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Protein

Otospiralin

Gene

OTOS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be essential for the survival of the neurosensory epithelium of the inner ear.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Otospiralin
Gene namesi
Name:OTOS
Synonyms:OTOSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000178602.7.
HGNCiHGNC:22644. OTOS.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178602.
PharmGKBiPA134906408.

Polymorphism and mutation databases

BioMutaiOTOS.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002197622 – 89OtospiralinAdd BLAST68

Proteomic databases

PaxDbiQ8NHW6.
PRIDEiQ8NHW6.

Expressioni

Tissue specificityi

Ear specific.

Gene expression databases

BgeeiENSG00000178602.
CleanExiHS_OTOS.
GenevisibleiQ8NHW6. HS.

Interactioni

Protein-protein interaction databases

IntActiQ8NHW6. 4 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ8NHW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the otospiralin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2XA. Eukaryota.
ENOG41122J4. LUCA.
GeneTreeiENSGT00390000011600.
HOGENOMiHOG000261689.
HOVERGENiHBG053382.
InParanoidiQ8NHW6.
OMAiAVPYWPY.
OrthoDBiEOG091G0ZD5.
PhylomeDBiQ8NHW6.
TreeFamiTF336889.

Family and domain databases

InterProiView protein in InterPro
IPR028224. Otospiralin.
PfamiView protein in Pfam
PF15182. OTOS. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD684821. PD684821. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NHW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQACMVPGLA LCLLLGPLAG AKPVQEEGDP YAELPAMPYW PFSTSDFWNY
60 70 80
VQHFQALGAY PQIEDMARTF FAHFPLGSTL GFHVPYQED
Length:89
Mass (Da):9,939
Last modified:October 1, 2002 - v1
Checksum:i42637BEBABCC4083
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0206017P → L1 PublicationCorresponds to variant dbSNP:rs35889242Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY062256 Genomic DNA. Translation: AAL47489.1.
AC013469 Genomic DNA. Translation: AAY14739.1.
BC105085 mRNA. Translation: AAI05086.1.
BC105087 mRNA. Translation: AAI05088.1.
CCDSiCCDS2533.1.
RefSeqiNP_683764.1. NM_148961.3.
XP_016858899.1. XM_017003410.1.
UniGeneiHs.148586.

Genome annotation databases

EnsembliENST00000319460; ENSP00000322486; ENSG00000178602.
ENST00000391989; ENSP00000375849; ENSG00000178602.
GeneIDi150677.
KEGGihsa:150677.
UCSCiuc002vyv.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOTOSP_HUMAN
AccessioniPrimary (citable) accession number: Q8NHW6
Secondary accession number(s): Q53SW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families