Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nuclear receptor coactivator 7

Gene

NCOA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.1 Publication

GO - Molecular functioni

  • ligand-dependent nuclear receptor transcription coactivator activity Source: UniProtKB
  • nuclear hormone receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111912-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivator 7
Alternative name(s):
140 kDa estrogen receptor-associated protein
Estrogen nuclear receptor coactivator 1
Gene namesi
Name:NCOA7
Synonyms:ERAP140, ESNA1
ORF Names:Nbla00052, Nbla10993
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21081. NCOA7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi511 – 517LNIHEDL → ANAHEDA: No action on the E2-induced ESR1 binding. 1 Publication7
Mutagenesisi522 – 523LI → AA: Abolishes completely the E2-induced ESR1 binding. 1 Publication2

Organism-specific databases

DisGeNETi135112.
OpenTargetsiENSG00000111912.
PharmGKBiPA134905581.

Polymorphism and mutation databases

BioMutaiNCOA7.
DMDMi110287684.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002452291 – 942Nuclear receptor coactivator 7Add BLAST942

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei134PhosphothreonineCombined sources1
Modified residuei179PhosphoserineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei209PhosphoserineBy similarity1
Modified residuei211PhosphoserineCombined sources1
Modified residuei441PhosphoserineCombined sources1
Modified residuei500PhosphoserineBy similarity1
Modified residuei502PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8NI08.
MaxQBiQ8NI08.
PaxDbiQ8NI08.
PeptideAtlasiQ8NI08.
PRIDEiQ8NI08.

PTM databases

iPTMnetiQ8NI08.
PhosphoSitePlusiQ8NI08.
SwissPalmiQ8NI08.

Expressioni

Tissue specificityi

Highly expressed in brain. Weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord and pancreas. Expressed in cancer cell line.1 Publication

Gene expression databases

BgeeiENSG00000111912.
ExpressionAtlasiQ8NI08. baseline and differential.
GenevisibleiQ8NI08. HS.

Organism-specific databases

HPAiHPA030289.
HPA030290.
HPA030291.
HPA030292.

Interactioni

Subunit structurei

Interacts with ESR1, ESR2A, ESR2B, THRB, PPARG and RARA in a ligand-inducible manner. Interacts with the heterodimer AHR-ARNT.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AHRP358692EBI-80799,EBI-80780
ARNTP275402EBI-80799,EBI-80809
GABARAPO951664EBI-80799,EBI-712001
GABARAPL1Q9H0R82EBI-80799,EBI-746969

GO - Molecular functioni

  • nuclear hormone receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi126419. 7 interactors.
IntActiQ8NI08. 10 interactors.
STRINGi9606.ENSP00000357341.

Structurei

3D structure databases

ProteinModelPortaliQ8NI08.
SMRiQ8NI08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 157LysMPROSITE-ProRule annotationAdd BLAST44
Domaini806 – 942TLDAdd BLAST137

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili4 – 29Sequence analysisAdd BLAST26

Sequence similaritiesi

Belongs to the OXR1 family.Curated
Contains 1 LysM domain.PROSITE-ProRule annotation
Contains 1 TLD domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IMGK. Eukaryota.
ENOG4110T63. LUCA.
GeneTreeiENSGT00410000025363.
HOVERGENiHBG065488.
InParanoidiQ8NI08.
OMAiIQVPIED.
OrthoDBiEOG091G0L15.
PhylomeDBiQ8NI08.
TreeFamiTF313530.

Family and domain databases

CDDicd00118. LysM. 1 hit.
Gene3Di3.10.350.10. 1 hit.
InterProiIPR018392. LysM_dom.
IPR006571. TLDc_dom.
[Graphical view]
PfamiPF01476. LysM. 1 hit.
PF07534. TLD. 1 hit.
[Graphical view]
SMARTiSM00257. LysM. 1 hit.
SM00584. TLDc. 1 hit.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 1 hit.
PROSITEiPS51782. LYSM. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NI08-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTKEEKKER KQSYFARLKK KKQAKQNAET ASAVATRTHT GKEDNNTVVL
60 70 80 90 100
EPDKCNIAVE EEYMTDEKKK RKSNQLKEIR RTELKRYYSI DDNQNKTHDK
110 120 130 140 150
KEKKMVVQKP HGTMEYTAGN QDTLNSIALK FNITPNKLVE LNKLFTHTIV
160 170 180 190 200
PGQVLFVPDA NSPSSTLRLS SSSPGATVSP SSSDAEYDKL PDADLARKAL
210 220 230 240 250
KPIERVLSST SEEDEPGVVK FLKMNCRYFT DGKGVVGGVM IVTPNNIMFD
260 270 280 290 300
PHKSDPLVIE NGCEEYGLIC PMEEVVSIAL YNDISHMKIK DALPSDLPQD
310 320 330 340 350
LCPLYRPGEW EDLASEKDIN PFSKFKSINK EKRQQNGEKI MTSDSRPIVP
360 370 380 390 400
LEKSTGHTPT KPSGSSVSEK LKKLDSSRET SHGSPTVTKL SKEPSDTSSA
410 420 430 440 450
FESTAKENFL GEDDDFVDLE ELSSQTGGGM HKKDTLKECL SLDPEERKKA
460 470 480 490 500
ESQINNSAVE MQVQSALAFL GTENDVELKG ALDLETCEKQ DIMPEVDKQS
510 520 530 540 550
GSPESRVENT LNIHEDLDKV KLIEYYLTKN KEGPQVSENL QKTELSDGKS
560 570 580 590 600
IEPGGIDITL SSSLSQAGDP ITEGNKEPDK TWVKKGEPLP VKLNSSTEAN
610 620 630 640 650
VIKEALDSSL ESTLDNSCQG AQMDNKSEVQ LWLLKRIQVP IEDILPSKEE
660 670 680 690 700
KSKTPPMFLC IKVGKPMRKS FATHTAAMVQ QYGKRRKQPE YWFAVPRERV
710 720 730 740 750
DHLYTFFVQW SPDVYGKDAK EQGFVVVEKE ELNMIDNFFS EPTTKSWEII
760 770 780 790 800
TVEEAKRRKS TCSYYEDEDE EVLPVLRPHS ALLENMHIEQ LARRLPARVQ
810 820 830 840 850
GYPWRLAYST LEHGTSLKTL YRKSASLDSP VLLVIKDMDN QIFGAYATHP
860 870 880 890 900
FKFSDHYYGT GETFLYTFSP HFKVFKWSGE NSYFINGDIS SLELGGGGGR
910 920 930 940
FGLWLDADLY HGRSNSCSTF NNDILSKKED FIVQDLEVWA FD
Length:942
Mass (Da):106,162
Last modified:July 11, 2006 - v2
Checksum:iAFD13F06F38C6C5D
GO
Isoform 2 (identifier: Q8NI08-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-306: Missing.

Note: No experimental confirmation available.
Show »
Length:931
Mass (Da):104,847
Checksum:i59EF69310C7FBE9F
GO
Isoform 3 (identifier: Q8NI08-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-942: Missing.

Note: No experimental confirmation available.
Show »
Length:295
Mass (Da):33,145
Checksum:i698C5760DD9A3D61
GO
Isoform 4 (identifier: Q8NI08-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-249: GVVGGVMIVTPNNIMF → VYSNVICFLSLKSMKN
     250-942: Missing.

Note: No experimental confirmation available.
Show »
Length:249
Mass (Da):28,246
Checksum:i211C53B01C7D5AF0
GO
Isoform 5 (identifier: Q8NI08-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-723: Missing.
     724-748: FVVVEKEELNMIDNFFSEPTTKSWE → MRGQRLPLDIQIFYCARPDEEPFVK

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):25,270
Checksum:i1C0052E860872FAA
GO
Isoform 6 (identifier: Q8NI08-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-102: DDNQNKTHDKKE → GEYSWRYCSIFI
     103-942: Missing.

Note: No experimental confirmation available.
Show »
Length:102
Mass (Da):12,189
Checksum:iEB558581700DAE15
GO
Isoform 7 (identifier: Q8NI08-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     296-306: Missing.

Note: No experimental confirmation available.
Show »
Length:827
Mass (Da):92,472
Checksum:i37F6E9A7D3465DBF
GO

Sequence cautioni

The sequence CAD89948 differs from that shown. Reason: Frameshift at position 782.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32S → T in BAE45732 (PubMed:12880961).Curated1
Sequence conflicti118A → T in CAD89948 (PubMed:17974005).Curated1
Sequence conflicti177T → A in AAM27392 (PubMed:11971969).Curated1
Sequence conflicti228Y → H in CAD89948 (PubMed:17974005).Curated1
Sequence conflicti249F → C in AAM27392 (PubMed:11971969).Curated1
Sequence conflicti266Y → H in CAD97627 (PubMed:17974005).Curated1
Sequence conflicti278I → T in AAM27392 (PubMed:11971969).Curated1
Sequence conflicti369E → G in CAD89948 (PubMed:17974005).Curated1
Sequence conflicti723G → S in BAH11810 (PubMed:14702039).Curated1
Sequence conflicti752V → A in CAD89948 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026965399S → A.4 PublicationsCorresponds to variant rs6919947dbSNPEnsembl.1
Natural variantiVAR_050438533G → R.Corresponds to variant rs35223550dbSNPEnsembl.1
Natural variantiVAR_026966942D → E.Corresponds to variant rs1567dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0196321 – 723Missing in isoform 5. 1 PublicationAdd BLAST723
Alternative sequenceiVSP_0448591 – 104Missing in isoform 7. 1 PublicationAdd BLAST104
Alternative sequenceiVSP_01963391 – 102DDNQN…HDKKE → GEYSWRYCSIFI in isoform 6. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_019634103 – 942Missing in isoform 6. 1 PublicationAdd BLAST840
Alternative sequenceiVSP_019635234 – 249GVVGG…NNIMF → VYSNVICFLSLKSMKN in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_019636250 – 942Missing in isoform 4. 1 PublicationAdd BLAST693
Alternative sequenceiVSP_019637296 – 942Missing in isoform 3. 1 PublicationAdd BLAST647
Alternative sequenceiVSP_019638296 – 306Missing in isoform 2 and isoform 7. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_019639724 – 748FVVVE…TKSWE → MRGQRLPLDIQIFYCARPDE EPFVK in isoform 5. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF493978 mRNA. Translation: AAM27392.1.
AB074157 mRNA. Translation: BAE45732.1.
AK094706 mRNA. Translation: BAC04402.1.
AK294558 mRNA. Translation: BAH11810.1.
BX537385 mRNA. Translation: CAD97627.1.
AL832628 mRNA. Translation: CAD89948.1. Frameshift.
AL078594, AL035689, AL136163 Genomic DNA. Translation: CAI20072.1.
AL136163, AL035689, AL078594 Genomic DNA. Translation: CAI42386.1.
AL035689, AL136163, AL078594 Genomic DNA. Translation: CAI42397.1.
CH471051 Genomic DNA. Translation: EAW48133.1.
BC036461 mRNA. Translation: AAH36461.1.
BC071782 mRNA. Translation: AAH71782.1.
BC137094 mRNA. Translation: AAI37095.1.
BC137095 mRNA. Translation: AAI37096.1.
CCDSiCCDS5132.1. [Q8NI08-1]
CCDS56448.1. [Q8NI08-7]
CCDS83125.1. [Q8NI08-5]
RefSeqiNP_001116314.1. NM_001122842.2. [Q8NI08-2]
NP_001186548.1. NM_001199619.1. [Q8NI08-1]
NP_001186549.1. NM_001199620.1. [Q8NI08-1]
NP_001186550.1. NM_001199621.1. [Q8NI08-7]
NP_001186551.1. NM_001199622.1. [Q8NI08-5]
NP_861447.3. NM_181782.4. [Q8NI08-1]
XP_005266879.1. XM_005266822.4. [Q8NI08-1]
XP_006715403.1. XM_006715340.3. [Q8NI08-1]
XP_011533757.1. XM_011535455.2. [Q8NI08-1]
XP_016865758.1. XM_017010269.1. [Q8NI08-1]
XP_016865759.1. XM_017010270.1. [Q8NI08-2]
XP_016865760.1. XM_017010271.1. [Q8NI08-2]
XP_016865761.1. XM_017010272.1. [Q8NI08-2]
XP_016865762.1. XM_017010273.1. [Q8NI08-2]
XP_016865763.1. XM_017010274.1. [Q8NI08-2]
UniGeneiHs.171426.

Genome annotation databases

EnsembliENST00000229634; ENSP00000229634; ENSG00000111912. [Q8NI08-7]
ENST00000368357; ENSP00000357341; ENSG00000111912. [Q8NI08-1]
ENST00000392477; ENSP00000376269; ENSG00000111912. [Q8NI08-1]
ENST00000438495; ENSP00000398268; ENSG00000111912. [Q8NI08-5]
GeneIDi135112.
KEGGihsa:135112.
UCSCiuc003qae.5. human. [Q8NI08-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF493978 mRNA. Translation: AAM27392.1.
AB074157 mRNA. Translation: BAE45732.1.
AK094706 mRNA. Translation: BAC04402.1.
AK294558 mRNA. Translation: BAH11810.1.
BX537385 mRNA. Translation: CAD97627.1.
AL832628 mRNA. Translation: CAD89948.1. Frameshift.
AL078594, AL035689, AL136163 Genomic DNA. Translation: CAI20072.1.
AL136163, AL035689, AL078594 Genomic DNA. Translation: CAI42386.1.
AL035689, AL136163, AL078594 Genomic DNA. Translation: CAI42397.1.
CH471051 Genomic DNA. Translation: EAW48133.1.
BC036461 mRNA. Translation: AAH36461.1.
BC071782 mRNA. Translation: AAH71782.1.
BC137094 mRNA. Translation: AAI37095.1.
BC137095 mRNA. Translation: AAI37096.1.
CCDSiCCDS5132.1. [Q8NI08-1]
CCDS56448.1. [Q8NI08-7]
CCDS83125.1. [Q8NI08-5]
RefSeqiNP_001116314.1. NM_001122842.2. [Q8NI08-2]
NP_001186548.1. NM_001199619.1. [Q8NI08-1]
NP_001186549.1. NM_001199620.1. [Q8NI08-1]
NP_001186550.1. NM_001199621.1. [Q8NI08-7]
NP_001186551.1. NM_001199622.1. [Q8NI08-5]
NP_861447.3. NM_181782.4. [Q8NI08-1]
XP_005266879.1. XM_005266822.4. [Q8NI08-1]
XP_006715403.1. XM_006715340.3. [Q8NI08-1]
XP_011533757.1. XM_011535455.2. [Q8NI08-1]
XP_016865758.1. XM_017010269.1. [Q8NI08-1]
XP_016865759.1. XM_017010270.1. [Q8NI08-2]
XP_016865760.1. XM_017010271.1. [Q8NI08-2]
XP_016865761.1. XM_017010272.1. [Q8NI08-2]
XP_016865762.1. XM_017010273.1. [Q8NI08-2]
XP_016865763.1. XM_017010274.1. [Q8NI08-2]
UniGeneiHs.171426.

3D structure databases

ProteinModelPortaliQ8NI08.
SMRiQ8NI08.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126419. 7 interactors.
IntActiQ8NI08. 10 interactors.
STRINGi9606.ENSP00000357341.

PTM databases

iPTMnetiQ8NI08.
PhosphoSitePlusiQ8NI08.
SwissPalmiQ8NI08.

Polymorphism and mutation databases

BioMutaiNCOA7.
DMDMi110287684.

Proteomic databases

EPDiQ8NI08.
MaxQBiQ8NI08.
PaxDbiQ8NI08.
PeptideAtlasiQ8NI08.
PRIDEiQ8NI08.

Protocols and materials databases

DNASUi135112.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229634; ENSP00000229634; ENSG00000111912. [Q8NI08-7]
ENST00000368357; ENSP00000357341; ENSG00000111912. [Q8NI08-1]
ENST00000392477; ENSP00000376269; ENSG00000111912. [Q8NI08-1]
ENST00000438495; ENSP00000398268; ENSG00000111912. [Q8NI08-5]
GeneIDi135112.
KEGGihsa:135112.
UCSCiuc003qae.5. human. [Q8NI08-1]

Organism-specific databases

CTDi135112.
DisGeNETi135112.
GeneCardsiNCOA7.
H-InvDBHIX0006198.
HGNCiHGNC:21081. NCOA7.
HPAiHPA030289.
HPA030290.
HPA030291.
HPA030292.
MIMi609752. gene.
neXtProtiNX_Q8NI08.
OpenTargetsiENSG00000111912.
PharmGKBiPA134905581.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMGK. Eukaryota.
ENOG4110T63. LUCA.
GeneTreeiENSGT00410000025363.
HOVERGENiHBG065488.
InParanoidiQ8NI08.
OMAiIQVPIED.
OrthoDBiEOG091G0L15.
PhylomeDBiQ8NI08.
TreeFamiTF313530.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111912-MONOMER.

Miscellaneous databases

ChiTaRSiNCOA7. human.
GeneWikiiNCOA7.
GenomeRNAii135112.
PROiQ8NI08.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111912.
ExpressionAtlasiQ8NI08. baseline and differential.
GenevisibleiQ8NI08. HS.

Family and domain databases

CDDicd00118. LysM. 1 hit.
Gene3Di3.10.350.10. 1 hit.
InterProiIPR018392. LysM_dom.
IPR006571. TLDc_dom.
[Graphical view]
PfamiPF01476. LysM. 1 hit.
PF07534. TLD. 1 hit.
[Graphical view]
SMARTiSM00257. LysM. 1 hit.
SM00584. TLDc. 1 hit.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 1 hit.
PROSITEiPS51782. LYSM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNCOA7_HUMAN
AccessioniPrimary (citable) accession number: Q8NI08
Secondary accession number(s): B2RNS2
, B7Z2C4, B9EH71, G8JL91, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.