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Protein

Profilin-4

Gene

PFN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to phosphatidylinositol 3-phosphate (PtdIns3P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidic acid (PA). Does not bind to actin (PubMed:19419568), contrary to other family members.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-4
Alternative name(s):
Profilin IV
Gene namesi
Name:PFN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:31103. PFN4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134919643.

Polymorphism and mutation databases

BioMutaiPFN4.
DMDMi48474487.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 129129Profilin-4PRO_0000199581Add
BLAST

Proteomic databases

PaxDbiQ8NHR9.
PRIDEiQ8NHR9.

PTM databases

iPTMnetiQ8NHR9.
PhosphoSiteiQ8NHR9.

Expressioni

Tissue specificityi

Detected in testis (at protein level).1 Publication

Inductioni

Reduced levels in Sertoli cell-only syndrome (SCOS) patients.1 Publication

Gene expression databases

BgeeiQ8NHR9.
CleanExiHS_PFN4.
GenevisibleiQ8NHR9. HS.

Organism-specific databases

HPAiHPA039135.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322170.

Structurei

3D structure databases

ProteinModelPortaliQ8NHR9.
SMRiQ8NHR9. Positions 5-124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiKOG1755. Eukaryota.
ENOG41126PD. LUCA.
GeneTreeiENSGT00390000017067.
HOGENOMiHOG000171591.
HOVERGENiHBG053684.
InParanoidiQ8NHR9.
KOiK05759.
OMAiSPGFSVM.
OrthoDBiEOG72VH85.
PhylomeDBiQ8NHR9.
TreeFamiTF101075.

Family and domain databases

InterProiIPR005455. PFN.
IPR029894. Profilin-4_vertebrate.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PTHR11604:SF2. PTHR11604:SF2. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NHR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLQSLLLD TLLGTKHVDS AALIKIQERS LCVASPGFNV TPSDVRTLVN
60 70 80 90 100
GFAKNPLQAR REGLYFKGKD YRCVRADEYS LYAKNENTGV VVVKTHLYLL
110 120
VATYTEGMYP SICVEATESL GDYLRKKGS
Length:129
Mass (Da):14,319
Last modified:October 1, 2002 - v1
Checksum:i2BB7C78E66C0EAEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292601 mRNA. Translation: BAF85290.1.
AC008073 Genomic DNA. Translation: AAY14666.1.
CH471053 Genomic DNA. Translation: EAX00760.1.
CH471053 Genomic DNA. Translation: EAX00761.1.
BC029523 mRNA. Translation: AAH29523.1.
CCDSiCCDS1709.1.
RefSeqiNP_955378.1. NM_199346.2.
XP_005264349.1. XM_005264292.2.
XP_006712070.1. XM_006712007.2.
XP_011531125.1. XM_011532823.1.
XP_011531126.1. XM_011532824.1.
UniGeneiHs.442718.

Genome annotation databases

EnsembliENST00000313213; ENSP00000322170; ENSG00000176732.
GeneIDi375189.
KEGGihsa:375189.
UCSCiuc002rfa.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292601 mRNA. Translation: BAF85290.1.
AC008073 Genomic DNA. Translation: AAY14666.1.
CH471053 Genomic DNA. Translation: EAX00760.1.
CH471053 Genomic DNA. Translation: EAX00761.1.
BC029523 mRNA. Translation: AAH29523.1.
CCDSiCCDS1709.1.
RefSeqiNP_955378.1. NM_199346.2.
XP_005264349.1. XM_005264292.2.
XP_006712070.1. XM_006712007.2.
XP_011531125.1. XM_011532823.1.
XP_011531126.1. XM_011532824.1.
UniGeneiHs.442718.

3D structure databases

ProteinModelPortaliQ8NHR9.
SMRiQ8NHR9. Positions 5-124.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000322170.

PTM databases

iPTMnetiQ8NHR9.
PhosphoSiteiQ8NHR9.

Polymorphism and mutation databases

BioMutaiPFN4.
DMDMi48474487.

Proteomic databases

PaxDbiQ8NHR9.
PRIDEiQ8NHR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313213; ENSP00000322170; ENSG00000176732.
GeneIDi375189.
KEGGihsa:375189.
UCSCiuc002rfa.2. human.

Organism-specific databases

CTDi375189.
GeneCardsiPFN4.
HGNCiHGNC:31103. PFN4.
HPAiHPA039135.
neXtProtiNX_Q8NHR9.
PharmGKBiPA134919643.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1755. Eukaryota.
ENOG41126PD. LUCA.
GeneTreeiENSGT00390000017067.
HOGENOMiHOG000171591.
HOVERGENiHBG053684.
InParanoidiQ8NHR9.
KOiK05759.
OMAiSPGFSVM.
OrthoDBiEOG72VH85.
PhylomeDBiQ8NHR9.
TreeFamiTF101075.

Miscellaneous databases

GenomeRNAii375189.
PROiQ8NHR9.

Gene expression databases

BgeeiQ8NHR9.
CleanExiHS_PFN4.
GenevisibleiQ8NHR9. HS.

Family and domain databases

InterProiIPR005455. PFN.
IPR029894. Profilin-4_vertebrate.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PTHR11604:SF2. PTHR11604:SF2. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. "Novel testis-expressed profilin IV associated with acrosome biogenesis and spermatid elongation."
    Obermann H., Raabe I., Balvers M., Brunswig B., Schulze W., Kirchhoff C.
    Mol. Hum. Reprod. 11:53-64(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.
  6. "Testis-expressed profilins 3 and 4 show distinct functional characteristics and localize in the acroplaxome-manchette complex in spermatids."
    Behnen M., Murk K., Kursula P., Cappallo-Obermann H., Rothkegel M., Kierszenbaum A.L., Kirchhoff C.
    BMC Cell Biol. 10:34-34(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiPROF4_HUMAN
AccessioniPrimary (citable) accession number: Q8NHR9
Secondary accession number(s): Q53TL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.