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Protein

Putative aspartate aminotransferase, cytoplasmic 2

Gene

GOT1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aspartate aminotransferase, cytoplasmic 2 (EC:2.6.1.-)
Alternative name(s):
Glutamate oxaloacetate transaminase 1-like protein 1
Transaminase A-like protein 1
Gene namesi
Name:GOT1L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:28487. GOT1L1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671724.

Polymorphism and mutation databases

BioMutaiGOT1L1.
DMDMi269849534.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Putative aspartate aminotransferase, cytoplasmic 2PRO_0000332999Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei249 – 2491N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiQ8NHS2.
PRIDEiQ8NHS2.

Expressioni

Gene expression databases

BgeeiQ8NHS2.
CleanExiHS_GOT1L1.
ExpressionAtlasiQ8NHS2. baseline and differential.
GenevisibleiQ8NHS2. HS.

Organism-specific databases

HPAiHPA028778.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126475. 4 interactions.
STRINGi9606.ENSP00000303077.

Structurei

3D structure databases

ProteinModelPortaliQ8NHS2.
SMRiQ8NHS2. Positions 20-399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1411. Eukaryota.
COG1448. LUCA.
GeneTreeiENSGT00390000014081.
HOGENOMiHOG000185898.
HOVERGENiHBG000951.
InParanoidiQ8NHS2.
OMAiLAYKVCM.
OrthoDBiEOG7NSB2G.
PhylomeDBiQ8NHS2.
TreeFamiTF314089.

Family and domain databases

Gene3Di3.90.1150.10. 2 hits.
InterProiIPR004839. Aminotransferase_I/II.
IPR000796. Asp_trans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11879. PTHR11879. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PRINTSiPR00799. TRANSAMINASE.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NHS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTLSVFMDV PLAHKLEGSL LKTYKQDDYP NKIFLAYRVC MTNEGHPWVS
60 70 80 90 100
LVVQKTRLQI SQDPSLNYEY LPTMGLKSFI QASLALLFGK HSQAIVENRV
110 120 130 140 150
GGVHTVGDSG AFQLGVQFLR AWHKDARIVY IISSQKELHG LVFQDMGFTV
160 170 180 190 200
YEYSVWDPKK LCMDPDILLN VVEQIPHGCV LVMGNIIDCK LTPSGWAKLM
210 220 230 240 250
SMIKSKQIFP FFDIPCQGLY TSDLEEDTRI LQYFVSQGFE FFCSQSLSKN
260 270 280 290 300
FGIYDEGVGM LVVVAVNNQQ LLCVLSQLEG LAQALWLNPP NTGARVITSI
310 320 330 340 350
LCNPALLGEW KQSLKEVVEN IMLTKEKVKE KLQLLGTPGS WGHITEQSGT
360 370 380 390 400
HGYLGLNSQQ VEYLVRKKHI YIPKNGQINF SCINANNINY ITEGINEAVL
410 420
LTESSEMCLP KEKKTLIGIK L
Length:421
Mass (Da):47,305
Last modified:November 24, 2009 - v2
Checksum:i020AB902540E5B90
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti223 – 2231D → G in AAH29504 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130304 Genomic DNA. No translation available.
BC029504 mRNA. Translation: AAH29504.1.
CCDSiCCDS47839.1.
RefSeqiNP_689626.2. NM_152413.2.
UniGeneiHs.380740.

Genome annotation databases

EnsembliENST00000307599; ENSP00000303077; ENSG00000169154.
GeneIDi137362.
KEGGihsa:137362.
UCSCiuc011lbj.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130304 Genomic DNA. No translation available.
BC029504 mRNA. Translation: AAH29504.1.
CCDSiCCDS47839.1.
RefSeqiNP_689626.2. NM_152413.2.
UniGeneiHs.380740.

3D structure databases

ProteinModelPortaliQ8NHS2.
SMRiQ8NHS2. Positions 20-399.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126475. 4 interactions.
STRINGi9606.ENSP00000303077.

Polymorphism and mutation databases

BioMutaiGOT1L1.
DMDMi269849534.

Proteomic databases

PaxDbiQ8NHS2.
PRIDEiQ8NHS2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307599; ENSP00000303077; ENSG00000169154.
GeneIDi137362.
KEGGihsa:137362.
UCSCiuc011lbj.2. human.

Organism-specific databases

CTDi137362.
GeneCardsiGOT1L1.
HGNCiHGNC:28487. GOT1L1.
HPAiHPA028778.
neXtProtiNX_Q8NHS2.
PharmGKBiPA142671724.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1411. Eukaryota.
COG1448. LUCA.
GeneTreeiENSGT00390000014081.
HOGENOMiHOG000185898.
HOVERGENiHBG000951.
InParanoidiQ8NHS2.
OMAiLAYKVCM.
OrthoDBiEOG7NSB2G.
PhylomeDBiQ8NHS2.
TreeFamiTF314089.

Miscellaneous databases

GenomeRNAii137362.
NextBioi83639.
PROiQ8NHS2.

Gene expression databases

BgeeiQ8NHS2.
CleanExiHS_GOT1L1.
ExpressionAtlasiQ8NHS2. baseline and differential.
GenevisibleiQ8NHS2. HS.

Family and domain databases

Gene3Di3.90.1150.10. 2 hits.
InterProiIPR004839. Aminotransferase_I/II.
IPR000796. Asp_trans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11879. PTHR11879. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PRINTSiPR00799. TRANSAMINASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiAATC2_HUMAN
AccessioniPrimary (citable) accession number: Q8NHS2
Secondary accession number(s): A8MWL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 24, 2009
Last modified: March 16, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

Caution

The residues that bind the substrate in other aspartate aminotransferases are not conserved.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.