Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8NI60

- ADCK3_HUMAN

UniProt

Q8NI60 - ADCK3_HUMAN

Protein

Chaperone activity of bc1 complex-like, mitochondrial

Gene

ADCK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Putative protein kinase involved in the biosynthesis of coenzyme Q since it is able to rescue partially coenzyme Q6 biosynthesis of yeast COQ8 mutants. May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain.1 Publication

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. cell death Source: UniProtKB-KW
    2. ubiquinone biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Ubiquinone biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chaperone activity of bc1 complex-like, mitochondrial (EC:2.7.11.-)
    Short name:
    Chaperone-ABC1-like
    Alternative name(s):
    aarF domain-containing protein kinase 3
    Gene namesi
    Name:ADCK3
    Synonyms:CABC1
    ORF Names:PP265
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:16812. ADCK3.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Involvement in diseasei

    Coenzyme Q10 deficiency, primary, 4 (COQ10D4) [MIM:612016]: An autosomal recessive disorder characterized by childhood-onset of cerebellar ataxia and exercise intolerance. Patient manifest gait ataxia and cerebellar atrophy with slow progression. Additional features include brisk tendon reflexes and Hoffmann sign, variable psychomotor retardation and variable seizures.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti213 – 2131R → W in COQ10D4. 1 Publication
    VAR_044402
    Natural varianti272 – 2721G → D in COQ10D4. 1 Publication
    VAR_044403
    Natural varianti272 – 2721G → V in COQ10D4. 1 Publication
    VAR_044404
    Natural varianti514 – 5141Y → C in COQ10D4. 1 Publication
    VAR_044405
    Natural varianti549 – 5491G → S in COQ10D4. 1 Publication
    VAR_044406
    Natural varianti551 – 5511E → K in COQ10D4. 1 Publication
    VAR_044407
    Natural varianti584 – 5841Missing in COQ10D4. 1 Publication
    VAR_044408

    Keywords - Diseasei

    Disease mutation, Neurodegeneration

    Organism-specific databases

    MIMi612016. phenotype.
    Orphaneti139485. Autosomal recessive ataxia due to ubiquinone deficiency.
    PharmGKBiPA25999.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 647Chaperone activity of bc1 complex-like, mitochondrialPRO_0000000262
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    MaxQBiQ8NI60.
    PaxDbiQ8NI60.
    PRIDEiQ8NI60.

    PTM databases

    PhosphoSiteiQ8NI60.

    Expressioni

    Tissue specificityi

    Widely expressed, with highest levels in adrenal gland, heart, pancreas, nasal mucosa, stomach, uterus and skeletal muscle.1 Publication

    Inductioni

    By p53/TP53.

    Gene expression databases

    ArrayExpressiQ8NI60.
    BgeeiQ8NI60.
    CleanExiHS_CABC1.
    GenevestigatoriQ8NI60.

    Organism-specific databases

    HPAiHPA018217.

    Interactioni

    Protein-protein interaction databases

    BioGridi121312. 8 interactions.
    IntActiQ8NI60. 7 interactions.
    MINTiMINT-1479202.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NI60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini329 – 518190Protein kinaseAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0661.
    HOGENOMiHOG000201140.
    HOVERGENiHBG061318.
    InParanoidiQ8NI60.
    KOiK08869.
    OMAiHQDQSPV.
    OrthoDBiEOG7X9G6H.
    PhylomeDBiQ8NI60.
    TreeFamiTF300630.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR004147. UbiB_dom.
    [Graphical view]
    PfamiPF03109. ABC1. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NI60-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAILGDTIM VAKGLVKLTQ AAVETHLQHL GIGGELIMAA RALQSTAVEQ    50
    IGMFLGKVQG QDKHEEYFAE NFGGPEGEFH FSVPHAAGAS TDFSSASAPD 100
    QSAPPSLGHA HSEGPAPAYV ASGPFREAGF PGQASSPLGR ANGRLFANPR 150
    DSFSAMGFQR RFFHQDQSPV GGLTAEDIEK ARQAKARPEN KQHKQTLSEH 200
    ARERKVPVTR IGRLANFGGL AVGLGFGALA EVAKKSLRSE DPSGKKAVLG 250
    SSPFLSEANA ERIVRTLCKV RGAALKLGQM LSIQDDAFIN PHLAKIFERV 300
    RQSADFMPLK QMMKTLNNDL GPNWRDKLEY FEERPFAAAS IGQVHLARMK 350
    GGREVAMKIQ YPGVAQSINS DVNNLMAVLN MSNMLPEGLF PEHLIDVLRR 400
    ELALECDYQR EAACARKFRD LLKGHPFFYV PEIVDELCSP HVLTTELVSG 450
    FPLDQAEGLS QEIRNEICYN ILVLCLRELF EFHFMQTDPN WSNFFYDPQQ 500
    HKVALLDFGA TREYDRSFTD LYIQIIRAAA DRDRETVRAK SIEMKFLTGY 550
    EVKVMEDAHL DAILILGEAF ASDEPFDFGT QSTTEKIHNL IPVMLRHRLV 600
    PPPEETYSLH RKMGGSFLIC SKLKARFPCK AMFEEAYSNY CKRQAQQ 647
    Length:647
    Mass (Da):71,950
    Last modified:October 1, 2002 - v1
    Checksum:iDEF8F022027BF6CC
    GO
    Isoform 2 (identifier: Q8NI60-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-484: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:163
    Mass (Da):18,937
    Checksum:iA309AB9DDBE67C56
    GO
    Isoform 3 (identifier: Q8NI60-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-52: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:595
    Mass (Da):66,627
    Checksum:i83F12FA56BCB190E
    GO
    Isoform 4 (identifier: Q8NI60-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-279: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:368
    Mass (Da):42,537
    Checksum:i8522AEA0D7547110
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti283 – 2842IQ → VR in BAC11143. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti85 – 851H → Q.
    Corresponds to variant rs2297411 [ dbSNP | Ensembl ].
    VAR_020319
    Natural varianti213 – 2131R → W in COQ10D4. 1 Publication
    VAR_044402
    Natural varianti272 – 2721G → D in COQ10D4. 1 Publication
    VAR_044403
    Natural varianti272 – 2721G → V in COQ10D4. 1 Publication
    VAR_044404
    Natural varianti341 – 3411I → T.1 Publication
    Corresponds to variant rs55798516 [ dbSNP | Ensembl ].
    VAR_045576
    Natural varianti514 – 5141Y → C in COQ10D4. 1 Publication
    VAR_044405
    Natural varianti549 – 5491G → S in COQ10D4. 1 Publication
    VAR_044406
    Natural varianti551 – 5511E → K in COQ10D4. 1 Publication
    VAR_044407
    Natural varianti584 – 5841Missing in COQ10D4. 1 Publication
    VAR_044408

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 484484Missing in isoform 2. 1 PublicationVSP_022351Add
    BLAST
    Alternative sequencei1 – 279279Missing in isoform 4. 1 PublicationVSP_022352Add
    BLAST
    Alternative sequencei1 – 5252Missing in isoform 3. 1 PublicationVSP_022353Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB073905 mRNA. Translation: BAB91363.1.
    AJ278126 mRNA. Translation: CAC00482.1.
    AF218003 mRNA. Translation: AAG17245.1.
    AK074693 mRNA. Translation: BAC11143.1.
    BX648860 mRNA. Translation: CAH56132.1.
    AL353689 Genomic DNA. Translation: CAI19103.1.
    AL353689 Genomic DNA. Translation: CAI19105.1.
    BC005171 mRNA. Translation: AAH05171.2.
    CCDSiCCDS1557.1. [Q8NI60-1]
    RefSeqiNP_064632.2. NM_020247.4. [Q8NI60-1]
    XP_005273258.1. XM_005273201.1. [Q8NI60-1]
    XP_005273259.1. XM_005273202.2. [Q8NI60-1]
    XP_005273260.1. XM_005273203.1. [Q8NI60-1]
    UniGeneiHs.118241.

    Genome annotation databases

    EnsembliENST00000366777; ENSP00000355739; ENSG00000163050. [Q8NI60-1]
    ENST00000366778; ENSP00000355740; ENSG00000163050. [Q8NI60-3]
    ENST00000366779; ENSP00000355741; ENSG00000163050. [Q8NI60-1]
    GeneIDi56997.
    KEGGihsa:56997.
    UCSCiuc001hqm.1. human. [Q8NI60-1]
    uc009xer.1. human. [Q8NI60-2]

    Polymorphism databases

    DMDMi27923741.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB073905 mRNA. Translation: BAB91363.1 .
    AJ278126 mRNA. Translation: CAC00482.1 .
    AF218003 mRNA. Translation: AAG17245.1 .
    AK074693 mRNA. Translation: BAC11143.1 .
    BX648860 mRNA. Translation: CAH56132.1 .
    AL353689 Genomic DNA. Translation: CAI19103.1 .
    AL353689 Genomic DNA. Translation: CAI19105.1 .
    BC005171 mRNA. Translation: AAH05171.2 .
    CCDSi CCDS1557.1. [Q8NI60-1 ]
    RefSeqi NP_064632.2. NM_020247.4. [Q8NI60-1 ]
    XP_005273258.1. XM_005273201.1. [Q8NI60-1 ]
    XP_005273259.1. XM_005273202.2. [Q8NI60-1 ]
    XP_005273260.1. XM_005273203.1. [Q8NI60-1 ]
    UniGenei Hs.118241.

    3D structure databases

    ProteinModelPortali Q8NI60.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121312. 8 interactions.
    IntActi Q8NI60. 7 interactions.
    MINTi MINT-1479202.

    Chemistry

    BindingDBi Q8NI60.
    ChEMBLi CHEMBL5550.
    GuidetoPHARMACOLOGYi 1927.

    PTM databases

    PhosphoSitei Q8NI60.

    Polymorphism databases

    DMDMi 27923741.

    Proteomic databases

    MaxQBi Q8NI60.
    PaxDbi Q8NI60.
    PRIDEi Q8NI60.

    Protocols and materials databases

    DNASUi 56997.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366777 ; ENSP00000355739 ; ENSG00000163050 . [Q8NI60-1 ]
    ENST00000366778 ; ENSP00000355740 ; ENSG00000163050 . [Q8NI60-3 ]
    ENST00000366779 ; ENSP00000355741 ; ENSG00000163050 . [Q8NI60-1 ]
    GeneIDi 56997.
    KEGGi hsa:56997.
    UCSCi uc001hqm.1. human. [Q8NI60-1 ]
    uc009xer.1. human. [Q8NI60-2 ]

    Organism-specific databases

    CTDi 56997.
    GeneCardsi GC01P227087.
    H-InvDB HIX0001648.
    HGNCi HGNC:16812. ADCK3.
    HPAi HPA018217.
    MIMi 606980. gene.
    612016. phenotype.
    neXtProti NX_Q8NI60.
    Orphaneti 139485. Autosomal recessive ataxia due to ubiquinone deficiency.
    PharmGKBi PA25999.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0661.
    HOGENOMi HOG000201140.
    HOVERGENi HBG061318.
    InParanoidi Q8NI60.
    KOi K08869.
    OMAi HQDQSPV.
    OrthoDBi EOG7X9G6H.
    PhylomeDBi Q8NI60.
    TreeFami TF300630.

    Miscellaneous databases

    ChiTaRSi ADCK3. human.
    GeneWikii CABC1.
    GenomeRNAii 56997.
    NextBioi 62711.
    PROi Q8NI60.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NI60.
    Bgeei Q8NI60.
    CleanExi HS_CABC1.
    Genevestigatori Q8NI60.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR004147. UbiB_dom.
    [Graphical view ]
    Pfami PF03109. ABC1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a novel gene, CABC1, encoding a mitochondrial protein that is highly homologous to yeast activity of bc1 complex."
      Iiizumi M., Arakawa H., Mori T., Ando A., Nakamura Y.
      Cancer Res. 62:1246-1250(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
    2. "Full length sequencing of some human and murine muscular transcript (Telethon Italy project B41)."
      Ievolella C., Stanchi F., Bertocco E., Millino C., Faulkner G., Valle G., Lanfranchi G.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Skeletal muscle.
    3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Mammary gland.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Small intestine.
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Uterus.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Expression of the human atypical kinase ADCK3 rescues coenzyme Q biosynthesis and phosphorylation of Coq polypeptides in yeast coq8 mutants."
      Xie L.X., Hsieh E.J., Watanabe S., Allan C.M., Chen J.Y., Tran U.C., Clarke C.F.
      Biochim. Biophys. Acta 1811:348-360(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. Cited for: TISSUE SPECIFICITY.
    11. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-341.
    12. Cited for: VARIANTS COQ10D4 TRP-213; VAL-272; ASP-272 AND LYS-551.
    13. Cited for: VARIANTS COQ10D4 CYS-514; SER-549 AND THR-584 DEL.

    Entry informationi

    Entry nameiADCK3_HUMAN
    AccessioniPrimary (citable) accession number: Q8NI60
    Secondary accession number(s): Q5T7A5
    , Q63HK0, Q8NCJ6, Q9HBQ1, Q9NQ67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 27, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3