Reviewed, UniProtKB/Swiss-Prot Q8NHS0 (DNJB8_HUMAN)

Names and origin

Protein names

Recommended name:
    DnaJ homolog subfamily B member 8

Gene names

Name:

DNAJB8

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 1 J domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Chaperone
Technical term	3D-structure
Gene Ontology (GO)
Molecular function	heat shock protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 232	232	DnaJ homolog subfamily B member 8		PRO_0000071029
Regions
	Domain	3 – 69	67	J
Natural variations
	Natural variant	153	1	M → L: dbSNP rs35948511.		VAR_033881

Sequences

	Sequence		Length	Mass (Da)
	Q8NHS0-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 058B180995B772F6	FASTA	232	25,686
	10 20 30 40 50 60 MANYYEVLGV QASASPEDIK KAYRKLALRW HPDKNPDNKE EAEKKFKLVS EAYEVLSDSK 70 80 90 100 110 120 KRSLYDRAGC DSWRAGGGAS TPYHSPFDTG YTFRNPEDIF REFFGGLDPF SFEFWDSPFN 130 140 150 160 170 180 SDRGGRGHGL RGAFSAGFGE FPAFMEAFSS FNMLGCSGGS HTTFSSTSFG GSSSGSSGFK 190 200 210 220 230 SVMSSTEMIN GHKVTTKRIV ENGQERVEVE EDGQLKSVTV NGKEQLKWMD SK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"Solution structure of the J domain of DnaJ homolog subfamily B member 8." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 1-82.

Cross-references

Sequence databases

EMBLGenBankDDBJ

BC029521 mRNA. Translation: AAH29521.1.
BC050288 mRNA. Translation: AAH50288.1.

IPI

IPI00169308.

RefSeq

NP_699161.1.

UniGene

Hs.518241

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DMX	NMR	-	A	1-79	[»]

ModBase

Search...

Genome annotation databases

Ensembl

ENSG00000179407. Homo sapiens. [Contig view]

GeneID

165721.

KEGG

hsa:165721.

Organism-specific databases

GeneCards

GC03M129663.

HGNC

HGNC:23699. DNAJB8.

MIM

611337. gene.

PharmGKB

PA134881798.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q8NHS0.

HOVERGEN

Q8NHS0.

OMA

Q8NHS0. SSTEMIN.

Gene expression databases

ArrayExpress

Q8NHS0.

Bgee

Q8NHS0.

CleanEx

HS_DNAJB8.

GermOnline

ENSG00000179407. Homo sapiens.

Family and domain databases

InterPro

IPR001623. DnaJ_N.
IPR018253. Heat_shock_DnaJ_CS.
IPR015609. Hsp40/DnaJ_Rel.
[Graphical view]

Gene3D

G3DSA:1.10.287.110. DnaJ_N. 1 hit.

PANTHER

PTHR11821. Hsp40/DnaJ_Rel. 1 hit.

Pfam

PF00226. DnaJ. 1 hit.
[Graphical view]

SMART

SM00271. DnaJ. 1 hit.
[Graphical view]

PROSITE

PS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

88560.

SOURCE

Search...

Entry information

Entry name

DNJB8_HUMAN

Accession

Primary (citable) accession number: Q8NHS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 17, 2003
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)