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Protein

Nuclear receptor coactivator 7

Gene

NCOA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.1 Publication

GO - Molecular functioni

  1. ligand-dependent nuclear receptor transcription coactivator activity Source: UniProtKB
  2. nuclear hormone receptor binding Source: UniProtKB

GO - Biological processi

  1. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivator 7
Alternative name(s):
140 kDa estrogen receptor-associated protein
Estrogen nuclear receptor coactivator 1
Gene namesi
Name:NCOA7
Synonyms:ERAP140, ESNA1
ORF Names:Nbla00052, Nbla10993
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21081. NCOA7.

Subcellular locationi

  1. Nucleus Curated

GO - Cellular componenti

  1. intracellular Source: LIFEdb
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi511 – 5177LNIHEDL → ANAHEDA: No action on the E2-induced ESR1 binding. 1 Publication
Mutagenesisi522 – 5232LI → AA: Abolishes completely the E2-induced ESR1 binding. 1 Publication

Organism-specific databases

PharmGKBiPA134905581.

Polymorphism and mutation databases

BioMutaiNCOA7.
DMDMi110287684.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 942942Nuclear receptor coactivator 7PRO_0000245229Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei179 – 1791Phosphoserine1 Publication
Modified residuei183 – 1831Phosphoserine1 Publication
Modified residuei208 – 2081Phosphoserine3 Publications
Modified residuei211 – 2111Phosphoserine3 Publications
Modified residuei441 – 4411Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8NI08.
PaxDbiQ8NI08.
PRIDEiQ8NI08.

Expressioni

Tissue specificityi

Highly expressed in brain. Weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord and pancreas. Expressed in cancer cell line.1 Publication

Gene expression databases

BgeeiQ8NI08.
ExpressionAtlasiQ8NI08. baseline and differential.
GenevestigatoriQ8NI08.

Organism-specific databases

HPAiHPA030289.
HPA030290.
HPA030291.
HPA030292.

Interactioni

Subunit structurei

Interacts with ESR1, ESR2A, ESR2B, THRB, PPARG and RARA in a ligand-inducible manner. Interacts with the heterodimer AHR-ARNT.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AHRP358692EBI-80799,EBI-80780
ARNTP275402EBI-80799,EBI-80809
GABARAPO951664EBI-80799,EBI-712001
GABARAPL1Q9H0R82EBI-80799,EBI-746969

Protein-protein interaction databases

BioGridi126419. 9 interactions.
IntActiQ8NI08. 8 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8NI08.
SMRiQ8NI08. Positions 780-942.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati116 – 15843LysMAdd
BLAST
Domaini806 – 942137TLDAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili4 – 2926Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the OXR1 family.Curated
Contains 1 LysM repeat.Curated
Contains 1 TLD domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5142.
GeneTreeiENSGT00410000025363.
HOVERGENiHBG065488.
InParanoidiQ8NI08.
OMAiRKQPEYW.
OrthoDBiEOG77M8PQ.
PhylomeDBiQ8NI08.
TreeFamiTF313530.

Family and domain databases

Gene3Di3.10.350.10. 1 hit.
InterProiIPR018392. LysM_dom.
IPR006571. TLDc_dom.
[Graphical view]
PfamiPF01476. LysM. 1 hit.
PF07534. TLD. 1 hit.
[Graphical view]
SMARTiSM00257. LysM. 1 hit.
SM00584. TLDc. 1 hit.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 1 hit.

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NI08-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTKEEKKER KQSYFARLKK KKQAKQNAET ASAVATRTHT GKEDNNTVVL
60 70 80 90 100
EPDKCNIAVE EEYMTDEKKK RKSNQLKEIR RTELKRYYSI DDNQNKTHDK
110 120 130 140 150
KEKKMVVQKP HGTMEYTAGN QDTLNSIALK FNITPNKLVE LNKLFTHTIV
160 170 180 190 200
PGQVLFVPDA NSPSSTLRLS SSSPGATVSP SSSDAEYDKL PDADLARKAL
210 220 230 240 250
KPIERVLSST SEEDEPGVVK FLKMNCRYFT DGKGVVGGVM IVTPNNIMFD
260 270 280 290 300
PHKSDPLVIE NGCEEYGLIC PMEEVVSIAL YNDISHMKIK DALPSDLPQD
310 320 330 340 350
LCPLYRPGEW EDLASEKDIN PFSKFKSINK EKRQQNGEKI MTSDSRPIVP
360 370 380 390 400
LEKSTGHTPT KPSGSSVSEK LKKLDSSRET SHGSPTVTKL SKEPSDTSSA
410 420 430 440 450
FESTAKENFL GEDDDFVDLE ELSSQTGGGM HKKDTLKECL SLDPEERKKA
460 470 480 490 500
ESQINNSAVE MQVQSALAFL GTENDVELKG ALDLETCEKQ DIMPEVDKQS
510 520 530 540 550
GSPESRVENT LNIHEDLDKV KLIEYYLTKN KEGPQVSENL QKTELSDGKS
560 570 580 590 600
IEPGGIDITL SSSLSQAGDP ITEGNKEPDK TWVKKGEPLP VKLNSSTEAN
610 620 630 640 650
VIKEALDSSL ESTLDNSCQG AQMDNKSEVQ LWLLKRIQVP IEDILPSKEE
660 670 680 690 700
KSKTPPMFLC IKVGKPMRKS FATHTAAMVQ QYGKRRKQPE YWFAVPRERV
710 720 730 740 750
DHLYTFFVQW SPDVYGKDAK EQGFVVVEKE ELNMIDNFFS EPTTKSWEII
760 770 780 790 800
TVEEAKRRKS TCSYYEDEDE EVLPVLRPHS ALLENMHIEQ LARRLPARVQ
810 820 830 840 850
GYPWRLAYST LEHGTSLKTL YRKSASLDSP VLLVIKDMDN QIFGAYATHP
860 870 880 890 900
FKFSDHYYGT GETFLYTFSP HFKVFKWSGE NSYFINGDIS SLELGGGGGR
910 920 930 940
FGLWLDADLY HGRSNSCSTF NNDILSKKED FIVQDLEVWA FD
Length:942
Mass (Da):106,162
Last modified:July 11, 2006 - v2
Checksum:iAFD13F06F38C6C5D
GO
Isoform 2 (identifier: Q8NI08-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-306: Missing.

Note: No experimental confirmation available.

Show »
Length:931
Mass (Da):104,847
Checksum:i59EF69310C7FBE9F
GO
Isoform 3 (identifier: Q8NI08-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-942: Missing.

Note: No experimental confirmation available.

Show »
Length:295
Mass (Da):33,145
Checksum:i698C5760DD9A3D61
GO
Isoform 4 (identifier: Q8NI08-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-249: GVVGGVMIVTPNNIMF → VYSNVICFLSLKSMKN
     250-942: Missing.

Note: No experimental confirmation available.

Show »
Length:249
Mass (Da):28,246
Checksum:i211C53B01C7D5AF0
GO
Isoform 5 (identifier: Q8NI08-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-723: Missing.
     724-748: FVVVEKEELNMIDNFFSEPTTKSWE → MRGQRLPLDIQIFYCARPDEEPFVK

Note: No experimental confirmation available.

Show »
Length:219
Mass (Da):25,270
Checksum:i1C0052E860872FAA
GO
Isoform 6 (identifier: Q8NI08-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-102: DDNQNKTHDKKE → GEYSWRYCSIFI
     103-942: Missing.

Note: No experimental confirmation available.

Show »
Length:102
Mass (Da):12,189
Checksum:iEB558581700DAE15
GO
Isoform 7 (identifier: Q8NI08-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     296-306: Missing.

Note: No experimental confirmation available.

Show »
Length:827
Mass (Da):92,472
Checksum:i37F6E9A7D3465DBF
GO

Sequence cautioni

The sequence CAD89948.1 differs from that shown. Reason: Frameshift at position 782. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321S → T in BAE45732 (PubMed:12880961).Curated
Sequence conflicti118 – 1181A → T in CAD89948 (PubMed:17974005).Curated
Sequence conflicti177 – 1771T → A in AAM27392 (PubMed:11971969).Curated
Sequence conflicti228 – 2281Y → H in CAD89948 (PubMed:17974005).Curated
Sequence conflicti249 – 2491F → C in AAM27392 (PubMed:11971969).Curated
Sequence conflicti266 – 2661Y → H in CAD97627 (PubMed:17974005).Curated
Sequence conflicti278 – 2781I → T in AAM27392 (PubMed:11971969).Curated
Sequence conflicti369 – 3691E → G in CAD89948 (PubMed:17974005).Curated
Sequence conflicti723 – 7231G → S in BAH11810 (PubMed:14702039).Curated
Sequence conflicti752 – 7521V → A in CAD89948 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti399 – 3991S → A.4 Publications
Corresponds to variant rs6919947 [ dbSNP | Ensembl ].
VAR_026965
Natural varianti533 – 5331G → R.
Corresponds to variant rs35223550 [ dbSNP | Ensembl ].
VAR_050438
Natural varianti942 – 9421D → E.
Corresponds to variant rs1567 [ dbSNP | Ensembl ].
VAR_026966

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 723723Missing in isoform 5. 1 PublicationVSP_019632Add
BLAST
Alternative sequencei1 – 104104Missing in isoform 7. 1 PublicationVSP_044859Add
BLAST
Alternative sequencei91 – 10212DDNQN…HDKKE → GEYSWRYCSIFI in isoform 6. 1 PublicationVSP_019633Add
BLAST
Alternative sequencei103 – 942840Missing in isoform 6. 1 PublicationVSP_019634Add
BLAST
Alternative sequencei234 – 24916GVVGG…NNIMF → VYSNVICFLSLKSMKN in isoform 4. 1 PublicationVSP_019635Add
BLAST
Alternative sequencei250 – 942693Missing in isoform 4. 1 PublicationVSP_019636Add
BLAST
Alternative sequencei296 – 942647Missing in isoform 3. 1 PublicationVSP_019637Add
BLAST
Alternative sequencei296 – 30611Missing in isoform 2 and isoform 7. 2 PublicationsVSP_019638Add
BLAST
Alternative sequencei724 – 74825FVVVE…TKSWE → MRGQRLPLDIQIFYCARPDE EPFVK in isoform 5. 1 PublicationVSP_019639Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF493978 mRNA. Translation: AAM27392.1.
AB074157 mRNA. Translation: BAE45732.1.
AK094706 mRNA. Translation: BAC04402.1.
AK294558 mRNA. Translation: BAH11810.1.
BX537385 mRNA. Translation: CAD97627.1.
AL832628 mRNA. Translation: CAD89948.1. Frameshift.
AL078594, AL035689, AL136163 Genomic DNA. Translation: CAI20072.1.
AL136163, AL035689, AL078594 Genomic DNA. Translation: CAI42386.1.
AL035689, AL136163, AL078594 Genomic DNA. Translation: CAI42397.1.
CH471051 Genomic DNA. Translation: EAW48133.1.
BC036461 mRNA. Translation: AAH36461.1.
BC071782 mRNA. Translation: AAH71782.1.
BC137094 mRNA. Translation: AAI37095.1.
BC137095 mRNA. Translation: AAI37096.1.
CCDSiCCDS5132.1. [Q8NI08-1]
CCDS56448.1. [Q8NI08-7]
RefSeqiNP_001116314.1. NM_001122842.2. [Q8NI08-2]
NP_001186548.1. NM_001199619.1. [Q8NI08-1]
NP_001186549.1. NM_001199620.1. [Q8NI08-1]
NP_001186550.1. NM_001199621.1. [Q8NI08-7]
NP_001186551.1. NM_001199622.1. [Q8NI08-5]
NP_861447.3. NM_181782.4. [Q8NI08-1]
XP_005266879.1. XM_005266822.3. [Q8NI08-1]
XP_006715403.1. XM_006715340.2. [Q8NI08-1]
UniGeneiHs.171426.

Genome annotation databases

EnsembliENST00000229634; ENSP00000229634; ENSG00000111912. [Q8NI08-7]
ENST00000368357; ENSP00000357341; ENSG00000111912. [Q8NI08-1]
ENST00000392477; ENSP00000376269; ENSG00000111912. [Q8NI08-1]
GeneIDi135112.
KEGGihsa:135112.
UCSCiuc003qae.4. human. [Q8NI08-1]
uc003qaf.3. human. [Q8NI08-4]
uc003qag.3. human. [Q8NI08-3]
uc003qah.3. human. [Q8NI08-2]
uc003qaj.3. human. [Q8NI08-6]
uc003qak.3. human. [Q8NI08-5]

Polymorphism and mutation databases

BioMutaiNCOA7.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF493978 mRNA. Translation: AAM27392.1.
AB074157 mRNA. Translation: BAE45732.1.
AK094706 mRNA. Translation: BAC04402.1.
AK294558 mRNA. Translation: BAH11810.1.
BX537385 mRNA. Translation: CAD97627.1.
AL832628 mRNA. Translation: CAD89948.1. Frameshift.
AL078594, AL035689, AL136163 Genomic DNA. Translation: CAI20072.1.
AL136163, AL035689, AL078594 Genomic DNA. Translation: CAI42386.1.
AL035689, AL136163, AL078594 Genomic DNA. Translation: CAI42397.1.
CH471051 Genomic DNA. Translation: EAW48133.1.
BC036461 mRNA. Translation: AAH36461.1.
BC071782 mRNA. Translation: AAH71782.1.
BC137094 mRNA. Translation: AAI37095.1.
BC137095 mRNA. Translation: AAI37096.1.
CCDSiCCDS5132.1. [Q8NI08-1]
CCDS56448.1. [Q8NI08-7]
RefSeqiNP_001116314.1. NM_001122842.2. [Q8NI08-2]
NP_001186548.1. NM_001199619.1. [Q8NI08-1]
NP_001186549.1. NM_001199620.1. [Q8NI08-1]
NP_001186550.1. NM_001199621.1. [Q8NI08-7]
NP_001186551.1. NM_001199622.1. [Q8NI08-5]
NP_861447.3. NM_181782.4. [Q8NI08-1]
XP_005266879.1. XM_005266822.3. [Q8NI08-1]
XP_006715403.1. XM_006715340.2. [Q8NI08-1]
UniGeneiHs.171426.

3D structure databases

ProteinModelPortaliQ8NI08.
SMRiQ8NI08. Positions 780-942.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126419. 9 interactions.
IntActiQ8NI08. 8 interactions.

Polymorphism and mutation databases

BioMutaiNCOA7.
DMDMi110287684.

Proteomic databases

MaxQBiQ8NI08.
PaxDbiQ8NI08.
PRIDEiQ8NI08.

Protocols and materials databases

DNASUi135112.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229634; ENSP00000229634; ENSG00000111912. [Q8NI08-7]
ENST00000368357; ENSP00000357341; ENSG00000111912. [Q8NI08-1]
ENST00000392477; ENSP00000376269; ENSG00000111912. [Q8NI08-1]
GeneIDi135112.
KEGGihsa:135112.
UCSCiuc003qae.4. human. [Q8NI08-1]
uc003qaf.3. human. [Q8NI08-4]
uc003qag.3. human. [Q8NI08-3]
uc003qah.3. human. [Q8NI08-2]
uc003qaj.3. human. [Q8NI08-6]
uc003qak.3. human. [Q8NI08-5]

Organism-specific databases

CTDi135112.
GeneCardsiGC06P126102.
H-InvDBHIX0006198.
HGNCiHGNC:21081. NCOA7.
HPAiHPA030289.
HPA030290.
HPA030291.
HPA030292.
MIMi609752. gene.
neXtProtiNX_Q8NI08.
PharmGKBiPA134905581.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5142.
GeneTreeiENSGT00410000025363.
HOVERGENiHBG065488.
InParanoidiQ8NI08.
OMAiRKQPEYW.
OrthoDBiEOG77M8PQ.
PhylomeDBiQ8NI08.
TreeFamiTF313530.

Miscellaneous databases

ChiTaRSiNCOA7. human.
GeneWikiiNCOA7.
GenomeRNAii135112.
NextBioi83445.
PROiQ8NI08.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NI08.
ExpressionAtlasiQ8NI08. baseline and differential.
GenevestigatoriQ8NI08.

Family and domain databases

Gene3Di3.10.350.10. 1 hit.
InterProiIPR018392. LysM_dom.
IPR006571. TLDc_dom.
[Graphical view]
PfamiPF01476. LysM. 1 hit.
PF07534. TLD. 1 hit.
[Graphical view]
SMARTiSM00257. LysM. 1 hit.
SM00584. TLDc. 1 hit.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "ERAP140, a conserved tissue-specific nuclear receptor coactivator."
    Shao W., Halachmi S., Brown M.
    Mol. Cell. Biol. 22:3358-3372(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH ESR1; ESR2A; ESR2B; THRB; PPARG AND RARA, TISSUE SPECIFICITY, MUTAGENESIS OF 511-LEU--LEU-517 AND 522-LEU-ILE-523, VARIANT ALA-399.
  2. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
    Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
    Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Neuroblastoma.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 7), VARIANT ALA-399.
    Tissue: Amygdala.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Amygdala, Fetal kidney and Spinal cord.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-399.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4 AND 6), VARIANT ALA-399.
    Tissue: Brain, Kidney, Lung, Muscle, Placenta and Testis.
  8. "Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex."
    Nguyen T.A., Hoivik D., Lee J.-E., Safe S.
    Arch. Biochem. Biophys. 367:250-257(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HETERODIMER AHR-ARNT.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183 AND SER-441, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179; SER-208 AND SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208 AND SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208 AND SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiNCOA7_HUMAN
AccessioniPrimary (citable) accession number: Q8NI08
Secondary accession number(s): B2RNS2
, B7Z2C4, B9EH71, G8JL91, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: April 29, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.