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Protein

Cancer/testis antigen family 45 member A3

Gene

CT45A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Cancer/testis antigen family 45 member A3Imported
Alternative name(s):
Cancer/testis antigen 45-31 Publication
Cancer/testis antigen 45-41 Publication
Cancer/testis antigen 45A3Curated
Cancer/testis antigen 45A4Curated
Cancer/testis antigen family 45 member A4Imported
Gene namesi
Name:CT45A3Imported
Synonyms:CT45-31 Publication, CT45-41 Publication, CT45A4Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:33268. CT45A3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164718201.

Polymorphism and mutation databases

BioMutaiCT45A3.
DMDMi74751086.
74751317.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Cancer/testis antigen family 45 member A3PRO_0000308948Add
BLAST

Proteomic databases

PaxDbiQ8NHU0.
PeptideAtlasiQ8NHU0.
PRIDEiQ8NHU0.

PTM databases

iPTMnetiQ8NHU0.
PhosphoSiteiQ8NHU0.

Expressioni

Tissue specificityi

Testis specific. Expressed in cancer cell lines.1 Publication

Gene expression databases

BgeeiENSG00000232417.
GenevisibleiQ8NHU0. HS.

Organism-specific databases

HPAiHPA044735.
HPA044757.
HPA046872.
HPA046987.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SDCBPO005603EBI-8643558,EBI-727004
SDCBP2Q9H1904EBI-8643558,EBI-742426

Protein-protein interaction databases

BioGridi137546. 2 interactions.
IntActiQ8NHU0. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8NHU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CT45 family.

Phylogenomic databases

eggNOGiENOG410JH2S. Eukaryota.
ENOG41115DR. LUCA.
GeneTreeiENSGT00390000016655.
HOGENOMiHOG000082503.
HOVERGENiHBG095520.
InParanoidiQ8NHU0.
OMAiMEDELMN.
OrthoDBiEOG091G0L2U.
PhylomeDBiQ8NHU0.

Family and domain databases

InterProiIPR029307. INT_SG_DDX_CT_C.
[Graphical view]
PfamiPF15300. INT_SG_DDX_CT_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDKTEKVAV DPETVFKRPR ECDSPSYQKR QRMALLARKQ GAGDSLIAGS
60 70 80 90 100
AMSKEKKLMT GHAIPPSQLD SQIDDFTGFS KDRMMQKPGS NAPVGGNVTS
110 120 130 140 150
SFSGDDLECR ETASSPKSQR EINADIKRKL VKELRCVGQK YEKIFEMLEG
160 170 180
VQGPTAVRKR FFESIIKEAA RCMRRDFVKH LKKKLKRMI
Length:189
Mass (Da):21,331
Last modified:October 1, 2002 - v1
Checksum:i3A86AC9CB6D6F042
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201R → Q in AAW66467 (PubMed:15905330).Curated
Sequence conflicti120 – 1201R → Q in BAC05380 (PubMed:14702039).Curated
Sequence conflicti120 – 1201R → Q in CAI41549 (PubMed:15772651).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti55 – 551E → A.3 Publications
Corresponds to variant rs200277856 [ dbSNP | Ensembl ].
VAR_075898

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY743711 mRNA. Translation: AAW66466.1.
AY743712 mRNA. Translation: AAW66467.1.
AK098689 mRNA. Translation: BAC05380.1.
AC240441 Genomic DNA. No translation available.
AL590618 Genomic DNA. Translation: CAI41546.1.
AL590618 Genomic DNA. Translation: CAI41549.1.
CH471107 Genomic DNA. Translation: EAX11718.1.
CH471107 Genomic DNA. Translation: EAX11719.1.
BC028711 mRNA. Translation: AAH28711.1.
BC140735 mRNA. Translation: AAI40736.1.
BC144437 mRNA. Translation: AAI44438.1.
BC140926 mRNA. Translation: AAI40927.1.
CCDSiCCDS76030.1.
RefSeqiNP_001017435.1. NM_001017435.1.
XP_006724821.1. XM_006724758.3.
XP_011529642.1. XM_011531340.2.
UniGeneiHs.535080.
Hs.632281.

Genome annotation databases

EnsembliENST00000597510; ENSP00000471418; ENSG00000269096.
ENST00000598716; ENSP00000471571; ENSG00000269096.
GeneIDi441519.
KEGGihsa:441519.
hsa:441520.
UCSCiuc065bga.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY743711 mRNA. Translation: AAW66466.1.
AY743712 mRNA. Translation: AAW66467.1.
AK098689 mRNA. Translation: BAC05380.1.
AC240441 Genomic DNA. No translation available.
AL590618 Genomic DNA. Translation: CAI41546.1.
AL590618 Genomic DNA. Translation: CAI41549.1.
CH471107 Genomic DNA. Translation: EAX11718.1.
CH471107 Genomic DNA. Translation: EAX11719.1.
BC028711 mRNA. Translation: AAH28711.1.
BC140735 mRNA. Translation: AAI40736.1.
BC144437 mRNA. Translation: AAI44438.1.
BC140926 mRNA. Translation: AAI40927.1.
CCDSiCCDS76030.1.
RefSeqiNP_001017435.1. NM_001017435.1.
XP_006724821.1. XM_006724758.3.
XP_011529642.1. XM_011531340.2.
UniGeneiHs.535080.
Hs.632281.

3D structure databases

ProteinModelPortaliQ8NHU0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137546. 2 interactions.
IntActiQ8NHU0. 4 interactions.

PTM databases

iPTMnetiQ8NHU0.
PhosphoSiteiQ8NHU0.

Polymorphism and mutation databases

BioMutaiCT45A3.
DMDMi74751086.
74751317.

Proteomic databases

PaxDbiQ8NHU0.
PeptideAtlasiQ8NHU0.
PRIDEiQ8NHU0.

Protocols and materials databases

DNASUi441519.
441520.
541465.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000597510; ENSP00000471418; ENSG00000269096.
ENST00000598716; ENSP00000471571; ENSG00000269096.
GeneIDi441519.
KEGGihsa:441519.
hsa:441520.
UCSCiuc065bga.1. human.

Organism-specific databases

CTDi441519.
GeneCardsiCT45A3.
HGNCiHGNC:33268. CT45A3.
HPAiHPA044735.
HPA044757.
HPA046872.
HPA046987.
MIMi300794. gene.
300795. gene.
neXtProtiNX_P0DMU6.
NX_Q8NHU0.
PharmGKBiPA164718201.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JH2S. Eukaryota.
ENOG41115DR. LUCA.
GeneTreeiENSGT00390000016655.
HOGENOMiHOG000082503.
HOVERGENiHBG095520.
InParanoidiQ8NHU0.
OMAiMEDELMN.
OrthoDBiEOG091G0L2U.
PhylomeDBiQ8NHU0.

Miscellaneous databases

ChiTaRSiCT45A4. human.
GenomeRNAii441520.
PROiQ8NHU0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000232417.
GenevisibleiQ8NHU0. HS.

Family and domain databases

InterProiIPR029307. INT_SG_DDX_CT_C.
[Graphical view]
PfamiPF15300. INT_SG_DDX_CT_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCT453_HUMAN
AccessioniPrimary (citable) accession number: Q8NHU0
Secondary accession number(s): B2RU20
, B7ZMC9, D3DTG6, P0DMU6, Q8N7B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.