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Protein

Putative aspartate aminotransferase, cytoplasmic 2

Gene

GOT1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

Caution

The residues that bind the substrate in other aspartate aminotransferases are not conserved.Curated

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aspartate aminotransferase, cytoplasmic 2 (EC:2.6.1.-)
Alternative name(s):
Glutamate oxaloacetate transaminase 1-like protein 1
Transaminase A-like protein 1
Gene namesi
Name:GOT1L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000169154.5
HGNCiHGNC:28487 GOT1L1
neXtProtiNX_Q8NHS2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169154
PharmGKBiPA142671724

Polymorphism and mutation databases

BioMutaiGOT1L1
DMDMi269849534

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003329991 – 421Putative aspartate aminotransferase, cytoplasmic 2Add BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei249N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ8NHS2
PeptideAtlasiQ8NHS2
PRIDEiQ8NHS2
ProteomicsDBi73746

Expressioni

Gene expression databases

BgeeiENSG00000169154
CleanExiHS_GOT1L1
ExpressionAtlasiQ8NHS2 baseline and differential
GenevisibleiQ8NHS2 HS

Organism-specific databases

HPAiHPA028778

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi126475, 5 interactors
STRINGi9606.ENSP00000303077

Structurei

3D structure databases

ProteinModelPortaliQ8NHS2
SMRiQ8NHS2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1411 Eukaryota
COG1448 LUCA
GeneTreeiENSGT00390000014081
HOGENOMiHOG000185898
HOVERGENiHBG000951
InParanoidiQ8NHS2
OMAiLAYKVCM
OrthoDBiEOG091G0AF2
PhylomeDBiQ8NHS2
TreeFamiTF314089

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR000796 Asp_trans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11879 PTHR11879, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
PRINTSiPR00799 TRANSAMINASE
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NHS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTLSVFMDV PLAHKLEGSL LKTYKQDDYP NKIFLAYRVC MTNEGHPWVS
60 70 80 90 100
LVVQKTRLQI SQDPSLNYEY LPTMGLKSFI QASLALLFGK HSQAIVENRV
110 120 130 140 150
GGVHTVGDSG AFQLGVQFLR AWHKDARIVY IISSQKELHG LVFQDMGFTV
160 170 180 190 200
YEYSVWDPKK LCMDPDILLN VVEQIPHGCV LVMGNIIDCK LTPSGWAKLM
210 220 230 240 250
SMIKSKQIFP FFDIPCQGLY TSDLEEDTRI LQYFVSQGFE FFCSQSLSKN
260 270 280 290 300
FGIYDEGVGM LVVVAVNNQQ LLCVLSQLEG LAQALWLNPP NTGARVITSI
310 320 330 340 350
LCNPALLGEW KQSLKEVVEN IMLTKEKVKE KLQLLGTPGS WGHITEQSGT
360 370 380 390 400
HGYLGLNSQQ VEYLVRKKHI YIPKNGQINF SCINANNINY ITEGINEAVL
410 420
LTESSEMCLP KEKKTLIGIK L
Length:421
Mass (Da):47,305
Last modified:November 24, 2009 - v2
Checksum:i020AB902540E5B90
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti223D → G in AAH29504 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130304 Genomic DNA No translation available.
BC029504 mRNA Translation: AAH29504.1
CCDSiCCDS47839.1
RefSeqiNP_689626.2, NM_152413.2
UniGeneiHs.380740

Genome annotation databases

EnsembliENST00000307599; ENSP00000303077; ENSG00000169154
GeneIDi137362
KEGGihsa:137362
UCSCiuc011lbj.2 human

Similar proteinsi

Entry informationi

Entry nameiAATC2_HUMAN
AccessioniPrimary (citable) accession number: Q8NHS2
Secondary accession number(s): A8MWL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 24, 2009
Last modified: June 20, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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