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Q8NI08 (NCOA7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear receptor coactivator 7
Alternative name(s):
140 kDa estrogen receptor-associated protein
Estrogen nuclear receptor coactivator 1
Gene names
Name:NCOA7
Synonyms:ERAP140, ESNA1
ORF Names:Nbla00052, Nbla10993
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length942 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. Ref.1

Subunit structure

Interacts with ESR1, ESR2A, ESR2B, THRB, PPARG and RARA in a ligand-inducible manner. Interacts with the heterodimer AHR-ARNT. Ref.1 Ref.8

Subcellular location

Nucleus Probable.

Tissue specificity

Highly expressed in brain. Weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord and pancreas. Expressed in cancer cell line. Ref.1

Sequence similarities

Belongs to the OXR1 family.

Contains 1 LysM repeat.

Contains 1 TLD domain.

Sequence caution

The sequence CAD89948.1 differs from that shown. Reason: Frameshift at position 782.

Binary interactions

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NI08-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8NI08-2)

The sequence of this isoform differs from the canonical sequence as follows:
     296-306: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8NI08-3)

The sequence of this isoform differs from the canonical sequence as follows:
     296-942: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q8NI08-4)

The sequence of this isoform differs from the canonical sequence as follows:
     234-249: GVVGGVMIVTPNNIMF → VYSNVICFLSLKSMKN
     250-942: Missing.
Note: No experimental confirmation available.
Isoform 5 (identifier: Q8NI08-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-723: Missing.
     724-748: FVVVEKEELNMIDNFFSEPTTKSWE → MRGQRLPLDIQIFYCARPDEEPFVK
Note: No experimental confirmation available.
Isoform 6 (identifier: Q8NI08-6)

The sequence of this isoform differs from the canonical sequence as follows:
     91-102: DDNQNKTHDKKE → GEYSWRYCSIFI
     103-942: Missing.
Note: No experimental confirmation available.
Isoform 7 (identifier: Q8NI08-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     296-306: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 942942Nuclear receptor coactivator 7
PRO_0000245229

Regions

Repeat116 – 15843LysM
Domain806 – 942137TLD
Coiled coil4 – 2926 Potential

Amino acid modifications

Modified residue11N-acetylmethionine Ref.13
Modified residue1791Phosphoserine Ref.11
Modified residue1831Phosphoserine Ref.9
Modified residue2081Phosphoserine Ref.11 Ref.12
Modified residue2111Phosphoserine Ref.11 Ref.12
Modified residue4411Phosphoserine Ref.9

Natural variations

Alternative sequence1 – 723723Missing in isoform 5.
VSP_019632
Alternative sequence1 – 104104Missing in isoform 7.
VSP_044859
Alternative sequence91 – 10212DDNQN…HDKKE → GEYSWRYCSIFI in isoform 6.
VSP_019633
Alternative sequence103 – 942840Missing in isoform 6.
VSP_019634
Alternative sequence234 – 24916GVVGG…NNIMF → VYSNVICFLSLKSMKN in isoform 4.
VSP_019635
Alternative sequence250 – 942693Missing in isoform 4.
VSP_019636
Alternative sequence296 – 942647Missing in isoform 3.
VSP_019637
Alternative sequence296 – 30611Missing in isoform 2 and isoform 7.
VSP_019638
Alternative sequence724 – 74825FVVVE…TKSWE → MRGQRLPLDIQIFYCARPDE EPFVK in isoform 5.
VSP_019639
Natural variant3991S → A. Ref.1 Ref.3 Ref.6 Ref.7
Corresponds to variant rs6919947 [ dbSNP | Ensembl ].
VAR_026965
Natural variant5331G → R.
Corresponds to variant rs35223550 [ dbSNP | Ensembl ].
VAR_050438
Natural variant9421D → E.
Corresponds to variant rs1567 [ dbSNP | Ensembl ].
VAR_026966

Experimental info

Mutagenesis511 – 5177LNIHEDL → ANAHEDA: No action on the E2-induced ESR1 binding. Ref.1
Mutagenesis522 – 5232LI → AA: Abolishes completely the E2-induced ESR1 binding.
Sequence conflict321S → T in BAE45732. Ref.2
Sequence conflict1181A → T in CAD89948. Ref.4
Sequence conflict1771T → A in AAM27392. Ref.1
Sequence conflict2281Y → H in CAD89948. Ref.4
Sequence conflict2491F → C in AAM27392. Ref.1
Sequence conflict2661Y → H in CAD97627. Ref.4
Sequence conflict2781I → T in AAM27392. Ref.1
Sequence conflict3691E → G in CAD89948. Ref.4
Sequence conflict7231G → S in BAH11810. Ref.3
Sequence conflict7521V → A in CAD89948. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 11, 2006. Version 2.
Checksum: AFD13F06F38C6C5D

FASTA942106,162
        10         20         30         40         50         60 
MDTKEEKKER KQSYFARLKK KKQAKQNAET ASAVATRTHT GKEDNNTVVL EPDKCNIAVE 

        70         80         90        100        110        120 
EEYMTDEKKK RKSNQLKEIR RTELKRYYSI DDNQNKTHDK KEKKMVVQKP HGTMEYTAGN 

       130        140        150        160        170        180 
QDTLNSIALK FNITPNKLVE LNKLFTHTIV PGQVLFVPDA NSPSSTLRLS SSSPGATVSP 

       190        200        210        220        230        240 
SSSDAEYDKL PDADLARKAL KPIERVLSST SEEDEPGVVK FLKMNCRYFT DGKGVVGGVM 

       250        260        270        280        290        300 
IVTPNNIMFD PHKSDPLVIE NGCEEYGLIC PMEEVVSIAL YNDISHMKIK DALPSDLPQD 

       310        320        330        340        350        360 
LCPLYRPGEW EDLASEKDIN PFSKFKSINK EKRQQNGEKI MTSDSRPIVP LEKSTGHTPT 

       370        380        390        400        410        420 
KPSGSSVSEK LKKLDSSRET SHGSPTVTKL SKEPSDTSSA FESTAKENFL GEDDDFVDLE 

       430        440        450        460        470        480 
ELSSQTGGGM HKKDTLKECL SLDPEERKKA ESQINNSAVE MQVQSALAFL GTENDVELKG 

       490        500        510        520        530        540 
ALDLETCEKQ DIMPEVDKQS GSPESRVENT LNIHEDLDKV KLIEYYLTKN KEGPQVSENL 

       550        560        570        580        590        600 
QKTELSDGKS IEPGGIDITL SSSLSQAGDP ITEGNKEPDK TWVKKGEPLP VKLNSSTEAN 

       610        620        630        640        650        660 
VIKEALDSSL ESTLDNSCQG AQMDNKSEVQ LWLLKRIQVP IEDILPSKEE KSKTPPMFLC 

       670        680        690        700        710        720 
IKVGKPMRKS FATHTAAMVQ QYGKRRKQPE YWFAVPRERV DHLYTFFVQW SPDVYGKDAK 

       730        740        750        760        770        780 
EQGFVVVEKE ELNMIDNFFS EPTTKSWEII TVEEAKRRKS TCSYYEDEDE EVLPVLRPHS 

       790        800        810        820        830        840 
ALLENMHIEQ LARRLPARVQ GYPWRLAYST LEHGTSLKTL YRKSASLDSP VLLVIKDMDN 

       850        860        870        880        890        900 
QIFGAYATHP FKFSDHYYGT GETFLYTFSP HFKVFKWSGE NSYFINGDIS SLELGGGGGR 

       910        920        930        940 
FGLWLDADLY HGRSNSCSTF NNDILSKKED FIVQDLEVWA FD 

« Hide

Isoform 2 [UniParc].

Checksum: 59EF69310C7FBE9F
Show »

FASTA931104,847
Isoform 3 [UniParc].

Checksum: 698C5760DD9A3D61
Show »

FASTA29533,145
Isoform 4 [UniParc].

Checksum: 211C53B01C7D5AF0
Show »

FASTA24928,246
Isoform 5 [UniParc].

Checksum: 1C0052E860872FAA
Show »

FASTA21925,270
Isoform 6 [UniParc].

Checksum: EB558581700DAE15
Show »

FASTA10212,189
Isoform 7 [UniParc].

Checksum: 37F6E9A7D3465DBF
Show »

FASTA82792,472

References

« Hide 'large scale' references
[1]"ERAP140, a conserved tissue-specific nuclear receptor coactivator."
Shao W., Halachmi S., Brown M.
Mol. Cell. Biol. 22:3358-3372(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH ESR1; ESR2A; ESR2B; THRB; PPARG AND RARA, TISSUE SPECIFICITY, MUTAGENESIS OF 511-LEU--LEU-517 AND 522-LEU-ILE-523, VARIANT ALA-399.
[2]"Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Neuroblastoma.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 7), VARIANT ALA-399.
Tissue: Amygdala.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Amygdala, Fetal kidney and Spinal cord.
[5]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-399.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4 AND 6), VARIANT ALA-399.
Tissue: Brain, Kidney, Lung, Muscle, Placenta and Testis.
[8]"Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex."
Nguyen T.A., Hoivik D., Lee J.-E., Safe S.
Arch. Biochem. Biophys. 367:250-257(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HETERODIMER AHR-ARNT.
[9]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183 AND SER-441, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179; SER-208 AND SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[12]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208 AND SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[13]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF493978 mRNA. Translation: AAM27392.1.
AB074157 mRNA. Translation: BAE45732.1.
AK094706 mRNA. Translation: BAC04402.1.
AK294558 mRNA. Translation: BAH11810.1.
BX537385 mRNA. Translation: CAD97627.1.
AL832628 mRNA. Translation: CAD89948.1. Frameshift.
AL078594, AL035689, AL136163 Genomic DNA. Translation: CAI20072.1.
AL136163, AL035689, AL078594 Genomic DNA. Translation: CAI42386.1.
AL035689, AL136163, AL078594 Genomic DNA. Translation: CAI42397.1.
CH471051 Genomic DNA. Translation: EAW48133.1.
BC036461 mRNA. Translation: AAH36461.1.
BC071782 mRNA. Translation: AAH71782.1.
BC137094 mRNA. Translation: AAI37095.1.
BC137095 mRNA. Translation: AAI37096.1.
CCDSCCDS5132.1. [Q8NI08-1]
CCDS56448.1. [Q8NI08-7]
RefSeqNP_001116314.1. NM_001122842.2. [Q8NI08-2]
NP_001186548.1. NM_001199619.1. [Q8NI08-1]
NP_001186549.1. NM_001199620.1. [Q8NI08-1]
NP_001186550.1. NM_001199621.1. [Q8NI08-7]
NP_001186551.1. NM_001199622.1. [Q8NI08-5]
NP_861447.3. NM_181782.4. [Q8NI08-1]
XP_005266879.1. XM_005266822.2. [Q8NI08-1]
XP_006715403.1. XM_006715340.1. [Q8NI08-1]
UniGeneHs.171426.

3D structure databases

ProteinModelPortalQ8NI08.
SMRQ8NI08. Positions 780-942.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126419. 7 interactions.
IntActQ8NI08. 8 interactions.

Polymorphism databases

DMDM110287684.

Proteomic databases

MaxQBQ8NI08.
PaxDbQ8NI08.
PRIDEQ8NI08.

Protocols and materials databases

DNASU135112.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000229634; ENSP00000229634; ENSG00000111912. [Q8NI08-7]
ENST00000368357; ENSP00000357341; ENSG00000111912. [Q8NI08-1]
ENST00000392477; ENSP00000376269; ENSG00000111912. [Q8NI08-1]
GeneID135112.
KEGGhsa:135112.
UCSCuc003qae.4. human. [Q8NI08-1]
uc003qaf.3. human. [Q8NI08-4]
uc003qag.3. human. [Q8NI08-3]
uc003qah.3. human. [Q8NI08-2]
uc003qaj.3. human. [Q8NI08-6]
uc003qak.3. human. [Q8NI08-5]

Organism-specific databases

CTD135112.
GeneCardsGC06P126102.
H-InvDBHIX0006198.
HGNCHGNC:21081. NCOA7.
HPAHPA030289.
HPA030290.
HPA030291.
HPA030292.
MIM609752. gene.
neXtProtNX_Q8NI08.
PharmGKBPA134905581.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5142.
HOVERGENHBG065488.
InParanoidQ8NI08.
OMAETCEKQD.
OrthoDBEOG77M8PQ.
PhylomeDBQ8NI08.
TreeFamTF313530.

Gene expression databases

ArrayExpressQ8NI08.
BgeeQ8NI08.
GenevestigatorQ8NI08.

Family and domain databases

Gene3D3.10.350.10. 1 hit.
InterProIPR018392. LysM_dom.
IPR006571. TLDc.
[Graphical view]
PfamPF01476. LysM. 1 hit.
PF07534. TLD. 1 hit.
[Graphical view]
SMARTSM00257. LysM. 1 hit.
SM00584. TLDc. 1 hit.
[Graphical view]
SUPFAMSSF54106. SSF54106. 1 hit.
ProtoNetSearch...

Other

ChiTaRSNCOA7. human.
GeneWikiNCOA7.
GenomeRNAi135112.
NextBio83445.
PROQ8NI08.
SOURCESearch...

Entry information

Entry nameNCOA7_HUMAN
AccessionPrimary (citable) accession number: Q8NI08
Secondary accession number(s): B2RNS2 expand/collapse secondary AC list , B7Z2C4, B9EH71, G8JL91, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM