Q8NI60 (ADCK3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chaperone activity of bc1 complex-like, mitochondrial
Short name=Chaperone-ABC1-like
EC=2.7.11.-

Alternative name(s):
aarF domain-containing protein kinase 3

Gene names

Name:	ADCK3
Synonyms:	CABC1
ORF Names:	PP265

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	647 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain.
Subcellular location	Mitochondrion Ref.1.
Tissue specificity	Ubiquitously expressed with a relatively greater abundance in heart and skeletal muscle.
Induction	By p53/TP53.
Involvement in disease	Coenzyme Q10 deficiency, primary, 4 (COQ10D4) [MIM:612016]: An autosomal recessive disorder characterized by childhood-onset of cerebellar ataxia and exercise intolerance. Patient manifest gait ataxia and cerebellar atrophy with slow progression. Additional features include brisk tendon reflexes and Hoffmann sign, variable psychomotor retardation and variable seizures. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10 Ref.11
Sequence similarities	Belongs to the protein kinase superfamily. ADCK protein kinase family. Contains 1 protein kinase domain.
Caution	It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Neurodegeneration
Domain	Transit peptide
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell death Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NI60-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NI60-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-484: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8NI60-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8NI60-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-279: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 647		Chaperone activity of bc1 complex-like, mitochondrial		PRO_0000000262
Regions
	Domain	329 – 518	190	Protein kinase
Natural variations
	Alternative sequence	1 – 484	484	Missing in isoform 2.		VSP_022351
	Alternative sequence	1 – 279	279	Missing in isoform 4.		VSP_022352
	Alternative sequence	1 – 52	52	Missing in isoform 3.		VSP_022353
	Natural variant	85	1	H → Q. Corresponds to variant rs2297411 [ dbSNP | Ensembl ].		VAR_020319
	Natural variant	213	1	R → W in COQ10D4. Ref.10		VAR_044402
	Natural variant	272	1	G → D in COQ10D4. Ref.10		VAR_044403
	Natural variant	272	1	G → V in COQ10D4. Ref.10		VAR_044404
	Natural variant	341	1	I → T. Ref.9 Corresponds to variant rs55798516 [ dbSNP | Ensembl ].		VAR_045576
	Natural variant	514	1	Y → C in COQ10D4. Ref.11		VAR_044405
	Natural variant	549	1	G → S in COQ10D4. Ref.11		VAR_044406
	Natural variant	551	1	E → K in COQ10D4. Ref.10		VAR_044407
	Natural variant	584	1	Missing in COQ10D4. Ref.11		VAR_044408
Experimental info
	Sequence conflict	283 – 284	2	IQ → VR in BAC11143. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: DEF8F022027BF6CC	FASTA	647	71,950
	10 20 30 40 50 60 MAAILGDTIM VAKGLVKLTQ AAVETHLQHL GIGGELIMAA RALQSTAVEQ IGMFLGKVQG 70 80 90 100 110 120 QDKHEEYFAE NFGGPEGEFH FSVPHAAGAS TDFSSASAPD QSAPPSLGHA HSEGPAPAYV 130 140 150 160 170 180 ASGPFREAGF PGQASSPLGR ANGRLFANPR DSFSAMGFQR RFFHQDQSPV GGLTAEDIEK 190 200 210 220 230 240 ARQAKARPEN KQHKQTLSEH ARERKVPVTR IGRLANFGGL AVGLGFGALA EVAKKSLRSE 250 260 270 280 290 300 DPSGKKAVLG SSPFLSEANA ERIVRTLCKV RGAALKLGQM LSIQDDAFIN PHLAKIFERV 310 320 330 340 350 360 RQSADFMPLK QMMKTLNNDL GPNWRDKLEY FEERPFAAAS IGQVHLARMK GGREVAMKIQ 370 380 390 400 410 420 YPGVAQSINS DVNNLMAVLN MSNMLPEGLF PEHLIDVLRR ELALECDYQR EAACARKFRD 430 440 450 460 470 480 LLKGHPFFYV PEIVDELCSP HVLTTELVSG FPLDQAEGLS QEIRNEICYN ILVLCLRELF 490 500 510 520 530 540 EFHFMQTDPN WSNFFYDPQQ HKVALLDFGA TREYDRSFTD LYIQIIRAAA DRDRETVRAK 550 560 570 580 590 600 SIEMKFLTGY EVKVMEDAHL DAILILGEAF ASDEPFDFGT QSTTEKIHNL IPVMLRHRLV 610 620 630 640 PPPEETYSLH RKMGGSFLIC SKLKARFPCK AMFEEAYSNY CKRQAQQ
	Isoform 2 [UniParc]. Checksum: A309AB9DDBE67C56	FASTA	163	18,937
	10 20 30 40 50 60 MQTDPNWSNF FYDPQQHKVA LLDFGATREY DRSFTDLYIQ IIRAAADRDR ETVRAKSIEM 70 80 90 100 110 120 KFLTGYEVKV MEDAHLDAIL ILGEAFASDE PFDFGTQSTT EKIHNLIPVM LRHRLVPPPE 130 140 150 160 ETYSLHRKMG GSFLICSKLK ARFPCKAMFE EAYSNYCKRQ AQQ
	Isoform 3 [UniParc]. Checksum: 83F12FA56BCB190E	FASTA	595	66,627
	10 20 30 40 50 60 MFLGKVQGQD KHEEYFAENF GGPEGEFHFS VPHAAGASTD FSSASAPDQS APPSLGHAHS 70 80 90 100 110 120 EGPAPAYVAS GPFREAGFPG QASSPLGRAN GRLFANPRDS FSAMGFQRRF FHQDQSPVGG 130 140 150 160 170 180 LTAEDIEKAR QAKARPENKQ HKQTLSEHAR ERKVPVTRIG RLANFGGLAV GLGFGALAEV 190 200 210 220 230 240 AKKSLRSEDP SGKKAVLGSS PFLSEANAER IVRTLCKVRG AALKLGQMLS IQDDAFINPH 250 260 270 280 290 300 LAKIFERVRQ SADFMPLKQM MKTLNNDLGP NWRDKLEYFE ERPFAAASIG QVHLARMKGG 310 320 330 340 350 360 REVAMKIQYP GVAQSINSDV NNLMAVLNMS NMLPEGLFPE HLIDVLRREL ALECDYQREA 370 380 390 400 410 420 ACARKFRDLL KGHPFFYVPE IVDELCSPHV LTTELVSGFP LDQAEGLSQE IRNEICYNIL 430 440 450 460 470 480 VLCLRELFEF HFMQTDPNWS NFFYDPQQHK VALLDFGATR EYDRSFTDLY IQIIRAAADR 490 500 510 520 530 540 DRETVRAKSI EMKFLTGYEV KVMEDAHLDA ILILGEAFAS DEPFDFGTQS TTEKIHNLIP 550 560 570 580 590 VMLRHRLVPP PEETYSLHRK MGGSFLICSK LKARFPCKAM FEEAYSNYCK RQAQQ
	Isoform 4 [UniParc]. Checksum: 8522AEA0D7547110	FASTA	368	42,537
	10 20 30 40 50 60 MLSIQDDAFI NPHLAKIFER VRQSADFMPL KQMMKTLNND LGPNWRDKLE YFEERPFAAA 70 80 90 100 110 120 SIGQVHLARM KGGREVAMKI QYPGVAQSIN SDVNNLMAVL NMSNMLPEGL FPEHLIDVLR 130 140 150 160 170 180 RELALECDYQ REAACARKFR DLLKGHPFFY VPEIVDELCS PHVLTTELVS GFPLDQAEGL 190 200 210 220 230 240 SQEIRNEICY NILVLCLREL FEFHFMQTDP NWSNFFYDPQ QHKVALLDFG ATREYDRSFT 250 260 270 280 290 300 DLYIQIIRAA ADRDRETVRA KSIEMKFLTG YEVKVMEDAH LDAILILGEA FASDEPFDFG 310 320 330 340 350 360 TQSTTEKIHN LIPVMLRHRL VPPPEETYSL HRKMGGSFLI CSKLKARFPC KAMFEEAYSN YCKRQAQQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a novel gene, CABC1, encoding a mitochondrial protein that is highly homologous to yeast activity of bc1 complex." Iiizumi M., Arakawa H., Mori T., Ando A., Nakamura Y. Cancer Res. 62:1246-1250(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
[2]	"Full length sequencing of some human and murine muscular transcript (Telethon Italy project B41)." Ievolella C., Stanchi F., Bertocco E., Millino C., Faulkner G., Valle G., Lanfranchi G. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Skeletal muscle.
[3]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Mammary gland.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Small intestine.
[6]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Uterus.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-341.
[10]	"CABC1 gene mutations cause ubiquinone deficiency with cerebellar ataxia and seizures." Mollet J., Delahodde A., Serre V., Chretien D., Schlemmer D., Lombes A., Boddaert N., Desguerre I., de Lonlay P., de Baulny H.O., Munnich A., Roetig A. Am. J. Hum. Genet. 82:623-630(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS COQ10D4 TRP-213; VAL-272; ASP-272 AND LYS-551.
[11]	"ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency." Lagier-Tourenne C., Tazir M., Lopez L.C., Quinzii C.M., Assoum M., Drouot N., Busso C., Makri S., Ali-Pacha L., Benhassine T., Anheim M., Lynch D.R., Thibault C., Plewniak F., Bianchetti L., Tranchant C., Poch O., DiMauro S. , Mandel J.-L., Barros M.H., Hirano M., Koenig M. Am. J. Hum. Genet. 82:661-672(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS COQ10D4 CYS-514; SER-549 AND THR-584 DEL.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB073905 mRNA. Translation: BAB91363.1. AJ278126 mRNA. Translation: CAC00482.1. AF218003 mRNA. Translation: AAG17245.1. AK074693 mRNA. Translation: BAC11143.1. BX648860 mRNA. Translation: CAH56132.1. AL353689 Genomic DNA. Translation: CAI19103.1. AL353689 Genomic DNA. Translation: CAI19105.1. BC005171 mRNA. Translation: AAH05171.2.
IPI	IPI00176469. IPI00641178. IPI00645029. IPI00909535.
RefSeq	NP_064632.2. NM_020247.4.
UniGene	Hs.118241.
3D structure databases
ProteinModelPortal	Q8NI60.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NI60. 5 interactions.
MINT	MINT-1479202.
PTM databases
PhosphoSite	Q8NI60.
Polymorphism databases
DMDM	27923741.
Proteomic databases
PaxDb	Q8NI60.
PRIDE	Q8NI60.
Protocols and materials databases
DNASU	56997.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000366777; ENSP00000355739; ENSG00000163050. ENST00000366778; ENSP00000355740; ENSG00000163050. ENST00000366779; ENSP00000355741; ENSG00000163050. ENST00000458507; ENSP00000403704; ENSG00000163050.
GeneID	56997.
KEGG	hsa:56997.
UCSC	uc001hqm.1. human. uc009xer.1. human.
Organism-specific databases
CTD	56997.
GeneCards	GC01P227087.
H-InvDB	HIX0001648.
HGNC	HGNC:16812. ADCK3.
HPA	HPA018217.
MIM	606980. gene. 612016. phenotype.
neXtProt	NX_Q8NI60.
Orphanet	139485. Autosomal recessive ataxia due to ubiquinone deficiency.
PharmGKB	PA25999.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0661.
HOGENOM	HOG000201140.
HOVERGEN	HBG061318.
InParanoid	Q8NI60.
KO	K08869.
OMA	GATREYD.
OrthoDB	EOG4K0QNB.
PhylomeDB	Q8NI60.
Gene expression databases
ArrayExpress	Q8NI60.
Bgee	Q8NI60.
CleanEx	HS_CABC1.
Genevestigator	Q8NI60.
GermOnline	ENSG00000163050. Homo sapiens.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR004147. UbiB_dom. [Graphical view]
Pfam	PF03109. ABC1. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50011. PROTEIN_KINASE_DOM. False negative. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q8NI60.
ChEMBL	CHEMBL5550.
ChiTaRS	ADCK3. human.
GenomeRNAi	56997.
NextBio	62711.
SOURCE	Search...

Entry information

Entry name

ADCK3_HUMAN

Accession

Primary (citable) accession number: Q8NI60
Secondary accession number(s): Q5T7A5 , Q63HK0, Q8NCJ6, Q9HBQ1, Q9NQ67

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.