Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8NI08

- NCOA7_HUMAN

UniProt

Q8NI08 - NCOA7_HUMAN

Protein

Nuclear receptor coactivator 7

Gene

NCOA7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (11 Jul 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.1 Publication

    GO - Molecular functioni

    1. ligand-dependent nuclear receptor transcription coactivator activity Source: UniProtKB
    2. nuclear hormone receptor binding Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear receptor coactivator 7
    Alternative name(s):
    140 kDa estrogen receptor-associated protein
    Estrogen nuclear receptor coactivator 1
    Gene namesi
    Name:NCOA7
    Synonyms:ERAP140, ESNA1
    ORF Names:Nbla00052, Nbla10993
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21081. NCOA7.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. intracellular Source: LIFEdb
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi511 – 5177LNIHEDL → ANAHEDA: No action on the E2-induced ESR1 binding. 1 Publication
    Mutagenesisi522 – 5232LI → AA: Abolishes completely the E2-induced ESR1 binding. 1 Publication

    Organism-specific databases

    PharmGKBiPA134905581.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 942942Nuclear receptor coactivator 7PRO_0000245229Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei179 – 1791Phosphoserine1 Publication
    Modified residuei183 – 1831Phosphoserine1 Publication
    Modified residuei208 – 2081Phosphoserine2 Publications
    Modified residuei211 – 2111Phosphoserine2 Publications
    Modified residuei441 – 4411Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8NI08.
    PaxDbiQ8NI08.
    PRIDEiQ8NI08.

    Expressioni

    Tissue specificityi

    Highly expressed in brain. Weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord and pancreas. Expressed in cancer cell line.1 Publication

    Gene expression databases

    ArrayExpressiQ8NI08.
    BgeeiQ8NI08.
    GenevestigatoriQ8NI08.

    Organism-specific databases

    HPAiHPA030289.
    HPA030290.
    HPA030291.
    HPA030292.

    Interactioni

    Subunit structurei

    Interacts with ESR1, ESR2A, ESR2B, THRB, PPARG and RARA in a ligand-inducible manner. Interacts with the heterodimer AHR-ARNT.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AHRP358692EBI-80799,EBI-80780
    ARNTP275402EBI-80799,EBI-80809
    GABARAPO951664EBI-80799,EBI-712001
    GABARAPL1Q9H0R82EBI-80799,EBI-746969

    Protein-protein interaction databases

    BioGridi126419. 8 interactions.
    IntActiQ8NI08. 8 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NI08.
    SMRiQ8NI08. Positions 780-942.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati116 – 15843LysMAdd
    BLAST
    Domaini806 – 942137TLDAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili4 – 2926Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the OXR1 family.Curated
    Contains 1 LysM repeat.Curated
    Contains 1 TLD domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5142.
    HOVERGENiHBG065488.
    InParanoidiQ8NI08.
    OMAiETCEKQD.
    OrthoDBiEOG77M8PQ.
    PhylomeDBiQ8NI08.
    TreeFamiTF313530.

    Family and domain databases

    Gene3Di3.10.350.10. 1 hit.
    InterProiIPR018392. LysM_dom.
    IPR006571. TLDc.
    [Graphical view]
    PfamiPF01476. LysM. 1 hit.
    PF07534. TLD. 1 hit.
    [Graphical view]
    SMARTiSM00257. LysM. 1 hit.
    SM00584. TLDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF54106. SSF54106. 1 hit.

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NI08-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDTKEEKKER KQSYFARLKK KKQAKQNAET ASAVATRTHT GKEDNNTVVL    50
    EPDKCNIAVE EEYMTDEKKK RKSNQLKEIR RTELKRYYSI DDNQNKTHDK 100
    KEKKMVVQKP HGTMEYTAGN QDTLNSIALK FNITPNKLVE LNKLFTHTIV 150
    PGQVLFVPDA NSPSSTLRLS SSSPGATVSP SSSDAEYDKL PDADLARKAL 200
    KPIERVLSST SEEDEPGVVK FLKMNCRYFT DGKGVVGGVM IVTPNNIMFD 250
    PHKSDPLVIE NGCEEYGLIC PMEEVVSIAL YNDISHMKIK DALPSDLPQD 300
    LCPLYRPGEW EDLASEKDIN PFSKFKSINK EKRQQNGEKI MTSDSRPIVP 350
    LEKSTGHTPT KPSGSSVSEK LKKLDSSRET SHGSPTVTKL SKEPSDTSSA 400
    FESTAKENFL GEDDDFVDLE ELSSQTGGGM HKKDTLKECL SLDPEERKKA 450
    ESQINNSAVE MQVQSALAFL GTENDVELKG ALDLETCEKQ DIMPEVDKQS 500
    GSPESRVENT LNIHEDLDKV KLIEYYLTKN KEGPQVSENL QKTELSDGKS 550
    IEPGGIDITL SSSLSQAGDP ITEGNKEPDK TWVKKGEPLP VKLNSSTEAN 600
    VIKEALDSSL ESTLDNSCQG AQMDNKSEVQ LWLLKRIQVP IEDILPSKEE 650
    KSKTPPMFLC IKVGKPMRKS FATHTAAMVQ QYGKRRKQPE YWFAVPRERV 700
    DHLYTFFVQW SPDVYGKDAK EQGFVVVEKE ELNMIDNFFS EPTTKSWEII 750
    TVEEAKRRKS TCSYYEDEDE EVLPVLRPHS ALLENMHIEQ LARRLPARVQ 800
    GYPWRLAYST LEHGTSLKTL YRKSASLDSP VLLVIKDMDN QIFGAYATHP 850
    FKFSDHYYGT GETFLYTFSP HFKVFKWSGE NSYFINGDIS SLELGGGGGR 900
    FGLWLDADLY HGRSNSCSTF NNDILSKKED FIVQDLEVWA FD 942
    Length:942
    Mass (Da):106,162
    Last modified:July 11, 2006 - v2
    Checksum:iAFD13F06F38C6C5D
    GO
    Isoform 2 (identifier: Q8NI08-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         296-306: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:931
    Mass (Da):104,847
    Checksum:i59EF69310C7FBE9F
    GO
    Isoform 3 (identifier: Q8NI08-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         296-942: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:295
    Mass (Da):33,145
    Checksum:i698C5760DD9A3D61
    GO
    Isoform 4 (identifier: Q8NI08-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         234-249: GVVGGVMIVTPNNIMF → VYSNVICFLSLKSMKN
         250-942: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:249
    Mass (Da):28,246
    Checksum:i211C53B01C7D5AF0
    GO
    Isoform 5 (identifier: Q8NI08-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-723: Missing.
         724-748: FVVVEKEELNMIDNFFSEPTTKSWE → MRGQRLPLDIQIFYCARPDEEPFVK

    Note: No experimental confirmation available.

    Show »
    Length:219
    Mass (Da):25,270
    Checksum:i1C0052E860872FAA
    GO
    Isoform 6 (identifier: Q8NI08-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         91-102: DDNQNKTHDKKE → GEYSWRYCSIFI
         103-942: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:102
    Mass (Da):12,189
    Checksum:iEB558581700DAE15
    GO
    Isoform 7 (identifier: Q8NI08-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-104: Missing.
         296-306: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:827
    Mass (Da):92,472
    Checksum:i37F6E9A7D3465DBF
    GO

    Sequence cautioni

    The sequence CAD89948.1 differs from that shown. Reason: Frameshift at position 782.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321S → T in BAE45732. (PubMed:12880961)Curated
    Sequence conflicti118 – 1181A → T in CAD89948. (PubMed:17974005)Curated
    Sequence conflicti177 – 1771T → A in AAM27392. (PubMed:11971969)Curated
    Sequence conflicti228 – 2281Y → H in CAD89948. (PubMed:17974005)Curated
    Sequence conflicti249 – 2491F → C in AAM27392. (PubMed:11971969)Curated
    Sequence conflicti266 – 2661Y → H in CAD97627. (PubMed:17974005)Curated
    Sequence conflicti278 – 2781I → T in AAM27392. (PubMed:11971969)Curated
    Sequence conflicti369 – 3691E → G in CAD89948. (PubMed:17974005)Curated
    Sequence conflicti723 – 7231G → S in BAH11810. (PubMed:14702039)Curated
    Sequence conflicti752 – 7521V → A in CAD89948. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti399 – 3991S → A.4 Publications
    Corresponds to variant rs6919947 [ dbSNP | Ensembl ].
    VAR_026965
    Natural varianti533 – 5331G → R.
    Corresponds to variant rs35223550 [ dbSNP | Ensembl ].
    VAR_050438
    Natural varianti942 – 9421D → E.
    Corresponds to variant rs1567 [ dbSNP | Ensembl ].
    VAR_026966

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 723723Missing in isoform 5. 1 PublicationVSP_019632Add
    BLAST
    Alternative sequencei1 – 104104Missing in isoform 7. 1 PublicationVSP_044859Add
    BLAST
    Alternative sequencei91 – 10212DDNQN…HDKKE → GEYSWRYCSIFI in isoform 6. 1 PublicationVSP_019633Add
    BLAST
    Alternative sequencei103 – 942840Missing in isoform 6. 1 PublicationVSP_019634Add
    BLAST
    Alternative sequencei234 – 24916GVVGG…NNIMF → VYSNVICFLSLKSMKN in isoform 4. 1 PublicationVSP_019635Add
    BLAST
    Alternative sequencei250 – 942693Missing in isoform 4. 1 PublicationVSP_019636Add
    BLAST
    Alternative sequencei296 – 942647Missing in isoform 3. 1 PublicationVSP_019637Add
    BLAST
    Alternative sequencei296 – 30611Missing in isoform 2 and isoform 7. 2 PublicationsVSP_019638Add
    BLAST
    Alternative sequencei724 – 74825FVVVE…TKSWE → MRGQRLPLDIQIFYCARPDE EPFVK in isoform 5. 1 PublicationVSP_019639Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF493978 mRNA. Translation: AAM27392.1.
    AB074157 mRNA. Translation: BAE45732.1.
    AK094706 mRNA. Translation: BAC04402.1.
    AK294558 mRNA. Translation: BAH11810.1.
    BX537385 mRNA. Translation: CAD97627.1.
    AL832628 mRNA. Translation: CAD89948.1. Frameshift.
    AL078594, AL035689, AL136163 Genomic DNA. Translation: CAI20072.1.
    AL136163, AL035689, AL078594 Genomic DNA. Translation: CAI42386.1.
    AL035689, AL136163, AL078594 Genomic DNA. Translation: CAI42397.1.
    CH471051 Genomic DNA. Translation: EAW48133.1.
    BC036461 mRNA. Translation: AAH36461.1.
    BC071782 mRNA. Translation: AAH71782.1.
    BC137094 mRNA. Translation: AAI37095.1.
    BC137095 mRNA. Translation: AAI37096.1.
    CCDSiCCDS5132.1. [Q8NI08-1]
    CCDS56448.1. [Q8NI08-7]
    RefSeqiNP_001116314.1. NM_001122842.2. [Q8NI08-2]
    NP_001186548.1. NM_001199619.1. [Q8NI08-1]
    NP_001186549.1. NM_001199620.1. [Q8NI08-1]
    NP_001186550.1. NM_001199621.1. [Q8NI08-7]
    NP_001186551.1. NM_001199622.1. [Q8NI08-5]
    NP_861447.3. NM_181782.4. [Q8NI08-1]
    XP_005266879.1. XM_005266822.2. [Q8NI08-1]
    XP_006715403.1. XM_006715340.1. [Q8NI08-1]
    UniGeneiHs.171426.

    Genome annotation databases

    EnsembliENST00000229634; ENSP00000229634; ENSG00000111912. [Q8NI08-7]
    ENST00000368357; ENSP00000357341; ENSG00000111912. [Q8NI08-1]
    ENST00000392477; ENSP00000376269; ENSG00000111912. [Q8NI08-1]
    GeneIDi135112.
    KEGGihsa:135112.
    UCSCiuc003qae.4. human. [Q8NI08-1]
    uc003qaf.3. human. [Q8NI08-4]
    uc003qag.3. human. [Q8NI08-3]
    uc003qah.3. human. [Q8NI08-2]
    uc003qaj.3. human. [Q8NI08-6]
    uc003qak.3. human. [Q8NI08-5]

    Polymorphism databases

    DMDMi110287684.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF493978 mRNA. Translation: AAM27392.1 .
    AB074157 mRNA. Translation: BAE45732.1 .
    AK094706 mRNA. Translation: BAC04402.1 .
    AK294558 mRNA. Translation: BAH11810.1 .
    BX537385 mRNA. Translation: CAD97627.1 .
    AL832628 mRNA. Translation: CAD89948.1 . Frameshift.
    AL078594 , AL035689 , AL136163 Genomic DNA. Translation: CAI20072.1 .
    AL136163 , AL035689 , AL078594 Genomic DNA. Translation: CAI42386.1 .
    AL035689 , AL136163 , AL078594 Genomic DNA. Translation: CAI42397.1 .
    CH471051 Genomic DNA. Translation: EAW48133.1 .
    BC036461 mRNA. Translation: AAH36461.1 .
    BC071782 mRNA. Translation: AAH71782.1 .
    BC137094 mRNA. Translation: AAI37095.1 .
    BC137095 mRNA. Translation: AAI37096.1 .
    CCDSi CCDS5132.1. [Q8NI08-1 ]
    CCDS56448.1. [Q8NI08-7 ]
    RefSeqi NP_001116314.1. NM_001122842.2. [Q8NI08-2 ]
    NP_001186548.1. NM_001199619.1. [Q8NI08-1 ]
    NP_001186549.1. NM_001199620.1. [Q8NI08-1 ]
    NP_001186550.1. NM_001199621.1. [Q8NI08-7 ]
    NP_001186551.1. NM_001199622.1. [Q8NI08-5 ]
    NP_861447.3. NM_181782.4. [Q8NI08-1 ]
    XP_005266879.1. XM_005266822.2. [Q8NI08-1 ]
    XP_006715403.1. XM_006715340.1. [Q8NI08-1 ]
    UniGenei Hs.171426.

    3D structure databases

    ProteinModelPortali Q8NI08.
    SMRi Q8NI08. Positions 780-942.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126419. 8 interactions.
    IntActi Q8NI08. 8 interactions.

    Polymorphism databases

    DMDMi 110287684.

    Proteomic databases

    MaxQBi Q8NI08.
    PaxDbi Q8NI08.
    PRIDEi Q8NI08.

    Protocols and materials databases

    DNASUi 135112.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000229634 ; ENSP00000229634 ; ENSG00000111912 . [Q8NI08-7 ]
    ENST00000368357 ; ENSP00000357341 ; ENSG00000111912 . [Q8NI08-1 ]
    ENST00000392477 ; ENSP00000376269 ; ENSG00000111912 . [Q8NI08-1 ]
    GeneIDi 135112.
    KEGGi hsa:135112.
    UCSCi uc003qae.4. human. [Q8NI08-1 ]
    uc003qaf.3. human. [Q8NI08-4 ]
    uc003qag.3. human. [Q8NI08-3 ]
    uc003qah.3. human. [Q8NI08-2 ]
    uc003qaj.3. human. [Q8NI08-6 ]
    uc003qak.3. human. [Q8NI08-5 ]

    Organism-specific databases

    CTDi 135112.
    GeneCardsi GC06P126102.
    H-InvDB HIX0006198.
    HGNCi HGNC:21081. NCOA7.
    HPAi HPA030289.
    HPA030290.
    HPA030291.
    HPA030292.
    MIMi 609752. gene.
    neXtProti NX_Q8NI08.
    PharmGKBi PA134905581.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5142.
    HOVERGENi HBG065488.
    InParanoidi Q8NI08.
    OMAi ETCEKQD.
    OrthoDBi EOG77M8PQ.
    PhylomeDBi Q8NI08.
    TreeFami TF313530.

    Miscellaneous databases

    ChiTaRSi NCOA7. human.
    GeneWikii NCOA7.
    GenomeRNAii 135112.
    NextBioi 83445.
    PROi Q8NI08.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NI08.
    Bgeei Q8NI08.
    Genevestigatori Q8NI08.

    Family and domain databases

    Gene3Di 3.10.350.10. 1 hit.
    InterProi IPR018392. LysM_dom.
    IPR006571. TLDc.
    [Graphical view ]
    Pfami PF01476. LysM. 1 hit.
    PF07534. TLD. 1 hit.
    [Graphical view ]
    SMARTi SM00257. LysM. 1 hit.
    SM00584. TLDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54106. SSF54106. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "ERAP140, a conserved tissue-specific nuclear receptor coactivator."
      Shao W., Halachmi S., Brown M.
      Mol. Cell. Biol. 22:3358-3372(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH ESR1; ESR2A; ESR2B; THRB; PPARG AND RARA, TISSUE SPECIFICITY, MUTAGENESIS OF 511-LEU--LEU-517 AND 522-LEU-ILE-523, VARIANT ALA-399.
    2. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
      Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
      Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Neuroblastoma.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 7), VARIANT ALA-399.
      Tissue: Amygdala.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Amygdala, Fetal kidney and Spinal cord.
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-399.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4 AND 6), VARIANT ALA-399.
      Tissue: Brain, Kidney, Lung, Muscle, Placenta and Testis.
    8. "Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex."
      Nguyen T.A., Hoivik D., Lee J.-E., Safe S.
      Arch. Biochem. Biophys. 367:250-257(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HETERODIMER AHR-ARNT.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183 AND SER-441, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179; SER-208 AND SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208 AND SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNCOA7_HUMAN
    AccessioniPrimary (citable) accession number: Q8NI08
    Secondary accession number(s): B2RNS2
    , B7Z2C4, B9EH71, G8JL91, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3