Q8NHZ7 (MB3L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Methyl-CpG-binding domain protein 3-like 2
Short name=MBD3-like protein 2

Gene names

Name:

MBD3L2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Detected at low levels in several somatic tissues. Highly expressed in the ovarian teratocarcinoma cell line PA-1. Ref.1
Miscellaneous	The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number of functional copies is unclear, and some of them may represent pseudogenes.
Sequence similarities	Belongs to the MBD3L family.
Sequence caution	The sequence AAM28154.2 differs from that shown. Reason: Frameshift at position 204.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Methyl-CpG-binding domain protein 3-like 2		PRO_0000096253
Experimental info
	Sequence conflict	124	1	G → S in AAM28154. Ref.1
	Sequence conflict	124	1	G → S in BE502398. Ref.3
	Sequence conflict	207 – 208	2	GG → CR in AAM28154. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8NHZ7 [UniParc]. Last modified April 5, 2011. Version 3. Checksum: 55F7F5E2275F15CB	FASTA	208	22,994
	10 20 30 40 50 60 MGEPAFTSFP SLPVLGKLKR NMMPWALQKK REIHMAKAHR RRAARSALPM RLTSCIFRRP 70 80 90 100 110 120 VTRIRSHPDN QVRRRKGDEH LEKPQQLCAY RRLQALQPCS SQGEGSSPLH LESVLSILAP 130 140 150 160 170 180 GTAGESLDRA GAERVRSPLE PTPGRFPAVA GGPTPGMGCQ LPPPLSGQLV TPADIRRQAR 190 200 RVKKARERLA KALQADRLAR RAEMLTGG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor." Jiang C.-L., Jin S.-G., Lee D.-H., Lan Z.-J., Xu X., O'Connor T.R., Szabo P.E., Mann J.R., Cooney A.J., Pfeifer G.P. Genomics 80:621-629(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-208.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF503919 mRNA. Translation: AAM28154.2. Frameshift. AC010606 Genomic DNA. No translation available. BE502398 mRNA. No translation available.
IPI	IPI00180476.
RefSeq	NP_653215.2. NM_144614.3. XP_003403895.1. XM_003403847.1.
UniGene	Hs.567667. Hs.589629.
3D structure databases
ProteinModelPortal	Q8NHZ7.
SMR	Q8NHZ7. Positions 167-199.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000351254.
Proteomic databases
PaxDb	Q8NHZ7.
PRIDE	Q8NHZ7.
Protocols and materials databases
DNASU	125997.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000381393; ENSP00000370800; ENSG00000230522.
GeneID	125997. 729458.
KEGG	hsa:125997. hsa:729458.
UCSC	uc010dvf.1. human.
Organism-specific databases
CTD	125997.
GeneCards	GC19M007018. GC19P007049.
H-InvDB	HIX0040015.
HGNC	HGNC:18532. MBD3L2.
HPA	HPA051259.
MIM	607964. gene.
neXtProt	NX_Q8NHZ7.
PharmGKB	PA38567.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG283461.
HOGENOM	HOG000013073.
HOVERGEN	HBG052417.
InParanoid	Q8NHZ7.
OMA	CASSSEG.
OrthoDB	EOG48KRCS.
Enzyme and pathway databases
Pathway_Interaction_DB	hdac_classi_pathway. Signaling events mediated by HDAC Class I.
Gene expression databases
CleanEx	HS_MBD3L2.
Genevestigator	Q8NHZ7.
GermOnline	ENSG00000196589. Homo sapiens. ENSG00000205717. Homo sapiens.
Family and domain databases
InterPro	IPR025884. MeCpG-bd_2/3_C_dom. [Graphical view]
Pfam	PF14048. MBD_C. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	81613.
SOURCE	Search...

Entry information

Entry name

MB3L2_HUMAN

Accession

Primary (citable) accession number: Q8NHZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 78 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.