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Q8NHU6

- TDRD7_HUMAN

UniProt

Q8NHU6 - TDRD7_HUMAN

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Protein

Tudor domain-containing protein 7

Gene

TDRD7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.1 Publication

GO - Molecular functioni

  1. mRNA binding Source: UniProtKB

GO - Biological processi

  1. germ cell development Source: Ensembl
  2. lens fiber cell differentiation Source: UniProtKB
  3. lens morphogenesis in camera-type eye Source: UniProtKB
  4. posttranscriptional regulation of gene expression Source: UniProtKB
  5. spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tudor domain-containing protein 7
Alternative name(s):
PCTAIRE2-binding protein
Tudor repeat associator with PCTAIRE-2
Short name:
Trap
Gene namesi
Name:TDRD7
Synonyms:PCTAIRE2BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:30831. TDRD7.

Subcellular locationi

Cytoplasm 1 Publication
Note: Localizes to cytoplasmic RNA granules. Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids (By similarity).By similarity

GO - Cellular componenti

  1. chromatoid body Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. mitochondrial matrix Source: Ensembl
  4. P granule Source: Ensembl
  5. ribonucleoprotein granule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Cataract 36 (CTRCT36) [MIM:613887]: An opacification of the crystalline lens of the eye becoming evident at birth. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti618 – 6181Missing in CTRCT36. 1 Publication
VAR_065247

Keywords - Diseasei

Cataract, Disease mutation

Organism-specific databases

MIMi613887. phenotype.
PharmGKBiPA134937960.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10981098Tudor domain-containing protein 7PRO_0000183169Add
BLAST

Proteomic databases

MaxQBiQ8NHU6.
PaxDbiQ8NHU6.
PRIDEiQ8NHU6.

PTM databases

PhosphoSiteiQ8NHU6.

Expressioni

Gene expression databases

BgeeiQ8NHU6.
CleanExiHS_TDRD7.
GenevestigatoriQ8NHU6.

Organism-specific databases

HPAiCAB020800.
HPA024529.

Interactioni

Subunit structurei

Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CDKN2AP427712EBI-624505,EBI-375053
TACC1O754104EBI-624505,EBI-624237
TACC1O75410-13EBI-624505,EBI-624252

Protein-protein interaction databases

BioGridi116994. 9 interactions.
IntActiQ8NHU6. 6 interactions.
MINTiMINT-2871006.
STRINGi9606.ENSP00000347444.

Structurei

Secondary structure

1
1098
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1614
Helixi24 – 3512
Turni41 – 455
Helixi49 – 546
Turni57 – 593
Beta strandi60 – 645
Beta strandi70 – 745

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3RCOX-ray1.80A/B1-82[»]
ProteinModelPortaliQ8NHU6.
SMRiQ8NHU6. Positions 1-77, 234-412, 663-787, 970-1077.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 7674HTH OST-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini233 – 30270HTH OST-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini337 – 40670HTH OST-type 3PROSITE-ProRule annotationAdd
BLAST
Domaini513 – 57058Tudor 1PROSITE-ProRule annotationAdd
BLAST
Domaini703 – 76058Tudor 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni861 – 1098238Interacts with CDK17By similarityAdd
BLAST
Regioni893 – 1098206Interacts with CABLES1By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the TDRD7 family.Curated
Contains 3 HTH OST-type domains.PROSITE-ProRule annotation
Contains 2 Tudor domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG256635.
GeneTreeiENSGT00760000119374.
HOVERGENiHBG103662.
InParanoidiQ8NHU6.
KOiK18405.
OMAiYDTSGED.
OrthoDBiEOG7BW0HQ.
PhylomeDBiQ8NHU6.

Family and domain databases

InterProiIPR025605. OST-HTH/LOTUS_dom.
IPR002999. Tudor.
[Graphical view]
PfamiPF12872. OST-HTH. 1 hit.
PF00567. TUDOR. 3 hits.
[Graphical view]
SMARTiSM00333. TUDOR. 2 hits.
[Graphical view]
PROSITEiPS51644. HTH_OST. 3 hits.
PS50304. TUDOR. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NHU6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLEGDLVSKM LRAVLQSHKN GVALPRLQGE YRSLTGDWIP FKQLGFPTLE
60 70 80 90 100
AYLRSVPAVV RIETSRSGEI TCYAMACTET ARIAQLVARQ RSSKRKTGRQ
110 120 130 140 150
VNCQMRVKKT MPFFLEGKPK ATLRQPGFAS NFSVGKKPNP APLRDKGNSV
160 170 180 190 200
GVKPDAEMSP YMLHTTLGNE AFKDIPVQRH VTMSTNNRFS PKASLQPPLQ
210 220 230 240 250
MHLSRTSTKE MSDNLNQTVE KPNVKPPASY TYKMDEVQNR IKEILNKHNN
260 270 280 290 300
GIWISKLPHF YKELYKEDLN QGILQQFEHW PHICTVEKPC SGGQDLLLYP
310 320 330 340 350
AKRKQLLRSE LDTEKVPLSP LPGPKQTPPL KGCPTVMAGD FKEKVADLLV
360 370 380 390 400
KYTSGLWASA LPKAFEEMYK VKFPEDALKN LASLSDVCSI DYISGNPQKA
410 420 430 440 450
ILYAKLPLPT DKIQKDAGQA HGDNDIKAMV EQEYLQVEES IAESANTFME
460 470 480 490 500
DITVPPLMIP TEASPSVLVV ELSNTNEVVI RYVGKDYSAA QELMEDEMKE
510 520 530 540 550
YYSKNPKITP VQAVNVGQLL AVNAEEDAWL RAQVISTEEN KIKVCYVDYG
560 570 580 590 600
FSENVEKSKA YKLNPKFCSL SFQATKCKLA GLEVLSDDPD LVKVVESLTC
610 620 630 640 650
GKIFAVEILD KADIPLVVLY DTSGEDDINI NATCLKAICD KSLEVHLQVD
660 670 680 690 700
AMYTNVKVTN ICSDGTLYCQ VPCKGLNKLS DLLRKIEDYF HCKHMTSECF
710 720 730 740 750
VSLPFCGKIC LFHCKGKWLR VEITNVHSSR ALDVQFLDSG TVTSVKVSEL
760 770 780 790 800
REIPPRFLQE MIAIPPQAIK CCLADLPQSI GMWTPDAVLW LRDSVLNCSD
810 820 830 840 850
CSIKVTKVDE TRGIAHVYLF TPKNFPDPHR SINRQITNAD LWKHQKDVFL
860 870 880 890 900
SAISSGADSP NSKNGNMPMS GNTGENFRKN LTDVIKKSMV DHTSAFSTEE
910 920 930 940 950
LPPPVHLSKP GEHMDVYVPV ACHPGYFVIQ PWQEIHKLEV LMEEMILYYS
960 970 980 990 1000
VSEERHIAVE KDQVYAAKVE NKWHRVLLKG ILTNGLVSVY ELDYGKHELV
1010 1020 1030 1040 1050
NIRKVQPLVD MFRKLPFQAV TAQLAGVKCN QWSEEASMVF RNHVEKKPLV
1060 1070 1080 1090
ALVQTVIENA NPWDRKVVVY LVDTSLPDTD TWIHDFMSEY LIELSKVN
Length:1,098
Mass (Da):123,586
Last modified:July 10, 2007 - v2
Checksum:iF27E383E5B18C428
GO
Isoform 2 (identifier: Q8NHU6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.

Note: No experimental confirmation available.

Show »
Length:1,024
Mass (Da):115,338
Checksum:i37280FAC875C7EE5
GO
Isoform 3 (identifier: Q8NHU6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-651: Missing.
     694-722: Missing.

Note: No experimental confirmation available.

Show »
Length:418
Mass (Da):47,539
Checksum:iADDFA5052CF8D146
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti659 – 6591T → A in BAG63369. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti150 – 1501V → A.2 Publications
Corresponds to variant rs2045732 [ dbSNP | Ensembl ].
VAR_019070
Natural varianti456 – 4561P → L.1 Publication
Corresponds to variant rs17852595 [ dbSNP | Ensembl ].
VAR_033044
Natural varianti618 – 6181Missing in CTRCT36. 1 Publication
VAR_065247

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 651651Missing in isoform 3. 1 PublicationVSP_041314Add
BLAST
Alternative sequencei1 – 7474Missing in isoform 2. 1 PublicationVSP_041315Add
BLAST
Alternative sequencei694 – 72229Missing in isoform 3. 1 PublicationVSP_041316Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK294488 mRNA. Translation: BAG57710.1.
AK301954 mRNA. Translation: BAG63369.1.
AK314853 mRNA. Translation: BAG37370.1.
AL512590, AL449464 Genomic DNA. Translation: CAH71605.1.
AL449464, AL512590 Genomic DNA. Translation: CAI14933.1.
CH471105 Genomic DNA. Translation: EAW58844.1.
BC028694 mRNA. Translation: AAH28694.1.
AB025254 mRNA. Translation: BAA76379.1.
AL122110 mRNA. Translation: CAB59271.1.
CCDSiCCDS6725.1. [Q8NHU6-1]
PIRiT34547.
RefSeqiNP_055105.2. NM_014290.2. [Q8NHU6-1]
XP_006717088.1. XM_006717025.1. [Q8NHU6-2]
UniGeneiHs.193842.

Genome annotation databases

EnsembliENST00000355295; ENSP00000347444; ENSG00000196116. [Q8NHU6-1]
GeneIDi23424.
KEGGihsa:23424.
UCSCiuc004axj.3. human. [Q8NHU6-1]
uc011luy.2. human. [Q8NHU6-3]

Polymorphism databases

DMDMi152031705.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK294488 mRNA. Translation: BAG57710.1 .
AK301954 mRNA. Translation: BAG63369.1 .
AK314853 mRNA. Translation: BAG37370.1 .
AL512590 , AL449464 Genomic DNA. Translation: CAH71605.1 .
AL449464 , AL512590 Genomic DNA. Translation: CAI14933.1 .
CH471105 Genomic DNA. Translation: EAW58844.1 .
BC028694 mRNA. Translation: AAH28694.1 .
AB025254 mRNA. Translation: BAA76379.1 .
AL122110 mRNA. Translation: CAB59271.1 .
CCDSi CCDS6725.1. [Q8NHU6-1 ]
PIRi T34547.
RefSeqi NP_055105.2. NM_014290.2. [Q8NHU6-1 ]
XP_006717088.1. XM_006717025.1. [Q8NHU6-2 ]
UniGenei Hs.193842.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3RCO X-ray 1.80 A/B 1-82 [» ]
ProteinModelPortali Q8NHU6.
SMRi Q8NHU6. Positions 1-77, 234-412, 663-787, 970-1077.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116994. 9 interactions.
IntActi Q8NHU6. 6 interactions.
MINTi MINT-2871006.
STRINGi 9606.ENSP00000347444.

PTM databases

PhosphoSitei Q8NHU6.

Polymorphism databases

DMDMi 152031705.

Proteomic databases

MaxQBi Q8NHU6.
PaxDbi Q8NHU6.
PRIDEi Q8NHU6.

Protocols and materials databases

DNASUi 23424.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355295 ; ENSP00000347444 ; ENSG00000196116 . [Q8NHU6-1 ]
GeneIDi 23424.
KEGGi hsa:23424.
UCSCi uc004axj.3. human. [Q8NHU6-1 ]
uc011luy.2. human. [Q8NHU6-3 ]

Organism-specific databases

CTDi 23424.
GeneCardsi GC09P100174.
H-InvDB HIX0008211.
HGNCi HGNC:30831. TDRD7.
HPAi CAB020800.
HPA024529.
MIMi 611258. gene.
613887. phenotype.
neXtProti NX_Q8NHU6.
PharmGKBi PA134937960.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG256635.
GeneTreei ENSGT00760000119374.
HOVERGENi HBG103662.
InParanoidi Q8NHU6.
KOi K18405.
OMAi YDTSGED.
OrthoDBi EOG7BW0HQ.
PhylomeDBi Q8NHU6.

Miscellaneous databases

GeneWikii TDRD7.
GenomeRNAii 23424.
NextBioi 45647.
PROi Q8NHU6.
SOURCEi Search...

Gene expression databases

Bgeei Q8NHU6.
CleanExi HS_TDRD7.
Genevestigatori Q8NHU6.

Family and domain databases

InterProi IPR025605. OST-HTH/LOTUS_dom.
IPR002999. Tudor.
[Graphical view ]
Pfami PF12872. OST-HTH. 1 hit.
PF00567. TUDOR. 3 hits.
[Graphical view ]
SMARTi SM00333. TUDOR. 2 hits.
[Graphical view ]
PROSITEi PS51644. HTH_OST. 3 hits.
PS50304. TUDOR. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT ALA-150.
    Tissue: Amygdala and Testis.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-150.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-456.
    Tissue: Testis.
  5. "Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain."
    Hirose T., Kawabuchi M., Tamaru T., Okumura N., Nagai K., Okada M.
    Eur. J. Biochem. 267:2113-2121(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 631-1098.
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 837-1098.
    Tissue: Testis.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "LOTUS, a new domain associated with small RNA pathways in the germline."
    Callebaut I., Mornon J.P.
    Bioinformatics 26:1140-1144(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF THE HTH OST-TYPE DOMAIN.
  10. "OST-HTH: a novel predicted RNA-binding domain."
    Anantharaman V., Zhang D., Aravind L.
    Biol. Direct 5:13-13(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF THE HTH OST-TYPE DOMAIN.
  11. Cited for: FUNCTION, RNA-BINDING, SUBCELLULAR LOCATION, VARIANT CTRCT36 VAL-618 DEL.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTDRD7_HUMAN
AccessioniPrimary (citable) accession number: Q8NHU6
Secondary accession number(s): A6NCI6
, B2RBX3, B4DG99, B4DXF7, E7EQD4, Q5VV27, Q96JT1, Q9UFF0, Q9Y2M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: July 10, 2007
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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