEMLLKEN
460 470 480 490 500
ELKSFYQQQC HKQIEMMCSE DKVEKATGKR DHRLAMLKTR RSYLEKRREE
510 520 530 540 550
ELKQFDENTN WLHRVEKEMG LLSQNGHIPK ELKKDLHCHH LHLQNKDLKA
560 570 580 590 600
QIRHMMDLAC LQEQQHRQTE AVLNALLPTL RKQYCTLKEA GLSNAAFESD
610 620 630 640 650
FKEIEHLVER KKVVVWADQT AEQPKQNDLP GISVLMTFPQ LGPVQPIPCC
660 670 680 690 700
SSSGGTNLVK IPTEKRTRRK LMPSPLKGQH TLKSPPSQSV QLNDSLSKEL
710 720 730 740 750
QPIVYTPEDC RKAFQNPSTV TLMKPSSFTT SFQAISSNIN SDNCLKMLCE
760 770 780 790 800
VAIPHNRRKE CGQEDLDSTF TICEDIKSSK CKLPEQESLP NDNKDILQRL
810 820 830 840 850
DPSSFSTKHS MPVPSMVPSY MAMTTAAKRK RKLTSSTSNS SLTADVNSGF
860 870 880 890
AKRVRQDNSS EKHLQENKPT MEHKRNICKI NPSMVRKFGR NISKGNLR
Length:898
Mass (Da):102,281
Last modified:May 10, 2005 - v2
Checksum:i6DFD904378BF9B27
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti621A → G in BAB93508 (Ref. 2) Curated1
Sequence conflicti639P → S in BAB93508 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049701273T → A.Corresponds to variant rs12272419dbSNPEnsembl.1
Natural variantiVAR_049702334P → S.Corresponds to variant rs34913484dbSNPEnsembl.1
Natural variantiVAR_038354735I → V.2 PublicationsCorresponds to variant rs10458896dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY791349 mRNA. Translation: AAX16185.1.
AB062483 mRNA. Translation: BAB93508.1.
AL136819 mRNA. Translation: CAB66753.1.
BC048347 mRNA. Translation: AAH48347.1.
CCDSiCCDS7867.1.
RefSeqiNP_112494.3. NM_031217.3.
XP_016873868.1. XM_017018379.1.
UniGeneiHs.301052.

Genome annotation databases

EnsembliENST00000263181; ENSP00000263181; ENSG00000121621.
GeneIDi81930.
KEGGihsa:81930.
UCSCiuc001msc.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY791349 mRNA. Translation: AAX16185.1.
AB062483 mRNA. Translation: BAB93508.1.
AL136819 mRNA. Translation: CAB66753.1.
BC048347 mRNA. Translation: AAH48347.1.
CCDSiCCDS7867.1.
RefSeqiNP_112494.3. NM_031217.3.
XP_016873868.1. XM_017018379.1.
UniGeneiHs.301052.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LREX-ray2.20A/B1-355[»]
ProteinModelPortaliQ8NI77.
SMRiQ8NI77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123630. 30 interactors.
IntActiQ8NI77. 27 interactors.
MINTiMINT-1199710.
STRINGi9606.ENSP00000263181.

PTM databases

iPTMnetiQ8NI77.
PhosphoSitePlusiQ8NI77.

Polymorphism and mutation databases

BioMutaiKIF18A.
DMDMi66774137.

Proteomic databases

EPDiQ8NI77.
MaxQBiQ8NI77.
PaxDbiQ8NI77.
PeptideAtlasiQ8NI77.
PRIDEiQ8NI77.

Protocols and materials databases

DNASUi81930.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263181; ENSP00000263181; ENSG00000121621.
GeneIDi81930.
KEGGihsa:81930.
UCSCiuc001msc.3. human.

Organism-specific databases

CTDi81930.
DisGeNETi81930.
GeneCardsiKIF18A.
HGNCiHGNC:29441. KIF18A.
HPAiHPA039312.
HPA039484.
MIMi611271. gene.
neXtProtiNX_Q8NI77.
OpenTargetsiENSG00000121621.
PharmGKBiPA134951326.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0242. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00860000133670.
HOGENOMiHOG000231436.
HOVERGENiHBG052245.
InParanoidiQ8NI77.
KOiK10401.
OMAiCRKAFQN.
OrthoDBiEOG091G0438.
PhylomeDBiQ8NI77.
TreeFamiTF105231.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121621-MONOMER.
BRENDAi3.6.4.4. 2681.
ReactomeiR-HSA-2132295. MHC class II antigen presentation.
R-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.
R-HSA-5663220. RHO GTPases Activate Formins.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-68877. Mitotic Prometaphase.
R-HSA-983189. Kinesins.

Miscellaneous databases

EvolutionaryTraceiQ8NI77.
GeneWikiiKIF18A.
GenomeRNAii81930.
PROiQ8NI77.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121621.
CleanExiHS_KIF18A.
GenevisibleiQ8NI77. HS.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKI18A_HUMAN
AccessioniPrimary (citable) accession number: Q8NI77
Secondary accession number(s): Q4VPE3, Q86VS5, Q9H0F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 30, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.