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Protein

Claudin domain-containing protein 2

Gene

CLDND2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin domain-containing protein 2
Gene namesi
Name:CLDND2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28511. CLDND2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence analysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence analysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence analysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596447.

Polymorphism and mutation databases

BioMutaiCLDND2.
DMDMi74760361.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Claudin domain-containing protein 2PRO_0000271020Add
BLAST

Proteomic databases

PaxDbiQ8NHS1.
PRIDEiQ8NHS1.

PTM databases

PhosphoSiteiQ8NHS1.

Expressioni

Gene expression databases

BgeeiQ8NHS1.
ExpressionAtlasiQ8NHS1. baseline and differential.
GenevisibleiQ8NHS1. HS.

Organism-specific databases

HPAiHPA056971.

Interactioni

Protein-protein interaction databases

BioGridi125932. 1 interaction.
STRINGi9606.ENSP00000291715.

Structurei

3D structure databases

ProteinModelPortaliQ8NHS1.
SMRiQ8NHS1. Positions 6-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXHU. Eukaryota.
ENOG41115R8. LUCA.
GeneTreeiENSGT00730000111504.
HOGENOMiHOG000116021.
HOVERGENiHBG079671.
InParanoidiQ8NHS1.
OMAiICSNIPC.
OrthoDBiEOG7J70HN.
PhylomeDBiQ8NHS1.
TreeFamiTF330587.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01221. PMP22_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVKRSLQSG GILLSLVANV LMVLSTATNY WTRQQEGHSG LWQECNHGIC
60 70 80 90 100
SSIPCQTTLA VTVACMVLAV GVGVVGMVMG LRIRCDEGES LRGQTTSAFL
110 120 130 140 150
FLGGLLLLTA LIGYTVKNAW KNNVFFSWSY FSGWLALPFS ILAGFCFLLA
160
DMIMQSTDAI SGFPVCL
Length:167
Mass (Da):17,984
Last modified:October 1, 2002 - v1
Checksum:iE204F0B6366C22F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029518 mRNA. Translation: AAH29518.1.
CCDSiCCDS12829.1.
RefSeqiNP_689566.1. NM_152353.2.
XP_006723068.1. XM_006723005.2.
UniGeneiHs.720536.

Genome annotation databases

EnsembliENST00000291715; ENSP00000291715; ENSG00000160318.
ENST00000601435; ENSP00000472077; ENSG00000160318.
GeneIDi125875.
KEGGihsa:125875.
UCSCiuc002pwi.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029518 mRNA. Translation: AAH29518.1.
CCDSiCCDS12829.1.
RefSeqiNP_689566.1. NM_152353.2.
XP_006723068.1. XM_006723005.2.
UniGeneiHs.720536.

3D structure databases

ProteinModelPortaliQ8NHS1.
SMRiQ8NHS1. Positions 6-149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125932. 1 interaction.
STRINGi9606.ENSP00000291715.

PTM databases

PhosphoSiteiQ8NHS1.

Polymorphism and mutation databases

BioMutaiCLDND2.
DMDMi74760361.

Proteomic databases

PaxDbiQ8NHS1.
PRIDEiQ8NHS1.

Protocols and materials databases

DNASUi125875.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291715; ENSP00000291715; ENSG00000160318.
ENST00000601435; ENSP00000472077; ENSG00000160318.
GeneIDi125875.
KEGGihsa:125875.
UCSCiuc002pwi.1. human.

Organism-specific databases

CTDi125875.
GeneCardsiCLDND2.
HGNCiHGNC:28511. CLDND2.
HPAiHPA056971.
neXtProtiNX_Q8NHS1.
PharmGKBiPA144596447.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXHU. Eukaryota.
ENOG41115R8. LUCA.
GeneTreeiENSGT00730000111504.
HOGENOMiHOG000116021.
HOVERGENiHBG079671.
InParanoidiQ8NHS1.
OMAiICSNIPC.
OrthoDBiEOG7J70HN.
PhylomeDBiQ8NHS1.
TreeFamiTF330587.

Miscellaneous databases

GenomeRNAii125875.
NextBioi81556.
PROiQ8NHS1.

Gene expression databases

BgeeiQ8NHS1.
ExpressionAtlasiQ8NHS1. baseline and differential.
GenevisibleiQ8NHS1. HS.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01221. PMP22_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiCLDN2_HUMAN
AccessioniPrimary (citable) accession number: Q8NHS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2002
Last modified: April 13, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.