Q8NI37 (PPTC7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein phosphatase PTC7 homolog
EC=3.1.3.16

Alternative name(s):
T-cell activation protein phosphatase 2C
Short name=TA-PP2C
T-cell activation protein phosphatase 2C-like

Gene names

Name:	PPTC7
Synonyms:	TAPP2C

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Magnesium or manganese Potential.
Induction	Up-regulated during lymphocyte activation. Ref.1
Sequence similarities	Belongs to the PP2C family. Contains 1 PP2C-like domain.

Ontologies

Keywords
Ligand	Magnesium Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	metabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	mitochondrion Inferred from electronic annotation. Source: Compara
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	Protein phosphatase PTC7 homolog		PRO_0000328745
Regions
	Domain	38 – 297	260	PP2C-like
	Compositional bias	17 – 87	71	Gly-rich
Sites
	Metal binding	78	1	Manganese 1 By similarity
	Metal binding	78	1	Manganese 2 By similarity
	Metal binding	79	1	Manganese 1; via carbonyl oxygen By similarity
	Metal binding	223	1	Manganese 2 By similarity
Experimental info
	Sequence conflict	27	1	Missing in AAQ57274. Ref.2
	Sequence conflict	124	1	C → R in AAQ57274. Ref.2
	Sequence conflict	282	1	L → S in CAH18073. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Q8NI37 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: E27F2FAF8C44793B	FASTA	304	32,646
	10 20 30 40 50 60 MFSVLSYGRL VARAVLGGLS QTDPRAGGGG GGDYGLVTAG CGFGKDFRKG LLKKGACYGD 70 80 90 100 110 120 DACFVARHRS ADVLGVADGV GGWRDYGVDP SQFSGTLMRT CERLVKEGRF VPSNPIGILT 130 140 150 160 170 180 TSYCELLQNK VPLLGSSTAC IVVLDRTSHR LHTANLGDSG FLVVRGGEVV HRSDEQQHYF 190 200 210 220 230 240 NTPFQLSIAP PEAEGVVLSD SPDAADSTSF DVQLGDIILT ATDGLFDNMP DYMILQELKK 250 260 270 280 290 300 LKNSNYESIQ QTARSIAEQA HELAYDPNYM SPFAQFACDN GLNVRGGKPD DITVLLSIVA EYTD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"T lymphocyte activation gene identification by coregulated expression on DNA microarrays." Mao M., Biery M.C., Kobayashi S.V., Ward T., Schimmack G., Burchard J., Schelter J.M., Dai H., He Y.D., Linsley P.S. Genomics 83:989-999(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
[2]	Zhou G., Zhong G., Yu R., Li H., Shen C., Li M., Ke R., Xiao W., Zheng G., Lin L., Yang S. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 218-304. Tissue: Fetal kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF385435 mRNA. Translation: AAM43836.1. AY357944 mRNA. Translation: AAQ57274.1. AK124744 mRNA. Translation: BAG54087.1. CH471054 Genomic DNA. Translation: EAW97928.1. BC111551 mRNA. Translation: AAI11552.1. CR749216 mRNA. Translation: CAH18073.1.
IPI	IPI00169326.
RefSeq	NP_644812.1. NM_139283.1.
UniGene	Hs.13854.
3D structure databases
ProteinModelPortal	Q8NI37.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000346255.
PTM databases
PhosphoSite	Q8NI37.
Polymorphism databases
DMDM	74715714.
Proteomic databases
PaxDb	Q8NI37.
PRIDE	Q8NI37.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000354300; ENSP00000346255; ENSG00000196850.
GeneID	160760.
KEGG	hsa:160760.
UCSC	uc001trh.1. human.
Organism-specific databases
CTD	160760.
GeneCards	GC12M110972.
HGNC	HGNC:30695. PPTC7.
HPA	HPA039335. HPA040614.
MIM	609668. gene.
neXtProt	NX_Q8NI37.
PharmGKB	PA143485580.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0631.
HOGENOM	HOG000239282.
HOVERGEN	HBG060636.
InParanoid	Q8NI37.
OMA	FLMRTCE.
OrthoDB	EOG41RPVT.
PhylomeDB	Q8NI37.
Gene expression databases
Bgee	Q8NI37.
CleanEx	HS_PPTC7.
Genevestigator	Q8NI37.
Family and domain databases
Gene3D	3.60.40.10. 1 hit.
InterPro	IPR001932. PP2C-like. [Graphical view]
Pfam	PF07228. SpoIIE. 1 hit. [Graphical view]
SMART	SM00331. PP2C_SIG. 1 hit. SM00332. PP2Cc. 1 hit. [Graphical view]
SUPFAM	SSF81606. PP2C-related. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	160760.
NextBio	87987.
SOURCE	Search...

Entry information

Entry name

PPTC7_HUMAN

Accession

Primary (citable) accession number: Q8NI37
Secondary accession number(s): B3KWC5, Q68DZ7, Q6UY82

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.