ID   DNJB8_HUMAN             Reviewed;         232 AA.
AC   Q8NHS0;
DT   17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-JAN-2012, entry version 75.
DE   RecName: Full=DnaJ homolog subfamily B member 8;
GN   Name=DNAJB8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   STRUCTURE BY NMR OF 1-82.
RG   RIKEN structural genomics initiative (RSGI);
RT   "Solution structure of the J domain of DnaJ homolog subfamily B member
RT   8.";
RL   Submitted (OCT-2006) to the PDB data bank.
CC   -!- SIMILARITY: Contains 1 J domain.
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DR   EMBL; BC029521; AAH29521.1; -; mRNA.
DR   EMBL; BC050288; AAH50288.1; -; mRNA.
DR   IPI; IPI00169308; -.
DR   RefSeq; NP_699161.1; NM_153330.2.
DR   UniGene; Hs.518241; -.
DR   PDB; 2DMX; NMR; -; A=1-79.
DR   PDBsum; 2DMX; -.
DR   ProteinModelPortal; Q8NHS0; -.
DR   SMR; Q8NHS0; 1-74.
DR   STRING; Q8NHS0; -.
DR   PhosphoSite; Q8NHS0; -.
DR   DMDM; 27805461; -.
DR   PRIDE; Q8NHS0; -.
DR   Ensembl; ENST00000319153; ENSP00000316053; ENSG00000179407.
DR   Ensembl; ENST00000469083; ENSP00000417418; ENSG00000179407.
DR   GeneID; 165721; -.
DR   KEGG; hsa:165721; -.
DR   UCSC; uc003ekk.1; human.
DR   CTD; 165721; -.
DR   GeneCards; GC03M128181; -.
DR   HGNC; HGNC:23699; DNAJB8.
DR   HPA; HPA034733; -.
DR   MIM; 611337; gene.
DR   neXtProt; NX_Q8NHS0; -.
DR   eggNOG; prNOG04969; -.
DR   GeneTree; ENSGT00600000084029; -.
DR   HOGENOM; HBG716471; -.
DR   HOVERGEN; HBG066998; -.
DR   InParanoid; Q8NHS0; -.
DR   OMA; ASTPYHS; -.
DR   OrthoDB; EOG47H5QG; -.
DR   PhylomeDB; Q8NHS0; -.
DR   NextBio; 88560; -.
DR   ArrayExpress; Q8NHS0; -.
DR   Bgee; Q8NHS0; -.
DR   CleanEx; HS_DNAJB8; -.
DR   Genevestigator; Q8NHS0; -.
DR   GermOnline; ENSG00000179407; Homo sapiens.
DR   GO; GO:0031072; F:heat shock protein binding; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   InterPro; IPR001623; DnaJ_N.
DR   InterPro; IPR018253; Heat_shock_DnaJ_CS.
DR   InterPro; IPR003095; Hsp_DnaJ.
DR   Gene3D; G3DSA:1.10.287.110; DnaJ_N; 1.
DR   KO; K09514; -.
DR   Pfam; PF00226; DnaJ; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; DnaJ_N; 1.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Chaperone; Complete proteome; Polymorphism;
KW   Reference proteome.
FT   CHAIN         1    232       DnaJ homolog subfamily B member 8.
FT                                /FTId=PRO_0000071029.
FT   DOMAIN        3     69       J.
FT   VARIANT     153    153       M -> L (in dbSNP:rs35948511).
FT                                /FTId=VAR_033881.
FT   HELIX         4      7
FT   HELIX        18     29
FT   TURN         32     34
FT   HELIX        40     57
FT   HELIX        59     67
SQ   SEQUENCE   232 AA;  25686 MW;  058B180995B772F6 CRC64;
     MANYYEVLGV QASASPEDIK KAYRKLALRW HPDKNPDNKE EAEKKFKLVS EAYEVLSDSK
     KRSLYDRAGC DSWRAGGGAS TPYHSPFDTG YTFRNPEDIF REFFGGLDPF SFEFWDSPFN
     SDRGGRGHGL RGAFSAGFGE FPAFMEAFSS FNMLGCSGGS HTTFSSTSFG GSSSGSSGFK
     SVMSSTEMIN GHKVTTKRIV ENGQERVEVE EDGQLKSVTV NGKEQLKWMD SK
//