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Protein

Ly6/PLAUR domain-containing protein 6B

Gene

LYPD6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Protein family/group databases

TCDBi8.A.31.1.2. the ly-6 neurotoxin-like protein1 precursor (lynx1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Ly6/PLAUR domain-containing protein 6B
Gene namesi
Name:LYPD6B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:27018. LYPD6B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394734.

Polymorphism and mutation databases

DMDMi74715711.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence analysisAdd
BLAST
Chaini40 – 164125Ly6/PLAUR domain-containing protein 6BPRO_0000321950Add
BLAST
Propeptidei165 – 18319Removed in mature formSequence analysisPRO_0000321951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi164 – 1641GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ8NI32.
PeptideAtlasiQ8NI32.
PRIDEiQ8NI32.

Expressioni

Gene expression databases

BgeeiQ8NI32.
CleanExiHS_LYPD6B.
ExpressionAtlasiQ8NI32. baseline and differential.
GenevisibleiQ8NI32. HS.

Organism-specific databases

HPAiHPA049239.

Interactioni

Protein-protein interaction databases

BioGridi126243. 1 interaction.
STRINGi9606.ENSP00000387077.

Structurei

3D structure databases

ProteinModelPortaliQ8NI32.
SMRiQ8NI32. Positions 56-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 15192UPAR/Ly6Add
BLAST

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IT28. Eukaryota.
ENOG4111P33. LUCA.
GeneTreeiENSGT00390000000220.
HOGENOMiHOG000231796.
HOVERGENiHBG054166.
InParanoidiQ8NI32.
OMAiMLLLCHA.
OrthoDBiEOG7XH6RK.
PhylomeDBiQ8NI32.
TreeFamiTF332443.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NI32-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLYKSSDRPA HKVSMLLLCH ALAIAVVQIV IFSESWAFAK NINFYNVRPP
60 70 80 90 100
LDPTPFPNSF KCFTCENAGD NYNCNRWAED KWCPQNTQYC LTVHHFTSHG
110 120 130 140 150
RSTSITKKCA SRSECHFVGC HHSRDSEHTE CRSCCEGMIC NVELPTNHTN
160 170 180
AVFAVMHAQR TSGSSAPTLY LPVLAWVFVL PLL
Length:183
Mass (Da):20,656
Last modified:October 1, 2002 - v1
Checksum:i817D3D181568C5A2
GO
Isoform 2 (identifier: Q8NI32-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-2: L → LLITLSANLFTVPERSLTTTFSFSR

Note: No experimental confirmation available.
Show »
Length:207
Mass (Da):23,340
Checksum:i6F760FFC205B8822
GO

Sequence cautioni

The sequence AAH18203.1 differs from that shown. Reason: Frameshift at position 150. Curated
The sequence AAH18203.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 21L → LLITLSANLFTVPERSLTTT FSFSR in isoform 2. 1 PublicationVSP_031842

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF435957 mRNA. Translation: AAM20908.1.
AC009230 Genomic DNA. Translation: AAY14974.1.
AC073271 Genomic DNA. No translation available.
CH471058 Genomic DNA. Translation: EAX11541.1.
CH471058 Genomic DNA. Translation: EAX11542.1.
CH471058 Genomic DNA. Translation: EAX11543.1.
BC018203 mRNA. Translation: AAH18203.1. Sequence problems.
BC040176 mRNA. Translation: AAH40176.2.
CCDSiCCDS46423.1. [Q8NI32-2]
RefSeqiNP_001303931.1. NM_001317002.1. [Q8NI32-2]
NP_001303932.1. NM_001317003.1. [Q8NI32-1]
NP_001303933.1. NM_001317004.1. [Q8NI32-1]
NP_001303934.1. NM_001317005.1. [Q8NI32-1]
NP_001303935.1. NM_001317006.1.
NP_808879.2. NM_177964.4. [Q8NI32-2]
XP_006712344.1. XM_006712281.2. [Q8NI32-1]
XP_011508925.1. XM_011510623.1. [Q8NI32-1]
UniGeneiHs.357567.

Genome annotation databases

EnsembliENST00000409029; ENSP00000386650; ENSG00000150556. [Q8NI32-1]
ENST00000409642; ENSP00000387077; ENSG00000150556. [Q8NI32-2]
ENST00000409876; ENSP00000386479; ENSG00000150556. [Q8NI32-1]
GeneIDi130576.
KEGGihsa:130576.
UCSCiuc002twv.2. human. [Q8NI32-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF435957 mRNA. Translation: AAM20908.1.
AC009230 Genomic DNA. Translation: AAY14974.1.
AC073271 Genomic DNA. No translation available.
CH471058 Genomic DNA. Translation: EAX11541.1.
CH471058 Genomic DNA. Translation: EAX11542.1.
CH471058 Genomic DNA. Translation: EAX11543.1.
BC018203 mRNA. Translation: AAH18203.1. Sequence problems.
BC040176 mRNA. Translation: AAH40176.2.
CCDSiCCDS46423.1. [Q8NI32-2]
RefSeqiNP_001303931.1. NM_001317002.1. [Q8NI32-2]
NP_001303932.1. NM_001317003.1. [Q8NI32-1]
NP_001303933.1. NM_001317004.1. [Q8NI32-1]
NP_001303934.1. NM_001317005.1. [Q8NI32-1]
NP_001303935.1. NM_001317006.1.
NP_808879.2. NM_177964.4. [Q8NI32-2]
XP_006712344.1. XM_006712281.2. [Q8NI32-1]
XP_011508925.1. XM_011510623.1. [Q8NI32-1]
UniGeneiHs.357567.

3D structure databases

ProteinModelPortaliQ8NI32.
SMRiQ8NI32. Positions 56-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126243. 1 interaction.
STRINGi9606.ENSP00000387077.

Protein family/group databases

TCDBi8.A.31.1.2. the ly-6 neurotoxin-like protein1 precursor (lynx1) family.

Polymorphism and mutation databases

DMDMi74715711.

Proteomic databases

PaxDbiQ8NI32.
PeptideAtlasiQ8NI32.
PRIDEiQ8NI32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409029; ENSP00000386650; ENSG00000150556. [Q8NI32-1]
ENST00000409642; ENSP00000387077; ENSG00000150556. [Q8NI32-2]
ENST00000409876; ENSP00000386479; ENSG00000150556. [Q8NI32-1]
GeneIDi130576.
KEGGihsa:130576.
UCSCiuc002twv.2. human. [Q8NI32-1]

Organism-specific databases

CTDi130576.
GeneCardsiLYPD6B.
HGNCiHGNC:27018. LYPD6B.
HPAiHPA049239.
neXtProtiNX_Q8NI32.
PharmGKBiPA162394734.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT28. Eukaryota.
ENOG4111P33. LUCA.
GeneTreeiENSGT00390000000220.
HOGENOMiHOG000231796.
HOVERGENiHBG054166.
InParanoidiQ8NI32.
OMAiMLLLCHA.
OrthoDBiEOG7XH6RK.
PhylomeDBiQ8NI32.
TreeFamiTF332443.

Miscellaneous databases

ChiTaRSiLYPD6B. human.
GenomeRNAii130576.
PROiQ8NI32.

Gene expression databases

BgeeiQ8NI32.
CleanExiHS_LYPD6B.
ExpressionAtlasiQ8NI32. baseline and differential.
GenevisibleiQ8NI32. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. Guo J.H., Yu L.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Ovary.

Entry informationi

Entry nameiLPD6B_HUMAN
AccessioniPrimary (citable) accession number: Q8NI32
Secondary accession number(s): D3DP90
, Q53TK0, Q7Z747, Q8IXK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.