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Protein

Protein NEDD1

Gene

NEDD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.2 Publications

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. G2/M transition of mitotic cell cycle Source: Reactome
  3. mitotic cell cycle Source: Reactome
  4. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiREACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_15510. Recruitment of NuMA to mitotic centrosomes.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.
SignaLinkiQ8NHV4.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NEDD1
Alternative name(s):
Neural precursor cell expressed developmentally down-regulated protein 1
Short name:
NEDD-1
Gene namesi
Name:NEDD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:7723. NEDD1.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication

GO - Cellular componenti

  1. apical part of cell Source: Ensembl
  2. centriole Source: Ensembl
  3. centrosome Source: UniProtKB
  4. ciliary basal body Source: Ensembl
  5. cytosol Source: Reactome
  6. nucleolus Source: HPA
  7. nucleoplasm Source: HPA
  8. pericentriolar material Source: Ensembl
  9. plasma membrane Source: HPA
  10. spindle pole Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31531.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 660660Protein NEDD1PRO_0000051095Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei382 – 3821Phosphothreonine; by PLK11 Publication
Modified residuei397 – 3971Phosphoserine; by PLK11 Publication
Modified residuei411 – 4111Phosphoserine1 Publication
Modified residuei426 – 4261Phosphoserine; by PLK11 Publication
Modified residuei516 – 5161Phosphoserine2 Publications
Modified residuei550 – 5501Phosphothreonine; by CDK11 Publication
Modified residuei637 – 6371Phosphoserine; by PLK11 Publication

Post-translational modificationi

During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397, Ser-426 and Ser-637. Phosphorylated NEDD1 can interact with gamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation.4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8NHV4.
PaxDbiQ8NHV4.
PRIDEiQ8NHV4.

PTM databases

PhosphoSiteiQ8NHV4.

Expressioni

Gene expression databases

BgeeiQ8NHV4.
CleanExiHS_NEDD1.
ExpressionAtlasiQ8NHV4. baseline and differential.
GenevestigatoriQ8NHV4.

Organism-specific databases

HPAiHPA038591.

Interactioni

Subunit structurei

Interacts with FAM29A and gamma-tubulin.1 Publication

Protein-protein interaction databases

BioGridi125728. 72 interactions.
DIPiDIP-48838N.
IntActiQ8NHV4. 6 interactions.
STRINGi9606.ENSP00000407964.

Structurei

3D structure databases

ProteinModelPortaliQ8NHV4.
SMRiQ8NHV4. Positions 7-298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 3131WD 1Add
BLAST
Repeati32 – 7140WD 2Add
BLAST
Repeati75 – 11440WD 3Add
BLAST
Repeati117 – 15640WD 4Add
BLAST
Repeati160 – 20041WD 5Add
BLAST
Repeati204 – 24441WD 6Add
BLAST
Repeati246 – 28540WD 7Add
BLAST
Repeati289 – 33244WD 8Add
BLAST

Sequence similaritiesi

Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00390000001561.
HOGENOMiHOG000034642.
HOVERGENiHBG055623.
InParanoidiQ8NHV4.
KOiK16547.
OMAiNKTVNIW.
OrthoDBiEOG79KPDX.
PhylomeDBiQ8NHV4.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NHV4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQENLRFASS GDDIKIWDAS SMTLVDKFNP HTSPHGISSI CWSSNNNFLV
60 70 80 90 100
TASSSGDKIV VSSCKCKPVP LLELAEGQKQ TCVNLNSTSM YLVSGGLNNT
110 120 130 140 150
VNIWDLKSKR VHRSLKDHKD QVTCVTYNWN DCYIASGSLS GEIILHSVTT
160 170 180 190 200
NLSSTPFGHG SNQSVRHLKY SLFKKSLLGS VSDNGIVTLW DVNSQSPYHN
210 220 230 240 250
FDSVHKAPAS GICFSPVNEL LFVTIGLDKR IILYDTSSKK LVKTLVADTP
260 270 280 290 300
LTAVDFMPDG ATLAIGSSRG KIYQYDLRML KSPVKTISAH KTSVQCIAFQ
310 320 330 340 350
YSTVLTKSSL NKGCSNKPTT VNKRSVNVNA ASGGVQNSGI VREAPATSIA
360 370 380 390 400
TVLPQPMTSA MGKGTVAVQE KAGLPRSINT DTLSKETDSG KNQDFSSFDD
410 420 430 440 450
TGKSSLGDMF SPIRDDAVVN KGSDESIGKG DGFDFLPQLN SVFPPRKNPV
460 470 480 490 500
TSSTSVLHSS PLNVFMGSPG KEENENRDLT AESKKIYMGK QESKDSFKQL
510 520 530 540 550
AKLVTSGAES GNLNTSPSSN QTRNSEKFEK PENEIEAQLI CEPPINGSST
560 570 580 590 600
PNPKIASSVT AGVASSLSEK IADSIGNNRQ NAPLTSIQIR FIQNMIQETL
610 620 630 640 650
DDFREACHRD IVNLQVEMIK QFHMQLNEMH SLLERYSVNE GLVAEIERLR
660
EENKRLRAHF
Length:660
Mass (Da):71,966
Last modified:October 1, 2002 - v1
Checksum:i12817A567C13098B
GO
Isoform 2 (identifier: Q8NHV4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.

Note: No experimental confirmation available.

Show »
Length:571
Mass (Da):62,379
Checksum:i1FBE4E895B36789B
GO
Isoform 3 (identifier: Q8NHV4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHFTGAVM

Show »
Length:667
Mass (Da):72,710
Checksum:iCD60E653689DF81A
GO

Sequence cautioni

The sequence AAH27605.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti170 – 1701Y → C in BAC04099. (PubMed:14702039)Curated
Sequence conflicti409 – 4091M → V in BAC04099. (PubMed:14702039)Curated
Sequence conflicti649 – 6491L → P in BAC04099. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8989Missing in isoform 2. 1 PublicationVSP_043411Add
BLAST
Alternative sequencei1 – 11M → MHFTGAVM in isoform 3. 1 PublicationVSP_053794

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093221 mRNA. Translation: BAC04099.1.
AK303656 mRNA. Translation: BAG64657.1.
AK315821 mRNA. Translation: BAF98712.1.
AC007564 Genomic DNA. No translation available.
AC013417 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97577.1.
CH471054 Genomic DNA. Translation: EAW97579.1.
CH471054 Genomic DNA. Translation: EAW97580.1.
BC027605 mRNA. Translation: AAH27605.1. Different initiation.
CCDSiCCDS44955.1. [Q8NHV4-3]
CCDS44956.1. [Q8NHV4-2]
CCDS9063.1. [Q8NHV4-1]
RefSeqiNP_001128647.1. NM_001135175.1. [Q8NHV4-3]
NP_001128648.1. NM_001135176.1. [Q8NHV4-1]
NP_001128649.1. NM_001135177.1. [Q8NHV4-2]
NP_690869.1. NM_152905.3. [Q8NHV4-1]
XP_005268701.1. XM_005268644.1. [Q8NHV4-3]
XP_006719299.1. XM_006719236.1. [Q8NHV4-1]
XP_006719300.1. XM_006719237.1. [Q8NHV4-2]
UniGeneiHs.270084.

Genome annotation databases

EnsembliENST00000266742; ENSP00000266742; ENSG00000139350. [Q8NHV4-1]
ENST00000411739; ENSP00000411307; ENSG00000139350. [Q8NHV4-2]
ENST00000429527; ENSP00000404978; ENSG00000139350. [Q8NHV4-1]
ENST00000457368; ENSP00000407964; ENSG00000139350. [Q8NHV4-2]
ENST00000557644; ENSP00000451211; ENSG00000139350. [Q8NHV4-3]
GeneIDi121441.
KEGGihsa:121441.
UCSCiuc001teu.4. human. [Q8NHV4-1]
uc001tew.3. human.

Polymorphism databases

DMDMi74762597.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093221 mRNA. Translation: BAC04099.1.
AK303656 mRNA. Translation: BAG64657.1.
AK315821 mRNA. Translation: BAF98712.1.
AC007564 Genomic DNA. No translation available.
AC013417 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97577.1.
CH471054 Genomic DNA. Translation: EAW97579.1.
CH471054 Genomic DNA. Translation: EAW97580.1.
BC027605 mRNA. Translation: AAH27605.1. Different initiation.
CCDSiCCDS44955.1. [Q8NHV4-3]
CCDS44956.1. [Q8NHV4-2]
CCDS9063.1. [Q8NHV4-1]
RefSeqiNP_001128647.1. NM_001135175.1. [Q8NHV4-3]
NP_001128648.1. NM_001135176.1. [Q8NHV4-1]
NP_001128649.1. NM_001135177.1. [Q8NHV4-2]
NP_690869.1. NM_152905.3. [Q8NHV4-1]
XP_005268701.1. XM_005268644.1. [Q8NHV4-3]
XP_006719299.1. XM_006719236.1. [Q8NHV4-1]
XP_006719300.1. XM_006719237.1. [Q8NHV4-2]
UniGeneiHs.270084.

3D structure databases

ProteinModelPortaliQ8NHV4.
SMRiQ8NHV4. Positions 7-298.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125728. 72 interactions.
DIPiDIP-48838N.
IntActiQ8NHV4. 6 interactions.
STRINGi9606.ENSP00000407964.

PTM databases

PhosphoSiteiQ8NHV4.

Polymorphism databases

DMDMi74762597.

Proteomic databases

MaxQBiQ8NHV4.
PaxDbiQ8NHV4.
PRIDEiQ8NHV4.

Protocols and materials databases

DNASUi121441.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266742; ENSP00000266742; ENSG00000139350. [Q8NHV4-1]
ENST00000411739; ENSP00000411307; ENSG00000139350. [Q8NHV4-2]
ENST00000429527; ENSP00000404978; ENSG00000139350. [Q8NHV4-1]
ENST00000457368; ENSP00000407964; ENSG00000139350. [Q8NHV4-2]
ENST00000557644; ENSP00000451211; ENSG00000139350. [Q8NHV4-3]
GeneIDi121441.
KEGGihsa:121441.
UCSCiuc001teu.4. human. [Q8NHV4-1]
uc001tew.3. human.

Organism-specific databases

CTDi121441.
GeneCardsiGC12P097301.
HGNCiHGNC:7723. NEDD1.
HPAiHPA038591.
MIMi600372. gene.
neXtProtiNX_Q8NHV4.
PharmGKBiPA31531.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00390000001561.
HOGENOMiHOG000034642.
HOVERGENiHBG055623.
InParanoidiQ8NHV4.
KOiK16547.
OMAiNKTVNIW.
OrthoDBiEOG79KPDX.
PhylomeDBiQ8NHV4.

Enzyme and pathway databases

ReactomeiREACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_15510. Recruitment of NuMA to mitotic centrosomes.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.
SignaLinkiQ8NHV4.

Miscellaneous databases

ChiTaRSiNEDD1. human.
GeneWikiiNEDD1.
GenomeRNAii121441.
NextBioi80736.
PROiQ8NHV4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NHV4.
CleanExiHS_NEDD1.
ExpressionAtlasiQ8NHV4. baseline and differential.
GenevestigatoriQ8NHV4.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis, Thymus and Tongue.
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  5. "FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle."
    Zhu H., Coppinger J.A., Jang C.-Y., Yates J.R. III, Fang G.
    J. Cell Biol. 183:835-848(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FAM29A, SUBCELLULAR LOCATION, FUNCTION.
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-516, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome."
    Zhang X., Chen Q., Feng J., Hou J., Yang F., Liu J., Jiang Q., Zhang C.
    J. Cell Sci. 122:2240-2251(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION AT THR-550 BY CDK1, PHOSPHORYLATION AT THR-382; SER-397; SER-426 AND SER-637 BY PLK1.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-516, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiNEDD1_HUMAN
AccessioniPrimary (citable) accession number: Q8NHV4
Secondary accession number(s): B0AZN0
, B4E145, G3V3F1, Q8NA30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2002
Last modified: February 4, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.