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Q8NI37

- PPTC7_HUMAN

UniProt

Q8NI37 - PPTC7_HUMAN

Protein

Protein phosphatase PTC7 homolog

Gene

PPTC7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Magnesium or manganese.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi78 – 781Manganese 1By similarity
    Metal bindingi78 – 781Manganese 2By similarity
    Metal bindingi79 – 791Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi223 – 2231Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase PTC7 homolog (EC:3.1.3.16)
    Alternative name(s):
    T-cell activation protein phosphatase 2C
    Short name:
    TA-PP2C
    T-cell activation protein phosphatase 2C-like
    Gene namesi
    Name:PPTC7
    Synonyms:TAPP2C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:30695. PPTC7.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485580.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 304304Protein phosphatase PTC7 homologPRO_0000328745Add
    BLAST

    Proteomic databases

    MaxQBiQ8NI37.
    PaxDbiQ8NI37.
    PRIDEiQ8NI37.

    PTM databases

    PhosphoSiteiQ8NI37.

    Expressioni

    Inductioni

    Up-regulated during lymphocyte activation.1 Publication

    Gene expression databases

    BgeeiQ8NI37.
    CleanExiHS_PPTC7.
    GenevestigatoriQ8NI37.

    Organism-specific databases

    HPAiHPA039335.
    HPA040614.

    Interactioni

    Protein-protein interaction databases

    BioGridi127764. 3 interactions.
    IntActiQ8NI37. 1 interaction.
    STRINGi9606.ENSP00000346255.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NI37.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 297260PP2C-likeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi17 – 8771Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000239282.
    HOVERGENiHBG060636.
    InParanoidiQ8NI37.
    KOiK17508.
    OMAiMKAREHG.
    OrthoDBiEOG7DRJ3F.
    PhylomeDBiQ8NI37.
    TreeFamiTF315105.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    [Graphical view]
    PfamiPF07228. SpoIIE. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8NI37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFSVLSYGRL VARAVLGGLS QTDPRAGGGG GGDYGLVTAG CGFGKDFRKG    50
    LLKKGACYGD DACFVARHRS ADVLGVADGV GGWRDYGVDP SQFSGTLMRT 100
    CERLVKEGRF VPSNPIGILT TSYCELLQNK VPLLGSSTAC IVVLDRTSHR 150
    LHTANLGDSG FLVVRGGEVV HRSDEQQHYF NTPFQLSIAP PEAEGVVLSD 200
    SPDAADSTSF DVQLGDIILT ATDGLFDNMP DYMILQELKK LKNSNYESIQ 250
    QTARSIAEQA HELAYDPNYM SPFAQFACDN GLNVRGGKPD DITVLLSIVA 300
    EYTD 304
    Length:304
    Mass (Da):32,646
    Last modified:October 1, 2002 - v1
    Checksum:iE27F2FAF8C44793B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271Missing in AAQ57274. 1 PublicationCurated
    Sequence conflicti124 – 1241C → R in AAQ57274. 1 PublicationCurated
    Sequence conflicti282 – 2821L → S in CAH18073. (PubMed:17974005)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF385435 mRNA. Translation: AAM43836.1.
    AY357944 mRNA. Translation: AAQ57274.1.
    AK124744 mRNA. Translation: BAG54087.1.
    CH471054 Genomic DNA. Translation: EAW97928.1.
    BC111551 mRNA. Translation: AAI11552.1.
    CR749216 mRNA. Translation: CAH18073.1.
    CCDSiCCDS9149.1.
    RefSeqiNP_644812.1. NM_139283.1.
    UniGeneiHs.13854.

    Genome annotation databases

    EnsembliENST00000354300; ENSP00000346255; ENSG00000196850.
    GeneIDi160760.
    KEGGihsa:160760.
    UCSCiuc001trh.1. human.

    Polymorphism databases

    DMDMi74715714.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF385435 mRNA. Translation: AAM43836.1 .
    AY357944 mRNA. Translation: AAQ57274.1 .
    AK124744 mRNA. Translation: BAG54087.1 .
    CH471054 Genomic DNA. Translation: EAW97928.1 .
    BC111551 mRNA. Translation: AAI11552.1 .
    CR749216 mRNA. Translation: CAH18073.1 .
    CCDSi CCDS9149.1.
    RefSeqi NP_644812.1. NM_139283.1.
    UniGenei Hs.13854.

    3D structure databases

    ProteinModelPortali Q8NI37.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127764. 3 interactions.
    IntActi Q8NI37. 1 interaction.
    STRINGi 9606.ENSP00000346255.

    PTM databases

    PhosphoSitei Q8NI37.

    Polymorphism databases

    DMDMi 74715714.

    Proteomic databases

    MaxQBi Q8NI37.
    PaxDbi Q8NI37.
    PRIDEi Q8NI37.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354300 ; ENSP00000346255 ; ENSG00000196850 .
    GeneIDi 160760.
    KEGGi hsa:160760.
    UCSCi uc001trh.1. human.

    Organism-specific databases

    CTDi 160760.
    GeneCardsi GC12M110972.
    HGNCi HGNC:30695. PPTC7.
    HPAi HPA039335.
    HPA040614.
    MIMi 609668. gene.
    neXtProti NX_Q8NI37.
    PharmGKBi PA143485580.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000239282.
    HOVERGENi HBG060636.
    InParanoidi Q8NI37.
    KOi K17508.
    OMAi MKAREHG.
    OrthoDBi EOG7DRJ3F.
    PhylomeDBi Q8NI37.
    TreeFami TF315105.

    Miscellaneous databases

    GenomeRNAii 160760.
    NextBioi 87987.
    PROi Q8NI37.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8NI37.
    CleanExi HS_PPTC7.
    Genevestigatori Q8NI37.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    [Graphical view ]
    Pfami PF07228. SpoIIE. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "T lymphocyte activation gene identification by coregulated expression on DNA microarrays."
      Mao M., Biery M.C., Kobayashi S.V., Ward T., Schimmack G., Burchard J., Schelter J.M., Dai H., He Y.D., Linsley P.S.
      Genomics 83:989-999(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
    2. Zhou G., Zhong G., Yu R., Li H., Shen C., Li M., Ke R., Xiao W., Zheng G., Lin L., Yang S.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 218-304.
      Tissue: Fetal kidney.

    Entry informationi

    Entry nameiPPTC7_HUMAN
    AccessioniPrimary (citable) accession number: Q8NI37
    Secondary accession number(s): B3KWC5, Q68DZ7, Q6UY82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3