Unreviewed, UniProtKB/TrEMBL Q8NHX1 (Q8NHX1_HUMAN)

Names and origin

Protein names	Submitted name:     Extracellular signal-related kinase 1b EMBL AAK52329.1
Organism	Homo sapiens (Human) EMBL AAK52329.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein. Spearmint SPM003527
Sequence similarities	Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Spearmint SPM003527 RuleBase RU000304V2 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Spearmint SPM003527 Transferase
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoskeleton Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW MAP kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8NHX1-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 58C92773983ADA79	FASTA	357	40,062
	10 20 30 40 50 60 MAAAAAQGGG GGEPRRTEGV GPGVPGEVEM VKGQPFDVGP RYTQLQYIGE GAYGMVSSAY 70 80 90 100 110 120 DHVRKTRVAI KKISPFEHQT YCQRTLREIQ ILLRFRHENV IGIRDILRAS TLEAMRDVYI 130 140 150 160 170 180 VQDLMETDLY KLLKSQQLSN DHICYFLYQI LRGLKYIHSA NVLHRDLKPS NLLSNTTCDL 190 200 210 220 230 240 KICDFGLARI ADPEHDHTGF LTEYVATRWY RAPEIMLNSK GYTKSIDIWS VGCILAEMLS 250 260 270 280 290 300 NRPIFPGKHY LDQLNHILGI LGSPSQEDLN CIINMKARNY LQSLPSKTKV AWAKLFPKSD 310 320 330 340 350 SKALDLLDRM LTFNPNKRIT VEEALAHPYL EQYYDPTDEV GQSPAAVGLG AGEQGGT

References

[1]	"Properties of human ERK1b." Aebersold D.M., Yung Y., Seger R. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY033607 mRNA. Translation: AAK52329.1.
IPI	IPI00742900.
RefSeq	NP_001035145.1.
UniGene	Hs.861
3D structure databases
HSSP	HSSP built from PDB template 1PME based on UniProtKB P28482.
SMR	Q8NHX1. Positions 19-344.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8NHX1.
Genome annotation databases
Ensembl	ENST00000395199; ENSP00000378625; ENSG00000102882; Homo sapiens. [Genome view] ENST00000403394; ENSP00000384895; ENSG00000102882; Homo sapiens. [Genome view]
GeneID	5595.
KEGG	hsa:5595.
UCSC	uc002dwt.1. human.
Organism-specific databases
CTD	5595.
HGNC	HGNC:6877. MAPK3.
Phylogenomic databases
HOVERGEN	Q8NHX1.
PhylomeDB	Q8NHX1.
Gene expression databases
ArrayExpress	Q8NHX1.
Bgee	Q8NHX1.
Family and domain databases
InterPro	IPR008349. Erk_1_2_MAPK. IPR011009. Kinase-like_dom. IPR003527. MAP_kinase_CS. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR01770. ERK1ERK2MAPK.
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS01351. MAPK. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	21714.

Entry information

Entry name

Q8NHX1_HUMAN

Accession

Primary (citable) accession number: Q8NHX1

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	February 9, 2010
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.