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Q8NI60 (ADCK3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chaperone activity of bc1 complex-like, mitochondrial

Short name=Chaperone-ABC1-like
EC=2.7.11.-
Alternative name(s):
aarF domain-containing protein kinase 3
Gene names
Name:ADCK3
Synonyms:CABC1
ORF Names:PP265
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length647 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Putative protein kinase involved in the biosynthesis of coenzyme Q since it is able to rescue partially coenzyme Q6 biosynthesis of yeast COQ8 mutants. May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain. Ref.9

Subcellular location

Mitochondrion Ref.1.

Tissue specificity

Widely expressed, with highest levels in adrenal gland, heart, pancreas, nasal mucosa, stomach, uterus and skeletal muscle. Ref.10

Induction

By p53/TP53.

Involvement in disease

Coenzyme Q10 deficiency, primary, 4 (COQ10D4) [MIM:612016]: An autosomal recessive disorder characterized by childhood-onset of cerebellar ataxia and exercise intolerance. Patient manifest gait ataxia and cerebellar atrophy with slow progression. Additional features include brisk tendon reflexes and Hoffmann sign, variable psychomotor retardation and variable seizures.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12 Ref.13

Sequence similarities

Belongs to the protein kinase superfamily. ADCK protein kinase family.

Contains 1 protein kinase domain.

Caution

It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Ontologies

Keywords
   Biological processUbiquinone biosynthesis
   Cellular componentMitochondrion
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseDisease mutation
Neurodegeneration
   DomainTransit peptide
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
Kinase
Serine/threonine-protein kinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell death

Inferred from electronic annotation. Source: UniProtKB-KW

ubiquinone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NI60-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8NI60-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-484: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8NI60-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q8NI60-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-279: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 647Chaperone activity of bc1 complex-like, mitochondrialPRO_0000000262

Regions

Domain329 – 518190Protein kinase

Natural variations

Alternative sequence1 – 484484Missing in isoform 2.
VSP_022351
Alternative sequence1 – 279279Missing in isoform 4.
VSP_022352
Alternative sequence1 – 5252Missing in isoform 3.
VSP_022353
Natural variant851H → Q.
Corresponds to variant rs2297411 [ dbSNP | Ensembl ].
VAR_020319
Natural variant2131R → W in COQ10D4. Ref.12
VAR_044402
Natural variant2721G → D in COQ10D4. Ref.12
VAR_044403
Natural variant2721G → V in COQ10D4. Ref.12
VAR_044404
Natural variant3411I → T. Ref.11
Corresponds to variant rs55798516 [ dbSNP | Ensembl ].
VAR_045576
Natural variant5141Y → C in COQ10D4. Ref.13
VAR_044405
Natural variant5491G → S in COQ10D4. Ref.13
VAR_044406
Natural variant5511E → K in COQ10D4. Ref.12
VAR_044407
Natural variant5841Missing in COQ10D4. Ref.13
VAR_044408

Experimental info

Sequence conflict283 – 2842IQ → VR in BAC11143. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: DEF8F022027BF6CC

FASTA64771,950
        10         20         30         40         50         60 
MAAILGDTIM VAKGLVKLTQ AAVETHLQHL GIGGELIMAA RALQSTAVEQ IGMFLGKVQG 

        70         80         90        100        110        120 
QDKHEEYFAE NFGGPEGEFH FSVPHAAGAS TDFSSASAPD QSAPPSLGHA HSEGPAPAYV 

       130        140        150        160        170        180 
ASGPFREAGF PGQASSPLGR ANGRLFANPR DSFSAMGFQR RFFHQDQSPV GGLTAEDIEK 

       190        200        210        220        230        240 
ARQAKARPEN KQHKQTLSEH ARERKVPVTR IGRLANFGGL AVGLGFGALA EVAKKSLRSE 

       250        260        270        280        290        300 
DPSGKKAVLG SSPFLSEANA ERIVRTLCKV RGAALKLGQM LSIQDDAFIN PHLAKIFERV 

       310        320        330        340        350        360 
RQSADFMPLK QMMKTLNNDL GPNWRDKLEY FEERPFAAAS IGQVHLARMK GGREVAMKIQ 

       370        380        390        400        410        420 
YPGVAQSINS DVNNLMAVLN MSNMLPEGLF PEHLIDVLRR ELALECDYQR EAACARKFRD 

       430        440        450        460        470        480 
LLKGHPFFYV PEIVDELCSP HVLTTELVSG FPLDQAEGLS QEIRNEICYN ILVLCLRELF 

       490        500        510        520        530        540 
EFHFMQTDPN WSNFFYDPQQ HKVALLDFGA TREYDRSFTD LYIQIIRAAA DRDRETVRAK 

       550        560        570        580        590        600 
SIEMKFLTGY EVKVMEDAHL DAILILGEAF ASDEPFDFGT QSTTEKIHNL IPVMLRHRLV 

       610        620        630        640 
PPPEETYSLH RKMGGSFLIC SKLKARFPCK AMFEEAYSNY CKRQAQQ 

« Hide

Isoform 2 [UniParc].

Checksum: A309AB9DDBE67C56
Show »

FASTA16318,937
Isoform 3 [UniParc].

Checksum: 83F12FA56BCB190E
Show »

FASTA59566,627
Isoform 4 [UniParc].

Checksum: 8522AEA0D7547110
Show »

FASTA36842,537

References

« Hide 'large scale' references
[1]"Isolation of a novel gene, CABC1, encoding a mitochondrial protein that is highly homologous to yeast activity of bc1 complex."
Iiizumi M., Arakawa H., Mori T., Ando A., Nakamura Y.
Cancer Res. 62:1246-1250(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
[2]"Full length sequencing of some human and murine muscular transcript (Telethon Italy project B41)."
Ievolella C., Stanchi F., Bertocco E., Millino C., Faulkner G., Valle G., Lanfranchi G.
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Skeletal muscle.
[3]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Mammary gland.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Small intestine.
[6]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Uterus.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Expression of the human atypical kinase ADCK3 rescues coenzyme Q biosynthesis and phosphorylation of Coq polypeptides in yeast coq8 mutants."
Xie L.X., Hsieh E.J., Watanabe S., Allan C.M., Chen J.Y., Tran U.C., Clarke C.F.
Biochim. Biophys. Acta 1811:348-360(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[10]"ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption."
Ashraf S., Gee H.Y., Woerner S., Xie L.X., Vega-Warner V., Lovric S., Fang H., Song X., Cattran D.C., Avila-Casado C., Paterson A.D., Nitschke P., Bole-Feysot C., Cochat P., Esteve-Rudd J., Haberberger B., Allen S.J., Zhou W. expand/collapse author list , Airik R., Otto E.A., Barua M., Al-Hamed M.H., Kari J.A., Evans J., Bierzynska A., Saleem M.A., Bockenhauer D., Kleta R., El Desoky S., Hacihamdioglu D.O., Gok F., Washburn J., Wiggins R.C., Choi M., Lifton R.P., Levy S., Han Z., Salviati L., Prokisch H., Williams D.S., Pollak M., Clarke C.F., Pei Y., Antignac C., Hildebrandt F.
J. Clin. Invest. 123:5179-5189(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[11]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-341.
[12]"CABC1 gene mutations cause ubiquinone deficiency with cerebellar ataxia and seizures."
Mollet J., Delahodde A., Serre V., Chretien D., Schlemmer D., Lombes A., Boddaert N., Desguerre I., de Lonlay P., de Baulny H.O., Munnich A., Roetig A.
Am. J. Hum. Genet. 82:623-630(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS COQ10D4 TRP-213; VAL-272; ASP-272 AND LYS-551.
[13]"ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency."
Lagier-Tourenne C., Tazir M., Lopez L.C., Quinzii C.M., Assoum M., Drouot N., Busso C., Makri S., Ali-Pacha L., Benhassine T., Anheim M., Lynch D.R., Thibault C., Plewniak F., Bianchetti L., Tranchant C., Poch O., DiMauro S. expand/collapse author list , Mandel J.-L., Barros M.H., Hirano M., Koenig M.
Am. J. Hum. Genet. 82:661-672(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS COQ10D4 CYS-514; SER-549 AND THR-584 DEL.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB073905 mRNA. Translation: BAB91363.1.
AJ278126 mRNA. Translation: CAC00482.1.
AF218003 mRNA. Translation: AAG17245.1.
AK074693 mRNA. Translation: BAC11143.1.
BX648860 mRNA. Translation: CAH56132.1.
AL353689 Genomic DNA. Translation: CAI19103.1.
AL353689 Genomic DNA. Translation: CAI19105.1.
BC005171 mRNA. Translation: AAH05171.2.
CCDSCCDS1557.1. [Q8NI60-1]
RefSeqNP_064632.2. NM_020247.4. [Q8NI60-1]
XP_005273258.1. XM_005273201.1. [Q8NI60-1]
XP_005273259.1. XM_005273202.2. [Q8NI60-1]
XP_005273260.1. XM_005273203.1. [Q8NI60-1]
UniGeneHs.118241.

3D structure databases

ProteinModelPortalQ8NI60.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121312. 8 interactions.
IntActQ8NI60. 6 interactions.
MINTMINT-1479202.

Chemistry

BindingDBQ8NI60.
ChEMBLCHEMBL5550.
GuidetoPHARMACOLOGY1927.

PTM databases

PhosphoSiteQ8NI60.

Polymorphism databases

DMDM27923741.

Proteomic databases

MaxQBQ8NI60.
PaxDbQ8NI60.
PRIDEQ8NI60.

Protocols and materials databases

DNASU56997.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000366777; ENSP00000355739; ENSG00000163050. [Q8NI60-1]
ENST00000366778; ENSP00000355740; ENSG00000163050. [Q8NI60-3]
ENST00000366779; ENSP00000355741; ENSG00000163050. [Q8NI60-1]
ENST00000458507; ENSP00000403704; ENSG00000163050. [Q8NI60-4]
GeneID56997.
KEGGhsa:56997.
UCSCuc001hqm.1. human. [Q8NI60-1]
uc009xer.1. human. [Q8NI60-2]

Organism-specific databases

CTD56997.
GeneCardsGC01P227087.
H-InvDBHIX0001648.
HGNCHGNC:16812. ADCK3.
HPAHPA018217.
MIM606980. gene.
612016. phenotype.
neXtProtNX_Q8NI60.
Orphanet139485. Autosomal recessive ataxia due to ubiquinone deficiency.
PharmGKBPA25999.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0661.
HOGENOMHOG000201140.
HOVERGENHBG061318.
InParanoidQ8NI60.
KOK08869.
OMAHQDQSPV.
OrthoDBEOG7X9G6H.
PhylomeDBQ8NI60.
TreeFamTF300630.

Gene expression databases

ArrayExpressQ8NI60.
BgeeQ8NI60.
CleanExHS_CABC1.
GenevestigatorQ8NI60.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
ProtoNetSearch...

Other

ChiTaRSADCK3. human.
GeneWikiCABC1.
GenomeRNAi56997.
NextBio62711.
PROQ8NI60.
SOURCESearch...

Entry information

Entry nameADCK3_HUMAN
AccessionPrimary (citable) accession number: Q8NI60
Secondary accession number(s): Q5T7A5 expand/collapse secondary AC list , Q63HK0, Q8NCJ6, Q9HBQ1, Q9NQ67
Entry history
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM