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Protein

Methyl-CpG-binding domain protein 3-like 2

Gene

MBD3L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33125-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-CpG-binding domain protein 3-like 2
Short name:
MBD3-like protein 2
Gene namesi
Name:MBD3L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:18532. MBD3L2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi125997.
OpenTargetsiENSG00000230522.
PharmGKBiPA38567.

Polymorphism and mutation databases

BioMutaiMBD3L2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000962531 – 208Methyl-CpG-binding domain protein 3-like 2Add BLAST208

Proteomic databases

PaxDbiQ8NHZ7.
PRIDEiQ8NHZ7.

Expressioni

Tissue specificityi

Detected at low levels in several somatic tissues. Highly expressed in the ovarian teratocarcinoma cell line PA-1.1 Publication

Gene expression databases

CleanExiHS_MBD3L2.
GenevisibleiQ8NHZ7. HS.

Organism-specific databases

HPAiHPA051259.

Interactioni

Protein-protein interaction databases

BioGridi125944. 10 interactors.
IntActiQ8NHZ7. 3 interactors.
STRINGi9606.ENSP00000370800.

Structurei

3D structure databases

ProteinModelPortaliQ8NHZ7.
SMRiQ8NHZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MBD3L family.Curated

Phylogenomic databases

eggNOGiKOG4161. Eukaryota.
ENOG4111HPQ. LUCA.
GeneTreeiENSGT00410000025376.
HOGENOMiHOG000013073.
HOVERGENiHBG052417.
InParanoidiQ8NHZ7.
OMAiYPENETR.
OrthoDBiEOG091G0KY1.
PhylomeDBiQ8NHZ7.
TreeFamiTF325032.

Family and domain databases

InterProiIPR032343. MBD2/MBD3_p55-bd.
IPR025884. MeCpG-bd_2/3_C_dom.
[Graphical view]
PfamiPF14048. MBD_C. 1 hit.
PF16564. MBDa. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEPAFTSFP SLPVLGKLKR NMMPWALQKK REIHMAKAHR RRAARSALPM
60 70 80 90 100
RLTSCIFRRP VTRIRSHPDN QVRRRKGDEH LEKPQQLCAY RRLQALQPCS
110 120 130 140 150
SQGEGSSPLH LESVLSILAP GTAGESLDRA GAERVRSPLE PTPGRFPAVA
160 170 180 190 200
GGPTPGMGCQ LPPPLSGQLV TPADIRRQAR RVKKARERLA KALQADRLAR

RAEMLTGG
Length:208
Mass (Da):22,994
Last modified:April 5, 2011 - v3
Checksum:i55F7F5E2275F15CB
GO

Sequence cautioni

The sequence AAM28154 differs from that shown. Reason: Frameshift at position 204.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124G → S in AAM28154 (PubMed:12504854).Curated1
Sequence conflicti124G → S in BE502398 (PubMed:15489334).Curated1
Sequence conflicti207 – 208GG → CR in AAM28154 (PubMed:12504854).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503919 mRNA. Translation: AAM28154.2. Frameshift.
AC010606 Genomic DNA. No translation available.
BE502398 mRNA. No translation available.
CCDSiCCDS42483.1.
RefSeqiNP_653215.2. NM_144614.3.
UniGeneiHs.567667.

Genome annotation databases

EnsembliENST00000381393; ENSP00000370800; ENSG00000230522.
GeneIDi125997.
KEGGihsa:125997.
UCSCiuc010dvf.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503919 mRNA. Translation: AAM28154.2. Frameshift.
AC010606 Genomic DNA. No translation available.
BE502398 mRNA. No translation available.
CCDSiCCDS42483.1.
RefSeqiNP_653215.2. NM_144614.3.
UniGeneiHs.567667.

3D structure databases

ProteinModelPortaliQ8NHZ7.
SMRiQ8NHZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125944. 10 interactors.
IntActiQ8NHZ7. 3 interactors.
STRINGi9606.ENSP00000370800.

Polymorphism and mutation databases

BioMutaiMBD3L2.

Proteomic databases

PaxDbiQ8NHZ7.
PRIDEiQ8NHZ7.

Protocols and materials databases

DNASUi125997.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381393; ENSP00000370800; ENSG00000230522.
GeneIDi125997.
KEGGihsa:125997.
UCSCiuc010dvf.2. human.

Organism-specific databases

CTDi125997.
DisGeNETi125997.
GeneCardsiMBD3L2.
H-InvDBHIX0040015.
HGNCiHGNC:18532. MBD3L2.
HPAiHPA051259.
MIMi607964. gene.
neXtProtiNX_Q8NHZ7.
OpenTargetsiENSG00000230522.
PharmGKBiPA38567.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4161. Eukaryota.
ENOG4111HPQ. LUCA.
GeneTreeiENSGT00410000025376.
HOGENOMiHOG000013073.
HOVERGENiHBG052417.
InParanoidiQ8NHZ7.
OMAiYPENETR.
OrthoDBiEOG091G0KY1.
PhylomeDBiQ8NHZ7.
TreeFamiTF325032.

Enzyme and pathway databases

BioCyciZFISH:G66-33125-MONOMER.

Miscellaneous databases

GenomeRNAii125997.
PROiQ8NHZ7.
SOURCEiSearch...

Gene expression databases

CleanExiHS_MBD3L2.
GenevisibleiQ8NHZ7. HS.

Family and domain databases

InterProiIPR032343. MBD2/MBD3_p55-bd.
IPR025884. MeCpG-bd_2/3_C_dom.
[Graphical view]
PfamiPF14048. MBD_C. 1 hit.
PF16564. MBDa. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMB3L2_HUMAN
AccessioniPrimary (citable) accession number: Q8NHZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number of functional copies is unclear, and some of them may represent pseudogenes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.