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Protein

Protein NEDD1

Gene

NEDD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139350-MONOMER.
ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-380320. Recruitment of NuMA to mitotic centrosomes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.
SignaLinkiQ8NHV4.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NEDD1
Alternative name(s):
Neural precursor cell expressed developmentally down-regulated protein 1
Short name:
NEDD-1
Gene namesi
Name:NEDD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:7723. NEDD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi121441.
OpenTargetsiENSG00000139350.
PharmGKBiPA31531.

Polymorphism and mutation databases

BioMutaiNEDD1.
DMDMi74762597.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510951 – 660Protein NEDD1Add BLAST660

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei325PhosphoserineCombined sources1
Modified residuei382Phosphothreonine; by PLK11 Publication1
Modified residuei397Phosphoserine; by PLK1Combined sources1 Publication1
Modified residuei411PhosphoserineCombined sources1
Modified residuei426Phosphoserine; by PLK11 Publication1
Modified residuei468PhosphoserineCombined sources1
Modified residuei516PhosphoserineCombined sources1
Modified residuei550Phosphothreonine; by CDK11 Publication1
Modified residuei637Phosphoserine; by PLK11 Publication1

Post-translational modificationi

During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397, Ser-426 and Ser-637. Phosphorylated NEDD1 can interact with gamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NHV4.
MaxQBiQ8NHV4.
PaxDbiQ8NHV4.
PeptideAtlasiQ8NHV4.
PRIDEiQ8NHV4.

PTM databases

iPTMnetiQ8NHV4.
PhosphoSitePlusiQ8NHV4.

Expressioni

Gene expression databases

BgeeiENSG00000139350.
CleanExiHS_NEDD1.
ExpressionAtlasiQ8NHV4. baseline and differential.
GenevisibleiQ8NHV4. HS.

Organism-specific databases

HPAiHPA038591.

Interactioni

Subunit structurei

Interacts with FAM29A and gamma-tubulin.1 Publication

Protein-protein interaction databases

BioGridi125728. 147 interactors.
DIPiDIP-48838N.
IntActiQ8NHV4. 91 interactors.
STRINGi9606.ENSP00000451211.

Structurei

3D structure databases

ProteinModelPortaliQ8NHV4.
SMRiQ8NHV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 31WD 1Add BLAST31
Repeati32 – 71WD 2Add BLAST40
Repeati75 – 114WD 3Add BLAST40
Repeati117 – 156WD 4Add BLAST40
Repeati160 – 200WD 5Add BLAST41
Repeati204 – 244WD 6Add BLAST41
Repeati246 – 285WD 7Add BLAST40
Repeati289 – 332WD 8Add BLAST44

Sequence similaritiesi

Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG4378. Eukaryota.
ENOG410ZQNY. LUCA.
GeneTreeiENSGT00390000001561.
HOGENOMiHOG000034642.
HOVERGENiHBG055623.
InParanoidiQ8NHV4.
KOiK16547.
OMAiNKTVNIW.
OrthoDBiEOG091G07XS.
PhylomeDBiQ8NHV4.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NHV4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQENLRFASS GDDIKIWDAS SMTLVDKFNP HTSPHGISSI CWSSNNNFLV
60 70 80 90 100
TASSSGDKIV VSSCKCKPVP LLELAEGQKQ TCVNLNSTSM YLVSGGLNNT
110 120 130 140 150
VNIWDLKSKR VHRSLKDHKD QVTCVTYNWN DCYIASGSLS GEIILHSVTT
160 170 180 190 200
NLSSTPFGHG SNQSVRHLKY SLFKKSLLGS VSDNGIVTLW DVNSQSPYHN
210 220 230 240 250
FDSVHKAPAS GICFSPVNEL LFVTIGLDKR IILYDTSSKK LVKTLVADTP
260 270 280 290 300
LTAVDFMPDG ATLAIGSSRG KIYQYDLRML KSPVKTISAH KTSVQCIAFQ
310 320 330 340 350
YSTVLTKSSL NKGCSNKPTT VNKRSVNVNA ASGGVQNSGI VREAPATSIA
360 370 380 390 400
TVLPQPMTSA MGKGTVAVQE KAGLPRSINT DTLSKETDSG KNQDFSSFDD
410 420 430 440 450
TGKSSLGDMF SPIRDDAVVN KGSDESIGKG DGFDFLPQLN SVFPPRKNPV
460 470 480 490 500
TSSTSVLHSS PLNVFMGSPG KEENENRDLT AESKKIYMGK QESKDSFKQL
510 520 530 540 550
AKLVTSGAES GNLNTSPSSN QTRNSEKFEK PENEIEAQLI CEPPINGSST
560 570 580 590 600
PNPKIASSVT AGVASSLSEK IADSIGNNRQ NAPLTSIQIR FIQNMIQETL
610 620 630 640 650
DDFREACHRD IVNLQVEMIK QFHMQLNEMH SLLERYSVNE GLVAEIERLR
660
EENKRLRAHF
Length:660
Mass (Da):71,966
Last modified:October 1, 2002 - v1
Checksum:i12817A567C13098B
GO
Isoform 2 (identifier: Q8NHV4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.

Note: No experimental confirmation available.
Show »
Length:571
Mass (Da):62,379
Checksum:i1FBE4E895B36789B
GO
Isoform 3 (identifier: Q8NHV4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHFTGAVM

Show »
Length:667
Mass (Da):72,710
Checksum:iCD60E653689DF81A
GO

Sequence cautioni

The sequence AAH27605 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170Y → C in BAC04099 (PubMed:14702039).Curated1
Sequence conflicti409M → V in BAC04099 (PubMed:14702039).Curated1
Sequence conflicti649L → P in BAC04099 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0434111 – 89Missing in isoform 2. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_0537941M → MHFTGAVM in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093221 mRNA. Translation: BAC04099.1.
AK303656 mRNA. Translation: BAG64657.1.
AK315821 mRNA. Translation: BAF98712.1.
AC007564 Genomic DNA. No translation available.
AC013417 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97577.1.
CH471054 Genomic DNA. Translation: EAW97579.1.
CH471054 Genomic DNA. Translation: EAW97580.1.
BC027605 mRNA. Translation: AAH27605.1. Different initiation.
CCDSiCCDS44955.1. [Q8NHV4-3]
CCDS44956.1. [Q8NHV4-2]
CCDS9063.1. [Q8NHV4-1]
RefSeqiNP_001128647.1. NM_001135175.1. [Q8NHV4-3]
NP_001128648.1. NM_001135176.1. [Q8NHV4-1]
NP_001128649.1. NM_001135177.1. [Q8NHV4-2]
NP_690869.1. NM_152905.3. [Q8NHV4-1]
XP_005268701.1. XM_005268644.2. [Q8NHV4-3]
XP_006719300.1. XM_006719237.3. [Q8NHV4-2]
XP_011536205.1. XM_011537903.2. [Q8NHV4-2]
UniGeneiHs.270084.

Genome annotation databases

EnsembliENST00000266742; ENSP00000266742; ENSG00000139350. [Q8NHV4-1]
ENST00000411739; ENSP00000411307; ENSG00000139350. [Q8NHV4-2]
ENST00000429527; ENSP00000404978; ENSG00000139350. [Q8NHV4-1]
ENST00000457368; ENSP00000407964; ENSG00000139350. [Q8NHV4-2]
ENST00000557644; ENSP00000451211; ENSG00000139350. [Q8NHV4-3]
GeneIDi121441.
KEGGihsa:121441.
UCSCiuc001teu.5. human. [Q8NHV4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093221 mRNA. Translation: BAC04099.1.
AK303656 mRNA. Translation: BAG64657.1.
AK315821 mRNA. Translation: BAF98712.1.
AC007564 Genomic DNA. No translation available.
AC013417 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97577.1.
CH471054 Genomic DNA. Translation: EAW97579.1.
CH471054 Genomic DNA. Translation: EAW97580.1.
BC027605 mRNA. Translation: AAH27605.1. Different initiation.
CCDSiCCDS44955.1. [Q8NHV4-3]
CCDS44956.1. [Q8NHV4-2]
CCDS9063.1. [Q8NHV4-1]
RefSeqiNP_001128647.1. NM_001135175.1. [Q8NHV4-3]
NP_001128648.1. NM_001135176.1. [Q8NHV4-1]
NP_001128649.1. NM_001135177.1. [Q8NHV4-2]
NP_690869.1. NM_152905.3. [Q8NHV4-1]
XP_005268701.1. XM_005268644.2. [Q8NHV4-3]
XP_006719300.1. XM_006719237.3. [Q8NHV4-2]
XP_011536205.1. XM_011537903.2. [Q8NHV4-2]
UniGeneiHs.270084.

3D structure databases

ProteinModelPortaliQ8NHV4.
SMRiQ8NHV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125728. 147 interactors.
DIPiDIP-48838N.
IntActiQ8NHV4. 91 interactors.
STRINGi9606.ENSP00000451211.

PTM databases

iPTMnetiQ8NHV4.
PhosphoSitePlusiQ8NHV4.

Polymorphism and mutation databases

BioMutaiNEDD1.
DMDMi74762597.

Proteomic databases

EPDiQ8NHV4.
MaxQBiQ8NHV4.
PaxDbiQ8NHV4.
PeptideAtlasiQ8NHV4.
PRIDEiQ8NHV4.

Protocols and materials databases

DNASUi121441.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266742; ENSP00000266742; ENSG00000139350. [Q8NHV4-1]
ENST00000411739; ENSP00000411307; ENSG00000139350. [Q8NHV4-2]
ENST00000429527; ENSP00000404978; ENSG00000139350. [Q8NHV4-1]
ENST00000457368; ENSP00000407964; ENSG00000139350. [Q8NHV4-2]
ENST00000557644; ENSP00000451211; ENSG00000139350. [Q8NHV4-3]
GeneIDi121441.
KEGGihsa:121441.
UCSCiuc001teu.5. human. [Q8NHV4-1]

Organism-specific databases

CTDi121441.
DisGeNETi121441.
GeneCardsiNEDD1.
HGNCiHGNC:7723. NEDD1.
HPAiHPA038591.
MIMi600372. gene.
neXtProtiNX_Q8NHV4.
OpenTargetsiENSG00000139350.
PharmGKBiPA31531.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4378. Eukaryota.
ENOG410ZQNY. LUCA.
GeneTreeiENSGT00390000001561.
HOGENOMiHOG000034642.
HOVERGENiHBG055623.
InParanoidiQ8NHV4.
KOiK16547.
OMAiNKTVNIW.
OrthoDBiEOG091G07XS.
PhylomeDBiQ8NHV4.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139350-MONOMER.
ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-380320. Recruitment of NuMA to mitotic centrosomes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.
SignaLinkiQ8NHV4.

Miscellaneous databases

ChiTaRSiNEDD1. human.
GeneWikiiNEDD1.
GenomeRNAii121441.
PROiQ8NHV4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139350.
CleanExiHS_NEDD1.
ExpressionAtlasiQ8NHV4. baseline and differential.
GenevisibleiQ8NHV4. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNEDD1_HUMAN
AccessioniPrimary (citable) accession number: Q8NHV4
Secondary accession number(s): B0AZN0
, B4E145, G3V3F1, Q8NA30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.