Unreviewed, UniProtKB/TrEMBL Q8NHX0 (Q8NHX0_HUMAN)

Names and origin

Protein names	Submitted name:     Extracellular signal-related kinase 1c EMBL AAK52330.1
Organism	Homo sapiens (Human) EMBL AAK52330.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein. Spearmint SPM003527
Sequence similarities	Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Spearmint SPM003527 RuleBase RU000304V2 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Spearmint SPM003527 Transferase
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW MAP kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8NHX0-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: A82027A684BA12E1	FASTA	335	38,249
	10 20 30 40 50 60 MAAAAAQGGG GGEPRRTEGV GPGVPGEVEM VKGQPFDVGP RYTQLQYIGE GAYGMVSSAY 70 80 90 100 110 120 DHVRKTRVAI KKISPFEHQT YCQRTLREIQ ILLRFRHENV IGIRDILRAS TLEAMRDVYI 130 140 150 160 170 180 VQDLMETDLY KLLKSQQLSN DHICYFLYQI LRGLKYIHSA NVLHRDLKPS NLLSNTTCDL 190 200 210 220 230 240 KICDFGLARI ADPEHDHTGF LTEYVATRWY RAPEIMLNSK GYTKSIDIWS VGCILAEMLS 250 260 270 280 290 300 NRPIFPGKHY LDQLNHILAL DLLDRMLTFN PNKRITVEEA LAHPYLEQYY DPTDEPVAEE 310 320 330 PFTFAMELDD LPKERLKELI FQETARFQPG VLEAP

References

[1]	"Properties of human ERK1c." Aebersold D.M., Yung Y., Seger R. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY033608 mRNA. Translation: AAK52330.1.
IPI	IPI00304111.
UniGene	Hs.861
3D structure databases
HSSP	HSSP built from PDB template 1PME based on UniProtKB P28482.
SMR	Q8NHX0. Positions 19-330.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8NHX0.
Proteomic databases
PRIDE	Q8NHX0.
Genome annotation databases
Ensembl	ENST00000322266; ENSP00000327293; ENSG00000102882; Homo sapiens. [Genome view] ENST00000395202; ENSP00000378628; ENSG00000102882; Homo sapiens. [Genome view]
Organism-specific databases
HGNC	HGNC:6877. MAPK3.
Phylogenomic databases
HOVERGEN	Q8NHX0.
PhylomeDB	Q8NHX0.
Gene expression databases
ArrayExpress	Q8NHX0.
Bgee	Q8NHX0.
Family and domain databases
InterPro	IPR008349. Erk_1_2_MAPK. IPR011009. Kinase-like_dom. IPR003527. MAP_kinase_CS. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR01770. ERK1ERK2MAPK.
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS01351. MAPK. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8NHX0_HUMAN

Accession

Primary (citable) accession number: Q8NHX0

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	January 19, 2010
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.