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Protein

Protein phosphatase PTC7 homolog

Gene

PPTC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+Curated, Mn2+Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Manganese 1By similarity
Metal bindingi78 – 781Manganese 2By similarity
Metal bindingi79 – 791Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi223 – 2231Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase PTC7 homolog (EC:3.1.3.16)
Alternative name(s):
T-cell activation protein phosphatase 2C
Short name:
TA-PP2C
T-cell activation protein phosphatase 2C-like
Gene namesi
Name:PPTC7
Synonyms:TAPP2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:30695. PPTC7.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485580.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Protein phosphatase PTC7 homologPRO_0000328745Add
BLAST

Proteomic databases

MaxQBiQ8NI37.
PaxDbiQ8NI37.
PRIDEiQ8NI37.

PTM databases

DEPODiQ8NI37.
PhosphoSiteiQ8NI37.

Expressioni

Inductioni

Up-regulated during lymphocyte activation.1 Publication

Gene expression databases

BgeeiQ8NI37.
CleanExiHS_PPTC7.
GenevestigatoriQ8NI37.

Organism-specific databases

HPAiHPA039335.
HPA040614.

Interactioni

Protein-protein interaction databases

BioGridi127764. 3 interactions.
IntActiQ8NI37. 1 interaction.
STRINGi9606.ENSP00000346255.

Structurei

3D structure databases

ProteinModelPortaliQ8NI37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 297260PP2C-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 8771Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00390000011937.
HOGENOMiHOG000239282.
HOVERGENiHBG060636.
InParanoidiQ8NI37.
KOiK17508.
OMAiWDNLSEQ.
OrthoDBiEOG7DRJ3F.
PhylomeDBiQ8NI37.
TreeFamiTF315105.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
[Graphical view]
PfamiPF07228. SpoIIE. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NI37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSVLSYGRL VARAVLGGLS QTDPRAGGGG GGDYGLVTAG CGFGKDFRKG
60 70 80 90 100
LLKKGACYGD DACFVARHRS ADVLGVADGV GGWRDYGVDP SQFSGTLMRT
110 120 130 140 150
CERLVKEGRF VPSNPIGILT TSYCELLQNK VPLLGSSTAC IVVLDRTSHR
160 170 180 190 200
LHTANLGDSG FLVVRGGEVV HRSDEQQHYF NTPFQLSIAP PEAEGVVLSD
210 220 230 240 250
SPDAADSTSF DVQLGDIILT ATDGLFDNMP DYMILQELKK LKNSNYESIQ
260 270 280 290 300
QTARSIAEQA HELAYDPNYM SPFAQFACDN GLNVRGGKPD DITVLLSIVA

EYTD
Length:304
Mass (Da):32,646
Last modified:October 1, 2002 - v1
Checksum:iE27F2FAF8C44793B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271Missing in AAQ57274 (Ref. 2) Curated
Sequence conflicti124 – 1241C → R in AAQ57274 (Ref. 2) Curated
Sequence conflicti282 – 2821L → S in CAH18073 (PubMed:17974005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385435 mRNA. Translation: AAM43836.1.
AY357944 mRNA. Translation: AAQ57274.1.
AK124744 mRNA. Translation: BAG54087.1.
CH471054 Genomic DNA. Translation: EAW97928.1.
BC111551 mRNA. Translation: AAI11552.1.
CR749216 mRNA. Translation: CAH18073.1.
CCDSiCCDS9149.1.
RefSeqiNP_644812.1. NM_139283.1.
UniGeneiHs.13854.

Genome annotation databases

EnsembliENST00000354300; ENSP00000346255; ENSG00000196850.
GeneIDi160760.
KEGGihsa:160760.
UCSCiuc001trh.1. human.

Polymorphism databases

DMDMi74715714.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385435 mRNA. Translation: AAM43836.1.
AY357944 mRNA. Translation: AAQ57274.1.
AK124744 mRNA. Translation: BAG54087.1.
CH471054 Genomic DNA. Translation: EAW97928.1.
BC111551 mRNA. Translation: AAI11552.1.
CR749216 mRNA. Translation: CAH18073.1.
CCDSiCCDS9149.1.
RefSeqiNP_644812.1. NM_139283.1.
UniGeneiHs.13854.

3D structure databases

ProteinModelPortaliQ8NI37.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127764. 3 interactions.
IntActiQ8NI37. 1 interaction.
STRINGi9606.ENSP00000346255.

PTM databases

DEPODiQ8NI37.
PhosphoSiteiQ8NI37.

Polymorphism databases

DMDMi74715714.

Proteomic databases

MaxQBiQ8NI37.
PaxDbiQ8NI37.
PRIDEiQ8NI37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354300; ENSP00000346255; ENSG00000196850.
GeneIDi160760.
KEGGihsa:160760.
UCSCiuc001trh.1. human.

Organism-specific databases

CTDi160760.
GeneCardsiGC12M110972.
HGNCiHGNC:30695. PPTC7.
HPAiHPA039335.
HPA040614.
MIMi609668. gene.
neXtProtiNX_Q8NI37.
PharmGKBiPA143485580.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00390000011937.
HOGENOMiHOG000239282.
HOVERGENiHBG060636.
InParanoidiQ8NI37.
KOiK17508.
OMAiWDNLSEQ.
OrthoDBiEOG7DRJ3F.
PhylomeDBiQ8NI37.
TreeFamiTF315105.

Miscellaneous databases

GenomeRNAii160760.
NextBioi87987.
PROiQ8NI37.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NI37.
CleanExiHS_PPTC7.
GenevestigatoriQ8NI37.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
[Graphical view]
PfamiPF07228. SpoIIE. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "T lymphocyte activation gene identification by coregulated expression on DNA microarrays."
    Mao M., Biery M.C., Kobayashi S.V., Ward T., Schimmack G., Burchard J., Schelter J.M., Dai H., He Y.D., Linsley P.S.
    Genomics 83:989-999(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
  2. Zhou G., Zhong G., Yu R., Li H., Shen C., Li M., Ke R., Xiao W., Zheng G., Lin L., Yang S.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 218-304.
    Tissue: Fetal kidney.

Entry informationi

Entry nameiPPTC7_HUMAN
AccessioniPrimary (citable) accession number: Q8NI37
Secondary accession number(s): B3KWC5, Q68DZ7, Q6UY82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 1, 2002
Last modified: March 4, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.