Q8NHY5 (HUS1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Checkpoint protein HUS1B
Short name=hHUS1B

Gene names

Name:

HUS1B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with RAD1 and RAD9B. Ref.1 Ref.4
Tissue specificity	Expressed strongly in testis, less in spleen, thymus, prostate, colon and leukocytes. Ref.1
Sequence similarities	Belongs to the HUS1 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Checkpoint protein HUS1B		PRO_0000226245
Natural variations
	Natural variant	130	1	H → Q. Corresponds to variant rs1766848 [ dbSNP | Ensembl ].		VAR_031206
	Natural variant	201	1	Q → R. Corresponds to variant rs17136239 [ dbSNP | Ensembl ].		VAR_031207
	Natural variant	268	1	D → Y. Ref.1 Ref.3 Corresponds to variant rs1211554 [ dbSNP | Ensembl ].		VAR_025497

Sequences

	Sequence		Length	Mass (Da)
	Q8NHY5 [UniParc]. Last modified November 2, 2010. Version 2. Checksum: 156F1ECAB50B2B54	FASTA	278	30,982
	10 20 30 40 50 60 MKFRAKITGK GCLELFIHVS GTVARLAKVC VLRVRPDSLC FGPAGSGGLH EARLWCEVRQ 70 80 90 100 110 120 GAFQQFRMEG VSEDLDEIHL ELTAEHLSRA ARSAAGASSL KLQLTHKRRP SLTVAVELVS 130 140 150 160 170 180 SLGRARSVVH DLPVRVLPRR VWRDCLPPSL RASDASIRLP RWRTLRSIVE RMANVGSHVL 190 200 210 220 230 240 VEANLSGRMT LSIETEVVSI QSYFKNLGNP PQSAVGVPEN RDLESMVQVR VDNRKLLQFL 250 260 270 EGQQIHPTTA LCNIWDNTLL QLVLVQEDVS LQYFIPAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1." Hang H., Zhang Y., Dunbrack R.L. Jr., Wang C., Lieberman H.B. Genomics 79:487-492(2002) [PubMed: 11944979] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RAD1, TISSUE SPECIFICITY, VARIANT TYR-268.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-268. Tissue: Liver.
[4]	"Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue." Hopkins K.M., Wang X., Berlin A., Hang H., Thaker H.M., Lieberman H.B. Cancer Res. 63:5291-5298(2003) [PubMed: 14500360] [Abstract] Cited for: INTERACTION WITH RAD9B.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF508547 mRNA. Translation: AAM28904.1. AL357054 Genomic DNA. Translation: CAI15190.1. BC101697 mRNA. Translation: AAI01698.1. BC101699 mRNA. Translation: AAI01700.1.
IPI	IPI00169381.
RefSeq	NP_683762.2. NM_148959.3.
UniGene	Hs.669039.
3D structure databases
ProteinModelPortal	Q8NHY5.
SMR	Q8NHY5. Positions 3-278.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8NHY5.
Polymorphism databases
DMDM	311033394.
Proteomic databases
PRIDE	Q8NHY5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000380907; ENSP00000370293; ENSG00000188996.
GeneID	135458.
KEGG	hsa:135458.
UCSC	uc003mtg.1. human.
Organism-specific databases
CTD	135458.
GeneCards	GC06M000600.
H-InvDB	HIX0032803.
HGNC	HGNC:16485. HUS1B.
MIM	609713. gene.
neXtProt	NX_Q8NHY5.
PharmGKB	PA134939889.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11828.
GeneTree	ENSGT00390000000706.
HOGENOM	HBG445708.
HOVERGEN	HBG053069.
InParanoid	Q8NHY5.
OMA	QVRVDNR.
OrthoDB	EOG42BX9C.
PhylomeDB	Q8NHY5.
Gene expression databases
ArrayExpress	Q8NHY5.
Bgee	Q8NHY5.
CleanEx	HS_HUS1B.
Genevestigator	Q8NHY5.
GermOnline	ENSG00000188996. Homo sapiens.
Family and domain databases
InterPro	IPR016580. Cell_cycle_HUS1. IPR007150. Hus1. [Graphical view]
KO	K10996.
PANTHER	PTHR12900. Hus1. 1 hit.
Pfam	PF04005. Hus1. 1 hit. [Graphical view]
PIRSF	PIRSF011312. Cell_cycle_HUS1. 1 hit.
ProtoNet	Search...
Other
NextBio	83490.
SOURCE	Search...

Entry information

Entry name

HUS1B_HUMAN

Accession

Primary (citable) accession number: Q8NHY5
Secondary accession number(s): Q5T4Z2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	November 2, 2010
Last modified:	December 14, 2011
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.