Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8NHY3 (GA2L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GAS2-like protein 2
Alternative name(s):
GAS2-related protein on chromosome 17
Growth arrest-specific protein 2-like 2
Gene names
Name:GAS2L2
Synonyms:GAR17
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length880 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to be involved in the cross-linking of microtubules and microfilaments. Ref.1

Subcellular location

Cytoplasmcytoskeleton Probable.

Tissue specificity

Expressed in skeletal muscle. Ref.1

Sequence similarities

Belongs to the GAS2 family.

Contains 1 CH (calponin-homology) domain.

Contains 1 GAR domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NHY3-1)

Also known as: Beta;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8NHY3-2)

Also known as: Alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     187-213: PPDPSPPAPPRRQPCHFRNLDQMVQSL → LPQPGPDGAEPCEPLHVPSAVLHGQSV
     214-800: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 880880GAS2-like protein 2
PRO_0000190444

Regions

Domain32 – 158127CH
Domain201 – 27373GAR

Natural variations

Alternative sequence187 – 21327PPDPS…MVQSL → LPQPGPDGAEPCEPLHVPSA VLHGQSV in isoform 2.
VSP_015497
Alternative sequence214 – 800587Missing in isoform 2.
VSP_015498
Natural variant1641A → V.
Corresponds to variant rs11654604 [ dbSNP | Ensembl ].
VAR_059975
Natural variant5401A → T.
Corresponds to variant rs12602590 [ dbSNP | Ensembl ].
VAR_053100
Natural variant6541A → V.
Corresponds to variant rs3744374 [ dbSNP | Ensembl ].
VAR_053101
Natural variant8291R → W.
Corresponds to variant rs56386706 [ dbSNP | Ensembl ].
VAR_062004

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Beta) [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 2AFCD96EE7F4AB22

FASTA88096,520
        10         20         30         40         50         60 
MSQPAGGRRK PRTLGPPVCS IRPFKSSEQY LEAMKEDLAE WLRDLYGLDI DAANFLQVLE 

        70         80         90        100        110        120 
TGLVLCQHAN VVTDAALAFL AEAPAQAQKI PMPRVGVSCN GAAQPGTFQA RDNVSNFIQW 

       130        140        150        160        170        180 
CRKEMGIQEV LMFETEDLVL RKNVKNVVLC LLELGRRAWR FGVAAPTLVQ LEEEIEEEVR 

       190        200        210        220        230        240 
RELALPPPDP SPPAPPRRQP CHFRNLDQMV QSLVSHCTCP VQFSMVKVSE GKYRVGDSNT 

       250        260        270        280        290        300 
LIFIRILRNH VMVRVGGGWD TLGHYLDKHD PCRCTSLSHK PGSFLKPPAP PVQHEVRVQD 

       310        320        330        340        350        360 
GPSQTQPTMT ISRSQSPPPP VDWKTYTSSD RRLRPPTPSS PRPRRERGAG TGASREMAPF 

       370        380        390        400        410        420 
LRCQERSLIP SWRQPTAGDS PPSPQSSSTQ KGRDPQCTSS GKREERYPPE LPRGRIPTSW 

       430        440        450        460        470        480 
VHEETDSWGT DAGNPTPQRL RAIEATTKGI SARGPSPLPR SFGPAECLGL RLPLRDEAKG 

       490        500        510        520        530        540 
AFFQFREPES VRSPTPVQGL TKIPIRLPPA RPPTPGRSFP GATSGSPRTE LGRDPIPLRA 

       550        560        570        580        590        600 
VTVDLAGSTH GDCSVEVRQE DQQLDIQVMA EARESWDLGL QEQEGRYTPL PLGGNKEQAI 

       610        620        630        640        650        660 
YCSLEEEILG NMKLLEVRSA CPQGTRSGVI PRSGVYIPRL AGQWPEPGGP YDKAIQELAQ 

       670        680        690        700        710        720 
GSPSLLKVDL EAWKAAPTGS PKPAVTPGPG SLKGKLGARQ SGPRTKASLS AKGTHMRKVP 

       730        740        750        760        770        780 
PQGGQDCSAS TVSASPEAPT PSPLDPNSDK AKACLSKGRR TLRKPKRVPS IYKLKLRPRI 

       790        800        810        820        830        840 
RPRRDHRPEK QPSRIPRPLA YVFLGPARQP PKDRLLRAVL GSKGGEASRV DGASVGEEEE 

       850        860        870        880 
EGKEEKEPAA PLESSPQPPE GLQPHWLNQA PLPPEEESWV 

« Hide

Isoform 2 (Alpha) [UniParc].

Checksum: 06BF535EA01A1EC4
Show »

FASTA29332,157

References

[1]"Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules."
Goriounov D., Leung C.L., Liem R.K.
J. Cell Sci. 116:1045-1058(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF508785 mRNA. Translation: AAM34265.1.
AF508784 mRNA. Translation: AAM34264.1.
CCDSCCDS11298.1. [Q8NHY3-1]
RefSeqNP_644814.1. NM_139285.3. [Q8NHY3-1]
UniGeneHs.591194.

3D structure databases

ProteinModelPortalQ8NHY3.
SMRQ8NHY3. Positions 27-162, 217-290.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128874. 2 interactions.
IntActQ8NHY3. 1 interaction.
MINTMINT-7969555.
STRING9606.ENSP00000254466.

PTM databases

PhosphoSiteQ8NHY3.

Polymorphism databases

DMDM73919614.

Proteomic databases

PaxDbQ8NHY3.
PRIDEQ8NHY3.

Protocols and materials databases

DNASU246176.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000254466; ENSP00000254466; ENSG00000132139. [Q8NHY3-1]
ENST00000604641; ENSP00000474529; ENSG00000270765. [Q8NHY3-1]
GeneID246176.
KEGGhsa:246176.
UCSCuc002hjv.2. human. [Q8NHY3-1]

Organism-specific databases

CTD246176.
GeneCardsGC17M034071.
HGNCHGNC:24846. GAS2L2.
HPAHPA044370.
MIM611398. gene.
neXtProtNX_Q8NHY3.
PharmGKBPA134986846.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG322939.
HOGENOMHOG000090245.
HOVERGENHBG081544.
InParanoidQ8NHY3.
OMATMTISRS.
OrthoDBEOG7VTDR1.
PhylomeDBQ8NHY3.
TreeFamTF323754.

Gene expression databases

ArrayExpressQ8NHY3.
BgeeQ8NHY3.
CleanExHS_GAS2L2.
GenevestigatorQ8NHY3.

Family and domain databases

Gene3D1.10.418.10. 1 hit.
3.30.920.20. 1 hit.
InterProIPR001715. CH-domain.
IPR003108. GAS2_dom.
[Graphical view]
PfamPF00307. CH. 1 hit.
PF02187. GAS2. 1 hit.
[Graphical view]
SMARTSM00033. CH. 1 hit.
[Graphical view]
SUPFAMSSF143575. SSF143575. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEPS50021. CH. 1 hit.
PS51460. GAR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi246176.
NextBio91874.
PROQ8NHY3.
SOURCESearch...

Entry information

Entry nameGA2L2_HUMAN
AccessionPrimary (citable) accession number: Q8NHY3
Secondary accession number(s): Q8NHY4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM