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Q8NHZ7

- MB3L2_HUMAN

UniProt

Q8NHZ7 - MB3L2_HUMAN

Protein

Methyl-CpG-binding domain protein 3-like 2

Gene

MBD3L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 3 (05 Apr 2011)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methyl-CpG-binding domain protein 3-like 2
    Short name:
    MBD3-like protein 2
    Gene namesi
    Name:MBD3L2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:18532. MBD3L2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38567.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208Methyl-CpG-binding domain protein 3-like 2PRO_0000096253Add
    BLAST

    Proteomic databases

    PaxDbiQ8NHZ7.
    PRIDEiQ8NHZ7.

    Expressioni

    Tissue specificityi

    Detected at low levels in several somatic tissues. Highly expressed in the ovarian teratocarcinoma cell line PA-1.1 Publication

    Gene expression databases

    CleanExiHS_MBD3L2.
    GenevestigatoriQ8NHZ7.

    Organism-specific databases

    HPAiHPA051259.

    Interactioni

    Protein-protein interaction databases

    BioGridi125944. 10 interactions.
    STRINGi9606.ENSP00000351254.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NHZ7.
    SMRiQ8NHZ7. Positions 167-199.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MBD3L family.Curated

    Phylogenomic databases

    eggNOGiNOG283461.
    HOGENOMiHOG000013073.
    HOVERGENiHBG052417.
    InParanoidiQ8NHZ7.
    OMAiYPENETR.
    OrthoDBiEOG7QNVMV.
    PhylomeDBiQ8NHZ7.
    TreeFamiTF325032.

    Family and domain databases

    InterProiIPR025884. MeCpG-bd_2/3_C_dom.
    [Graphical view]
    PfamiPF14048. MBD_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NHZ7-1 [UniParc]FASTAAdd to Basket

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    MGEPAFTSFP SLPVLGKLKR NMMPWALQKK REIHMAKAHR RRAARSALPM    50
    RLTSCIFRRP VTRIRSHPDN QVRRRKGDEH LEKPQQLCAY RRLQALQPCS 100
    SQGEGSSPLH LESVLSILAP GTAGESLDRA GAERVRSPLE PTPGRFPAVA 150
    GGPTPGMGCQ LPPPLSGQLV TPADIRRQAR RVKKARERLA KALQADRLAR 200
    RAEMLTGG 208
    Length:208
    Mass (Da):22,994
    Last modified:April 5, 2011 - v3
    Checksum:i55F7F5E2275F15CB
    GO

    Sequence cautioni

    The sequence AAM28154.2 differs from that shown. Reason: Frameshift at position 204.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti124 – 1241G → S in AAM28154. (PubMed:12504854)Curated
    Sequence conflicti124 – 1241G → S in BE502398. (PubMed:15489334)Curated
    Sequence conflicti207 – 2082GG → CR in AAM28154. (PubMed:12504854)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF503919 mRNA. Translation: AAM28154.2. Frameshift.
    AC010606 Genomic DNA. No translation available.
    BE502398 mRNA. No translation available.
    CCDSiCCDS42483.1.
    RefSeqiNP_653215.2. NM_144614.3.
    XP_003403895.1. XM_003403847.3.
    UniGeneiHs.567667.

    Genome annotation databases

    EnsembliENST00000381393; ENSP00000370800; ENSG00000230522.
    GeneIDi125997.
    729458.
    KEGGihsa:125997.
    hsa:729458.
    UCSCiuc010dvf.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF503919 mRNA. Translation: AAM28154.2 . Frameshift.
    AC010606 Genomic DNA. No translation available.
    BE502398 mRNA. No translation available.
    CCDSi CCDS42483.1.
    RefSeqi NP_653215.2. NM_144614.3.
    XP_003403895.1. XM_003403847.3.
    UniGenei Hs.567667.

    3D structure databases

    ProteinModelPortali Q8NHZ7.
    SMRi Q8NHZ7. Positions 167-199.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125944. 10 interactions.
    STRINGi 9606.ENSP00000351254.

    Proteomic databases

    PaxDbi Q8NHZ7.
    PRIDEi Q8NHZ7.

    Protocols and materials databases

    DNASUi 125997.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381393 ; ENSP00000370800 ; ENSG00000230522 .
    GeneIDi 125997.
    729458.
    KEGGi hsa:125997.
    hsa:729458.
    UCSCi uc010dvf.1. human.

    Organism-specific databases

    CTDi 125997.
    GeneCardsi GC19P007049.
    H-InvDB HIX0040015.
    HGNCi HGNC:18532. MBD3L2.
    HPAi HPA051259.
    MIMi 607964. gene.
    neXtProti NX_Q8NHZ7.
    PharmGKBi PA38567.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283461.
    HOGENOMi HOG000013073.
    HOVERGENi HBG052417.
    InParanoidi Q8NHZ7.
    OMAi YPENETR.
    OrthoDBi EOG7QNVMV.
    PhylomeDBi Q8NHZ7.
    TreeFami TF325032.

    Miscellaneous databases

    NextBioi 81613.
    PROi Q8NHZ7.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_MBD3L2.
    Genevestigatori Q8NHZ7.

    Family and domain databases

    InterProi IPR025884. MeCpG-bd_2/3_C_dom.
    [Graphical view ]
    Pfami PF14048. MBD_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor."
      Jiang C.-L., Jin S.-G., Lee D.-H., Lan Z.-J., Xu X., O'Connor T.R., Szabo P.E., Mann J.R., Cooney A.J., Pfeifer G.P.
      Genomics 80:621-629(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-208.

    Entry informationi

    Entry nameiMB3L2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NHZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 89 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number of functional copies is unclear, and some of them may represent pseudogenes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3