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Protein

F-box only protein 27

Gene

FBXO27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664. Neddylation.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 27
Alternative name(s):
F-box/G-domain protein 5
Gene namesi
Name:FBXO27
Synonyms:FBG5, FBX27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000161243.8.
HGNCiHGNC:18753. FBXO27.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi262 – 263FW → AA: Reduces interaction with glycosylated concanavalin-A in vitro. 1 Publication2

Organism-specific databases

OpenTargetsiENSG00000161243.
PharmGKBiPA38675.

Polymorphism and mutation databases

BioMutaiFBXO27.
DMDMi51338809.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199141 – 283F-box only protein 27Add BLAST283

Proteomic databases

MaxQBiQ8NI29.
PaxDbiQ8NI29.
PeptideAtlasiQ8NI29.
PRIDEiQ8NI29.

PTM databases

iPTMnetiQ8NI29.
PhosphoSitePlusiQ8NI29.

Expressioni

Tissue specificityi

Predominantly expressed in brain, heart and kidney. Expressed at lower levels in liver and lung.1 Publication

Gene expression databases

BgeeiENSG00000161243.
CleanExiHS_FBXO27.
ExpressionAtlasiQ8NI29. baseline and differential.
GenevisibleiQ8NI29. HS.

Organism-specific databases

HPAiHPA046800.
HPA062242.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P632086EBI-6425694,EBI-307486

Protein-protein interaction databases

BioGridi125992. 11 interactors.
IntActiQ8NI29. 2 interactors.
STRINGi9606.ENSP00000292853.

Structurei

3D structure databases

ProteinModelPortaliQ8NI29.
SMRiQ8NI29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 70F-boxPROSITE-ProRule annotationAdd BLAST48
Domaini104 – 280FBAPROSITE-ProRule annotationAdd BLAST177

Phylogenomic databases

eggNOGiENOG410J91C. Eukaryota.
ENOG4111NAA. LUCA.
GeneTreeiENSGT00390000003865.
HOGENOMiHOG000231084.
HOVERGENiHBG003593.
InParanoidiQ8NI29.
KOiK10102.
OMAiTSFSWCR.
OrthoDBiEOG091G0G3L.
PhylomeDBiQ8NI29.
TreeFamiTF320527.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiView protein in InterPro
IPR007397. F-box-assoc_dom.
IPR036047. F-box-like_dom_sf.
IPR001810. F-box_dom.
IPR008979. Galactose-bd-like_sf.
PfamiView protein in Pfam
PF00646. F-box. 1 hit.
PF04300. FBA. 1 hit.
SMARTiView protein in SMART
SM01198. FBA. 1 hit.
SM00256. FBOX. 1 hit.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiView protein in PROSITE
PS51114. FBA. 1 hit.
PS50181. FBOX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NI29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGASVSRGRA ARVPAPEPEP EEALDLSQLP PELLLVVLSH VPPRTLLGRC
60 70 80 90 100
RQVCRGWRAL VDGQALWLLI LARDHGATGR ALLHLARSCQ SPARNARPCP
110 120 130 140 150
LGRFCARRPI GRNLIRNPCG QEGLRKWMVQ HGGDGWVVEE NRTTVPGAPS
160 170 180 190 200
QTCFVTSFSW CCKKQVLDLE EEGLWPELLD SGRIEICVSD WWGARHDSGC
210 220 230 240 250
MYRLLVQLLD ANQTVLDKFS AVPDPIPQWN NNACLHVTHV FSNIKMGVRF
260 270 280
VSFEHRGQDT QFWAGHYGAR VTNSSVIVRV RLS
Length:283
Mass (Da):31,623
Last modified:August 16, 2004 - v2
Checksum:i0A66E26971320B5F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8G → C in AAM27918 (PubMed:12383498).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF436061 mRNA. Translation: AAM27918.1.
BC014527 mRNA. Translation: AAH14527.1.
BC030060 mRNA. Translation: AAH30060.1.
CCDSiCCDS12527.1.
RefSeqiNP_849142.1. NM_178820.4.
UniGeneiHs.187461.

Genome annotation databases

EnsembliENST00000292853; ENSP00000292853; ENSG00000161243.
ENST00000509137; ENSP00000437662; ENSG00000161243.
ENST00000635475; ENSP00000489487; ENSG00000283021.
ENST00000635513; ENSP00000489017; ENSG00000283021.
GeneIDi126433.
KEGGihsa:126433.
UCSCiuc002okh.5. human.

Similar proteinsi

Entry informationi

Entry nameiFBX27_HUMAN
AccessioniPrimary (citable) accession number: Q8NI29
Secondary accession number(s): Q96C87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: August 16, 2004
Last modified: November 22, 2017
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot