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Protein

Checkpoint protein HUS1B

Gene

HUS1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Checkpoint protein HUS1B
Short name:
hHUS1B
Gene namesi
Name:HUS1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000188996.4
HGNCiHGNC:16485 HUS1B
MIMi609713 gene
neXtProtiNX_Q8NHY5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188996
PharmGKBiPA134939889

Polymorphism and mutation databases

BioMutaiHUS1B
DMDMi311033394

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002262451 – 278Checkpoint protein HUS1BAdd BLAST278

Proteomic databases

PaxDbiQ8NHY5
PeptideAtlasiQ8NHY5
PRIDEiQ8NHY5
ProteomicsDBi73790

PTM databases

iPTMnetiQ8NHY5
PhosphoSitePlusiQ8NHY5

Expressioni

Tissue specificityi

Expressed strongly in testis, less in spleen, thymus, prostate, colon and leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000188996
CleanExiHS_HUS1B
GenevisibleiQ8NHY5 HS

Organism-specific databases

HPAiHPA034511
HPA063449

Interactioni

Subunit structurei

Interacts with RAD1 and RAD9B.2 Publications

Protein-protein interaction databases

BioGridi126430, 8 interactors
CORUMiQ8NHY5
IntActiQ8NHY5, 8 interactors
STRINGi9606.ENSP00000370293

Structurei

3D structure databases

ProteinModelPortaliQ8NHY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HUS1 family.Curated

Phylogenomic databases

eggNOGiKOG3999 Eukaryota
ENOG410ZQ9J LUCA
GeneTreeiENSGT00390000000706
HOGENOMiHOG000253011
HOVERGENiHBG053069
InParanoidiQ8NHY5
KOiK10996
OMAiQVRVDNR
OrthoDBiEOG091G0H06
PhylomeDBiQ8NHY5
TreeFamiTF314491

Family and domain databases

InterProiView protein in InterPro
IPR016580 Cell_cycle_HUS1
IPR007150 Hus1/Mec3
PfamiView protein in Pfam
PF04005 Hus1, 1 hit
PIRSFiPIRSF011312 Cell_cycle_HUS1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NHY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFRAKITGK GCLELFIHVS GTVARLAKVC VLRVRPDSLC FGPAGSGGLH
60 70 80 90 100
EARLWCEVRQ GAFQQFRMEG VSEDLDEIHL ELTAEHLSRA ARSAAGASSL
110 120 130 140 150
KLQLTHKRRP SLTVAVELVS SLGRARSVVH DLPVRVLPRR VWRDCLPPSL
160 170 180 190 200
RASDASIRLP RWRTLRSIVE RMANVGSHVL VEANLSGRMT LSIETEVVSI
210 220 230 240 250
QSYFKNLGNP PQSAVGVPEN RDLESMVQVR VDNRKLLQFL EGQQIHPTTA
260 270
LCNIWDNTLL QLVLVQEDVS LQYFIPAL
Length:278
Mass (Da):30,982
Last modified:November 2, 2010 - v2
Checksum:i156F1ECAB50B2B54
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031206130H → Q. Corresponds to variant dbSNP:rs1766848Ensembl.1
Natural variantiVAR_031207201Q → R. Corresponds to variant dbSNP:rs17136239Ensembl.1
Natural variantiVAR_025497268D → Y2 PublicationsCorresponds to variant dbSNP:rs1211554Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508547 mRNA Translation: AAM28904.1
AL357054 Genomic DNA No translation available.
BC101697 mRNA Translation: AAI01698.1
BC101699 mRNA Translation: AAI01700.1
CCDSiCCDS4470.1
RefSeqiNP_683762.2, NM_148959.3
UniGeneiHs.669039

Genome annotation databases

EnsembliENST00000380907; ENSP00000370293; ENSG00000188996
GeneIDi135458
KEGGihsa:135458
UCSCiuc003mtg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHUS1B_HUMAN
AccessioniPrimary (citable) accession number: Q8NHY5
Secondary accession number(s): Q5T4Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 2, 2010
Last modified: June 20, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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