Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Parkin isoform

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferaseSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Parkin isoformImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PaxDbiQ8NI42.
PeptideAtlasiQ8NI42.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355865.

Structurei

3D structure databases

ProteinModelPortaliQ8NI42.
SMRiQ8NI42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 186IBR-typeInterPro annotationAdd BLAST65

Sequence similaritiesi

Belongs to the RBR family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG0006. Eukaryota.
ENOG410YG4B. LUCA.
HOVERGENiHBG053682.

Family and domain databases

InterProiView protein in InterPro
IPR031127. E3_UB_ligase_RBR.
IPR002867. IBR_dom.
IPR003977. Parkin.
PANTHERiPTHR11685. PTHR11685. 1 hit.
PfamiView protein in Pfam
PF01485. IBR. 1 hit.
PRINTSiPR01475. PARKIN.
SMARTiView protein in SMART
SM00647. IBR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NI42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGECQSPHC PGTSAEFFFK CGAHPTSDKE TPVALHLIAT NSRNITCITC
60 70 80 90 100
TDVRSPVLVF QCNSRHVICL DCFHLYCVTR LNDRQFVHDP QLGYSLPCVA
110 120 130 140 150
GCPNSLIKEL HHFRILGEEQ YNRYQQYGAE ECVLQMGGVL CPRPGCGAGL
160 170 180 190 200
LPEPDQRKVT CEGGNGLGCG FAFCRECKEA YHEGECSAVF EASGTTTQEA

ACT
Length:203
Mass (Da):22,192
Last modified:October 1, 2002 - v1
Checksum:iF92E796F069DC818
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF381284 mRNA. Translation: AAM21459.1.
UniGeneiHs.132954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF381284 mRNA. Translation: AAM21459.1.
UniGeneiHs.132954.

3D structure databases

ProteinModelPortaliQ8NI42.
SMRiQ8NI42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355865.

Proteomic databases

PaxDbiQ8NI42.
PeptideAtlasiQ8NI42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0006. Eukaryota.
ENOG410YG4B. LUCA.
HOVERGENiHBG053682.

Family and domain databases

InterProiView protein in InterPro
IPR031127. E3_UB_ligase_RBR.
IPR002867. IBR_dom.
IPR003977. Parkin.
PANTHERiPTHR11685. PTHR11685. 1 hit.
PfamiView protein in Pfam
PF01485. IBR. 1 hit.
PRINTSiPR01475. PARKIN.
SMARTiView protein in SMART
SM00647. IBR. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ8NI42_HUMAN
AccessioniPrimary (citable) accession number: Q8NI42
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: May 10, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.