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Q8NHZ8

- CDC26_HUMAN

UniProt

Q8NHZ8 - CDC26_HUMAN

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Protein

Anaphase-promoting complex subunit CDC26

Gene

CDC26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.1 Publication

Pathwayi

GO - Biological processi

  1. anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
  2. mitotic cell cycle Source: Reactome
  3. mitotic nuclear division Source: UniProtKB-KW
  4. mitotic spindle assembly checkpoint Source: Reactome
  5. negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
  6. positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
  7. protein K11-linked ubiquitination Source: UniProtKB
  8. regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_1072. Inactivation of APC/C via direct inhibition of the APC/C complex.
REACT_150471. Separation of Sister Chromatids.
REACT_169168. Senescence-Associated Secretory Phenotype (SASP).
REACT_6761. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_6781. APC/C:Cdc20 mediated degradation of mitotic proteins.
REACT_6785. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_6820. APC/C:Cdc20 mediated degradation of Cyclin B.
REACT_6837. Regulation of APC/C activators between G1/S and early anaphase.
REACT_6867. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
REACT_6871. APC/C:Cdc20 mediated degradation of Securin.
REACT_6904. Phosphorylation of the APC/C.
REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit CDC26
Alternative name(s):
Anaphase-promoting complex subunit 12
Short name:
APC12
Cell division cycle protein 26 homolog
Gene namesi
Name:CDC26
Synonyms:ANAPC12, C9orf17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:17839. CDC26.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. anaphase-promoting complex Source: UniProtKB
  2. cytosol Source: Reactome
  3. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25974.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8585Anaphase-promoting complex subunit CDC26PRO_0000271194Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421Phosphoserine2 Publications
Modified residuei82 – 821Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8NHZ8.
PaxDbiQ8NHZ8.
PRIDEiQ8NHZ8.

PTM databases

PhosphoSiteiQ8NHZ8.

Expressioni

Gene expression databases

BgeeiQ8NHZ8.
CleanExiHS_CDC26.
GenevestigatoriQ8NHZ8.

Organism-specific databases

HPAiHPA044130.

Interactioni

Subunit structurei

The APC/C is composed of at least 12 subunits.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC16Q130423EBI-2555941,EBI-994830

Protein-protein interaction databases

BioGridi128878. 29 interactions.
DIPiDIP-48551N.
IntActiQ8NHZ8. 24 interactions.
STRINGi9606.ENSP00000363322.

Structurei

Secondary structure

1
85
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi14 – 163Combined sources
Helixi17 – 259Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HYMX-ray2.80A/C/E/G/I/K1-29[»]
ProteinModelPortaliQ8NHZ8.
SMRiQ8NHZ8. Positions 1-26.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NHZ8.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili7 – 3832Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the CDC26 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG42592.
GeneTreeiENSGT00390000008457.
HOGENOMiHOG000231545.
HOVERGENiHBG057346.
InParanoidiQ8NHZ8.
KOiK03359.
OMAiNENQNER.
OrthoDBiEOG7Q2N8D.
PhylomeDBiQ8NHZ8.
TreeFamiTF101057.

Family and domain databases

InterProiIPR018860. APC_suCDC26.
[Graphical view]
PfamiPF10471. APC_CDC26. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHZ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRRKPTRLE LKLDDIEEFE NIRKDLETRK KQKEDVEVVG GSDGEGAIGL
60 70 80
SSDPKSREQM INDRIGYKPQ PKPNNRSSQF GSLEF
Length:85
Mass (Da):9,777
Last modified:October 1, 2002 - v1
Checksum:i134970EE68F0142C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503918 mRNA. Translation: AAM34207.1.
AL449305 Genomic DNA. Translation: CAI10967.1.
BC042534 mRNA. Translation: AAH42534.1.
BC066300 mRNA. Translation: AAH66300.1.
CCDSiCCDS6790.1.
RefSeqiNP_644815.1. NM_139286.3.
UniGeneiHs.727648.

Genome annotation databases

EnsembliENST00000374206; ENSP00000363322; ENSG00000176386.
GeneIDi246184.
KEGGihsa:246184.
UCSCiuc004bgw.2. human.

Polymorphism databases

DMDMi74751322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503918 mRNA. Translation: AAM34207.1 .
AL449305 Genomic DNA. Translation: CAI10967.1 .
BC042534 mRNA. Translation: AAH42534.1 .
BC066300 mRNA. Translation: AAH66300.1 .
CCDSi CCDS6790.1.
RefSeqi NP_644815.1. NM_139286.3.
UniGenei Hs.727648.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3HYM X-ray 2.80 A/C/E/G/I/K 1-29 [» ]
ProteinModelPortali Q8NHZ8.
SMRi Q8NHZ8. Positions 1-26.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128878. 29 interactions.
DIPi DIP-48551N.
IntActi Q8NHZ8. 24 interactions.
STRINGi 9606.ENSP00000363322.

PTM databases

PhosphoSitei Q8NHZ8.

Polymorphism databases

DMDMi 74751322.

Proteomic databases

MaxQBi Q8NHZ8.
PaxDbi Q8NHZ8.
PRIDEi Q8NHZ8.

Protocols and materials databases

DNASUi 246184.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374206 ; ENSP00000363322 ; ENSG00000176386 .
GeneIDi 246184.
KEGGi hsa:246184.
UCSCi uc004bgw.2. human.

Organism-specific databases

CTDi 246184.
GeneCardsi GC09M116018.
HGNCi HGNC:17839. CDC26.
HPAi HPA044130.
MIMi 614533. gene.
neXtProti NX_Q8NHZ8.
PharmGKBi PA25974.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42592.
GeneTreei ENSGT00390000008457.
HOGENOMi HOG000231545.
HOVERGENi HBG057346.
InParanoidi Q8NHZ8.
KOi K03359.
OMAi NENQNER.
OrthoDBi EOG7Q2N8D.
PhylomeDBi Q8NHZ8.
TreeFami TF101057.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_1072. Inactivation of APC/C via direct inhibition of the APC/C complex.
REACT_150471. Separation of Sister Chromatids.
REACT_169168. Senescence-Associated Secretory Phenotype (SASP).
REACT_6761. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_6781. APC/C:Cdc20 mediated degradation of mitotic proteins.
REACT_6785. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_6820. APC/C:Cdc20 mediated degradation of Cyclin B.
REACT_6837. Regulation of APC/C activators between G1/S and early anaphase.
REACT_6867. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
REACT_6871. APC/C:Cdc20 mediated degradation of Securin.
REACT_6904. Phosphorylation of the APC/C.
REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

EvolutionaryTracei Q8NHZ8.
GenomeRNAii 246184.
NextBioi 91885.
PROi Q8NHZ8.
SOURCEi Search...

Gene expression databases

Bgeei Q8NHZ8.
CleanExi HS_CDC26.
Genevestigatori Q8NHZ8.

Family and domain databases

InterProi IPR018860. APC_suCDC26.
[Graphical view ]
Pfami PF10471. APC_CDC26. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex."
    Gmachl M., Gieffers C., Podtelejnikov A.V., Mann M., Peters J.-M.
    Proc. Natl. Acad. Sci. U.S.A. 97:8973-8978(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION IN THE APC/C COMPLEX.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Skin.
  4. "Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex."
    Jin L., Williamson A., Banerjee S., Philipp I., Rape M.
    Cell 133:653-665(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE APC/C.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND SER-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C."
    Dube P., Herzog F., Gieffers C., Sander B., Riedel D., Mueller S.A., Engel A., Peters J.-M., Stark H.
    Mol. Cell 20:867-879(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: ELECTRON MICROSCOPY OF THE APC/C.

Entry informationi

Entry nameiCDC26_HUMAN
AccessioniPrimary (citable) accession number: Q8NHZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3