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Protein

Interleukin-31 receptor subunit alpha

Gene

IL31RA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15627637, PubMed:15194700). May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity).By similarity5 Publications

GO - Molecular functioni

  • cytokine binding Source: UniProtKB
  • cytokine receptor activity Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

  • acute inflammatory response to antigenic stimulus Source: Ensembl
  • cytokine-mediated signaling pathway Source: UniProtKB
  • defense response Source: UniProtKB
  • defense response to other organism Source: Ensembl
  • glandular epithelial cell differentiation Source: Ensembl
  • homeostatic process Source: UniProtKB
  • JAK-STAT cascade Source: UniProtKB
  • macrophage differentiation Source: UniProtKB
  • MAPK cascade Source: UniProtKB
  • monocyte differentiation Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of macrophage activation Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of tyrosine phosphorylation of Stat3 protein Source: UniProtKB
  • positive regulation of tyrosine phosphorylation of Stat5 protein Source: UniProtKB
  • T-helper 2 cell cytokine production Source: Ensembl
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164509-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.
SignaLinkiQ8NI17.
SIGNORiQ8NI17.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-31 receptor subunit alpha
Short name:
IL-31 receptor subunit alpha
Short name:
IL-31R subunit alpha
Short name:
IL-31R-alpha
Short name:
IL-31RA
Alternative name(s):
Cytokine receptor-like 3
GLM-R
Short name:
hGLM-R
Gp130-like monocyte receptor
Short name:
Gp130-like receptor
ZcytoR17
Gene namesi
Name:IL31RA
Synonyms:CRL3, GPL
ORF Names:UNQ6368/PRO21073/PRO21384
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:18969. IL31RA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 519ExtracellularSequence analysisAdd BLAST500
Transmembranei520 – 540HelicalSequence analysisAdd BLAST21
Topological domaini541 – 732CytoplasmicSequence analysisAdd BLAST192

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Amyloidosis, primary localized cutaneous, 2 (PLCA2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.
See also OMIM:613955
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065809489S → F in PLCA2. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi639Y → A: No effect on STAT1 and STAT3 activation. Slight decrease; when associated with A-670 and A-708. 2 Publications1
Mutagenesisi639Y → F: Abrogates STAT5 activation. Mild effect on STAT1 activation. No effect on STAT3 activation. 2 Publications1
Mutagenesisi670Y → A: No effect on STAT1 and STAT3 activation. Slight decrease; when associated with A-639 and A-708. 2 Publications1
Mutagenesisi670Y → F: No effect on STAT3 and STAT5 activation. Mild effect on STAT1 activation. 2 Publications1
Mutagenesisi708Y → A: No effect on STAT1 and STAT3 activation. Slight decrease; when associated with A-639 and A-670. 2 Publications1
Mutagenesisi708Y → F: Abrogates STAT3 activation. Loss of interaction with STAT3. Mild effect on STAT1 activation. No effect on STAT5 activation. 2 Publications1

Keywords - Diseasei

Amyloidosis, Disease mutation

Organism-specific databases

DisGeNETi133396.
MalaCardsiIL31RA.
MIMi613955. phenotype.
OpenTargetsiENSG00000164509.
Orphaneti353220. Familial primary localized cutaneous amyloidosis.
PharmGKBiPA134952624.

Chemistry databases

GuidetoPHARMACOLOGYi1710.

Polymorphism and mutation databases

BioMutaiIL31RA.
DMDMi74730327.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000027457220 – 732Interleukin-31 receptor subunit alphaAdd BLAST713

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...)Sequence analysis1
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Glycosylationi93N-linked (GlcNAc...)Sequence analysis1
Glycosylationi166N-linked (GlcNAc...)Sequence analysis1
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1
Glycosylationi277N-linked (GlcNAc...)Sequence analysis1
Glycosylationi283N-linked (GlcNAc...)Sequence analysis1
Glycosylationi395N-linked (GlcNAc...)Sequence analysis1
Glycosylationi455N-linked (GlcNAc...)Sequence analysis1
Glycosylationi504N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8NI17.
PaxDbiQ8NI17.
PeptideAtlasiQ8NI17.
PRIDEiQ8NI17.

PTM databases

iPTMnetiQ8NI17.
PhosphoSitePlusiQ8NI17.

Expressioni

Tissue specificityi

Expressed in CD14- and CD56-positive blood cells (PubMed:11877449). Expressed in macrophages (PubMed:16461143, PubMed:18439099). Expressed in keratinocytes (PubMed:21261663). Expressed in a subset of dorsal root ganglia neurons (at protein level) (PubMed:24373353). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin (PubMed:15184896, PubMed:11877449, PubMed:14504285). Expressed in bronchial and alveolar epithelial cells and pulmonary fibroblasts (PubMed:18439099). Detected in all of the myelomonocytic lineage (PubMed:14504285). Isoform 6: Expressed at higher levels in lesional skin compared to healthy skin of atopic dermatitis patients (PubMed:24373353).7 Publications

Inductioni

Up-regulated in lesional keratinocytes of patients with atopic dermatitis (PubMed:16461143). Up-regulated by IFNG/IFN-gamma (PubMed:11877449, PubMed:14504285, PubMed:15184896, PubMed:21261663, PubMed:18439099). Up-regulated by bacterial lipopolysaccharides (LPS) (PubMed:11877449, PubMed:15184896, PubMed:14504285). Up-regulated by triacylated lipoprotein (Pam3Cys) (PubMed:21261663). Up-regulated by TGFB1/TGF-beta (PubMed:18439099).6 Publications

Gene expression databases

BgeeiENSG00000164509.
ExpressionAtlasiQ8NI17. baseline and differential.
GenevisibleiQ8NI17. HS.

Organism-specific databases

HPAiHPA051532.

Interactioni

Subunit structurei

Heterodimer with OSMR. Interacts with JAK1 and STAT3.1 Publication

GO - Molecular functioni

  • cytokine binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi126357. 23 interactors.
IntActiQ8NI17. 1 interactor.
STRINGi9606.ENSP00000415900.

Structurei

3D structure databases

ProteinModelPortaliQ8NI17.
SMRiQ8NI17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 122Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini124 – 225Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST102
Domaini223 – 315Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST93
Domaini319 – 416Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST98
Domaini421 – 515Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST95

Sequence similaritiesi

Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJG6. Eukaryota.
ENOG410YAI2. LUCA.
GeneTreeiENSGT00550000074436.
HOVERGENiHBG081788.
InParanoidiQ8NI17.
OMAiIWYFPEN.
OrthoDBiEOG091G01XM.
PhylomeDBiQ8NI17.
TreeFamiTF338122.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 3 hits.
[Graphical view]

Sequences (12)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 12 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NI17-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMWTWALWML PSLCKFSLAA LPAKPENISC VYYYRKNLTC TWSPGKETSY
60 70 80 90 100
TQYTVKRTYA FGEKHDNCTT NSSTSENRAS CSFFLPRITI PDNYTIEVEA
110 120 130 140 150
ENGDGVIKSH MTYWRLENIA KTEPPKIFRV KPVLGIKRMI QIEWIKPELA
160 170 180 190 200
PVSSDLKYTL RFRTVNSTSW MEVNFAKNRK DKNQTYNLTG LQPFTEYVIA
210 220 230 240 250
LRCAVKESKF WSDWSQEKMG MTEEEAPCGL ELWRVLKPAE ADGRRPVRLL
260 270 280 290 300
WKKARGAPVL EKTLGYNIWY YPESNTNLTE TMNTTNQQLE LHLGGESFWV
310 320 330 340 350
SMISYNSLGK SPVATLRIPA IQEKSFQCIE VMQACVAEDQ LVVKWQSSAL
360 370 380 390 400
DVNTWMIEWF PDVDSEPTTL SWESVSQATN WTIQQDKLKP FWCYNISVYP
410 420 430 440 450
MLHDKVGEPY SIQAYAKEGV PSEGPETKVE NIGVKTVTIT WKEIPKSERK
460 470 480 490 500
GIICNYTIFY QAEGGKGFSK TVNSSILQYG LESLKRKTSY IVQVMASTSA
510 520 530 540 550
GGTNGTSINF KTLSFSVFEI ILITSLIGGG LLILIILTVA YGLKKPNKLT
560 570 580 590 600
HLCWPTVPNP AESSIATWHG DDFKDKLNLK ESDDSVNTED RILKPCSTPS
610 620 630 640 650
DKLVIDKLVV NFGNVLQEIF TDEARTGQEN NLGGEKNGYV TCPFRPDCPL
660 670 680 690 700
GKSFEELPVS PEIPPRKSQY LRSRMPEGTR PEAKEQLLFS GQSLVPDHLC
710 720 730
EEGAPNPYLK NSVTAREFLV SEKLPEHTKG EV
Length:732
Mass (Da):82,954
Last modified:October 1, 2002 - v1
Checksum:i30F84BD3DD99A20E
GO
Isoform 2 (identifier: Q8NI17-2) [UniParc]FASTAAdd to basket
Also known as: v3

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCIRQLKFFTTACVCECPQNILSPQPSCVNLGM

Show »
Length:764
Mass (Da):86,481
Checksum:iDC1D6BB2EA6AF15F
GO
Isoform 3 (identifier: Q8NI17-3) [UniParc]FASTAAdd to basket
Also known as: v4

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKLSPQPSCVNLGM
     639-649: YVTCPFRPDCP → TRILSSCPTSI
     650-732: Missing.

Show »
Length:662
Mass (Da):74,876
Checksum:iA49F6363C4B33582
GO
Isoform 4 (identifier: Q8NI17-4) [UniParc]FASTAAdd to basket
Also known as: v2

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCIRQLKFFTTACVCECPQNILSPQPSCVNLGM
     325-732: Missing.

Show »
Length:356
Mass (Da):41,026
Checksum:iBF4DAD24F5048E1D
GO
Isoform 5 (identifier: Q8NI17-5) [UniParc]FASTAAdd to basket
Also known as: v1

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCIRQLKFFTTACVCECPQNILSPQPSCVNLGM
     639-649: YVTCPFRPDCP → TRILSSCPTSI
     650-732: Missing.

Show »
Length:681
Mass (Da):77,047
Checksum:iC69CC4EF9AC55E42
GO
Isoform 6 (identifier: Q8NI17-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Note: No experimental confirmation available.
Show »
Length:622
Mass (Da):70,363
Checksum:i80E4A3592D040EC6
GO
Isoform 7 (identifier: Q8NI17-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKLSPQPSCVNLGM
     464-469: GGKGFS → A
     498-501: TSAG → YSGG
     502-732: Missing.

Note: No experimental confirmation available.
Show »
Length:509
Mass (Da):58,390
Checksum:i5DC85C59E170D44B
GO
Isoform 8 (identifier: Q8NI17-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCIRQLKFFTTACVCECPQNILSPQPSCVNLGM
     469-550: SKTVNSSILQ...YGLKKPNKLT → CKHAHSEVEK...RVLRKWKELL
     551-732: Missing.

Note: No experimental confirmation available.
Show »
Length:582
Mass (Da):66,605
Checksum:i5EC7B07B84B36057
GO
Isoform 9 (identifier: Q8NI17-9) [UniParc]FASTAAdd to basket
Also known as: GPL560, short

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKLSPQPSCVNLGM
     548-732: Missing.

Note: Major isoform. Dominant negative IL31 receptor.
Show »
Length:560
Mass (Da):63,638
Checksum:iBDE67D9F753AED29
GO
Isoform 10 (identifier: Q8NI17-10) [UniParc]FASTAAdd to basket
Also known as: GPL610

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKLSPQPSCVNLGM
     593-598: LKPCST → RARYQA
     599-732: Missing.

Show »
Length:611
Mass (Da):69,491
Checksum:iEE437BBA84162525
GO
Isoform 11 (identifier: Q8NI17-11) [UniParc]FASTAAdd to basket
Also known as: GPL626

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKLSPQPSCVNLGM
     593-613: LKPCSTPSDKLVIDKLVVNFG → KGSELGTKLKFKPLISLDCAF
     614-732: Missing.

Show »
Length:626
Mass (Da):71,023
Checksum:iFA80DED660647A2F
GO
Isoform 12 (identifier: Q8NI17-12) [UniParc]FASTAAdd to basket
Also known as: GPL745, long

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKLSPQPSCVNLGM

Note: Major isoform. Functional IL31 receptor.
Show »
Length:745
Mass (Da):84,309
Checksum:iC4A17642CCC0549B
GO

Sequence cautioni

The sequence AAS86444 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAS86445 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030328155D → N.Corresponds to variant rs13184107dbSNPEnsembl.1
Natural variantiVAR_065809489S → F in PLCA2. 1 Publication1
Natural variantiVAR_030329497S → N.Corresponds to variant rs161704dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0227981 – 110Missing in isoform 6. 1 PublicationAdd BLAST110
Alternative sequenceiVSP_0227991M → MCIRQLKFFTTACVCECPQN ILSPQPSCVNLGM in isoform 2, isoform 4, isoform 5 and isoform 8. 2 Publications1
Alternative sequenceiVSP_0228001M → MKLSPQPSCVNLGM in isoform 3, isoform 7, isoform 9, isoform 10, isoform 11 and isoform 12. 2 Publications1
Alternative sequenceiVSP_022801325 – 732Missing in isoform 4. 1 PublicationAdd BLAST408
Alternative sequenceiVSP_022802464 – 469GGKGFS → A in isoform 7. 1 Publication6
Alternative sequenceiVSP_022803469 – 550SKTVN…PNKLT → CKHAHSEVEKNPKPQIDAMD RPVVGMAPPSHCDLQPGMNH LASLNLSENGAKSTHLLGFW GLNESEVTVPERRVLRKWKE LL in isoform 8. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_022804498 – 501TSAG → YSGG in isoform 7. 1 Publication4
Alternative sequenceiVSP_022805502 – 732Missing in isoform 7. 1 PublicationAdd BLAST231
Alternative sequenceiVSP_022806548 – 732Missing in isoform 9. CuratedAdd BLAST185
Alternative sequenceiVSP_022807551 – 732Missing in isoform 8. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_022808593 – 613LKPCS…VVNFG → KGSELGTKLKFKPLISLDCA F in isoform 11. CuratedAdd BLAST21
Alternative sequenceiVSP_022809593 – 598LKPCST → RARYQA in isoform 10. Curated6
Alternative sequenceiVSP_022810599 – 732Missing in isoform 10. CuratedAdd BLAST134
Alternative sequenceiVSP_022811614 – 732Missing in isoform 11. CuratedAdd BLAST119
Alternative sequenceiVSP_022812639 – 649YVTCPFRPDCP → TRILSSCPTSI in isoform 3 and isoform 5. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_022813650 – 732Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF486620 mRNA. Translation: AAM27958.1.
AY499339 mRNA. Translation: AAS86444.1. Different initiation.
AY499340 mRNA. Translation: AAS86445.1. Different initiation.
AY499341 mRNA. Translation: AAS86446.1.
AY499342 mRNA. Translation: AAS86447.1.
AF106913 mRNA. Translation: AAL36452.1.
AY358117 mRNA. Translation: AAQ88484.1.
AY358740 mRNA. Translation: AAQ89100.1.
AC008914 Genomic DNA. No translation available.
BC110490 mRNA. Translation: AAI10491.1.
CCDSiCCDS3970.2. [Q8NI17-2]
CCDS56365.1. [Q8NI17-5]
CCDS56366.1. [Q8NI17-3]
CCDS56367.1. [Q8NI17-6]
CCDS75244.1. [Q8NI17-8]
CCDS75245.1. [Q8NI17-12]
RefSeqiNP_001229565.1. NM_001242636.1. [Q8NI17-12]
NP_001229566.1. NM_001242637.1. [Q8NI17-5]
NP_001229567.1. NM_001242638.1. [Q8NI17-3]
NP_001229568.1. NM_001242639.1. [Q8NI17-6]
NP_001284499.1. NM_001297570.1. [Q8NI17-8]
NP_001284501.1. NM_001297572.1.
NP_620586.3. NM_139017.5. [Q8NI17-2]
XP_011541444.1. XM_011543142.2. [Q8NI17-1]
XP_011541445.1. XM_011543143.2. [Q8NI17-3]
XP_011541446.1. XM_011543144.2. [Q8NI17-6]
UniGeneiHs.55378.

Genome annotation databases

EnsembliENST00000297015; ENSP00000297015; ENSG00000164509. [Q8NI17-12]
ENST00000354961; ENSP00000347047; ENSG00000164509. [Q8NI17-3]
ENST00000359040; ENSP00000351935; ENSG00000164509. [Q8NI17-5]
ENST00000396834; ENSP00000380046; ENSG00000164509. [Q8NI17-3]
ENST00000396836; ENSP00000380048; ENSG00000164509. [Q8NI17-8]
ENST00000447346; ENSP00000415900; ENSG00000164509. [Q8NI17-2]
ENST00000490985; ENSP00000427533; ENSG00000164509. [Q8NI17-6]
GeneIDi133396.
KEGGihsa:133396.
UCSCiuc003jqk.3. human. [Q8NI17-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF486620 mRNA. Translation: AAM27958.1.
AY499339 mRNA. Translation: AAS86444.1. Different initiation.
AY499340 mRNA. Translation: AAS86445.1. Different initiation.
AY499341 mRNA. Translation: AAS86446.1.
AY499342 mRNA. Translation: AAS86447.1.
AF106913 mRNA. Translation: AAL36452.1.
AY358117 mRNA. Translation: AAQ88484.1.
AY358740 mRNA. Translation: AAQ89100.1.
AC008914 Genomic DNA. No translation available.
BC110490 mRNA. Translation: AAI10491.1.
CCDSiCCDS3970.2. [Q8NI17-2]
CCDS56365.1. [Q8NI17-5]
CCDS56366.1. [Q8NI17-3]
CCDS56367.1. [Q8NI17-6]
CCDS75244.1. [Q8NI17-8]
CCDS75245.1. [Q8NI17-12]
RefSeqiNP_001229565.1. NM_001242636.1. [Q8NI17-12]
NP_001229566.1. NM_001242637.1. [Q8NI17-5]
NP_001229567.1. NM_001242638.1. [Q8NI17-3]
NP_001229568.1. NM_001242639.1. [Q8NI17-6]
NP_001284499.1. NM_001297570.1. [Q8NI17-8]
NP_001284501.1. NM_001297572.1.
NP_620586.3. NM_139017.5. [Q8NI17-2]
XP_011541444.1. XM_011543142.2. [Q8NI17-1]
XP_011541445.1. XM_011543143.2. [Q8NI17-3]
XP_011541446.1. XM_011543144.2. [Q8NI17-6]
UniGeneiHs.55378.

3D structure databases

ProteinModelPortaliQ8NI17.
SMRiQ8NI17.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126357. 23 interactors.
IntActiQ8NI17. 1 interactor.
STRINGi9606.ENSP00000415900.

Chemistry databases

GuidetoPHARMACOLOGYi1710.

PTM databases

iPTMnetiQ8NI17.
PhosphoSitePlusiQ8NI17.

Polymorphism and mutation databases

BioMutaiIL31RA.
DMDMi74730327.

Proteomic databases

MaxQBiQ8NI17.
PaxDbiQ8NI17.
PeptideAtlasiQ8NI17.
PRIDEiQ8NI17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297015; ENSP00000297015; ENSG00000164509. [Q8NI17-12]
ENST00000354961; ENSP00000347047; ENSG00000164509. [Q8NI17-3]
ENST00000359040; ENSP00000351935; ENSG00000164509. [Q8NI17-5]
ENST00000396834; ENSP00000380046; ENSG00000164509. [Q8NI17-3]
ENST00000396836; ENSP00000380048; ENSG00000164509. [Q8NI17-8]
ENST00000447346; ENSP00000415900; ENSG00000164509. [Q8NI17-2]
ENST00000490985; ENSP00000427533; ENSG00000164509. [Q8NI17-6]
GeneIDi133396.
KEGGihsa:133396.
UCSCiuc003jqk.3. human. [Q8NI17-1]

Organism-specific databases

CTDi133396.
DisGeNETi133396.
GeneCardsiIL31RA.
HGNCiHGNC:18969. IL31RA.
HPAiHPA051532.
MalaCardsiIL31RA.
MIMi609510. gene.
613955. phenotype.
neXtProtiNX_Q8NI17.
OpenTargetsiENSG00000164509.
Orphaneti353220. Familial primary localized cutaneous amyloidosis.
PharmGKBiPA134952624.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJG6. Eukaryota.
ENOG410YAI2. LUCA.
GeneTreeiENSGT00550000074436.
HOVERGENiHBG081788.
InParanoidiQ8NI17.
OMAiIWYFPEN.
OrthoDBiEOG091G01XM.
PhylomeDBiQ8NI17.
TreeFamiTF338122.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164509-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.
SignaLinkiQ8NI17.
SIGNORiQ8NI17.

Miscellaneous databases

ChiTaRSiIL31RA. human.
GeneWikiiIL31RA.
GenomeRNAii133396.
PROiQ8NI17.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164509.
ExpressionAtlasiQ8NI17. baseline and differential.
GenevisibleiQ8NI17. HS.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL31R_HUMAN
AccessioniPrimary (citable) accession number: Q8NI17
Secondary accession number(s): A6NIF8
, Q2TBA1, Q6EBC3, Q6EBC4, Q6EBC5, Q6EBC6, Q6UWL8, Q8WYJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.