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Q8NI77

- KI18A_HUMAN

UniProt

Q8NI77 - KI18A_HUMAN

Protein

Kinesin-like protein KIF18A

Gene

KIF18A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (10 May 2005)
      Previous versions | rss
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    Functioni

    Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.4 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi113 – 1208ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. ATP binding Source: UniProtKB-KW
    3. microtubule binding Source: UniProtKB
    4. microtubule plus-end binding Source: UniProtKB
    5. plus-end-directed microtubule motor activity Source: UniProtKB
    6. protein binding Source: UniProtKB
    7. tubulin-dependent ATPase activity Source: UniProtKB
    8. ubiquitin binding Source: UniProtKB

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    2. ATP catabolic process Source: GOC
    3. blood coagulation Source: Reactome
    4. metabolic process Source: GOC
    5. microtubule-based movement Source: Reactome
    6. microtubule depolymerization Source: UniProtKB
    7. mitotic cell cycle Source: Reactome
    8. mitotic metaphase plate congression Source: UniProtKB
    9. protein transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Motor protein

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_121399. MHC class II antigen presentation.
    REACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_25201. Kinesins.
    REACT_682. Mitotic Prometaphase.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIF18A
    Alternative name(s):
    Marrow stromal KIF18A
    Short name:
    MS-KIF18A
    Gene namesi
    Name:KIF18A
    ORF Names:OK/SW-cl.108
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:29441. KIF18A.

    Subcellular locationi

    GO - Cellular componenti

    1. caveola Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. cytosol Source: Reactome
    4. kinesin complex Source: InterPro
    5. kinetochore microtubule Source: UniProtKB
    6. microtubule cytoskeleton Source: LIFEdb
    7. microtubule organizing center Source: UniProtKB-SubCell
    8. nucleus Source: UniProtKB
    9. ruffle Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134951326.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 898898Kinesin-like protein KIF18APRO_0000125458Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei674 – 6741Phosphoserine2 Publications

    Post-translational modificationi

    Glycosylated.1 Publication
    Ubiquitinated.1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ8NI77.
    PaxDbiQ8NI77.
    PRIDEiQ8NI77.

    PTM databases

    PhosphoSiteiQ8NI77.

    Expressioni

    Inductioni

    By estrogen.1 Publication

    Gene expression databases

    BgeeiQ8NI77.
    CleanExiHS_KIF18A.
    GenevestigatoriQ8NI77.

    Organism-specific databases

    HPAiHPA039312.
    HPA039484.

    Interactioni

    Subunit structurei

    Interacts with CENPE and ESR1.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ANAPC4Q9UJX52EBI-355426,EBI-2554854

    Protein-protein interaction databases

    BioGridi123630. 4 interactions.
    IntActiQ8NI77. 3 interactions.
    MINTiMINT-1199710.
    STRINGi9606.ENSP00000263181.

    Structurei

    Secondary structure

    1
    898
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi13 – 186
    Helixi23 – 275
    Beta strandi32 – 365
    Beta strandi38 – 447
    Beta strandi72 – 754
    Beta strandi77 – 804
    Helixi86 – 916
    Helixi94 – 1018
    Turni102 – 1043
    Beta strandi107 – 1126
    Helixi119 – 1235
    Beta strandi127 – 1304
    Helixi132 – 14615
    Turni147 – 1504
    Beta strandi151 – 16313
    Beta strandi166 – 1727
    Beta strandi177 – 1815
    Beta strandi187 – 1904
    Helixi200 – 21213
    Beta strandi229 – 24012
    Beta strandi252 – 2587
    Helixi283 – 29513
    Helixi307 – 3093
    Helixi311 – 3155
    Turni316 – 3194
    Beta strandi324 – 3329
    Helixi336 – 3383
    Helixi339 – 35113

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3LREX-ray2.20A/B1-355[»]
    ProteinModelPortaliQ8NI77.
    SMRiQ8NI77. Positions 10-384.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8NI77.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 355345Kinesin motorPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili368 – 45386Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5059.
    HOGENOMiHOG000231436.
    HOVERGENiHBG052245.
    InParanoidiQ8NI77.
    KOiK10401.
    OMAiWLHRVEN.
    OrthoDBiEOG7Z95KM.
    PhylomeDBiQ8NI77.
    TreeFamiTF105231.

    Family and domain databases

    Gene3Di3.40.850.10. 1 hit.
    InterProiIPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF00225. Kinesin. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NI77-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVTEEDLCH HMKVVVRVRP ENTKEKAAGF HKVVHVVDKH ILVFDPKQEE    50
    VSFFHGKKTT NQNVIKKQNK DLKFVFDAVF DETSTQSEVF EHTTKPILRS 100
    FLNGYNCTVL AYGATGAGKT HTMLGSADEP GVMYLTMLHL YKCMDEIKEE 150
    KICSTAVSYL EVYNEQIRDL LVNSGPLAVR EDTQKGVVVH GLTLHQPKSS 200
    EEILHLLDNG NKNRTQHPTD MNATSSRSHA VFQIYLRQQD KTASINQNVR 250
    IAKMSLIDLA GSERASTSGA KGTRFVEGTN INRSLLALGN VINALADSKR 300
    KNQHIPYRNS KLTRLLKDSL GGNCQTIMIA AVSPSSVFYD DTYNTLKYAN 350
    RAKDIKSSLK SNVLNVNNHI TQYVKICNEQ KAEILLLKEK LKAYEEQKAF 400
    TNENDQAKLM ISNPQEKEIE RFQEILNCLF QNREEIRQEY LKLEMLLKEN 450
    ELKSFYQQQC HKQIEMMCSE DKVEKATGKR DHRLAMLKTR RSYLEKRREE 500
    ELKQFDENTN WLHRVEKEMG LLSQNGHIPK ELKKDLHCHH LHLQNKDLKA 550
    QIRHMMDLAC LQEQQHRQTE AVLNALLPTL RKQYCTLKEA GLSNAAFESD 600
    FKEIEHLVER KKVVVWADQT AEQPKQNDLP GISVLMTFPQ LGPVQPIPCC 650
    SSSGGTNLVK IPTEKRTRRK LMPSPLKGQH TLKSPPSQSV QLNDSLSKEL 700
    QPIVYTPEDC RKAFQNPSTV TLMKPSSFTT SFQAISSNIN SDNCLKMLCE 750
    VAIPHNRRKE CGQEDLDSTF TICEDIKSSK CKLPEQESLP NDNKDILQRL 800
    DPSSFSTKHS MPVPSMVPSY MAMTTAAKRK RKLTSSTSNS SLTADVNSGF 850
    AKRVRQDNSS EKHLQENKPT MEHKRNICKI NPSMVRKFGR NISKGNLR 898
    Length:898
    Mass (Da):102,281
    Last modified:May 10, 2005 - v2
    Checksum:i6DFD904378BF9B27
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti621 – 6211A → G in BAB93508. 1 PublicationCurated
    Sequence conflicti639 – 6391P → S in BAB93508. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti273 – 2731T → A.
    Corresponds to variant rs12272419 [ dbSNP | Ensembl ].
    VAR_049701
    Natural varianti334 – 3341P → S.
    Corresponds to variant rs34913484 [ dbSNP | Ensembl ].
    VAR_049702
    Natural varianti735 – 7351I → V.2 Publications
    Corresponds to variant rs10458896 [ dbSNP | Ensembl ].
    VAR_038354

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY791349 mRNA. Translation: AAX16185.1.
    AB062483 mRNA. Translation: BAB93508.1.
    AL136819 mRNA. Translation: CAB66753.1.
    BC048347 mRNA. Translation: AAH48347.1.
    CCDSiCCDS7867.1.
    RefSeqiNP_112494.3. NM_031217.3.
    UniGeneiHs.301052.

    Genome annotation databases

    EnsembliENST00000263181; ENSP00000263181; ENSG00000121621.
    GeneIDi81930.
    KEGGihsa:81930.
    UCSCiuc001msc.2. human.

    Polymorphism databases

    DMDMi66774137.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY791349 mRNA. Translation: AAX16185.1 .
    AB062483 mRNA. Translation: BAB93508.1 .
    AL136819 mRNA. Translation: CAB66753.1 .
    BC048347 mRNA. Translation: AAH48347.1 .
    CCDSi CCDS7867.1.
    RefSeqi NP_112494.3. NM_031217.3.
    UniGenei Hs.301052.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3LRE X-ray 2.20 A/B 1-355 [» ]
    ProteinModelPortali Q8NI77.
    SMRi Q8NI77. Positions 10-384.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123630. 4 interactions.
    IntActi Q8NI77. 3 interactions.
    MINTi MINT-1199710.
    STRINGi 9606.ENSP00000263181.

    PTM databases

    PhosphoSitei Q8NI77.

    Polymorphism databases

    DMDMi 66774137.

    Proteomic databases

    MaxQBi Q8NI77.
    PaxDbi Q8NI77.
    PRIDEi Q8NI77.

    Protocols and materials databases

    DNASUi 81930.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263181 ; ENSP00000263181 ; ENSG00000121621 .
    GeneIDi 81930.
    KEGGi hsa:81930.
    UCSCi uc001msc.2. human.

    Organism-specific databases

    CTDi 81930.
    GeneCardsi GC11M028042.
    HGNCi HGNC:29441. KIF18A.
    HPAi HPA039312.
    HPA039484.
    MIMi 611271. gene.
    neXtProti NX_Q8NI77.
    PharmGKBi PA134951326.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5059.
    HOGENOMi HOG000231436.
    HOVERGENi HBG052245.
    InParanoidi Q8NI77.
    KOi K10401.
    OMAi WLHRVEN.
    OrthoDBi EOG7Z95KM.
    PhylomeDBi Q8NI77.
    TreeFami TF105231.

    Enzyme and pathway databases

    Reactomei REACT_121399. MHC class II antigen presentation.
    REACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_25201. Kinesins.
    REACT_682. Mitotic Prometaphase.

    Miscellaneous databases

    EvolutionaryTracei Q8NI77.
    GeneWikii KIF18A.
    GenomeRNAii 81930.
    NextBioi 72271.
    PROi Q8NI77.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8NI77.
    CleanExi HS_KIF18A.
    Genevestigatori Q8NI77.

    Family and domain databases

    Gene3Di 3.40.850.10. 1 hit.
    InterProi IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF00225. Kinesin. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MS-KIF18A, new kinesin; structure and cellular expression."
      Luboshits G., Benayahu D.
      Gene 351:19-28(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-735, SUBCELLULAR LOCATION.
      Tissue: Bone marrow stroma.
    2. "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
      Shichijo S., Itoh K.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon adenocarcinoma.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-735.
      Tissue: Testis.
    5. "The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression."
      Mayr M.I., Huemmer S., Bormann J., Gruener T., Adio S., Woehlke G., Mayer T.U.
      Curr. Biol. 17:488-498(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "MS-KIF18A, a kinesin, is associated with estrogen receptor."
      Luboshits G., Benayahu D.
      J. Cell. Biochem. 100:693-702(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH ESR1.
    7. "The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment."
      Stumpff J., von Dassow G., Wagenbach M., Asbury C., Wordeman L.
      Dev. Cell 14:252-262(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "New insights on cellular distribution, microtubule interactions and post-translational modifications of MS-KIF18A."
      Zusev M., Benayahu D.
      J. Cell. Physiol. 217:618-625(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, ASSOCIATION WITH MICROTUBULES, PHOSPHORYLATION, GLYCOSYLATION, UBIQUITINATION.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-674, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Kinesin-8 molecular motors: putting the brakes on chromosome oscillations."
      Gardner M.K., Odde D.J., Bloom K.
      Trends Cell Biol. 18:307-310(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E."
      Huang Y., Yao Y., Xu H.-Z., Wang Z.-G., Lu L., Dai W.
      Cell Cycle 8:2643-2649(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CENPE.
    12. "The regulation of MS-KIF18A expression and cross talk with estrogen receptor."
      Zusev M., Benayahu D.
      PLoS ONE 4:E6407-E6407(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, INTERACTION WITH ESR1.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiKI18A_HUMAN
    AccessioniPrimary (citable) accession number: Q8NI77
    Secondary accession number(s): Q4VPE3, Q86VS5, Q9H0F3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3