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Protein

GTPase IMAP family member 7

Gene

GIMAP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The dimer has GTPase activity; the active site contains residues from both subunits.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361GTP
Sitei103 – 1031Important for catalytic activity
Binding sitei169 – 1691GTP

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 239GTP
Nucleotide bindingi133 – 1353GTP

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase IMAP family member 7
Alternative name(s):
Immunity-associated nucleotide 7 protein
Short name:
IAN-7
Gene namesi
Name:GIMAP7
Synonyms:IAN7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22404. GIMAP7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • lipid particle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Lipid droplet

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi103 – 1031R → D: Abolishes GTPase activity. No effect on GTP binding and on dimerization. 1 Publication
Mutagenesisi136 – 1361E → W: Impairs dimerization and abolishes GTPase activity. No effect on GTP binding. 1 Publication

Organism-specific databases

PharmGKBiPA134915933.

Polymorphism and mutation databases

BioMutaiGIMAP7.
DMDMi55976538.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300GTPase IMAP family member 7PRO_0000190993Add
BLAST

Proteomic databases

EPDiQ8NHV1.
MaxQBiQ8NHV1.
PaxDbiQ8NHV1.
PeptideAtlasiQ8NHV1.
PRIDEiQ8NHV1.

PTM databases

iPTMnetiQ8NHV1.
PhosphoSiteiQ8NHV1.
SwissPalmiQ8NHV1.

Expressioni

Tissue specificityi

Detected in T-cells.1 Publication

Gene expression databases

BgeeiQ8NHV1.
CleanExiHS_GIMAP7.
ExpressionAtlasiQ8NHV1. baseline and differential.
GenevisibleiQ8NHV1. HS.

Organism-specific databases

HPAiHPA020266.
HPA020268.

Interactioni

Subunit structurei

Monomer in the presence of bound GDP and in the absence of bound nucleotide. Homodimer in the presence of bound GTP. Heterodimer with GIMAP2.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

DIPiDIP-60142N.

Structurei

Secondary structure

1
300
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 157Combined sources
Helixi21 – 299Combined sources
Beta strandi48 – 536Combined sources
Beta strandi55 – 639Combined sources
Helixi74 – 8815Combined sources
Beta strandi93 – 10210Combined sources
Helixi106 – 11914Combined sources
Helixi121 – 1255Combined sources
Beta strandi126 – 1327Combined sources
Helixi134 – 1363Combined sources
Helixi142 – 1476Combined sources
Helixi151 – 1599Combined sources
Beta strandi164 – 1663Combined sources
Helixi175 – 19521Combined sources
Helixi204 – 23734Combined sources
Helixi243 – 26119Combined sources
Helixi264 – 2718Combined sources
Helixi273 – 28715Combined sources
Helixi288 – 2903Combined sources
Helixi296 – 2983Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZJCX-ray3.15A/B/C/D/E/F1-300[»]
ProteinModelPortaliQ8NHV1.
SMRiQ8NHV1. Positions 8-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 210205AIG1-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IM0G. Eukaryota.
ENOG4111GYZ. LUCA.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000115747.
HOVERGENiHBG004016.
InParanoidiQ8NHV1.
OMAiIRECGNR.
OrthoDBiEOG7XM2Z9.
PhylomeDBiQ8NHV1.
TreeFamiTF330845.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51720. G_AIG1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESEDRSLR IVLVGKTGSG KSATANTILG EEIFDSRIAA QAVTKNCQKA
60 70 80 90 100
SREWQGRDLL VVDTPGLFDT KESLDTTCKE ISRCIISSCP GPHAIVLVLL
110 120 130 140 150
LGRYTEEEQK TVALIKAVFG KSAMKHMVIL FTRKEELEGQ SFHDFIADAD
160 170 180 190 200
VGLKSIVKEC GNRCCAFSNS KKTSKAEKES QVQELVELIE KMVQCNEGAY
210 220 230 240 250
FSDDIYKDTE ERLKQREEVL RKIYTDQLNE EIKLVEEDKH KSEEEKEKEI
260 270 280 290 300
KLLKLKYDEK IKNIREEAER NIFKDVFNRI WKMLSEIWHR FLSKCKFYSS
Length:300
Mass (Da):34,509
Last modified:October 1, 2002 - v1
Checksum:i1E4889F4D7A011A2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831R → C.
Corresponds to variant rs3735080 [ dbSNP | Ensembl ].
VAR_049534

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027613 mRNA. Translation: AAH27613.1.
CCDSiCCDS5903.1.
RefSeqiNP_694968.1. NM_153236.3.
UniGeneiHs.647074.

Genome annotation databases

EnsembliENST00000313543; ENSP00000315474; ENSG00000179144.
GeneIDi168537.
KEGGihsa:168537.
UCSCiuc003whk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027613 mRNA. Translation: AAH27613.1.
CCDSiCCDS5903.1.
RefSeqiNP_694968.1. NM_153236.3.
UniGeneiHs.647074.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZJCX-ray3.15A/B/C/D/E/F1-300[»]
ProteinModelPortaliQ8NHV1.
SMRiQ8NHV1. Positions 8-295.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60142N.

PTM databases

iPTMnetiQ8NHV1.
PhosphoSiteiQ8NHV1.
SwissPalmiQ8NHV1.

Polymorphism and mutation databases

BioMutaiGIMAP7.
DMDMi55976538.

Proteomic databases

EPDiQ8NHV1.
MaxQBiQ8NHV1.
PaxDbiQ8NHV1.
PeptideAtlasiQ8NHV1.
PRIDEiQ8NHV1.

Protocols and materials databases

DNASUi168537.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313543; ENSP00000315474; ENSG00000179144.
GeneIDi168537.
KEGGihsa:168537.
UCSCiuc003whk.4. human.

Organism-specific databases

CTDi168537.
GeneCardsiGIMAP7.
HGNCiHGNC:22404. GIMAP7.
HPAiHPA020266.
HPA020268.
neXtProtiNX_Q8NHV1.
PharmGKBiPA134915933.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IM0G. Eukaryota.
ENOG4111GYZ. LUCA.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000115747.
HOVERGENiHBG004016.
InParanoidiQ8NHV1.
OMAiIRECGNR.
OrthoDBiEOG7XM2Z9.
PhylomeDBiQ8NHV1.
TreeFamiTF330845.

Miscellaneous databases

ChiTaRSiGIMAP7. human.
GenomeRNAii168537.
PROiQ8NHV1.

Gene expression databases

BgeeiQ8NHV1.
CleanExiHS_GIMAP7.
ExpressionAtlasiQ8NHV1. baseline and differential.
GenevisibleiQ8NHV1. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51720. G_AIG1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (3.15 ANGSTROMS) IN COMPLEX WITH GTP ANALOG, FUNCTION, INTERACTION WITH GIMAP2, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF ARG-103 AND GLU-136.

Entry informationi

Entry nameiGIMA7_HUMAN
AccessioniPrimary (citable) accession number: Q8NHV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.