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Q8NHV4

- NEDD1_HUMAN

UniProt

Q8NHV4 - NEDD1_HUMAN

Protein

Protein NEDD1

Gene

NEDD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.2 Publications

    GO - Biological processi

    1. G2/M transition of mitotic cell cycle Source: Reactome
    2. mitotic cell cycle Source: Reactome
    3. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Enzyme and pathway databases

    ReactomeiREACT_15296. Recruitment of mitotic centrosome proteins and complexes.
    REACT_15364. Loss of Nlp from mitotic centrosomes.
    REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
    REACT_15510. Recruitment of NuMA to mitotic centrosomes.
    REACT_160315. Regulation of PLK1 Activity at G2/M Transition.
    SignaLinkiQ8NHV4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein NEDD1
    Alternative name(s):
    Neural precursor cell expressed developmentally down-regulated protein 1
    Short name:
    NEDD-1
    Gene namesi
    Name:NEDD1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:7723. NEDD1.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytosol Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31531.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 660660Protein NEDD1PRO_0000051095Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei382 – 3821Phosphothreonine; by PLK11 Publication
    Modified residuei397 – 3971Phosphoserine; by PLK11 Publication
    Modified residuei411 – 4111Phosphoserine1 Publication
    Modified residuei426 – 4261Phosphoserine; by PLK11 Publication
    Modified residuei516 – 5161Phosphoserine2 Publications
    Modified residuei550 – 5501Phosphothreonine; by CDK11 Publication
    Modified residuei637 – 6371Phosphoserine; by PLK11 Publication

    Post-translational modificationi

    During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397, Ser-426 and Ser-637. Phosphorylated NEDD1 can interact with gamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation.4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8NHV4.
    PaxDbiQ8NHV4.
    PRIDEiQ8NHV4.

    PTM databases

    PhosphoSiteiQ8NHV4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NHV4.
    BgeeiQ8NHV4.
    CleanExiHS_NEDD1.
    GenevestigatoriQ8NHV4.

    Organism-specific databases

    HPAiHPA038591.

    Interactioni

    Subunit structurei

    Interacts with FAM29A and gamma-tubulin.1 Publication

    Protein-protein interaction databases

    BioGridi125728. 13 interactions.
    DIPiDIP-48838N.
    IntActiQ8NHV4. 6 interactions.
    STRINGi9606.ENSP00000407964.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NHV4.
    SMRiQ8NHV4. Positions 7-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati1 – 3131WD 1Add
    BLAST
    Repeati32 – 7140WD 2Add
    BLAST
    Repeati75 – 11440WD 3Add
    BLAST
    Repeati117 – 15640WD 4Add
    BLAST
    Repeati160 – 20041WD 5Add
    BLAST
    Repeati204 – 24441WD 6Add
    BLAST
    Repeati246 – 28540WD 7Add
    BLAST
    Repeati289 – 33244WD 8Add
    BLAST

    Sequence similaritiesi

    Contains 8 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000034642.
    HOVERGENiHBG055623.
    InParanoidiQ8NHV4.
    KOiK16547.
    OMAiVFPPRKT.
    OrthoDBiEOG79KPDX.
    PhylomeDBiQ8NHV4.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 3 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 6 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NHV4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQENLRFASS GDDIKIWDAS SMTLVDKFNP HTSPHGISSI CWSSNNNFLV    50
    TASSSGDKIV VSSCKCKPVP LLELAEGQKQ TCVNLNSTSM YLVSGGLNNT 100
    VNIWDLKSKR VHRSLKDHKD QVTCVTYNWN DCYIASGSLS GEIILHSVTT 150
    NLSSTPFGHG SNQSVRHLKY SLFKKSLLGS VSDNGIVTLW DVNSQSPYHN 200
    FDSVHKAPAS GICFSPVNEL LFVTIGLDKR IILYDTSSKK LVKTLVADTP 250
    LTAVDFMPDG ATLAIGSSRG KIYQYDLRML KSPVKTISAH KTSVQCIAFQ 300
    YSTVLTKSSL NKGCSNKPTT VNKRSVNVNA ASGGVQNSGI VREAPATSIA 350
    TVLPQPMTSA MGKGTVAVQE KAGLPRSINT DTLSKETDSG KNQDFSSFDD 400
    TGKSSLGDMF SPIRDDAVVN KGSDESIGKG DGFDFLPQLN SVFPPRKNPV 450
    TSSTSVLHSS PLNVFMGSPG KEENENRDLT AESKKIYMGK QESKDSFKQL 500
    AKLVTSGAES GNLNTSPSSN QTRNSEKFEK PENEIEAQLI CEPPINGSST 550
    PNPKIASSVT AGVASSLSEK IADSIGNNRQ NAPLTSIQIR FIQNMIQETL 600
    DDFREACHRD IVNLQVEMIK QFHMQLNEMH SLLERYSVNE GLVAEIERLR 650
    EENKRLRAHF 660
    Length:660
    Mass (Da):71,966
    Last modified:October 1, 2002 - v1
    Checksum:i12817A567C13098B
    GO
    Isoform 2 (identifier: Q8NHV4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-89: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:571
    Mass (Da):62,379
    Checksum:i1FBE4E895B36789B
    GO
    Isoform 3 (identifier: Q8NHV4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MHFTGAVM

    Show »
    Length:667
    Mass (Da):72,710
    Checksum:iCD60E653689DF81A
    GO

    Sequence cautioni

    The sequence AAH27605.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti170 – 1701Y → C in BAC04099. (PubMed:14702039)Curated
    Sequence conflicti409 – 4091M → V in BAC04099. (PubMed:14702039)Curated
    Sequence conflicti649 – 6491L → P in BAC04099. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8989Missing in isoform 2. 1 PublicationVSP_043411Add
    BLAST
    Alternative sequencei1 – 11M → MHFTGAVM in isoform 3. 1 PublicationVSP_053794

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093221 mRNA. Translation: BAC04099.1.
    AK303656 mRNA. Translation: BAG64657.1.
    AK315821 mRNA. Translation: BAF98712.1.
    AC007564 Genomic DNA. No translation available.
    AC013417 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW97577.1.
    CH471054 Genomic DNA. Translation: EAW97579.1.
    CH471054 Genomic DNA. Translation: EAW97580.1.
    BC027605 mRNA. Translation: AAH27605.1. Different initiation.
    CCDSiCCDS44955.1. [Q8NHV4-3]
    CCDS44956.1. [Q8NHV4-2]
    CCDS9063.1. [Q8NHV4-1]
    RefSeqiNP_001128647.1. NM_001135175.1. [Q8NHV4-3]
    NP_001128648.1. NM_001135176.1. [Q8NHV4-1]
    NP_001128649.1. NM_001135177.1. [Q8NHV4-2]
    NP_690869.1. NM_152905.3. [Q8NHV4-1]
    XP_005268701.1. XM_005268644.1. [Q8NHV4-3]
    XP_006719299.1. XM_006719236.1. [Q8NHV4-1]
    XP_006719300.1. XM_006719237.1. [Q8NHV4-2]
    UniGeneiHs.270084.

    Genome annotation databases

    EnsembliENST00000266742; ENSP00000266742; ENSG00000139350. [Q8NHV4-1]
    ENST00000411739; ENSP00000411307; ENSG00000139350. [Q8NHV4-2]
    ENST00000429527; ENSP00000404978; ENSG00000139350. [Q8NHV4-1]
    ENST00000457368; ENSP00000407964; ENSG00000139350. [Q8NHV4-2]
    ENST00000557644; ENSP00000451211; ENSG00000139350. [Q8NHV4-3]
    GeneIDi121441.
    KEGGihsa:121441.
    UCSCiuc001teu.4. human. [Q8NHV4-1]
    uc001tew.3. human.

    Polymorphism databases

    DMDMi74762597.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093221 mRNA. Translation: BAC04099.1 .
    AK303656 mRNA. Translation: BAG64657.1 .
    AK315821 mRNA. Translation: BAF98712.1 .
    AC007564 Genomic DNA. No translation available.
    AC013417 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW97577.1 .
    CH471054 Genomic DNA. Translation: EAW97579.1 .
    CH471054 Genomic DNA. Translation: EAW97580.1 .
    BC027605 mRNA. Translation: AAH27605.1 . Different initiation.
    CCDSi CCDS44955.1. [Q8NHV4-3 ]
    CCDS44956.1. [Q8NHV4-2 ]
    CCDS9063.1. [Q8NHV4-1 ]
    RefSeqi NP_001128647.1. NM_001135175.1. [Q8NHV4-3 ]
    NP_001128648.1. NM_001135176.1. [Q8NHV4-1 ]
    NP_001128649.1. NM_001135177.1. [Q8NHV4-2 ]
    NP_690869.1. NM_152905.3. [Q8NHV4-1 ]
    XP_005268701.1. XM_005268644.1. [Q8NHV4-3 ]
    XP_006719299.1. XM_006719236.1. [Q8NHV4-1 ]
    XP_006719300.1. XM_006719237.1. [Q8NHV4-2 ]
    UniGenei Hs.270084.

    3D structure databases

    ProteinModelPortali Q8NHV4.
    SMRi Q8NHV4. Positions 7-294.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125728. 13 interactions.
    DIPi DIP-48838N.
    IntActi Q8NHV4. 6 interactions.
    STRINGi 9606.ENSP00000407964.

    PTM databases

    PhosphoSitei Q8NHV4.

    Polymorphism databases

    DMDMi 74762597.

    Proteomic databases

    MaxQBi Q8NHV4.
    PaxDbi Q8NHV4.
    PRIDEi Q8NHV4.

    Protocols and materials databases

    DNASUi 121441.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266742 ; ENSP00000266742 ; ENSG00000139350 . [Q8NHV4-1 ]
    ENST00000411739 ; ENSP00000411307 ; ENSG00000139350 . [Q8NHV4-2 ]
    ENST00000429527 ; ENSP00000404978 ; ENSG00000139350 . [Q8NHV4-1 ]
    ENST00000457368 ; ENSP00000407964 ; ENSG00000139350 . [Q8NHV4-2 ]
    ENST00000557644 ; ENSP00000451211 ; ENSG00000139350 . [Q8NHV4-3 ]
    GeneIDi 121441.
    KEGGi hsa:121441.
    UCSCi uc001teu.4. human. [Q8NHV4-1 ]
    uc001tew.3. human.

    Organism-specific databases

    CTDi 121441.
    GeneCardsi GC12P097301.
    HGNCi HGNC:7723. NEDD1.
    HPAi HPA038591.
    MIMi 600372. gene.
    neXtProti NX_Q8NHV4.
    PharmGKBi PA31531.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000034642.
    HOVERGENi HBG055623.
    InParanoidi Q8NHV4.
    KOi K16547.
    OMAi VFPPRKT.
    OrthoDBi EOG79KPDX.
    PhylomeDBi Q8NHV4.

    Enzyme and pathway databases

    Reactomei REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
    REACT_15364. Loss of Nlp from mitotic centrosomes.
    REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
    REACT_15510. Recruitment of NuMA to mitotic centrosomes.
    REACT_160315. Regulation of PLK1 Activity at G2/M Transition.
    SignaLinki Q8NHV4.

    Miscellaneous databases

    GeneWikii NEDD1.
    GenomeRNAii 121441.
    NextBioi 80736.
    PROi Q8NHV4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NHV4.
    Bgeei Q8NHV4.
    CleanExi HS_NEDD1.
    Genevestigatori Q8NHV4.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 3 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 6 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Testis, Thymus and Tongue.
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Testis.
    5. "FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle."
      Zhu H., Coppinger J.A., Jang C.-Y., Yates J.R. III, Fang G.
      J. Cell Biol. 183:835-848(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FAM29A, SUBCELLULAR LOCATION, FUNCTION.
    6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-516, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome."
      Zhang X., Chen Q., Feng J., Hou J., Yang F., Liu J., Jiang Q., Zhang C.
      J. Cell Sci. 122:2240-2251(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION AT THR-550 BY CDK1, PHOSPHORYLATION AT THR-382; SER-397; SER-426 AND SER-637 BY PLK1.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-516, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiNEDD1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NHV4
    Secondary accession number(s): B0AZN0
    , B4E145, G3V3F1, Q8NA30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3