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Protein

GTPase IMAP family member 7

Gene

GIMAP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The dimer has GTPase activity; the active site contains residues from both subunits.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36GTP1
Sitei103Important for catalytic activity1
Binding sitei169GTP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 23GTP9
Nucleotide bindingi133 – 135GTP3

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179144-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase IMAP family member 7
Alternative name(s):
Immunity-associated nucleotide 7 protein
Short name:
IAN-7
Gene namesi
Name:GIMAP7
Synonyms:IAN7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22404. GIMAP7.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB-SubCell
  • lipid particle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Lipid droplet

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi103R → D: Abolishes GTPase activity. No effect on GTP binding and on dimerization. 1 Publication1
Mutagenesisi136E → W: Impairs dimerization and abolishes GTPase activity. No effect on GTP binding. 1 Publication1

Organism-specific databases

DisGeNETi168537.
OpenTargetsiENSG00000179144.
PharmGKBiPA134915933.

Polymorphism and mutation databases

BioMutaiGIMAP7.
DMDMi55976538.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001909931 – 300GTPase IMAP family member 7Add BLAST300

Proteomic databases

MaxQBiQ8NHV1.
PaxDbiQ8NHV1.
PeptideAtlasiQ8NHV1.
PRIDEiQ8NHV1.

PTM databases

iPTMnetiQ8NHV1.
PhosphoSitePlusiQ8NHV1.
SwissPalmiQ8NHV1.

Expressioni

Tissue specificityi

Most abundantly expressed in spleen, lymph nodes, and fetal kidney, but also present in the heart and the small intestine. Lower expression levels are found in lung, kidney, liver, and thyroid, salivary, and mammary glands. Also detected in the thymus (PubMed:15474311). Detected in T-cells (PubMed:23454188).2 Publications

Gene expression databases

BgeeiENSG00000179144.
CleanExiHS_GIMAP7.
ExpressionAtlasiQ8NHV1. baseline and differential.
GenevisibleiQ8NHV1. HS.

Organism-specific databases

HPAiHPA020266.
HPA020268.

Interactioni

Subunit structurei

Monomer in the presence of bound GDP and in the absence of bound nucleotide. Homodimer in the presence of bound GTP. Heterodimer with GIMAP2.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

DIPiDIP-60142N.

Structurei

Secondary structure

1300
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 15Combined sources7
Helixi21 – 29Combined sources9
Beta strandi48 – 53Combined sources6
Beta strandi55 – 63Combined sources9
Helixi74 – 88Combined sources15
Beta strandi93 – 102Combined sources10
Helixi106 – 119Combined sources14
Helixi121 – 125Combined sources5
Beta strandi126 – 132Combined sources7
Helixi134 – 136Combined sources3
Helixi142 – 147Combined sources6
Helixi151 – 159Combined sources9
Beta strandi164 – 166Combined sources3
Helixi175 – 195Combined sources21
Helixi204 – 237Combined sources34
Helixi243 – 261Combined sources19
Helixi264 – 271Combined sources8
Helixi273 – 287Combined sources15
Helixi288 – 290Combined sources3
Helixi296 – 298Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZJCX-ray3.15A/B/C/D/E/F1-300[»]
ProteinModelPortaliQ8NHV1.
SMRiQ8NHV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 210AIG1-type GAdd BLAST205

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IM0G. Eukaryota.
ENOG4111GYZ. LUCA.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000115747.
HOVERGENiHBG004016.
InParanoidiQ8NHV1.
OMAiIRECGNR.
OrthoDBiEOG091G0I0X.
PhylomeDBiQ8NHV1.
TreeFamiTF330845.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51720. G_AIG1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESEDRSLR IVLVGKTGSG KSATANTILG EEIFDSRIAA QAVTKNCQKA
60 70 80 90 100
SREWQGRDLL VVDTPGLFDT KESLDTTCKE ISRCIISSCP GPHAIVLVLL
110 120 130 140 150
LGRYTEEEQK TVALIKAVFG KSAMKHMVIL FTRKEELEGQ SFHDFIADAD
160 170 180 190 200
VGLKSIVKEC GNRCCAFSNS KKTSKAEKES QVQELVELIE KMVQCNEGAY
210 220 230 240 250
FSDDIYKDTE ERLKQREEVL RKIYTDQLNE EIKLVEEDKH KSEEEKEKEI
260 270 280 290 300
KLLKLKYDEK IKNIREEAER NIFKDVFNRI WKMLSEIWHR FLSKCKFYSS
Length:300
Mass (Da):34,509
Last modified:October 1, 2002 - v1
Checksum:i1E4889F4D7A011A2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04953483R → C.Corresponds to variant rs3735080dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027613 mRNA. Translation: AAH27613.1.
CCDSiCCDS5903.1.
RefSeqiNP_694968.1. NM_153236.3.
UniGeneiHs.647074.

Genome annotation databases

EnsembliENST00000313543; ENSP00000315474; ENSG00000179144.
GeneIDi168537.
KEGGihsa:168537.
UCSCiuc003whk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027613 mRNA. Translation: AAH27613.1.
CCDSiCCDS5903.1.
RefSeqiNP_694968.1. NM_153236.3.
UniGeneiHs.647074.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZJCX-ray3.15A/B/C/D/E/F1-300[»]
ProteinModelPortaliQ8NHV1.
SMRiQ8NHV1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60142N.

PTM databases

iPTMnetiQ8NHV1.
PhosphoSitePlusiQ8NHV1.
SwissPalmiQ8NHV1.

Polymorphism and mutation databases

BioMutaiGIMAP7.
DMDMi55976538.

Proteomic databases

MaxQBiQ8NHV1.
PaxDbiQ8NHV1.
PeptideAtlasiQ8NHV1.
PRIDEiQ8NHV1.

Protocols and materials databases

DNASUi168537.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313543; ENSP00000315474; ENSG00000179144.
GeneIDi168537.
KEGGihsa:168537.
UCSCiuc003whk.4. human.

Organism-specific databases

CTDi168537.
DisGeNETi168537.
GeneCardsiGIMAP7.
HGNCiHGNC:22404. GIMAP7.
HPAiHPA020266.
HPA020268.
MIMi616961. gene.
neXtProtiNX_Q8NHV1.
OpenTargetsiENSG00000179144.
PharmGKBiPA134915933.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IM0G. Eukaryota.
ENOG4111GYZ. LUCA.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000115747.
HOVERGENiHBG004016.
InParanoidiQ8NHV1.
OMAiIRECGNR.
OrthoDBiEOG091G0I0X.
PhylomeDBiQ8NHV1.
TreeFamiTF330845.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179144-MONOMER.

Miscellaneous databases

ChiTaRSiGIMAP7. human.
GenomeRNAii168537.
PROiQ8NHV1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179144.
CleanExiHS_GIMAP7.
ExpressionAtlasiQ8NHV1. baseline and differential.
GenevisibleiQ8NHV1. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51720. G_AIG1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGIMA7_HUMAN
AccessioniPrimary (citable) accession number: Q8NHV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.