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Protein

Zinc finger protein 28 homolog

Gene

ZFP28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation. May have a role in embryonic development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri420 – 442C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 499C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri505 – 527C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri645 – 667C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri673 – 695C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri701 – 723C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri729 – 751C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri757 – 779C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri785 – 807C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri813 – 835C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 28 homolog
Short name:
Zfp-28
Alternative name(s):
Krueppel-like zinc finger factor X6
Gene namesi
Name:ZFP28
Synonyms:KIAA1431
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:17801. ZFP28.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196867.
PharmGKBiPA38469.

Polymorphism and mutation databases

BioMutaiZFP28.
DMDMi33517131.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472891 – 868Zinc finger protein 28 homologAdd BLAST868

Proteomic databases

MaxQBiQ8NHY6.
PaxDbiQ8NHY6.
PeptideAtlasiQ8NHY6.
PRIDEiQ8NHY6.

PTM databases

iPTMnetiQ8NHY6.
PhosphoSitePlusiQ8NHY6.

Expressioni

Gene expression databases

BgeeiENSG00000196867.
CleanExiHS_ZFP28.
ExpressionAtlasiQ8NHY6. baseline and differential.
GenevisibleiQ8NHY6. HS.

Organism-specific databases

HPAiHPA028879.

Interactioni

Protein-protein interaction databases

BioGridi126637. 5 interactors.
IntActiQ8NHY6. 5 interactors.
MINTiMINT-8247395.
STRINGi9606.ENSP00000301318.

Structurei

Secondary structure

1868
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni423 – 425Combined sources3
Helixi432 – 442Combined sources11
Beta strandi479 – 481Combined sources3
Beta strandi485 – 487Combined sources3
Helixi488 – 495Combined sources8
Turni496 – 501Combined sources6
Turni508 – 510Combined sources3
Beta strandi514 – 516Combined sources3
Helixi517 – 524Combined sources8
Turni525 – 529Combined sources5
Beta strandi532 – 534Combined sources3
Beta strandi536 – 538Combined sources3
Beta strandi541 – 544Combined sources4
Helixi545 – 552Combined sources8
Turni553 – 555Combined sources3
Beta strandi558 – 560Combined sources3
Turni564 – 566Combined sources3
Beta strandi571 – 573Combined sources3
Helixi574 – 579Combined sources6
Helixi580 – 582Combined sources3
Beta strandi588 – 590Combined sources3
Beta strandi592 – 594Combined sources3
Beta strandi597 – 600Combined sources4
Helixi601 – 611Combined sources11
Beta strandi616 – 618Combined sources3
Beta strandi620 – 623Combined sources4
Beta strandi625 – 628Combined sources4
Helixi629 – 639Combined sources11
Beta strandi644 – 646Combined sources3
Beta strandi648 – 650Combined sources3
Beta strandi653 – 656Combined sources4
Helixi657 – 667Combined sources11
Beta strandi668 – 670Combined sources3
Beta strandi676 – 678Combined sources3
Helixi685 – 695Combined sources11
Beta strandi700 – 703Combined sources4
Turni704 – 707Combined sources4
Helixi713 – 724Combined sources12
Beta strandi726 – 730Combined sources5
Beta strandi732 – 734Combined sources3
Beta strandi737 – 740Combined sources4
Helixi741 – 751Combined sources11
Beta strandi752 – 755Combined sources4
Beta strandi756 – 758Combined sources3
Beta strandi760 – 762Combined sources3
Beta strandi765 – 768Combined sources4
Helixi769 – 776Combined sources8
Helixi777 – 779Combined sources3
Beta strandi788 – 790Combined sources3
Helixi797 – 806Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EM2NMR-A584-616[»]
2EM3NMR-A640-672[»]
2EM4NMR-A724-756[»]
2EMJNMR-A612-644[»]
2EMKNMR-A668-700[»]
2EMLNMR-A752-784[»]
2EN9NMR-A415-447[»]
2ENHNMR-A556-588[»]
2EOHNMR-A780-812[»]
2EP0NMR-A528-560[»]
2EPXNMR-A471-504[»]
2EPZNMR-A500-532[»]
2YTMNMR-A696-728[»]
ProteinModelPortaliQ8NHY6.
SMRiQ8NHY6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NHY6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 174KRAB 1PROSITE-ProRule annotationAdd BLAST72
Domaini232 – 299KRAB 2PROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 2 KRAB domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri420 – 442C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 499C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri505 – 527C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri645 – 667C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri673 – 695C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri701 – 723C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri729 – 751C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri757 – 779C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri785 – 807C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri813 – 835C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8NHY6.
KOiK09228.
OMAiTGIYAGK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8NHY6.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 2 hits.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 2 hits.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 2 hits.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 2 hits.
PROSITEiPS50805. KRAB. 2 hits.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NHY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGAASASVR EPTPLPGRGA PRTKPRAGRG PTVGTPATLA LPARGRPRSR
60 70 80 90 100
NGLASKGQRG AAPTGPGHRA LPSRDTALPQ ERNKKLEAVG TGIEPKAMSQ
110 120 130 140 150
GLVTFGDVAV DFSQEEWEWL NPIQRNLYRK VMLENYRNLA SLGLCVSKPD
160 170 180 190 200
VISSLEQGKE PWTVKRKMTR AWCPDLKAVW KIKELPLKKD FCEGKLSQAV
210 220 230 240 250
ITERLTSYNL EYSLLGEHWD YDALFETQPG LVTIKNLAVD FRQQLHPAQK
260 270 280 290 300
NFCKNGIWEN NSDLGSAGHC VAKPDLVSLL EQEKEPWMVK RELTGSLFSG
310 320 330 340 350
QRSVHETQEL FPKQDSYAEG VTDRTSNTKL DCSSFRENWD SDYVFGRKLA
360 370 380 390 400
VGQETQFRQE PITHNKTLSK ERERTYNKSG RWFYLDDSEE KVHNRDSIKN
410 420 430 440 450
FQKSSVVIKQ TGIYAGKKLF KCNECKKTFT QSSSLTVHQR IHTGEKPYKC
460 470 480 490 500
NECGKAFSDG SSFARHQRCH TGKKPYECIE CGKAFIQNTS LIRHWRYYHT
510 520 530 540 550
GEKPFDCIDC GKAFSDHIGL NQHRRIHTGE KPYKCDVCHK SFRYGSSLTV
560 570 580 590 600
HQRIHTGEKP YECDVCRKAF SHHASLTQHQ RVHSGEKPFK CKECGKAFRQ
610 620 630 640 650
NIHLASHLRI HTGEKPFECA ECGKSFSISS QLATHQRIHT GEKPYECKVC
660 670 680 690 700
SKAFTQKAHL AQHQKTHTGE KPYECKECGK AFSQTTHLIQ HQRVHTGEKP
710 720 730 740 750
YKCMECGKAF GDNSSCTQHQ RLHTGQRPYE CIECGKAFKT KSSLICHRRS
760 770 780 790 800
HTGEKPYECS VCGKAFSHRQ SLSVHQRIHS GKKPYECKEC RKTFIQIGHL
810 820 830 840 850
NQHKRVHTGE RSYNYKKSRK VFRQTAHLAH HQRIHTGESS TCPSLPSTSN
860
PVDLFPKFLW NPSSLPSP
Length:868
Mass (Da):98,705
Last modified:October 1, 2002 - v1
Checksum:iE5959243B41CE3F3
GO
Isoform 2 (identifier: Q8NHY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-349: QRSVHETQEL...DSDYVFGRKL → ECRRAWCGKS...ERKLNSGSSK
     350-868: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:349
Mass (Da):38,512
Checksum:iDC42BF404E6EDC5C
GO

Sequence cautioni

The sequence BAA92669 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10R → H in AAH28416 (PubMed:15489334).Curated1
Sequence conflicti10R → H in AAH99903 (PubMed:15489334).Curated1
Sequence conflicti383F → S in BAA92669 (PubMed:10718198).Curated1
Sequence conflicti766 – 785Missing (Ref. 5) CuratedAdd BLAST20
Isoform 2 (identifier: Q8NHY6-2)
Sequence conflicti324S → F in AAH28416 (PubMed:15489334).Curated1
Sequence conflicti324S → F in AAH99903 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052738141S → W.Corresponds to variant rs34136271dbSNPEnsembl.1
Natural variantiVAR_024190620A → V.Corresponds to variant rs10409531dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055934301 – 349QRSVH…FGRKL → ECRRAWCGKSTARESGAFTK KAASSLIYSRKLYPGSLGLE RKLNSGSSK in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_055935350 – 868Missing in isoform 2. 1 PublicationAdd BLAST519

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF507045 mRNA. Translation: AAM28892.1.
AB037852 mRNA. Translation: BAA92669.1. Different initiation.
AC005498 Genomic DNA. No translation available.
BC028416 mRNA. Translation: AAH28416.1.
BC099903 mRNA. Translation: AAH99903.1.
BC127003 mRNA. Translation: AAI27004.1.
AF226995 mRNA. Translation: AAK28320.1.
CCDSiCCDS12946.1. [Q8NHY6-1]
CCDS77363.1. [Q8NHY6-2]
RefSeqiNP_001295369.1. NM_001308440.1. [Q8NHY6-2]
NP_065879.1. NM_020828.1. [Q8NHY6-1]
UniGeneiHs.14794.

Genome annotation databases

EnsembliENST00000301318; ENSP00000301318; ENSG00000196867. [Q8NHY6-1]
ENST00000591844; ENSP00000468603; ENSG00000196867. [Q8NHY6-2]
GeneIDi140612.
KEGGihsa:140612.
UCSCiuc002qni.4. human. [Q8NHY6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF507045 mRNA. Translation: AAM28892.1.
AB037852 mRNA. Translation: BAA92669.1. Different initiation.
AC005498 Genomic DNA. No translation available.
BC028416 mRNA. Translation: AAH28416.1.
BC099903 mRNA. Translation: AAH99903.1.
BC127003 mRNA. Translation: AAI27004.1.
AF226995 mRNA. Translation: AAK28320.1.
CCDSiCCDS12946.1. [Q8NHY6-1]
CCDS77363.1. [Q8NHY6-2]
RefSeqiNP_001295369.1. NM_001308440.1. [Q8NHY6-2]
NP_065879.1. NM_020828.1. [Q8NHY6-1]
UniGeneiHs.14794.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EM2NMR-A584-616[»]
2EM3NMR-A640-672[»]
2EM4NMR-A724-756[»]
2EMJNMR-A612-644[»]
2EMKNMR-A668-700[»]
2EMLNMR-A752-784[»]
2EN9NMR-A415-447[»]
2ENHNMR-A556-588[»]
2EOHNMR-A780-812[»]
2EP0NMR-A528-560[»]
2EPXNMR-A471-504[»]
2EPZNMR-A500-532[»]
2YTMNMR-A696-728[»]
ProteinModelPortaliQ8NHY6.
SMRiQ8NHY6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126637. 5 interactors.
IntActiQ8NHY6. 5 interactors.
MINTiMINT-8247395.
STRINGi9606.ENSP00000301318.

PTM databases

iPTMnetiQ8NHY6.
PhosphoSitePlusiQ8NHY6.

Polymorphism and mutation databases

BioMutaiZFP28.
DMDMi33517131.

Proteomic databases

MaxQBiQ8NHY6.
PaxDbiQ8NHY6.
PeptideAtlasiQ8NHY6.
PRIDEiQ8NHY6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301318; ENSP00000301318; ENSG00000196867. [Q8NHY6-1]
ENST00000591844; ENSP00000468603; ENSG00000196867. [Q8NHY6-2]
GeneIDi140612.
KEGGihsa:140612.
UCSCiuc002qni.4. human. [Q8NHY6-1]

Organism-specific databases

CTDi140612.
GeneCardsiZFP28.
HGNCiHGNC:17801. ZFP28.
HPAiHPA028879.
neXtProtiNX_Q8NHY6.
OpenTargetsiENSG00000196867.
PharmGKBiPA38469.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8NHY6.
KOiK09228.
OMAiTGIYAGK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8NHY6.
TreeFamiTF341817.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZFP28. human.
EvolutionaryTraceiQ8NHY6.
GenomeRNAii140612.
PROiQ8NHY6.

Gene expression databases

BgeeiENSG00000196867.
CleanExiHS_ZFP28.
ExpressionAtlasiQ8NHY6. baseline and differential.
GenevisibleiQ8NHY6. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 2 hits.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 2 hits.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 2 hits.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 2 hits.
PROSITEiPS50805. KRAB. 2 hits.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZFP28_HUMAN
AccessioniPrimary (citable) accession number: Q8NHY6
Secondary accession number(s): A0JNV6
, K7ES88, Q8NHU8, Q9BY30, Q9P2B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.