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Reviewed, UniProtKB/Swiss-Prot Q8NHY5 (HUS1B_HUMAN)

Last modified February 10, 2009. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Checkpoint protein HUS1B
      Short name=hHUS1B
Gene names
Name: HUS1B
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subunit structure

Interacts with RAD1 and RAD9B. Ref.1 Ref.4

Tissue specificity

Expressed strongly in testis, less in spleen, thymus, prostate, colon and leukocytes. Ref.1

Sequence similarities

Belongs to the HUS1 family.

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Ontologies

Keywords
   Coding sequence diversityPolymorphism
Gene Ontology (GO)
None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Checkpoint protein HUS1B
PRO_0000226245

Natural variations

Natural variant1301H → Q: dbSNP rs1766848.
VAR_031206
Natural variant2011Q → R: dbSNP rs17136239.
VAR_031207
Natural variant2681Y → D: dbSNP rs1211554. Ref.2
VAR_025497

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Sequences

Sequence LengthMass (Da)Tools
Q8NHY5-1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 156F04E3B50B2B54

FASTA27831,030
        10         20         30         40         50         60 
MKFRAKITGK GCLELFIHVS GTVARLAKVC VLRVRPDSLC FGPAGSGGLH EARLWCEVRQ 

        70         80         90        100        110        120 
GAFQQFRMEG VSEDLDEIHL ELTAEHLSRA ARSAAGASSL KLQLTHKRRP SLTVAVELVS 

       130        140        150        160        170        180 
SLGRARSVVH DLPVRVLPRR VWRDCLPPSL RASDASIRLP RWRTLRSIVE RMANVGSHVL 

       190        200        210        220        230        240 
VEANLSGRMT LSIETEVVSI QSYFKNLGNP PQSAVGVPEN RDLESMVQVR VDNRKLLQFL 

       250        260        270 
EGQQIHPTTA LCNIWDNTLL QLVLVQEYVS LQYFIPAL

« Hide

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References

« Hide 'large scale' references
[1]"Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1."
Hang H., Zhang Y., Dunbrack R.L. Jr., Wang C., Lieberman H.B.
Genomics 79:487-492(2002) [PubMed: 11944979] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RAD1, TISSUE SPECIFICITY.
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed: 14574404] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-268.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[4]"Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue."
Hopkins K.M., Wang X., Berlin A., Hang H., Thaker H.M., Lieberman H.B.
Cancer Res. 63:5291-5298(2003) [PubMed: 14500360] [Abstract]
Cited for: INTERACTION WITH RAD9B.

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Cross-references

Sequence databases

AF508547 mRNA. Translation: AAM28904.1.
AL357054 Genomic DNA. Translation: CAI15190.1.
BC101697 mRNA. Translation: AAI01698.1.
BC101699 mRNA. Translation: AAI01700.1.
IPIIPI00169381.
RefSeqNP_683762.2.
UniGeneHs.669039

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEQ8NHY5.

Genome annotation databases

EnsemblENSG00000188996. Homo sapiens. [Contig view]
GeneID135458.
KEGGhsa:135458.

Organism-specific databases

GeneCardsGC06M000600.
H-InvDBHIX0032803.
HGNCHGNC:16485. HUS1B.
MIM609713. gene.
PharmGKBPA134939889.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ8NHY5.
HOVERGENQ8NHY5.

Gene expression databases

ArrayExpressQ8NHY5.
BgeeQ8NHY5.
CleanExHS_HUS1B.
GermOnlineENSG00000188996. Homo sapiens.

Family and domain databases

InterProIPR016580. Cell_cycle_HUS1.
IPR007150. Hus1.
[Graphical view]
PANTHERPTHR12900. Hus1. 1 hit.
PfamPF04005. Hus1. 1 hit.
[Graphical view]
PIRSFPIRSF011312. Cell_cycle_HUS1. 1 hit.
ProtoNetSearch...

Other Resources

NextBio83490.
SOURCESearch...

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Entry information

Entry nameHUS1B_HUMAN
AccessionPrimary (citable) accession number: Q8NHY5
Secondary accession number(s): Q5T4Z2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2002
Last modified: February 10, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents