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Q8NHZ7

- MB3L2_HUMAN

UniProt

Q8NHZ7 - MB3L2_HUMAN

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Protein

Methyl-CpG-binding domain protein 3-like 2

Gene

MBD3L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-CpG-binding domain protein 3-like 2
Short name:
MBD3-like protein 2
Gene namesi
Name:MBD3L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:18532. MBD3L2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38567.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Methyl-CpG-binding domain protein 3-like 2PRO_0000096253Add
BLAST

Proteomic databases

PaxDbiQ8NHZ7.
PRIDEiQ8NHZ7.

Expressioni

Tissue specificityi

Detected at low levels in several somatic tissues. Highly expressed in the ovarian teratocarcinoma cell line PA-1.1 Publication

Gene expression databases

CleanExiHS_MBD3L2.
GenevestigatoriQ8NHZ7.

Organism-specific databases

HPAiHPA051259.

Interactioni

Protein-protein interaction databases

BioGridi125944. 10 interactions.
STRINGi9606.ENSP00000351254.

Structurei

3D structure databases

ProteinModelPortaliQ8NHZ7.
SMRiQ8NHZ7. Positions 167-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MBD3L family.Curated

Phylogenomic databases

eggNOGiNOG283461.
GeneTreeiENSGT00410000025376.
HOGENOMiHOG000013073.
HOVERGENiHBG052417.
InParanoidiQ8NHZ7.
OMAiYPENETR.
OrthoDBiEOG7QNVMV.
PhylomeDBiQ8NHZ7.
TreeFamiTF325032.

Family and domain databases

InterProiIPR025884. MeCpG-bd_2/3_C_dom.
[Graphical view]
PfamiPF14048. MBD_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHZ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGEPAFTSFP SLPVLGKLKR NMMPWALQKK REIHMAKAHR RRAARSALPM
60 70 80 90 100
RLTSCIFRRP VTRIRSHPDN QVRRRKGDEH LEKPQQLCAY RRLQALQPCS
110 120 130 140 150
SQGEGSSPLH LESVLSILAP GTAGESLDRA GAERVRSPLE PTPGRFPAVA
160 170 180 190 200
GGPTPGMGCQ LPPPLSGQLV TPADIRRQAR RVKKARERLA KALQADRLAR

RAEMLTGG
Length:208
Mass (Da):22,994
Last modified:April 5, 2011 - v3
Checksum:i55F7F5E2275F15CB
GO

Sequence cautioni

The sequence AAM28154.2 differs from that shown. Reason: Frameshift at position 204.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241G → S in AAM28154. (PubMed:12504854)Curated
Sequence conflicti124 – 1241G → S in BE502398. (PubMed:15489334)Curated
Sequence conflicti207 – 2082GG → CR in AAM28154. (PubMed:12504854)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF503919 mRNA. Translation: AAM28154.2. Frameshift.
AC010606 Genomic DNA. No translation available.
BE502398 mRNA. No translation available.
CCDSiCCDS42483.1.
RefSeqiNP_653215.2. NM_144614.3.
XP_003403895.1. XM_003403847.3.
UniGeneiHs.567667.

Genome annotation databases

EnsembliENST00000381393; ENSP00000370800; ENSG00000230522.
GeneIDi125997.
729458.
KEGGihsa:125997.
hsa:729458.
UCSCiuc010dvf.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF503919 mRNA. Translation: AAM28154.2 . Frameshift.
AC010606 Genomic DNA. No translation available.
BE502398 mRNA. No translation available.
CCDSi CCDS42483.1.
RefSeqi NP_653215.2. NM_144614.3.
XP_003403895.1. XM_003403847.3.
UniGenei Hs.567667.

3D structure databases

ProteinModelPortali Q8NHZ7.
SMRi Q8NHZ7. Positions 167-199.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125944. 10 interactions.
STRINGi 9606.ENSP00000351254.

Proteomic databases

PaxDbi Q8NHZ7.
PRIDEi Q8NHZ7.

Protocols and materials databases

DNASUi 125997.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381393 ; ENSP00000370800 ; ENSG00000230522 .
GeneIDi 125997.
729458.
KEGGi hsa:125997.
hsa:729458.
UCSCi uc010dvf.1. human.

Organism-specific databases

CTDi 125997.
GeneCardsi GC19P007049.
H-InvDB HIX0040015.
HGNCi HGNC:18532. MBD3L2.
HPAi HPA051259.
MIMi 607964. gene.
neXtProti NX_Q8NHZ7.
PharmGKBi PA38567.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG283461.
GeneTreei ENSGT00410000025376.
HOGENOMi HOG000013073.
HOVERGENi HBG052417.
InParanoidi Q8NHZ7.
OMAi YPENETR.
OrthoDBi EOG7QNVMV.
PhylomeDBi Q8NHZ7.
TreeFami TF325032.

Miscellaneous databases

NextBioi 81613.
PROi Q8NHZ7.
SOURCEi Search...

Gene expression databases

CleanExi HS_MBD3L2.
Genevestigatori Q8NHZ7.

Family and domain databases

InterProi IPR025884. MeCpG-bd_2/3_C_dom.
[Graphical view ]
Pfami PF14048. MBD_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor."
    Jiang C.-L., Jin S.-G., Lee D.-H., Lan Z.-J., Xu X., O'Connor T.R., Szabo P.E., Mann J.R., Cooney A.J., Pfeifer G.P.
    Genomics 80:621-629(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-208.

Entry informationi

Entry nameiMB3L2_HUMAN
AccessioniPrimary (citable) accession number: Q8NHZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number of functional copies is unclear, and some of them may represent pseudogenes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3