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Protein

Tudor domain-containing protein 7

Gene

TDRD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.1 Publication

GO - Molecular functioni

  • mRNA binding Source: UniProtKB

GO - Biological processi

  • lens fiber cell differentiation Source: UniProtKB
  • lens morphogenesis in camera-type eye Source: UniProtKB
  • posttranscriptional regulation of gene expression Source: UniProtKB
  • spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tudor domain-containing protein 7
Alternative name(s):
PCTAIRE2-binding protein
Tudor repeat associator with PCTAIRE-2
Short name:
Trap
Gene namesi
Name:TDRD7
Synonyms:PCTAIRE2BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:30831. TDRD7.

Subcellular locationi

GO - Cellular componenti

  • chromatoid body Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • mitochondrial matrix Source: Ensembl
  • ribonucleoprotein granule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Cataract 36 (CTRCT36)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn opacification of the crystalline lens of the eye becoming evident at birth. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.
See also OMIM:613887
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065247618Missing in CTRCT36. 1 Publication1

Keywords - Diseasei

Cataract, Disease mutation

Organism-specific databases

DisGeNETi23424.
MalaCardsiTDRD7.
MIMi613887. phenotype.
OpenTargetsiENSG00000196116.
PharmGKBiPA134937960.

Polymorphism and mutation databases

BioMutaiTDRD7.
DMDMi152031705.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001831691 – 1098Tudor domain-containing protein 7Add BLAST1098

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei319PhosphoserineCombined sources1
Modified residuei859PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NHU6.
MaxQBiQ8NHU6.
PaxDbiQ8NHU6.
PeptideAtlasiQ8NHU6.
PRIDEiQ8NHU6.

PTM databases

iPTMnetiQ8NHU6.
PhosphoSitePlusiQ8NHU6.

Expressioni

Gene expression databases

BgeeiENSG00000196116.
CleanExiHS_TDRD7.
GenevisibleiQ8NHU6. HS.

Organism-specific databases

HPAiCAB020800.
HPA024529.

Interactioni

Subunit structurei

Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CDKN2AP427712EBI-624505,EBI-375053
GABPB1Q065474EBI-624505,EBI-618165
TACC1O754104EBI-624505,EBI-624237
TACC1O75410-13EBI-624505,EBI-624252

Protein-protein interaction databases

BioGridi116994. 9 interactors.
IntActiQ8NHU6. 18 interactors.
MINTiMINT-2871006.
STRINGi9606.ENSP00000347444.

Structurei

Secondary structure

11098
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 16Combined sources14
Helixi24 – 35Combined sources12
Turni41 – 45Combined sources5
Helixi49 – 54Combined sources6
Turni57 – 59Combined sources3
Beta strandi60 – 64Combined sources5
Beta strandi70 – 74Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RCOX-ray1.80A/B1-82[»]
ProteinModelPortaliQ8NHU6.
SMRiQ8NHU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 76HTH OST-type 1PROSITE-ProRule annotationAdd BLAST74
Domaini233 – 302HTH OST-type 2PROSITE-ProRule annotationAdd BLAST70
Domaini337 – 406HTH OST-type 3PROSITE-ProRule annotationAdd BLAST70
Domaini513 – 570Tudor 1PROSITE-ProRule annotationAdd BLAST58
Domaini703 – 760Tudor 2PROSITE-ProRule annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni861 – 1098Interaction with CDK17By similarityAdd BLAST238
Regioni893 – 1098Interaction with CABLES1By similarityAdd BLAST206

Sequence similaritiesi

Belongs to the TDRD7 family.Curated
Contains 3 HTH OST-type domains.PROSITE-ProRule annotation
Contains 2 Tudor domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IPR1. Eukaryota.
ENOG410XST4. LUCA.
GeneTreeiENSGT00850000132373.
HOVERGENiHBG103662.
InParanoidiQ8NHU6.
KOiK18405.
OMAiVISTEEN.
OrthoDBiEOG091G00Z5.
PhylomeDBiQ8NHU6.

Family and domain databases

InterProiIPR025605. OST-HTH/LOTUS_dom.
IPR002999. Tudor.
[Graphical view]
PfamiPF12872. OST-HTH. 2 hits.
PF00567. TUDOR. 3 hits.
[Graphical view]
SMARTiSM00333. TUDOR. 2 hits.
[Graphical view]
PROSITEiPS51644. HTH_OST. 3 hits.
PS50304. TUDOR. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NHU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLEGDLVSKM LRAVLQSHKN GVALPRLQGE YRSLTGDWIP FKQLGFPTLE
60 70 80 90 100
AYLRSVPAVV RIETSRSGEI TCYAMACTET ARIAQLVARQ RSSKRKTGRQ
110 120 130 140 150
VNCQMRVKKT MPFFLEGKPK ATLRQPGFAS NFSVGKKPNP APLRDKGNSV
160 170 180 190 200
GVKPDAEMSP YMLHTTLGNE AFKDIPVQRH VTMSTNNRFS PKASLQPPLQ
210 220 230 240 250
MHLSRTSTKE MSDNLNQTVE KPNVKPPASY TYKMDEVQNR IKEILNKHNN
260 270 280 290 300
GIWISKLPHF YKELYKEDLN QGILQQFEHW PHICTVEKPC SGGQDLLLYP
310 320 330 340 350
AKRKQLLRSE LDTEKVPLSP LPGPKQTPPL KGCPTVMAGD FKEKVADLLV
360 370 380 390 400
KYTSGLWASA LPKAFEEMYK VKFPEDALKN LASLSDVCSI DYISGNPQKA
410 420 430 440 450
ILYAKLPLPT DKIQKDAGQA HGDNDIKAMV EQEYLQVEES IAESANTFME
460 470 480 490 500
DITVPPLMIP TEASPSVLVV ELSNTNEVVI RYVGKDYSAA QELMEDEMKE
510 520 530 540 550
YYSKNPKITP VQAVNVGQLL AVNAEEDAWL RAQVISTEEN KIKVCYVDYG
560 570 580 590 600
FSENVEKSKA YKLNPKFCSL SFQATKCKLA GLEVLSDDPD LVKVVESLTC
610 620 630 640 650
GKIFAVEILD KADIPLVVLY DTSGEDDINI NATCLKAICD KSLEVHLQVD
660 670 680 690 700
AMYTNVKVTN ICSDGTLYCQ VPCKGLNKLS DLLRKIEDYF HCKHMTSECF
710 720 730 740 750
VSLPFCGKIC LFHCKGKWLR VEITNVHSSR ALDVQFLDSG TVTSVKVSEL
760 770 780 790 800
REIPPRFLQE MIAIPPQAIK CCLADLPQSI GMWTPDAVLW LRDSVLNCSD
810 820 830 840 850
CSIKVTKVDE TRGIAHVYLF TPKNFPDPHR SINRQITNAD LWKHQKDVFL
860 870 880 890 900
SAISSGADSP NSKNGNMPMS GNTGENFRKN LTDVIKKSMV DHTSAFSTEE
910 920 930 940 950
LPPPVHLSKP GEHMDVYVPV ACHPGYFVIQ PWQEIHKLEV LMEEMILYYS
960 970 980 990 1000
VSEERHIAVE KDQVYAAKVE NKWHRVLLKG ILTNGLVSVY ELDYGKHELV
1010 1020 1030 1040 1050
NIRKVQPLVD MFRKLPFQAV TAQLAGVKCN QWSEEASMVF RNHVEKKPLV
1060 1070 1080 1090
ALVQTVIENA NPWDRKVVVY LVDTSLPDTD TWIHDFMSEY LIELSKVN
Length:1,098
Mass (Da):123,586
Last modified:July 10, 2007 - v2
Checksum:iF27E383E5B18C428
GO
Isoform 2 (identifier: Q8NHU6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.

Note: No experimental confirmation available.
Show »
Length:1,024
Mass (Da):115,338
Checksum:i37280FAC875C7EE5
GO
Isoform 3 (identifier: Q8NHU6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-651: Missing.
     694-722: Missing.

Note: No experimental confirmation available.
Show »
Length:418
Mass (Da):47,539
Checksum:iADDFA5052CF8D146
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti659T → A in BAG63369 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019070150V → A.2 PublicationsCorresponds to variant rs2045732dbSNPEnsembl.1
Natural variantiVAR_033044456P → L.1 PublicationCorresponds to variant rs17852595dbSNPEnsembl.1
Natural variantiVAR_065247618Missing in CTRCT36. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0413141 – 651Missing in isoform 3. 1 PublicationAdd BLAST651
Alternative sequenceiVSP_0413151 – 74Missing in isoform 2. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_041316694 – 722Missing in isoform 3. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294488 mRNA. Translation: BAG57710.1.
AK301954 mRNA. Translation: BAG63369.1.
AK314853 mRNA. Translation: BAG37370.1.
AL512590, AL449464 Genomic DNA. Translation: CAH71605.1.
AL449464, AL512590 Genomic DNA. Translation: CAI14933.1.
CH471105 Genomic DNA. Translation: EAW58844.1.
BC028694 mRNA. Translation: AAH28694.1.
AB025254 mRNA. Translation: BAA76379.1.
AL122110 mRNA. Translation: CAB59271.1.
CCDSiCCDS6725.1. [Q8NHU6-1]
PIRiT34547.
RefSeqiNP_001289813.1. NM_001302884.1. [Q8NHU6-2]
NP_055105.2. NM_014290.2. [Q8NHU6-1]
UniGeneiHs.193842.

Genome annotation databases

EnsembliENST00000355295; ENSP00000347444; ENSG00000196116. [Q8NHU6-1]
GeneIDi23424.
KEGGihsa:23424.
UCSCiuc004axj.4. human. [Q8NHU6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294488 mRNA. Translation: BAG57710.1.
AK301954 mRNA. Translation: BAG63369.1.
AK314853 mRNA. Translation: BAG37370.1.
AL512590, AL449464 Genomic DNA. Translation: CAH71605.1.
AL449464, AL512590 Genomic DNA. Translation: CAI14933.1.
CH471105 Genomic DNA. Translation: EAW58844.1.
BC028694 mRNA. Translation: AAH28694.1.
AB025254 mRNA. Translation: BAA76379.1.
AL122110 mRNA. Translation: CAB59271.1.
CCDSiCCDS6725.1. [Q8NHU6-1]
PIRiT34547.
RefSeqiNP_001289813.1. NM_001302884.1. [Q8NHU6-2]
NP_055105.2. NM_014290.2. [Q8NHU6-1]
UniGeneiHs.193842.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RCOX-ray1.80A/B1-82[»]
ProteinModelPortaliQ8NHU6.
SMRiQ8NHU6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116994. 9 interactors.
IntActiQ8NHU6. 18 interactors.
MINTiMINT-2871006.
STRINGi9606.ENSP00000347444.

PTM databases

iPTMnetiQ8NHU6.
PhosphoSitePlusiQ8NHU6.

Polymorphism and mutation databases

BioMutaiTDRD7.
DMDMi152031705.

Proteomic databases

EPDiQ8NHU6.
MaxQBiQ8NHU6.
PaxDbiQ8NHU6.
PeptideAtlasiQ8NHU6.
PRIDEiQ8NHU6.

Protocols and materials databases

DNASUi23424.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355295; ENSP00000347444; ENSG00000196116. [Q8NHU6-1]
GeneIDi23424.
KEGGihsa:23424.
UCSCiuc004axj.4. human. [Q8NHU6-1]

Organism-specific databases

CTDi23424.
DisGeNETi23424.
GeneCardsiTDRD7.
H-InvDBHIX0008211.
HGNCiHGNC:30831. TDRD7.
HPAiCAB020800.
HPA024529.
MalaCardsiTDRD7.
MIMi611258. gene.
613887. phenotype.
neXtProtiNX_Q8NHU6.
OpenTargetsiENSG00000196116.
PharmGKBiPA134937960.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPR1. Eukaryota.
ENOG410XST4. LUCA.
GeneTreeiENSGT00850000132373.
HOVERGENiHBG103662.
InParanoidiQ8NHU6.
KOiK18405.
OMAiVISTEEN.
OrthoDBiEOG091G00Z5.
PhylomeDBiQ8NHU6.

Miscellaneous databases

ChiTaRSiTDRD7. human.
GeneWikiiTDRD7.
GenomeRNAii23424.
PROiQ8NHU6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196116.
CleanExiHS_TDRD7.
GenevisibleiQ8NHU6. HS.

Family and domain databases

InterProiIPR025605. OST-HTH/LOTUS_dom.
IPR002999. Tudor.
[Graphical view]
PfamiPF12872. OST-HTH. 2 hits.
PF00567. TUDOR. 3 hits.
[Graphical view]
SMARTiSM00333. TUDOR. 2 hits.
[Graphical view]
PROSITEiPS51644. HTH_OST. 3 hits.
PS50304. TUDOR. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTDRD7_HUMAN
AccessioniPrimary (citable) accession number: Q8NHU6
Secondary accession number(s): A6NCI6
, B2RBX3, B4DG99, B4DXF7, E7EQD4, Q5VV27, Q96JT1, Q9UFF0, Q9Y2M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: July 10, 2007
Last modified: November 2, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.