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Protein

NF-kappa-B inhibitor delta

Gene

NFKBID

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
NF-kappa-B inhibitor delta
Alternative name(s):
I-kappa-B-delta
Short name:
IkB-delta
Short name:
IkappaBdelta
IkappaBNS
T-cell activation NFKB-like protein
TA-NFKBH
Gene namesi
Name:NFKBID
Synonyms:IKBNS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15671. NFKBID.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167604.
PharmGKBiPA162397453.

Polymorphism and mutation databases

BioMutaiNFKBID.
DMDMi74751323.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003311141 – 313NF-kappa-B inhibitor deltaAdd BLAST313

Proteomic databases

EPDiQ8NI38.
MaxQBiQ8NI38.
PaxDbiQ8NI38.
PRIDEiQ8NI38.

PTM databases

iPTMnetiQ8NI38.
PhosphoSitePlusiQ8NI38.

Expressioni

Gene expression databases

BgeeiENSG00000167604.
CleanExiHS_NFKBID.
ExpressionAtlasiQ8NI38. baseline and differential.
GenevisibleiQ8NI38. HS.

Organism-specific databases

HPAiHPA043573.

Interactioni

Subunit structurei

Interacts with NFKB1, RELA and RELB; in the nucleus.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
C1orf94Q6P1W55EBI-10271199,EBI-946029
KRT40Q6A1623EBI-10271199,EBI-10171697
SS18Q4VAX23EBI-10271199,EBI-10271195
TRIM9Q9C0263EBI-10271199,EBI-720828

Protein-protein interaction databases

BioGridi124269. 8 interactors.
IntActiQ8NI38. 22 interactors.
STRINGi9606.ENSP00000380109.

Structurei

3D structure databases

ProteinModelPortaliQ8NI38.
SMRiQ8NI38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati48 – 83ANK 1Add BLAST36
Repeati84 – 113ANK 2Add BLAST30
Repeati117 – 146ANK 3Add BLAST30
Repeati152 – 201ANK 4Add BLAST50
Repeati206 – 236ANK 5Add BLAST31
Repeati243 – 276ANK 6Add BLAST34

Sequence similaritiesi

Belongs to the NF-kappa-B inhibitor family.Curated
Contains 6 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00550000074527.
HOGENOMiHOG000113021.
HOVERGENiHBG098212.
InParanoidiQ8NI38.
KOiK14214.
OMAiCVHMLLQ.
OrthoDBiEOG091G06D9.
PhylomeDBiQ8NI38.
TreeFamiTF330224.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NI38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAGPWRVSA PPSGPPQFPA VVPGPSLEVA RAHMLALGPQ QLLAQDEEGD
60 70 80 90 100
TLLHLFAARG LRWAAYAAAE VLQVYRRLDI REHKGKTPLL VAAAANQPLI
110 120 130 140 150
VEDLLNLGAE PNAADHQGRS VLHVAATYGL PGVLLAVLNS GVQVDLEARD
160 170 180 190 200
FEGLTPLHTA ILALNVAMRP SDLCPRVLST QARDRLDCVH MLLQMGANHT
210 220 230 240 250
SQEIKSNKTV LHLAVQAANP TLVQLLLELP RGDLRTFVNM KAHGNTALHM
260 270 280 290 300
AAALPPGPAQ EAIVRHLLAA GADPTLRNLE NEQPVHLLRP GPGPEGLRQL
310
LKRSRVAPPG LSS
Length:313
Mass (Da):33,481
Last modified:October 1, 2002 - v1
Checksum:iB986234830428320
GO
Isoform 2 (identifier: Q8NI38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWVCLRGILD...GQPCPFPQGM

Note: No experimental confirmation available.
Show »
Length:465
Mass (Da):50,297
Checksum:i710CB1235A2AEF3E
GO
Isoform 3 (identifier: Q8NI38-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-201: Missing.
     202-202: Q → MRSCCVVQAGLQLLASSDPPSSASQSARITGVNHRTPPR

Show »
Length:150
Mass (Da):15,921
Checksum:iEBB4EDF1D8CCCBCC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04273729V → A.Corresponds to variant rs8113704dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0331431 – 201Missing in isoform 3. 1 PublicationAdd BLAST201
Alternative sequenceiVSP_0331441M → MWVCLRGILDSQAFWHETLR RWECLLAEMKVSRGERSHCP TQTVKKLLEEQRRRQQQQPD AGGVQGQFLPPPEQPLTPSV NEAVTGHPPFPAHSETVGSG PSSLGFPDWDPNTHAAYTDS PYSCPASAAENFLPPDFYPP SDPGQPCPFPQGM in isoform 2. 1 Publication1
Alternative sequenceiVSP_033145202Q → MRSCCVVQAGLQLLASSDPP SSASQSARITGVNHRTPPR in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385433 mRNA. Translation: AAM43834.1.
AF385434 mRNA. Translation: AAM43835.1.
BC006273 mRNA. Translation: AAH06273.1.
BC119646 mRNA. Translation: AAI19647.1.
BC119647 mRNA. Translation: AAI19648.1.
CCDSiCCDS42552.1. [Q8NI38-1]
RefSeqiNP_640332.1. NM_139239.2. [Q8NI38-1]
XP_011525721.1. XM_011527419.2. [Q8NI38-2]
XP_016882880.1. XM_017027391.1. [Q8NI38-1]
XP_016882881.1. XM_017027392.1. [Q8NI38-1]
XP_016882882.1. XM_017027393.1. [Q8NI38-1]
UniGeneiHs.466531.

Genome annotation databases

EnsembliENST00000396901; ENSP00000380109; ENSG00000167604. [Q8NI38-1]
ENST00000606253; ENSP00000475712; ENSG00000167604. [Q8NI38-1]
GeneIDi84807.
KEGGihsa:84807.
UCSCiuc002oci.1. human. [Q8NI38-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385433 mRNA. Translation: AAM43834.1.
AF385434 mRNA. Translation: AAM43835.1.
BC006273 mRNA. Translation: AAH06273.1.
BC119646 mRNA. Translation: AAI19647.1.
BC119647 mRNA. Translation: AAI19648.1.
CCDSiCCDS42552.1. [Q8NI38-1]
RefSeqiNP_640332.1. NM_139239.2. [Q8NI38-1]
XP_011525721.1. XM_011527419.2. [Q8NI38-2]
XP_016882880.1. XM_017027391.1. [Q8NI38-1]
XP_016882881.1. XM_017027392.1. [Q8NI38-1]
XP_016882882.1. XM_017027393.1. [Q8NI38-1]
UniGeneiHs.466531.

3D structure databases

ProteinModelPortaliQ8NI38.
SMRiQ8NI38.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124269. 8 interactors.
IntActiQ8NI38. 22 interactors.
STRINGi9606.ENSP00000380109.

PTM databases

iPTMnetiQ8NI38.
PhosphoSitePlusiQ8NI38.

Polymorphism and mutation databases

BioMutaiNFKBID.
DMDMi74751323.

Proteomic databases

EPDiQ8NI38.
MaxQBiQ8NI38.
PaxDbiQ8NI38.
PRIDEiQ8NI38.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396901; ENSP00000380109; ENSG00000167604. [Q8NI38-1]
ENST00000606253; ENSP00000475712; ENSG00000167604. [Q8NI38-1]
GeneIDi84807.
KEGGihsa:84807.
UCSCiuc002oci.1. human. [Q8NI38-1]

Organism-specific databases

CTDi84807.
GeneCardsiNFKBID.
H-InvDBHIX0202751.
HGNCiHGNC:15671. NFKBID.
HPAiHPA043573.
neXtProtiNX_Q8NI38.
OpenTargetsiENSG00000167604.
PharmGKBiPA162397453.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00550000074527.
HOGENOMiHOG000113021.
HOVERGENiHBG098212.
InParanoidiQ8NI38.
KOiK14214.
OMAiCVHMLLQ.
OrthoDBiEOG091G06D9.
PhylomeDBiQ8NI38.
TreeFamiTF330224.

Miscellaneous databases

ChiTaRSiNFKBID. human.
GenomeRNAii84807.
PROiQ8NI38.

Gene expression databases

BgeeiENSG00000167604.
CleanExiHS_NFKBID.
ExpressionAtlasiQ8NI38. baseline and differential.
GenevisibleiQ8NI38. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIKBD_HUMAN
AccessioniPrimary (citable) accession number: Q8NI38
Secondary accession number(s): Q8NI39, Q9BRG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.