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Q8NHZ7 (MB3L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Methyl-CpG-binding domain protein 3-like 2

Short name=MBD3-like protein 2
Gene names
Name:MBD3L2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Detected at low levels in several somatic tissues. Highly expressed in the ovarian teratocarcinoma cell line PA-1. Ref.1

Miscellaneous

The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number of functional copies is unclear, and some of them may represent pseudogenes.

Sequence similarities

Belongs to the MBD3L family.

Sequence caution

The sequence AAM28154.2 differs from that shown. Reason: Frameshift at position 204.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208Methyl-CpG-binding domain protein 3-like 2
PRO_0000096253

Experimental info

Sequence conflict1241G → S in AAM28154. Ref.1
Sequence conflict1241G → S in BE502398. Ref.3
Sequence conflict207 – 2082GG → CR in AAM28154. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8NHZ7 [UniParc].

Last modified April 5, 2011. Version 3.
Checksum: 55F7F5E2275F15CB

FASTA20822,994
        10         20         30         40         50         60 
MGEPAFTSFP SLPVLGKLKR NMMPWALQKK REIHMAKAHR RRAARSALPM RLTSCIFRRP 

        70         80         90        100        110        120 
VTRIRSHPDN QVRRRKGDEH LEKPQQLCAY RRLQALQPCS SQGEGSSPLH LESVLSILAP 

       130        140        150        160        170        180 
GTAGESLDRA GAERVRSPLE PTPGRFPAVA GGPTPGMGCQ LPPPLSGQLV TPADIRRQAR 

       190        200 
RVKKARERLA KALQADRLAR RAEMLTGG 

« Hide

References

« Hide 'large scale' references
[1]"MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor."
Jiang C.-L., Jin S.-G., Lee D.-H., Lan Z.-J., Xu X., O'Connor T.R., Szabo P.E., Mann J.R., Cooney A.J., Pfeifer G.P.
Genomics 80:621-629(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-208.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF503919 mRNA. Translation: AAM28154.2. Frameshift.
AC010606 Genomic DNA. No translation available.
BE502398 mRNA. No translation available.
CCDSCCDS42483.1.
RefSeqNP_653215.2. NM_144614.3.
XP_003403895.1. XM_003403847.3.
UniGeneHs.567667.

3D structure databases

ProteinModelPortalQ8NHZ7.
SMRQ8NHZ7. Positions 167-199.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125944. 10 interactions.
STRING9606.ENSP00000351254.

Proteomic databases

PaxDbQ8NHZ7.
PRIDEQ8NHZ7.

Protocols and materials databases

DNASU125997.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381393; ENSP00000370800; ENSG00000230522.
GeneID125997.
729458.
KEGGhsa:125997.
hsa:729458.
UCSCuc010dvf.1. human.

Organism-specific databases

CTD125997.
GeneCardsGC19P007049.
H-InvDBHIX0040015.
HGNCHGNC:18532. MBD3L2.
HPAHPA051259.
MIM607964. gene.
neXtProtNX_Q8NHZ7.
PharmGKBPA38567.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG283461.
HOGENOMHOG000013073.
HOVERGENHBG052417.
InParanoidQ8NHZ7.
OMAYPENETR.
OrthoDBEOG7QNVMV.
PhylomeDBQ8NHZ7.
TreeFamTF325032.

Gene expression databases

CleanExHS_MBD3L2.
GenevestigatorQ8NHZ7.

Family and domain databases

InterProIPR025884. MeCpG-bd_2/3_C_dom.
[Graphical view]
PfamPF14048. MBD_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio81613.
PROQ8NHZ7.
SOURCESearch...

Entry information

Entry nameMB3L2_HUMAN
AccessionPrimary (citable) accession number: Q8NHZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM