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Protein

Spermatogenesis-associated protein 22

Gene

SPATA22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Meiosis-specific protein required for homologous recombination in meiosis I.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Meiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 22
Alternative name(s):
Testis development protein NYD-SP20
Gene namesi
Name:SPATA22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30705. SPATA22.

Subcellular locationi

  • Chromosome By similarity

  • Note: Localizes on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on MEIOB (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670887.

Polymorphism and mutation databases

BioMutaiSPATA22.
DMDMi296452914.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Spermatogenesis-associated protein 22PRO_0000251605Add
BLAST

Proteomic databases

PaxDbiQ8NHS9.
PRIDEiQ8NHS9.

PTM databases

PhosphoSiteiQ8NHS9.

Expressioni

Tissue specificityi

Highly expressed in adult testis.1 Publication

Gene expression databases

BgeeiQ8NHS9.
CleanExiHS_SPATA22.
ExpressionAtlasiQ8NHS9. baseline and differential.
GenevisibleiQ8NHS9. HS.

Interactioni

Subunit structurei

Component of a multiprotein complex with MEIOB and SPATA22.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-7067260,EBI-618309

Protein-protein interaction databases

BioGridi124205. 7 interactions.
IntActiQ8NHS9. 5 interactions.
MINTiMINT-8201601.
STRINGi9606.ENSP00000380354.

Structurei

3D structure databases

ProteinModelPortaliQ8NHS9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IVC3. Eukaryota.
ENOG4111W26. LUCA.
GeneTreeiENSGT00390000018151.
HOGENOMiHOG000038032.
HOVERGENiHBG093993.
InParanoidiQ8NHS9.
OMAiQCKRTNL.
OrthoDBiEOG75F4FM.
PhylomeDBiQ8NHS9.
TreeFamiTF332549.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NHS9-1) [UniParc]FASTAAdd to basket

Also known as: NYD-SP20C, NYD-SP20D

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRSLNENSA RSTAGCLPVP LFNQKKRNRQ PLTSNPLKDD SGISTPSDNY
60 70 80 90 100
DFPPLPTDWA WEAVNPELAP VMKTVDTGQI PHSVSRPLRS QDSVFNSIQS
110 120 130 140 150
NTGRSQGGWS YRDGNKNTSL KTWNKNDFKP QCKRTNLVAN DGKNSCPVSS
160 170 180 190 200
GAQQQKQLRI PEPPNLSRNK ETELLRQTHS SKISGCTMRG LDKNSALQTL
210 220 230 240 250
KPNFQQNQYK KQMLDDIPED NTLKETSLYQ LQFKEKASSL RIISAVIESM
260 270 280 290 300
KYWREHAQKT VLLFEVLAVL DSAVTPGPYY SKTFLMRDGK NTLPCVFYEI
310 320 330 340 350
DRELPRLIRG RVHRCVGNYD QKKNIFQCVS VRPASVSEQK TFQAFVKIAD
360
VEMQYYINVM NET
Length:363
Mass (Da):41,318
Last modified:May 18, 2010 - v2
Checksum:i71E6C8E4BF2526B8
GO
Isoform 2 (identifier: Q8NHS9-2) [UniParc]FASTAAdd to basket

Also known as: NYD-SP20B

The sequence of this isoform differs from the canonical sequence as follows:
     15-57: Missing.

Show »
Length:320
Mass (Da):36,566
Checksum:iBF3BF821DB381707
GO
Isoform 3 (identifier: Q8NHS9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-363: AVLDSAVTPG...QYYINVMNET → GS

Note: No experimental confirmation available.
Show »
Length:269
Mass (Da):30,380
Checksum:iC77EE4552F17BCC2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61N → S in AAK51120 (PubMed:15713825).Curated
Sequence conflicti6 – 61N → S in AAK53408 (PubMed:15713825).Curated
Sequence conflicti6 – 61N → S in AAK61373 (PubMed:15713825).Curated
Sequence conflicti6 – 61N → S in AAK61374 (PubMed:15713825).Curated
Sequence conflicti84 – 841V → A in AAK53408 (PubMed:15713825).Curated
Sequence conflicti84 – 841V → A in AAK61373 (PubMed:15713825).Curated
Sequence conflicti84 – 841V → A in AAK61374 (PubMed:15713825).Curated
Sequence conflicti106 – 1061Q → R in BAG63323 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti112 – 1121R → T.
Corresponds to variant rs2291604 [ dbSNP | Ensembl ].
VAR_027693
Natural varianti148 – 1481V → M.1 Publication
Corresponds to variant rs1488690 [ dbSNP | Ensembl ].
VAR_027694
Natural varianti155 – 1551Q → R.
Corresponds to variant rs11556563 [ dbSNP | Ensembl ].
VAR_027695
Natural varianti160 – 1601I → T.1 Publication
Corresponds to variant rs1488689 [ dbSNP | Ensembl ].
VAR_027696

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei15 – 5743Missing in isoform 2. 1 PublicationVSP_020763Add
BLAST
Alternative sequencei268 – 36396AVLDS…VMNET → GS in isoform 3. 1 PublicationVSP_044858Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367472 mRNA. Translation: AAK53408.1.
AY032684 mRNA. Translation: AAK51120.1.
AY035867 mRNA. Translation: AAK61373.1.
AY035868 mRNA. Translation: AAK61374.1.
AK301892 mRNA. Translation: BAG63323.1.
AC025125 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90508.1.
CH471108 Genomic DNA. Translation: EAW90509.1.
CH471108 Genomic DNA. Translation: EAW90510.1.
CH471108 Genomic DNA. Translation: EAW90511.1.
BC029483 mRNA. Translation: AAH29483.1.
CCDSiCCDS11027.1. [Q8NHS9-1]
CCDS54066.1. [Q8NHS9-2]
CCDS54067.1. [Q8NHS9-3]
RefSeqiNP_001164166.1. NM_001170695.1. [Q8NHS9-1]
NP_001164167.1. NM_001170696.1. [Q8NHS9-2]
NP_001164168.1. NM_001170697.1. [Q8NHS9-1]
NP_001164169.1. NM_001170698.1. [Q8NHS9-1]
NP_001164170.1. NM_001170699.1. [Q8NHS9-3]
NP_115987.2. NM_032598.4. [Q8NHS9-1]
XP_005256886.1. XM_005256829.1. [Q8NHS9-1]
XP_011522345.1. XM_011524043.1. [Q8NHS9-1]
UniGeneiHs.351068.

Genome annotation databases

EnsembliENST00000268981; ENSP00000268981; ENSG00000141255. [Q8NHS9-3]
ENST00000355380; ENSP00000347541; ENSG00000141255. [Q8NHS9-2]
ENST00000397168; ENSP00000380354; ENSG00000141255. [Q8NHS9-1]
ENST00000572969; ENSP00000460187; ENSG00000141255. [Q8NHS9-1]
ENST00000573128; ENSP00000459580; ENSG00000141255. [Q8NHS9-1]
ENST00000575375; ENSP00000459329; ENSG00000141255. [Q8NHS9-1]
GeneIDi84690.
KEGGihsa:84690.
UCSCiuc002fvm.5. human. [Q8NHS9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367472 mRNA. Translation: AAK53408.1.
AY032684 mRNA. Translation: AAK51120.1.
AY035867 mRNA. Translation: AAK61373.1.
AY035868 mRNA. Translation: AAK61374.1.
AK301892 mRNA. Translation: BAG63323.1.
AC025125 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90508.1.
CH471108 Genomic DNA. Translation: EAW90509.1.
CH471108 Genomic DNA. Translation: EAW90510.1.
CH471108 Genomic DNA. Translation: EAW90511.1.
BC029483 mRNA. Translation: AAH29483.1.
CCDSiCCDS11027.1. [Q8NHS9-1]
CCDS54066.1. [Q8NHS9-2]
CCDS54067.1. [Q8NHS9-3]
RefSeqiNP_001164166.1. NM_001170695.1. [Q8NHS9-1]
NP_001164167.1. NM_001170696.1. [Q8NHS9-2]
NP_001164168.1. NM_001170697.1. [Q8NHS9-1]
NP_001164169.1. NM_001170698.1. [Q8NHS9-1]
NP_001164170.1. NM_001170699.1. [Q8NHS9-3]
NP_115987.2. NM_032598.4. [Q8NHS9-1]
XP_005256886.1. XM_005256829.1. [Q8NHS9-1]
XP_011522345.1. XM_011524043.1. [Q8NHS9-1]
UniGeneiHs.351068.

3D structure databases

ProteinModelPortaliQ8NHS9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124205. 7 interactions.
IntActiQ8NHS9. 5 interactions.
MINTiMINT-8201601.
STRINGi9606.ENSP00000380354.

PTM databases

PhosphoSiteiQ8NHS9.

Polymorphism and mutation databases

BioMutaiSPATA22.
DMDMi296452914.

Proteomic databases

PaxDbiQ8NHS9.
PRIDEiQ8NHS9.

Protocols and materials databases

DNASUi84690.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268981; ENSP00000268981; ENSG00000141255. [Q8NHS9-3]
ENST00000355380; ENSP00000347541; ENSG00000141255. [Q8NHS9-2]
ENST00000397168; ENSP00000380354; ENSG00000141255. [Q8NHS9-1]
ENST00000572969; ENSP00000460187; ENSG00000141255. [Q8NHS9-1]
ENST00000573128; ENSP00000459580; ENSG00000141255. [Q8NHS9-1]
ENST00000575375; ENSP00000459329; ENSG00000141255. [Q8NHS9-1]
GeneIDi84690.
KEGGihsa:84690.
UCSCiuc002fvm.5. human. [Q8NHS9-1]

Organism-specific databases

CTDi84690.
GeneCardsiSPATA22.
HGNCiHGNC:30705. SPATA22.
neXtProtiNX_Q8NHS9.
PharmGKBiPA142670887.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVC3. Eukaryota.
ENOG4111W26. LUCA.
GeneTreeiENSGT00390000018151.
HOGENOMiHOG000038032.
HOVERGENiHBG093993.
InParanoidiQ8NHS9.
OMAiQCKRTNL.
OrthoDBiEOG75F4FM.
PhylomeDBiQ8NHS9.
TreeFamiTF332549.

Miscellaneous databases

ChiTaRSiSPATA22. human.
GenomeRNAii84690.
NextBioi35534830.
PROiQ8NHS9.

Gene expression databases

BgeeiQ8NHS9.
CleanExiHS_SPATA22.
ExpressionAtlasiQ8NHS9. baseline and differential.
GenevisibleiQ8NHS9. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel development-related alternative splices in human testis identified by cDNA microarrays."
    Huang X., Li J., Lu L., Xu M., Xiao J., Yin L., Zhu H., Zhou Z., Sha J.H.
    J. Androl. 26:189-196(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS MET-148 AND THR-160.
    Tissue: Testis.

Entry informationi

Entry nameiSPT22_HUMAN
AccessioniPrimary (citable) accession number: Q8NHS9
Secondary accession number(s): B4DXB1
, D3DTI9, J3KN63, Q969H3, Q96JT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 18, 2010
Last modified: March 16, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.