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Protein

F-box only protein 27

Gene

FBXO27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.1 Publication

GO - Molecular functioni

  • glycoprotein binding Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 27
Alternative name(s):
F-box/G-domain protein 5
Gene namesi
Name:FBXO27
Synonyms:FBG5, FBX27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:18753. FBXO27.

Subcellular locationi

GO - Cellular componenti

  • SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi262 – 2632FW → AA: Reduces interaction with glycosylated concanavalin-A in vitro. 1 Publication

Organism-specific databases

PharmGKBiPA38675.

Polymorphism and mutation databases

BioMutaiFBXO27.
DMDMi51338809.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283F-box only protein 27PRO_0000119914Add
BLAST

Proteomic databases

MaxQBiQ8NI29.
PaxDbiQ8NI29.
PRIDEiQ8NI29.

Expressioni

Tissue specificityi

Predominantly expressed in brain, heart and kidney. Expressed at lower levels in liver and lung.1 Publication

Gene expression databases

BgeeiQ8NI29.
CleanExiHS_FBXO27.
ExpressionAtlasiQ8NI29. baseline and differential.
GenevisibleiQ8NI29. HS.

Organism-specific databases

HPAiHPA046800.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.1 Publication

GO - Molecular functioni

  • glycoprotein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi125992. 10 interactions.
IntActiQ8NI29. 1 interaction.
STRINGi9606.ENSP00000292853.

Structurei

3D structure databases

ProteinModelPortaliQ8NI29.
SMRiQ8NI29. Positions 37-278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 7048F-boxPROSITE-ProRule annotationAdd
BLAST
Domaini104 – 280177FBAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 1 FBA (F-box associated) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410J91C. Eukaryota.
ENOG4111NAA. LUCA.
GeneTreeiENSGT00390000003865.
HOGENOMiHOG000231084.
HOVERGENiHBG003593.
InParanoidiQ8NI29.
KOiK10102.
OMAiQQWNNNA.
OrthoDBiEOG7DRJ3R.
PhylomeDBiQ8NI29.
TreeFamiTF320527.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR007397. F-box-assoc_dom.
IPR001810. F-box_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF04300. FBA. 1 hit.
[Graphical view]
SMARTiSM01198. FBA. 1 hit.
SM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS51114. FBA. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NI29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGASVSRGRA ARVPAPEPEP EEALDLSQLP PELLLVVLSH VPPRTLLGRC
60 70 80 90 100
RQVCRGWRAL VDGQALWLLI LARDHGATGR ALLHLARSCQ SPARNARPCP
110 120 130 140 150
LGRFCARRPI GRNLIRNPCG QEGLRKWMVQ HGGDGWVVEE NRTTVPGAPS
160 170 180 190 200
QTCFVTSFSW CCKKQVLDLE EEGLWPELLD SGRIEICVSD WWGARHDSGC
210 220 230 240 250
MYRLLVQLLD ANQTVLDKFS AVPDPIPQWN NNACLHVTHV FSNIKMGVRF
260 270 280
VSFEHRGQDT QFWAGHYGAR VTNSSVIVRV RLS
Length:283
Mass (Da):31,623
Last modified:August 16, 2004 - v2
Checksum:i0A66E26971320B5F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81G → C in AAM27918 (PubMed:12383498).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF436061 mRNA. Translation: AAM27918.1.
BC014527 mRNA. Translation: AAH14527.1.
BC030060 mRNA. Translation: AAH30060.1.
CCDSiCCDS12527.1.
RefSeqiNP_849142.1. NM_178820.4.
UniGeneiHs.187461.

Genome annotation databases

EnsembliENST00000292853; ENSP00000292853; ENSG00000161243.
ENST00000509137; ENSP00000437662; ENSG00000161243.
GeneIDi126433.
KEGGihsa:126433.
UCSCiuc002okh.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF436061 mRNA. Translation: AAM27918.1.
BC014527 mRNA. Translation: AAH14527.1.
BC030060 mRNA. Translation: AAH30060.1.
CCDSiCCDS12527.1.
RefSeqiNP_849142.1. NM_178820.4.
UniGeneiHs.187461.

3D structure databases

ProteinModelPortaliQ8NI29.
SMRiQ8NI29. Positions 37-278.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125992. 10 interactions.
IntActiQ8NI29. 1 interaction.
STRINGi9606.ENSP00000292853.

Polymorphism and mutation databases

BioMutaiFBXO27.
DMDMi51338809.

Proteomic databases

MaxQBiQ8NI29.
PaxDbiQ8NI29.
PRIDEiQ8NI29.

Protocols and materials databases

DNASUi126433.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292853; ENSP00000292853; ENSG00000161243.
ENST00000509137; ENSP00000437662; ENSG00000161243.
GeneIDi126433.
KEGGihsa:126433.
UCSCiuc002okh.5. human.

Organism-specific databases

CTDi126433.
GeneCardsiFBXO27.
HGNCiHGNC:18753. FBXO27.
HPAiHPA046800.
MIMi609099. gene.
neXtProtiNX_Q8NI29.
PharmGKBiPA38675.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J91C. Eukaryota.
ENOG4111NAA. LUCA.
GeneTreeiENSGT00390000003865.
HOGENOMiHOG000231084.
HOVERGENiHBG003593.
InParanoidiQ8NI29.
KOiK10102.
OMAiQQWNNNA.
OrthoDBiEOG7DRJ3R.
PhylomeDBiQ8NI29.
TreeFamiTF320527.

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiFBXO27. human.
GenomeRNAii126433.
NextBioi81831.
PROiQ8NI29.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NI29.
CleanExiHS_FBXO27.
ExpressionAtlasiQ8NI29. baseline and differential.
GenevisibleiQ8NI29. HS.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR007397. F-box-assoc_dom.
IPR001810. F-box_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF04300. FBA. 1 hit.
[Graphical view]
SMARTiSM01198. FBA. 1 hit.
SM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS51114. FBA. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new subfamily of structurally related human F-box proteins."
    Ilyin G.P., Serandour A.L., Pigeon C., Rialland M., Glaise D., Guguen-Guillouzo C.
    Gene 296:11-20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas and Placenta.
  3. "Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases."
    Glenn K.A., Nelson R.F., Wen H.M., Mallinger A.J., Paulson H.L.
    J. Biol. Chem. 283:12717-12729(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUGAR-BINDING, FUNCTION, INTERACTION WITH CUL1 AND SKP1, IDENTIFICATION IN SCF-COMPLEX, MUTAGENESIS OF 262-PHE-TRP-263.

Entry informationi

Entry nameiFBX27_HUMAN
AccessioniPrimary (citable) accession number: Q8NI29
Secondary accession number(s): Q96C87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: August 16, 2004
Last modified: May 11, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.