ID CC4L_HUMAN Reviewed; 92 AA. AC Q8NHW4; B2RUZ3; B7ZMA8; Q50EM1; Q50EM2; Q50EM3; Q50EM4; Q50EM5; Q50EM6; AC Q50EM7; Q50EM8; Q569J2; Q6NSB0; DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 27-MAR-2024, entry version 166. DE RecName: Full=C-C motif chemokine 4-like; DE AltName: Full=Lymphocyte activation gene 1 protein; DE Short=LAG-1; DE AltName: Full=Macrophage inflammatory protein 1-beta; DE Short=MIP-1-beta; DE AltName: Full=Monocyte adherence-induced protein 5-alpha; DE AltName: Full=Small-inducible cytokine A4-like; DE Flags: Precursor; GN Name=CCL4L1; Synonyms=CCL4L, LAG1, SCYA4L1; GN and GN Name=CCL4L2; Synonyms=CCL4L, SCYA4L2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). RA Nibbs R.J., Barcellos L.F., Townson J.R.; RT "Variation in gene copy number of the human chemokines macrophage RT inflammatory protein-1a/CCL3 and macrophage inflammatory protein-1b/CCL4."; RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; RP 9 AND 10). RX PubMed=15843566; DOI=10.4049/jimmunol.174.9.5655; RA Colobran R., Adreani P., Ashhab Y., Llano A., Este J.A., Dominguez O., RA Pujol-Borrell R., Juan M.; RT "Multiple products derived from two CCL4 loci: high incidence of a new RT polymorphism in HIV+ patients."; RL J. Immunol. 174:5655-5664(2005). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5). RC TISSUE=Blood, and Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP IDENTIFICATION. RX PubMed=11685466; DOI=10.1007/s002510100366; RA Modi W.S., Bergeron J., Sanford M.; RT "The human MIP-1beta chemokine is encoded by two paralogous genes, ACT-2 RT and LAG-1."; RL Immunogenetics 53:543-549(2001). RN [5] RP FUNCTION, INTERACTION WITH CCR5, AND GENOMIC DUPLICATION. RX PubMed=15240137; DOI=10.1016/j.bbrc.2004.06.039; RA Howard O.M.Z., Turpin J.A., Goldman R., Modi W.S.; RT "Functional redundancy of the human CCL4 and CCL4L1 chemokine genes."; RL Biochem. Biophys. Res. Commun. 320:927-931(2004). RN [6] RP IDENTIFICATION, AND GENOMIC DUPLICATION. RX PubMed=15028295; DOI=10.1016/j.ygeno.2003.09.019; RA Modi W.S.; RT "CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication RT at chromosome 17q12."; RL Genomics 83:735-738(2004). RN [7] RP TISSUE SPECIFICITY. RX PubMed=14673550; DOI=10.1007/s00251-003-0636-z; RA Lu J., Honczarenko M., Sloan S.R.; RT "Independent expression of the two paralogous CCL4 genes in monocytes and B RT lymphocytes."; RL Immunogenetics 55:706-711(2004). RN [8] RP IDENTIFICATION, AND POLYMORPHISM OF GENE COPY NUMBER. RX PubMed=17330138; DOI=10.1038/sj.gene.6364378; RA Shao W., Tang J., Song W., Wang C., Li Y., Wilson C.M., Kaslow R.A.; RT "CCL3L1 and CCL4L1: variable gene copy number in adolescents with and RT without human immunodeficiency virus type 1 (HIV-1) infection."; RL Genes Immun. 8:224-231(2007). CC -!- FUNCTION: Chemokine that induces chemotaxis of cells expressing CCR5 or CC CCR1. Inhibits HIV replication in peripheral blood monocytes that CC express CCR5. {ECO:0000269|PubMed:15240137}. CC -!- SUBUNIT: Interacts with CCR5. {ECO:0000269|PubMed:15240137}. CC -!- INTERACTION: CC Q8NHW4; Q13520: AQP6; NbExp=3; IntAct=EBI-10271156, EBI-13059134; CC Q8NHW4; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-10271156, EBI-11343438; CC Q8NHW4; Q7RTX7: CATSPER4; NbExp=3; IntAct=EBI-10271156, EBI-21541251; CC Q8NHW4; Q9HA82: CERS4; NbExp=3; IntAct=EBI-10271156, EBI-2622997; CC Q8NHW4; P58418: CLRN1; NbExp=3; IntAct=EBI-10271156, EBI-17274839; CC Q8NHW4; P21964: COMT; NbExp=3; IntAct=EBI-10271156, EBI-372265; CC Q8NHW4; O75208: COQ9; NbExp=3; IntAct=EBI-10271156, EBI-724524; CC Q8NHW4; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-10271156, EBI-18013275; CC Q8NHW4; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-10271156, EBI-6942903; CC Q8NHW4; Q15125: EBP; NbExp=3; IntAct=EBI-10271156, EBI-3915253; CC Q8NHW4; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-10271156, EBI-18535450; CC Q8NHW4; P60508: ERVFRD-1; NbExp=3; IntAct=EBI-10271156, EBI-17973325; CC Q8NHW4; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-10271156, EBI-18304435; CC Q8NHW4; O00258: GET1; NbExp=3; IntAct=EBI-10271156, EBI-18908258; CC Q8NHW4; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-10271156, EBI-13345167; CC Q8NHW4; O15529: GPR42; NbExp=3; IntAct=EBI-10271156, EBI-18076404; CC Q8NHW4; Q9NQX7-3: ITM2C; NbExp=3; IntAct=EBI-10271156, EBI-12811565; CC Q8NHW4; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-10271156, EBI-10266796; CC Q8NHW4; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-10271156, EBI-373355; CC Q8NHW4; Q6N075: MFSD5; NbExp=3; IntAct=EBI-10271156, EBI-3920969; CC Q8NHW4; Q6IN84: MRM1; NbExp=3; IntAct=EBI-10271156, EBI-5454865; CC Q8NHW4; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-10271156, EBI-7545592; CC Q8NHW4; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-10271156, EBI-10192441; CC Q8NHW4; O95470: SGPL1; NbExp=3; IntAct=EBI-10271156, EBI-1046170; CC Q8NHW4; Q12908: SLC10A2; NbExp=3; IntAct=EBI-10271156, EBI-18114847; CC Q8NHW4; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-10271156, EBI-17595455; CC Q8NHW4; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-10271156, EBI-8644112; CC Q8NHW4; P30825: SLC7A1; NbExp=3; IntAct=EBI-10271156, EBI-4289564; CC Q8NHW4; Q8TBB6: SLC7A14; NbExp=3; IntAct=EBI-10271156, EBI-5235586; CC Q8NHW4; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-10271156, EBI-17280858; CC Q8NHW4; Q7Z7N9: TMEM179B; NbExp=3; IntAct=EBI-10271156, EBI-11724423; CC Q8NHW4; Q9NW97: TMEM51; NbExp=3; IntAct=EBI-10271156, EBI-726044; CC Q8NHW4; Q9H7M9: VSIR; NbExp=3; IntAct=EBI-10271156, EBI-744988; CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=10; CC Comment=CCL4L1 and CCL4L2 genes differ in their non-coding regions. CC Thus, alternative splicing events differ between the two genes.; CC Name=1; CC IsoId=Q8NHW4-1; Sequence=Displayed; CC Name=2; Synonyms=CCL4L2; CC IsoId=Q8NHW4-2; Sequence=VSP_032633; CC Name=3; Synonyms=CC4L2d; CC IsoId=Q8NHW4-3; Sequence=VSP_032629; CC Name=4; Synonyms=CC4L2f; CC IsoId=Q8NHW4-4; Sequence=VSP_032630; CC Name=5; Synonyms=CC4L2b1, CC4L2b2; CC IsoId=Q8NHW4-5; Sequence=VSP_032631; CC Name=6; Synonyms=CC4L2e; CC IsoId=Q8NHW4-6; Sequence=VSP_032632; CC Name=7; Synonyms=CC4L2d2; CC IsoId=Q8NHW4-7; Sequence=VSP_032625; CC Name=8; Synonyms=CC4L1d2; CC IsoId=Q8NHW4-8; Sequence=VSP_032626; CC Name=9; Synonyms=CC4L2bd2; CC IsoId=Q8NHW4-9; Sequence=VSP_032627; CC Name=10; Synonyms=CC44L2c; CC IsoId=Q8NHW4-10; Sequence=VSP_032628; CC -!- TISSUE SPECIFICITY: Detected in B-cells. {ECO:0000269|PubMed:14673550}. CC -!- POLYMORPHISM: The copy number of the CC4L1 gene varies among CC individuals; most individuals have 1 to 6 copies in the diploid genome. CC {ECO:0000269|PubMed:17330138}. CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY079147; AAL87008.1; -; Genomic_DNA. DR EMBL; AY766460; AAX07294.1; -; Genomic_DNA. DR EMBL; AY766460; AAX07295.1; -; Genomic_DNA. DR EMBL; AY766461; AAX07296.1; -; Genomic_DNA. DR EMBL; AY766461; AAX07297.1; -; Genomic_DNA. DR EMBL; AY766461; AAX07298.1; -; Genomic_DNA. DR EMBL; AY766461; AAX07299.1; -; Genomic_DNA. DR EMBL; AY766461; AAX07300.1; -; Genomic_DNA. DR EMBL; AY766461; AAX07301.1; -; Genomic_DNA. DR EMBL; AY766461; AAX07302.1; -; Genomic_DNA. DR EMBL; AY766461; AAX07303.1; -; Genomic_DNA. DR EMBL; AY766461; AAX07304.1; -; Genomic_DNA. DR EMBL; AY766447; AAX07306.1; -; mRNA. DR EMBL; AY766449; AAX07308.1; -; mRNA. DR EMBL; AY766450; AAX07309.1; -; mRNA. DR EMBL; AY766451; AAX07310.1; -; mRNA. DR EMBL; AY766452; AAX07311.1; -; mRNA. DR EMBL; AY766453; AAX07312.1; -; mRNA. DR EMBL; AY766454; AAX07313.1; -; mRNA. DR EMBL; AY766455; AAX07314.1; -; mRNA. DR EMBL; AY766456; AAX07315.1; -; mRNA. DR EMBL; AY766457; AAX07316.1; -; mRNA. DR EMBL; AY766458; AAX07317.1; -; mRNA. DR EMBL; BC070310; AAH70310.1; -; mRNA. DR EMBL; BC092445; AAH92445.1; -; mRNA. DR EMBL; BC130456; AAI30457.1; -; mRNA. DR EMBL; BC130458; AAI30459.1; -; mRNA. DR EMBL; BC144393; AAI44394.1; -; mRNA. DR EMBL; BC144394; AAI44395.1; -; mRNA. DR EMBL; BC171864; AAI71864.1; -; mRNA. DR EMBL; BC146944; AAI46945.1; -; mRNA. DR EMBL; BC146958; AAI46959.1; -; mRNA. DR PIR; C60407; C60407. DR RefSeq; NP_001278397.1; NM_001291468.1. [Q8NHW4-2] DR RefSeq; NP_001278398.1; NM_001291469.1. [Q8NHW4-5] DR RefSeq; NP_001278399.1; NM_001291470.1. [Q8NHW4-5] DR RefSeq; NP_001278400.1; NM_001291471.1. [Q8NHW4-10] DR RefSeq; NP_001278401.1; NM_001291472.1. [Q8NHW4-3] DR RefSeq; NP_001278402.1; NM_001291473.1. [Q8NHW4-6] DR RefSeq; NP_001278403.1; NM_001291474.1. [Q8NHW4-9] DR RefSeq; NP_001278404.1; NM_001291475.1. [Q8NHW4-4] DR RefSeq; NP_996890.1; NM_207007.3. [Q8NHW4-1] DR AlphaFoldDB; Q8NHW4; -. DR SMR; Q8NHW4; -. DR BioGRID; 114931; 33. DR BioGRID; 132664; 24. DR IntAct; Q8NHW4; 36. DR BioMuta; HGNC:10631; -. DR DMDM; 74727347; -. DR MassIVE; Q8NHW4; -. DR PaxDb; 9606-ENSP00000483609; -. DR PeptideAtlas; Q8NHW4; -. DR ProteomicsDB; 73770; -. [Q8NHW4-10] DR ProteomicsDB; 73776; -. [Q8NHW4-7] DR ProteomicsDB; 73777; -. [Q8NHW4-8] DR TopDownProteomics; Q8NHW4-4; -. [Q8NHW4-4] DR Antibodypedia; 72750; 117 antibodies from 20 providers. DR DNASU; 9560; -. DR Ensembl; ENST00000610565.4; ENSP00000484498.1; ENSG00000276070.5. [Q8NHW4-6] DR Ensembl; ENST00000613173.4; ENSP00000484455.1; ENSG00000276070.5. [Q8NHW4-9] DR Ensembl; ENST00000613828.2; ENSP00000484322.1; ENSG00000282604.1. [Q8NHW4-1] DR Ensembl; ENST00000614182.4; ENSP00000482862.2; ENSG00000276125.4. [Q8NHW4-3] DR Ensembl; ENST00000615418.4; ENSP00000483206.1; ENSG00000276070.5. [Q8NHW4-3] DR Ensembl; ENST00000616100.4; ENSP00000484148.2; ENSG00000282604.1. [Q8NHW4-6] DR Ensembl; ENST00000617405.5; ENSP00000483330.1; ENSG00000276070.5. [Q8NHW4-4] DR Ensembl; ENST00000617416.4; ENSP00000480089.1; ENSG00000276070.5. [Q8NHW4-5] DR Ensembl; ENST00000620055.4; ENSP00000481323.1; ENSG00000276070.5. [Q8NHW4-7] DR Ensembl; ENST00000620063.3; ENSP00000478376.1; ENSG00000276125.4. [Q8NHW4-1] DR Ensembl; ENST00000620098.4; ENSP00000479774.1; ENSG00000276070.5. [Q8NHW4-10] DR Ensembl; ENST00000620250.1; ENSP00000483609.1; ENSG00000276070.5. [Q8NHW4-1] DR Ensembl; ENST00000620576.4; ENSP00000479354.1; ENSG00000276070.5. [Q8NHW4-2] DR Ensembl; ENST00000620708.1; ENSP00000479126.1; ENSG00000275313.5. [Q8NHW4-1] DR Ensembl; ENST00000620732.4; ENSP00000481969.1; ENSG00000276070.5. [Q8NHW4-5] DR Ensembl; ENST00000622783.2; ENSP00000479833.2; ENSG00000276125.4. [Q8NHW4-7] DR Ensembl; ENST00000631554.1; ENSP00000487911.1; ENSG00000276125.4. [Q8NHW4-10] DR Ensembl; ENST00000631660.1; ENSP00000488687.1; ENSG00000275313.5. [Q8NHW4-7] DR Ensembl; ENST00000631768.1; ENSP00000488094.1; ENSG00000282604.1. [Q8NHW4-5] DR Ensembl; ENST00000631782.1; ENSP00000488541.1; ENSG00000276125.4. [Q8NHW4-6] DR Ensembl; ENST00000631808.1; ENSP00000487651.1; ENSG00000282604.1. [Q8NHW4-3] DR Ensembl; ENST00000632416.1; ENSP00000487859.1; ENSG00000275313.5. [Q8NHW4-2] DR Ensembl; ENST00000632480.1; ENSP00000488369.1; ENSG00000282604.1. [Q8NHW4-7] DR Ensembl; ENST00000632699.1; ENSP00000488366.1; ENSG00000276125.4. [Q8NHW4-2] DR Ensembl; ENST00000632710.1; ENSP00000488758.1; ENSG00000275313.5. [Q8NHW4-5] DR Ensembl; ENST00000633309.1; ENSP00000488719.1; ENSG00000282604.1. [Q8NHW4-4] DR Ensembl; ENST00000633550.1; ENSP00000488736.1; ENSG00000276125.4. [Q8NHW4-5] DR Ensembl; ENST00000633849.1; ENSP00000487792.1; ENSG00000282604.1. [Q8NHW4-10] DR Ensembl; ENST00000633897.1; ENSP00000488897.1; ENSG00000282604.1. [Q8NHW4-5] DR Ensembl; ENST00000633927.1; ENSP00000488430.1; ENSG00000276125.4. [Q8NHW4-9] DR Ensembl; ENST00000634027.1; ENSP00000488439.1; ENSG00000276125.4. [Q8NHW4-4] DR Ensembl; ENST00000634078.1; ENSP00000488231.1; ENSG00000275313.5. [Q8NHW4-6] DR Ensembl; ENST00000634191.1; ENSP00000487715.1; ENSG00000276125.4. [Q8NHW4-5] DR GeneID; 388372; -. DR GeneID; 9560; -. DR KEGG; hsa:388372; -. DR KEGG; hsa:9560; -. DR MANE-Select; ENST00000620576.5; ENSP00000479354.1; NM_001291468.2; NP_001278397.1. [Q8NHW4-2] DR UCSC; uc002hlh.2; human. [Q8NHW4-1] DR AGR; HGNC:10631; -. DR AGR; HGNC:24066; -. DR CTD; 388372; -. DR CTD; 9560; -. DR DisGeNET; 388372; -. DR DisGeNET; 9560; -. DR GeneCards; CCL4L1; -. DR GeneCards; CCL4L2; -. DR HGNC; HGNC:10631; CCL4L1. DR HGNC; HGNC:24066; CCL4L2. DR HPA; ENSG00000276070; Tissue enhanced (bone marrow, lymphoid tissue). DR MIM; 603782; gene. DR MIM; 610757; gene. DR neXtProt; NX_Q8NHW4; -. DR OpenTargets; ENSG00000276070; -. DR VEuPathDB; HostDB:ENSG00000276070; -. DR eggNOG; ENOG502S8M4; Eukaryota. DR GeneTree; ENSGT01100000263482; -. DR HOGENOM; CLU_2793265_0_0_1; -. DR InParanoid; Q8NHW4; -. DR OMA; PEKCCFT; -. DR OrthoDB; 4265193at2759; -. DR PhylomeDB; Q8NHW4; -. DR TreeFam; TF334888; -. DR PathwayCommons; Q8NHW4; -. DR Reactome; R-HSA-418594; G alpha (i) signalling events. DR SignaLink; Q8NHW4; -. DR SIGNOR; Q8NHW4; -. DR BioGRID-ORCS; 388372; 8 hits in 194 CRISPR screens. DR BioGRID-ORCS; 9560; 8 hits in 663 CRISPR screens. DR ChiTaRS; CCL4L2; human. DR Pharos; Q8NHW4; Tbio. DR PRO; PR:Q8NHW4; -. DR Proteomes; UP000005640; Chromosome 17. DR RNAct; Q8NHW4; Protein. DR Bgee; ENSG00000276070; Expressed in bone marrow and 103 other cell types or tissues. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central. DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central. DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central. DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central. DR GO; GO:0071346; P:cellular response to type II interferon; IBA:GO_Central. DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central. DR GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central. DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central. DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central. DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central. DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central. DR CDD; cd00272; Chemokine_CC; 1. DR Gene3D; 2.40.50.40; -; 1. DR InterPro; IPR039809; Chemokine_b/g/d. DR InterPro; IPR000827; Chemokine_CC_CS. DR InterPro; IPR001811; Chemokine_IL8-like_dom. DR InterPro; IPR036048; Interleukin_8-like_sf. DR PANTHER; PTHR12015:SF103; C-C MOTIF CHEMOKINE 4-RELATED; 1. DR PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1. DR Pfam; PF00048; IL8; 1. DR SMART; SM00199; SCY; 1. DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1. DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1. PE 1: Evidence at protein level; KW Alternative splicing; Chemotaxis; Cytokine; Disulfide bond; KW Inflammatory response; Reference proteome; Secreted; Signal. FT SIGNAL 1..23 FT /evidence="ECO:0000250" FT CHAIN 24..92 FT /note="C-C motif chemokine 4-like" FT /id="PRO_0000326234" FT DISULFID 34..58 FT /evidence="ECO:0000250" FT DISULFID 35..74 FT /evidence="ECO:0000250" FT VAR_SEQ 26..92 FT /note="MGSDPPTACCFSYTARKLPRNFVVDYYETSSLCSQPAVVFQTKRGKQVCADP FT SESWVQEYVYDLELN -> KASKSALTPVSPGSRSTCMTWN (in isoform 7)" FT /evidence="ECO:0000303|PubMed:15843566" FT /id="VSP_032625" FT VAR_SEQ 26..92 FT /note="MGSDPPTACCFSYTARKLPRNFVVDYYETSSLCSQPAVVFQTKRGKQVCADP FT SESWVQEYVYDLELN -> NSKPKEASKSALTPVSPGSRSTCMTWN (in isoform FT 8)" FT /evidence="ECO:0000303|PubMed:15843566" FT /id="VSP_032626" FT VAR_SEQ 26..92 FT /note="MGSDPPTACCFSYTARKLPRNFVVDYYETSSLCSQPAVVFQTKRGKQVCADP FT SESWVQEYVYDLELN -> TKSSEWKLQGVCFQCCSGKDPIHQSCPTWTMVRQRKMPTT FT GKG (in isoform 9)" FT /evidence="ECO:0000303|PubMed:15843566" FT /id="VSP_032627" FT VAR_SEQ 65..92 FT /note="FQTKRGKQVCADPSESWVQEYVYDLELN -> YRESASSAAPGRIPSTRAAP FT HGPWSGRGRCLPQARDKAR (in isoform 10)" FT /evidence="ECO:0000303|PubMed:15843566" FT /id="VSP_032628" FT VAR_SEQ 65..92 FT /note="FQTKRGKQVCADPSESWVQEYVYDLELN -> AAPGRIPSTRAAPHGPWSGR FT GRCLPQARDKAR (in isoform 3)" FT /evidence="ECO:0000303|PubMed:15843566" FT /id="VSP_032629" FT VAR_SEQ 65..92 FT /note="FQTKRGKQVCADPSESWVQEYVYDLELN -> EWKLQGVCFQCCSGKDPIHQ FT SCPTWTMVRQRKMPTTGKG (in isoform 4)" FT /evidence="ECO:0000303|PubMed:15843566" FT /id="VSP_032630" FT VAR_SEQ 65..92 FT /note="Missing (in isoform 5)" FT /evidence="ECO:0000303|PubMed:15489334, FT ECO:0000303|PubMed:15843566" FT /id="VSP_032631" FT VAR_SEQ 65..92 FT /note="FQTKRGKQVCADPSESWVQEYVYDLELN -> AAPHGPWSGRGRCLPQARDK FT AR (in isoform 6)" FT /evidence="ECO:0000303|PubMed:15843566" FT /id="VSP_032632" FT VAR_SEQ 65..69 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15843566" FT /id="VSP_032633" FT CONFLICT 45 FT /note="R -> H (in Ref. 3; AAH70310)" FT /evidence="ECO:0000305" SQ SEQUENCE 92 AA; 10166 MW; 4C8D01E926CDE882 CRC64; MKLCVTVLSL LVLVAAFCSL ALSAPMGSDP PTACCFSYTA RKLPRNFVVD YYETSSLCSQ PAVVFQTKRG KQVCADPSES WVQEYVYDLE LN //