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Protein

Checkpoint protein HUS1B

Gene

HUS1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Checkpoint protein HUS1B
Short name:
hHUS1B
Gene namesi
Name:HUS1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:16485. HUS1B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134939889.

Polymorphism and mutation databases

BioMutaiHUS1B.
DMDMi311033394.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Checkpoint protein HUS1BPRO_0000226245Add
BLAST

Proteomic databases

PaxDbiQ8NHY5.
PRIDEiQ8NHY5.

PTM databases

iPTMnetiQ8NHY5.
PhosphoSiteiQ8NHY5.

Expressioni

Tissue specificityi

Expressed strongly in testis, less in spleen, thymus, prostate, colon and leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000188996.
CleanExiHS_HUS1B.
GenevisibleiQ8NHY5. HS.

Organism-specific databases

HPAiCAB038417.

Interactioni

Subunit structurei

Interacts with RAD1 and RAD9B.2 Publications

Protein-protein interaction databases

BioGridi126430. 8 interactions.
IntActiQ8NHY5. 8 interactions.
STRINGi9606.ENSP00000370293.

Structurei

3D structure databases

ProteinModelPortaliQ8NHY5.
SMRiQ8NHY5. Positions 1-278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HUS1 family.Curated

Phylogenomic databases

eggNOGiKOG3999. Eukaryota.
ENOG410ZQ9J. LUCA.
GeneTreeiENSGT00390000000706.
HOGENOMiHOG000253011.
HOVERGENiHBG053069.
InParanoidiQ8NHY5.
KOiK10996.
OMAiQVRVDNR.
OrthoDBiEOG091G0H06.
PhylomeDBiQ8NHY5.
TreeFamiTF314491.

Family and domain databases

InterProiIPR016580. Cell_cycle_HUS1.
IPR007150. Hus1/Mec3.
[Graphical view]
PfamiPF04005. Hus1. 1 hit.
[Graphical view]
PIRSFiPIRSF011312. Cell_cycle_HUS1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NHY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFRAKITGK GCLELFIHVS GTVARLAKVC VLRVRPDSLC FGPAGSGGLH
60 70 80 90 100
EARLWCEVRQ GAFQQFRMEG VSEDLDEIHL ELTAEHLSRA ARSAAGASSL
110 120 130 140 150
KLQLTHKRRP SLTVAVELVS SLGRARSVVH DLPVRVLPRR VWRDCLPPSL
160 170 180 190 200
RASDASIRLP RWRTLRSIVE RMANVGSHVL VEANLSGRMT LSIETEVVSI
210 220 230 240 250
QSYFKNLGNP PQSAVGVPEN RDLESMVQVR VDNRKLLQFL EGQQIHPTTA
260 270
LCNIWDNTLL QLVLVQEDVS LQYFIPAL
Length:278
Mass (Da):30,982
Last modified:November 2, 2010 - v2
Checksum:i156F1ECAB50B2B54
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti130 – 1301H → Q.
Corresponds to variant rs1766848 [ dbSNP | Ensembl ].
VAR_031206
Natural varianti201 – 2011Q → R.
Corresponds to variant rs17136239 [ dbSNP | Ensembl ].
VAR_031207
Natural varianti268 – 2681D → Y.2 Publications
Corresponds to variant rs1211554 [ dbSNP | Ensembl ].
VAR_025497

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508547 mRNA. Translation: AAM28904.1.
AL357054 Genomic DNA. Translation: CAI15190.1.
BC101697 mRNA. Translation: AAI01698.1.
BC101699 mRNA. Translation: AAI01700.1.
CCDSiCCDS4470.1.
RefSeqiNP_683762.2. NM_148959.3.
UniGeneiHs.669039.

Genome annotation databases

EnsembliENST00000380907; ENSP00000370293; ENSG00000188996.
GeneIDi135458.
KEGGihsa:135458.
UCSCiuc003mtg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508547 mRNA. Translation: AAM28904.1.
AL357054 Genomic DNA. Translation: CAI15190.1.
BC101697 mRNA. Translation: AAI01698.1.
BC101699 mRNA. Translation: AAI01700.1.
CCDSiCCDS4470.1.
RefSeqiNP_683762.2. NM_148959.3.
UniGeneiHs.669039.

3D structure databases

ProteinModelPortaliQ8NHY5.
SMRiQ8NHY5. Positions 1-278.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126430. 8 interactions.
IntActiQ8NHY5. 8 interactions.
STRINGi9606.ENSP00000370293.

PTM databases

iPTMnetiQ8NHY5.
PhosphoSiteiQ8NHY5.

Polymorphism and mutation databases

BioMutaiHUS1B.
DMDMi311033394.

Proteomic databases

PaxDbiQ8NHY5.
PRIDEiQ8NHY5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380907; ENSP00000370293; ENSG00000188996.
GeneIDi135458.
KEGGihsa:135458.
UCSCiuc003mtg.4. human.

Organism-specific databases

CTDi135458.
GeneCardsiHUS1B.
H-InvDBHIX0032803.
HGNCiHGNC:16485. HUS1B.
HPAiCAB038417.
MIMi609713. gene.
neXtProtiNX_Q8NHY5.
PharmGKBiPA134939889.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3999. Eukaryota.
ENOG410ZQ9J. LUCA.
GeneTreeiENSGT00390000000706.
HOGENOMiHOG000253011.
HOVERGENiHBG053069.
InParanoidiQ8NHY5.
KOiK10996.
OMAiQVRVDNR.
OrthoDBiEOG091G0H06.
PhylomeDBiQ8NHY5.
TreeFamiTF314491.

Miscellaneous databases

GenomeRNAii135458.
PROiQ8NHY5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188996.
CleanExiHS_HUS1B.
GenevisibleiQ8NHY5. HS.

Family and domain databases

InterProiIPR016580. Cell_cycle_HUS1.
IPR007150. Hus1/Mec3.
[Graphical view]
PfamiPF04005. Hus1. 1 hit.
[Graphical view]
PIRSFiPIRSF011312. Cell_cycle_HUS1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHUS1B_HUMAN
AccessioniPrimary (citable) accession number: Q8NHY5
Secondary accession number(s): Q5T4Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 2, 2010
Last modified: September 7, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.