Q8NHS0 (DNJB8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DnaJ homolog subfamily B member 8

Gene names

Name:

DNAJB8

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 J domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Chaperone
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: InterPro
Molecular function	heat shock protein binding Inferred from electronic annotation. Source: InterPro unfolded protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 232

232

DnaJ homolog subfamily B member 8

PRO_0000071029

Regions

Domain

3 – 69

67

J

Natural variations

Natural variant

153

1

M → L.
Corresponds to variant rs35948511 [ dbSNP | Ensembl ].

VAR_033881

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

232

Helix Strand Turn

Details...

Helix

4 – 7

4

Helix

18 – 29

12

Turn

32 – 34

3

Helix

40 – 57

18

Helix

59 – 67

9

Sequences

	Sequence		Length	Mass (Da)
	Q8NHS0 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 058B180995B772F6	FASTA	232	25,686
	10 20 30 40 50 60 MANYYEVLGV QASASPEDIK KAYRKLALRW HPDKNPDNKE EAEKKFKLVS EAYEVLSDSK 70 80 90 100 110 120 KRSLYDRAGC DSWRAGGGAS TPYHSPFDTG YTFRNPEDIF REFFGGLDPF SFEFWDSPFN 130 140 150 160 170 180 SDRGGRGHGL RGAFSAGFGE FPAFMEAFSS FNMLGCSGGS HTTFSSTSFG GSSSGSSGFK 190 200 210 220 230 SVMSSTEMIN GHKVTTKRIV ENGQERVEVE EDGQLKSVTV NGKEQLKWMD SK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"Solution structure of the J domain of DnaJ homolog subfamily B member 8." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 1-82.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BC029521 mRNA. Translation: AAH29521.1.
BC050288 mRNA. Translation: AAH50288.1.

IPI

IPI00169308.

RefSeq

NP_699161.1. NM_153330.2.

UniGene

Hs.518241.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DMX	NMR	-	A	1-79	[»]

ProteinModelPortal

Q8NHS0.

SMR

Q8NHS0. Positions 1-74.

ModBase

Search...

Protein-protein interaction databases

STRING

Q8NHS0.

PTM databases

PhosphoSite

Q8NHS0.

Polymorphism databases

DMDM

27805461.

Proteomic databases

PRIDE

Q8NHS0.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000319153; ENSP00000316053; ENSG00000179407.
ENST00000469083; ENSP00000417418; ENSG00000179407.

GeneID

165721.

KEGG

hsa:165721.

UCSC

uc003ekk.1. human.

Organism-specific databases

CTD

165721.

GeneCards

GC03M128181.

HGNC

HGNC:23699. DNAJB8.

HPA

HPA034733.

MIM

611337. gene.

neXtProt

NX_Q8NHS0.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG04969.

GeneTree

ENSGT00600000084029.

HOGENOM

HBG716471.

HOVERGEN

HBG066998.

InParanoid

Q8NHS0.

OMA

ASTPYHS.

OrthoDB

EOG47H5QG.

PhylomeDB

Q8NHS0.

Gene expression databases

ArrayExpress

Q8NHS0.

Bgee

Q8NHS0.

CleanEx

HS_DNAJB8.

Genevestigator

Q8NHS0.

GermOnline

ENSG00000179407. Homo sapiens.

Family and domain databases

InterPro

IPR001623. DnaJ_N.
IPR018253. Heat_shock_DnaJ_CS.
IPR003095. Hsp_DnaJ.
[Graphical view]

Gene3D

G3DSA:1.10.287.110. DnaJ_N. 1 hit.

KO

K09514.

Pfam

PF00226. DnaJ. 1 hit.
[Graphical view]

PRINTS

PR00625. JDOMAIN.

SMART

SM00271. DnaJ. 1 hit.
[Graphical view]

SUPFAM

SSF46565. DnaJ_N. 1 hit.

PROSITE

PS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

88560.

SOURCE

Search...

Entry information

Entry name

DNJB8_HUMAN

Accession

Primary (citable) accession number: Q8NHS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 17, 2003
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.