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Protein

Rhox homeobox family member 1

Gene

RHOXF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi103 – 162HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • DNA binding transcription factor activity Source: UniProtKB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • gamete generation Source: UniProtKB
  • intracellular steroid hormone receptor signaling pathway Source: UniProtKB
  • multicellular organism development Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • sexual reproduction Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Rhox homeobox family member 1Curated
Alternative name(s):
Ovary-, testis- and epididymis-expressed gene protein
Paired-like homeobox protein PEPP-1
Gene namesi
Name:RHOXF1Imported
Synonyms:OTEX, PEPP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000101883.4
HGNCiHGNC:29993 RHOXF1
MIMi300446 gene
neXtProtiNX_Q8NHV9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101883
PharmGKBiPA162401287

Polymorphism and mutation databases

DMDMi37537960

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492451 – 184Rhox homeobox family member 1Add BLAST184

Proteomic databases

PaxDbiQ8NHV9
PeptideAtlasiQ8NHV9
PRIDEiQ8NHV9

Expressioni

Tissue specificityi

Ovary, testis and epididymis. Also detected in the prostate and the mammary gland. Expressed in many tumor cell lines derived from acute lymphocytic leukemia, prostate, endometrial adenocarcinoma, melanoma, bladder carcinoma, colon carcinoma, erythroleukemia and breast carcinoma. Not expressed in placenta. In testis, mainly expressed in germ cells, but also detected in somatic cells such as Sertoli cells, Leydig cells and peritubular cells (PubMed:28171660).2 Publications

Developmental stagei

Predominantly expressed in late stage germ cells, pachytene spermatocytes and round spermatides.1 Publication

Inductioni

By androgen.

Gene expression databases

BgeeiENSG00000101883
CleanExiHS_RHOXF1
GenevisibleiQ8NHV9 HS

Organism-specific databases

HPAiHPA056506

Interactioni

Subunit structurei

Does not interact with itself.

Protein-protein interaction databases

BioGridi127708, 2 interactors
IntActiQ8NHV9, 1 interactor
STRINGi9606.ENSP00000217999

Structurei

3D structure databases

ProteinModelPortaliQ8NHV9
SMRiQ8NHV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi155 – 164Nuclear localization signal10

Domaini

Mutagenesis of amino acids 147 to 164 and 155 to 164 lead to a major cytoplasmic localization, with only minor localization in the nucleus.

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00820000127081
HOGENOMiHOG000154120
InParanoidiQ8NHV9
OMAiGNMNPEG
OrthoDBiEOG091G0ZM6
PhylomeDBiQ8NHV9
TreeFamiTF339348

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NHV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSLVHDTV FYCLSVYQVK ISPTPQLGAA SSAEGHVGQG APGLMGNMNP
60 70 80 90 100
EGGVNHENGM NRDGGMIPEG GGGNQEPRQQ PQPPPEEPAQ AAMEGPQPEN
110 120 130 140 150
MQPRTRRTKF TLLQVEELES VFRHTQYPDV PTRRELAENL GVTEDKVRVW
160 170 180
FKNKRARCRR HQRELMLANE LRADPDDCVY IVVD
Length:184
Mass (Da):20,542
Last modified:October 1, 2002 - v1
Checksum:i90C67C7ACA2B292B
GO

Sequence cautioni

The sequence AAC78617 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049587172R → H Found in infertile men; unknown pathological significance; no effect on induction of target genes expression. 1 PublicationCorresponds to variant dbSNP:rs2301977Ensembl.1
Natural variantiVAR_077002177D → H1 PublicationCorresponds to variant dbSNP:rs138060880Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY099086 mRNA Translation: AAM22794.1
AC005023 Genomic DNA Translation: AAC78617.1 Sequence problems.
BC069324 mRNA Translation: AAH69324.1
BC069529 mRNA Translation: AAH69529.1
BC103857 mRNA Translation: AAI03858.1
BC103858 mRNA Translation: AAI03859.1
CCDSiCCDS14593.1
RefSeqiNP_644811.1, NM_139282.2
UniGeneiHs.644617

Genome annotation databases

EnsembliENST00000217999; ENSP00000217999; ENSG00000101883
GeneIDi158800
KEGGihsa:158800
UCSCiuc004esk.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRHXF1_HUMAN
AccessioniPrimary (citable) accession number: Q8NHV9
Secondary accession number(s): O95030, Q3SYE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health