ID CEP70_HUMAN Reviewed; 597 AA. AC Q8NHQ1; B7Z5I8; B7Z7E8; D3DNE9; F5GZX8; Q96B31; Q9H2C3; Q9H2Z1; Q9H940; DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-2005, sequence version 2. DT 24-JAN-2024, entry version 173. DE RecName: Full=Centrosomal protein of 70 kDa; DE Short=Cep70; DE AltName: Full=p10-binding protein; GN Name=CEP70; Synonyms=BITE; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Chronic myeloid leukemia cell; RA Tschan M.P., Cajot J.-F., Grob T.J., Fey M.F., Tobler A.; RT "Cloning and characterization of BITE: a binding partner of the cell cycle RT inhibitor p10."; RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 4 AND 5), AND RP VARIANT ASN-135. RC TISSUE=Teratocarcinoma, and Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASN-135. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1 AND 3), AND RP VARIANT ASN-135. RC TISSUE=Skin, and Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE RP ANALYSIS]. RC TISSUE=Lymphoblast; RX PubMed=14654843; DOI=10.1038/nature02166; RA Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.; RT "Proteomic characterization of the human centrosome by protein correlation RT profiling."; RL Nature 426:570-574(2003). RN [7] RP SUBCELLULAR LOCATION, AND INTERACTION WITH TUBULIN-GAMMA. RX PubMed=21795687; DOI=10.1074/jbc.m111.252262; RA Shi X., Sun X., Liu M., Li D., Aneja R., Zhou J.; RT "CEP70 protein interacts with gamma-tubulin to localize at the centrosome RT and is critical for mitotic spindle assembly."; RL J. Biol. Chem. 286:33401-33408(2011). CC -!- FUNCTION: Plays a role in the organization of both preexisting and CC nascent microtubules in interphase cells. During mitosis, required for CC the organization and orientation of the mitotic spindle. CC -!- SUBUNIT: Directly interacts with tubulin-gamma; this interaction CC determines centrosomal localization. {ECO:0000269|PubMed:21795687}. CC -!- INTERACTION: CC Q8NHQ1; Q9ULW3: ABT1; NbExp=6; IntAct=EBI-739624, EBI-2602396; CC Q8NHQ1; Q5U5Z8-3: AGBL2; NbExp=3; IntAct=EBI-739624, EBI-12226473; CC Q8NHQ1; Q02040: AKAP17A; NbExp=7; IntAct=EBI-739624, EBI-1042725; CC Q8NHQ1; Q02040-3: AKAP17A; NbExp=3; IntAct=EBI-739624, EBI-10222656; CC Q8NHQ1; Q9NR81: ARHGEF3; NbExp=7; IntAct=EBI-739624, EBI-10312733; CC Q8NHQ1; Q9P291: ARMCX1; NbExp=3; IntAct=EBI-739624, EBI-2843626; CC Q8NHQ1; Q7L5A3: ATOSB; NbExp=5; IntAct=EBI-739624, EBI-745689; CC Q8NHQ1; P48047: ATP5PO; NbExp=6; IntAct=EBI-739624, EBI-355815; CC Q8NHQ1; A0AVN2: BARD1; NbExp=3; IntAct=EBI-739624, EBI-9977322; CC Q8NHQ1; Q99728: BARD1; NbExp=3; IntAct=EBI-739624, EBI-473181; CC Q8NHQ1; Q9UIF8: BAZ2B; NbExp=3; IntAct=EBI-739624, EBI-741542; CC Q8NHQ1; Q9BXY8: BEX2; NbExp=6; IntAct=EBI-739624, EBI-745073; CC Q8NHQ1; O95696: BRD1; NbExp=3; IntAct=EBI-739624, EBI-714754; CC Q8NHQ1; Q9HCU9: BRMS1; NbExp=4; IntAct=EBI-739624, EBI-714781; CC Q8NHQ1; Q5PSV4: BRMS1L; NbExp=3; IntAct=EBI-739624, EBI-5666615; CC Q8NHQ1; P55201-2: BRPF1; NbExp=3; IntAct=EBI-739624, EBI-12065306; CC Q8NHQ1; Q13895: BYSL; NbExp=8; IntAct=EBI-739624, EBI-358049; CC Q8NHQ1; Q9H7E9: C8orf33; NbExp=5; IntAct=EBI-739624, EBI-715389; CC Q8NHQ1; Q9H257: CARD9; NbExp=3; IntAct=EBI-739624, EBI-751319; CC Q8NHQ1; Q969G5: CAVIN3; NbExp=3; IntAct=EBI-739624, EBI-3893101; CC Q8NHQ1; Q9HC52: CBX8; NbExp=3; IntAct=EBI-739624, EBI-712912; CC Q8NHQ1; Q16543: CDC37; NbExp=3; IntAct=EBI-739624, EBI-295634; CC Q8NHQ1; Q6P1J9: CDC73; NbExp=10; IntAct=EBI-739624, EBI-930143; CC Q8NHQ1; Q96GN5: CDCA7L; NbExp=7; IntAct=EBI-739624, EBI-5278764; CC Q8NHQ1; Q8IYX8: CEP57L1; NbExp=3; IntAct=EBI-739624, EBI-1104570; CC Q8NHQ1; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-739624, EBI-10181988; CC Q8NHQ1; Q8NHQ1: CEP70; NbExp=4; IntAct=EBI-739624, EBI-739624; CC Q8NHQ1; Q8NHQ1-3: CEP70; NbExp=3; IntAct=EBI-739624, EBI-11526150; CC Q8NHQ1; Q96M91: CFAP53; NbExp=3; IntAct=EBI-739624, EBI-742422; CC Q8NHQ1; Q9H078: CLPB; NbExp=3; IntAct=EBI-739624, EBI-2107221; CC Q8NHQ1; P38432: COIL; NbExp=3; IntAct=EBI-739624, EBI-945751; CC Q8NHQ1; Q2TBE0: CWF19L2; NbExp=3; IntAct=EBI-739624, EBI-5453285; CC Q8NHQ1; Q9UER7: DAXX; NbExp=3; IntAct=EBI-739624, EBI-77321; CC Q8NHQ1; Q9UJV9: DDX41; NbExp=3; IntAct=EBI-739624, EBI-1046350; CC Q8NHQ1; P26196: DDX6; NbExp=6; IntAct=EBI-739624, EBI-351257; CC Q8NHQ1; Q5QJE6: DNTTIP2; NbExp=3; IntAct=EBI-739624, EBI-5666736; CC Q8NHQ1; Q92997: DVL3; NbExp=3; IntAct=EBI-739624, EBI-739789; CC Q8NHQ1; Q96JC9: EAF1; NbExp=3; IntAct=EBI-739624, EBI-769261; CC Q8NHQ1; Q99848: EBNA1BP2; NbExp=3; IntAct=EBI-739624, EBI-1048111; CC Q8NHQ1; O15371: EIF3D; NbExp=3; IntAct=EBI-739624, EBI-353818; CC Q8NHQ1; Q14241: ELOA; NbExp=3; IntAct=EBI-739624, EBI-742350; CC Q8NHQ1; P50402: EMD; NbExp=6; IntAct=EBI-739624, EBI-489887; CC Q8NHQ1; P54849: EMP1; NbExp=3; IntAct=EBI-739624, EBI-4319440; CC Q8NHQ1; Q9H0I2: ENKD1; NbExp=4; IntAct=EBI-739624, EBI-744099; CC Q8NHQ1; P19447: ERCC3; NbExp=3; IntAct=EBI-739624, EBI-1183307; CC Q8NHQ1; Q86V42: FAM124A; NbExp=3; IntAct=EBI-739624, EBI-744506; CC Q8NHQ1; Q8N9E0: FAM133A; NbExp=6; IntAct=EBI-739624, EBI-10268158; CC Q8NHQ1; Q8NE31: FAM13C; NbExp=3; IntAct=EBI-739624, EBI-751248; CC Q8NHQ1; Q3B820: FAM161A; NbExp=6; IntAct=EBI-739624, EBI-719941; CC Q8NHQ1; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-739624, EBI-7225287; CC Q8NHQ1; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-739624, EBI-6658203; CC Q8NHQ1; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-739624, EBI-372506; CC Q8NHQ1; O95995: GAS8; NbExp=3; IntAct=EBI-739624, EBI-1052570; CC Q8NHQ1; Q8WXI9: GATAD2B; NbExp=3; IntAct=EBI-739624, EBI-923440; CC Q8NHQ1; Q96CN9: GCC1; NbExp=6; IntAct=EBI-739624, EBI-746252; CC Q8NHQ1; P55040: GEM; NbExp=3; IntAct=EBI-739624, EBI-744104; CC Q8NHQ1; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-739624, EBI-748515; CC Q8NHQ1; Q9NWQ4: GPATCH2L; NbExp=3; IntAct=EBI-739624, EBI-5666657; CC Q8NHQ1; Q5T3I0: GPATCH4; NbExp=6; IntAct=EBI-739624, EBI-2372076; CC Q8NHQ1; Q96SL4: GPX7; NbExp=3; IntAct=EBI-739624, EBI-749411; CC Q8NHQ1; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-739624, EBI-2514791; CC Q8NHQ1; Q96CS2-2: HAUS1; NbExp=3; IntAct=EBI-739624, EBI-11742270; CC Q8NHQ1; A0A024R4Z4: hCG_2042749; NbExp=3; IntAct=EBI-739624, EBI-14231181; CC Q8NHQ1; P56524-2: HDAC4; NbExp=3; IntAct=EBI-739624, EBI-11953488; CC Q8NHQ1; Q96JB3: HIC2; NbExp=3; IntAct=EBI-739624, EBI-726282; CC Q8NHQ1; Q6NSH1: HMGB4; NbExp=3; IntAct=EBI-739624, EBI-10250889; CC Q8NHQ1; Q8WW32: HMGB4; NbExp=6; IntAct=EBI-739624, EBI-10277297; CC Q8NHQ1; P09067: HOXB5; NbExp=3; IntAct=EBI-739624, EBI-3893317; CC Q8NHQ1; P31273: HOXC8; NbExp=3; IntAct=EBI-739624, EBI-1752118; CC Q8NHQ1; P10809: HSPD1; NbExp=6; IntAct=EBI-739624, EBI-352528; CC Q8NHQ1; Q13123: IK; NbExp=3; IntAct=EBI-739624, EBI-713456; CC Q8NHQ1; Q9C086: INO80B; NbExp=3; IntAct=EBI-739624, EBI-715611; CC Q8NHQ1; Q15735: INPP5J; NbExp=3; IntAct=EBI-739624, EBI-10236940; CC Q8NHQ1; Q8WWN9: IPCEF1; NbExp=3; IntAct=EBI-739624, EBI-4401965; CC Q8NHQ1; Q8NA54: IQUB; NbExp=3; IntAct=EBI-739624, EBI-10220600; CC Q8NHQ1; P27987: ITPKB; NbExp=3; IntAct=EBI-739624, EBI-751388; CC Q8NHQ1; Q63ZY3: KANK2; NbExp=6; IntAct=EBI-739624, EBI-2556193; CC Q8NHQ1; Q7Z3B3: KANSL1; NbExp=4; IntAct=EBI-739624, EBI-740244; CC Q8NHQ1; Q9H8E8: KAT14; NbExp=3; IntAct=EBI-739624, EBI-750907; CC Q8NHQ1; Q92993: KAT5; NbExp=3; IntAct=EBI-739624, EBI-399080; CC Q8NHQ1; O60341: KDM1A; NbExp=2; IntAct=EBI-739624, EBI-710124; CC Q8NHQ1; O14901: KLF11; NbExp=3; IntAct=EBI-739624, EBI-948266; CC Q8NHQ1; A0A494C108: KRI1; NbExp=3; IntAct=EBI-739624, EBI-12342761; CC Q8NHQ1; Q15323: KRT31; NbExp=3; IntAct=EBI-739624, EBI-948001; CC Q8NHQ1; O43504: LAMTOR5; NbExp=6; IntAct=EBI-739624, EBI-713382; CC Q8NHQ1; Q96JN0-2: LCOR; NbExp=3; IntAct=EBI-739624, EBI-10961483; CC Q8NHQ1; Q96BZ8: LENG1; NbExp=7; IntAct=EBI-739624, EBI-726510; CC Q8NHQ1; Q96PV6: LENG8; NbExp=3; IntAct=EBI-739624, EBI-739546; CC Q8NHQ1; Q96GY3: LIN37; NbExp=3; IntAct=EBI-739624, EBI-748884; CC Q8NHQ1; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-739624, EBI-739832; CC Q8NHQ1; Q9Y586: MAB21L2; NbExp=3; IntAct=EBI-739624, EBI-6659161; CC Q8NHQ1; P61326: MAGOH; NbExp=3; IntAct=EBI-739624, EBI-299134; CC Q8NHQ1; O95983-2: MBD3; NbExp=3; IntAct=EBI-739624, EBI-11978579; CC Q8NHQ1; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-739624, EBI-348259; CC Q8NHQ1; Q9H7H0: METTL17; NbExp=7; IntAct=EBI-739624, EBI-749353; CC Q8NHQ1; Q9H7H0-2: METTL17; NbExp=3; IntAct=EBI-739624, EBI-11098807; CC Q8NHQ1; P55081: MFAP1; NbExp=6; IntAct=EBI-739624, EBI-1048159; CC Q8NHQ1; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-739624, EBI-14086479; CC Q8NHQ1; Q13064: MKRN3; NbExp=3; IntAct=EBI-739624, EBI-2340269; CC Q8NHQ1; Q9BU76: MMTAG2; NbExp=5; IntAct=EBI-739624, EBI-742459; CC Q8NHQ1; O76041: NEBL; NbExp=3; IntAct=EBI-739624, EBI-2880203; CC Q8NHQ1; Q9UFN0: NIPSNAP3A; NbExp=3; IntAct=EBI-739624, EBI-716291; CC Q8NHQ1; Q6ZUT1: NKAPD1; NbExp=6; IntAct=EBI-739624, EBI-3920396; CC Q8NHQ1; Q6ZUT1-2: NKAPD1; NbExp=3; IntAct=EBI-739624, EBI-10180231; CC Q8NHQ1; Q9UGY1: NOL12; NbExp=4; IntAct=EBI-739624, EBI-716098; CC Q8NHQ1; P46087: NOP2; NbExp=3; IntAct=EBI-739624, EBI-356811; CC Q8NHQ1; Q9NZM5: NOP53; NbExp=3; IntAct=EBI-739624, EBI-720156; CC Q8NHQ1; Q86UR1-2: NOXA1; NbExp=3; IntAct=EBI-739624, EBI-12025760; CC Q8NHQ1; P48552: NRIP1; NbExp=4; IntAct=EBI-739624, EBI-746484; CC Q8NHQ1; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-739624, EBI-741158; CC Q8NHQ1; Q9BXS6: NUSAP1; NbExp=3; IntAct=EBI-739624, EBI-2555618; CC Q8NHQ1; Q96NG3: ODAD4; NbExp=3; IntAct=EBI-739624, EBI-1046387; CC Q8NHQ1; A0A087WUI6: PIBF1; NbExp=3; IntAct=EBI-739624, EBI-11749468; CC Q8NHQ1; Q9BSJ6: PIMREG; NbExp=6; IntAct=EBI-739624, EBI-2568609; CC Q8NHQ1; Q16512: PKN1; NbExp=3; IntAct=EBI-739624, EBI-602382; CC Q8NHQ1; Q13427: PPIG; NbExp=3; IntAct=EBI-739624, EBI-396072; CC Q8NHQ1; Q96T49: PPP1R16B; NbExp=3; IntAct=EBI-739624, EBI-10293968; CC Q8NHQ1; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-739624, EBI-2557469; CC Q8NHQ1; Q9H875: PRKRIP1; NbExp=3; IntAct=EBI-739624, EBI-744488; CC Q8NHQ1; Q99633: PRPF18; NbExp=3; IntAct=EBI-739624, EBI-2798416; CC Q8NHQ1; O43395: PRPF3; NbExp=3; IntAct=EBI-739624, EBI-744322; CC Q8NHQ1; Q8WWY3: PRPF31; NbExp=9; IntAct=EBI-739624, EBI-1567797; CC Q8NHQ1; P25786: PSMA1; NbExp=6; IntAct=EBI-739624, EBI-359352; CC Q8NHQ1; Q9UIG4: PSORS1C2; NbExp=3; IntAct=EBI-739624, EBI-11974061; CC Q8NHQ1; A6NK89: RASSF10; NbExp=3; IntAct=EBI-739624, EBI-6912267; CC Q8NHQ1; P98175: RBM10; NbExp=6; IntAct=EBI-739624, EBI-721525; CC Q8NHQ1; Q8TCX5: RHPN1; NbExp=3; IntAct=EBI-739624, EBI-746325; CC Q8NHQ1; Q8NCN4: RNF169; NbExp=3; IntAct=EBI-739624, EBI-6380946; CC Q8NHQ1; A0A0S2Z4G9: RNF6; NbExp=3; IntAct=EBI-739624, EBI-16428950; CC Q8NHQ1; P26373: RPL13; NbExp=3; IntAct=EBI-739624, EBI-356849; CC Q8NHQ1; Q6NZ55: RPL13; NbExp=3; IntAct=EBI-739624, EBI-10252046; CC Q8NHQ1; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-739624, EBI-748391; CC Q8NHQ1; Q92503: SEC14L1; NbExp=3; IntAct=EBI-739624, EBI-2855587; CC Q8NHQ1; Q9C0A6-2: SETD5; NbExp=3; IntAct=EBI-739624, EBI-10303449; CC Q8NHQ1; Q86XK3: SFR1; NbExp=3; IntAct=EBI-739624, EBI-1104535; CC Q8NHQ1; Q9H788: SH2D4A; NbExp=3; IntAct=EBI-739624, EBI-747035; CC Q8NHQ1; Q9H788-2: SH2D4A; NbExp=3; IntAct=EBI-739624, EBI-10308083; CC Q8NHQ1; O95391: SLU7; NbExp=3; IntAct=EBI-739624, EBI-750559; CC Q8NHQ1; Q969G3: SMARCE1; NbExp=6; IntAct=EBI-739624, EBI-455078; CC Q8NHQ1; P62316: SNRPD2; NbExp=3; IntAct=EBI-739624, EBI-297993; CC Q8NHQ1; Q13573: SNW1; NbExp=3; IntAct=EBI-739624, EBI-632715; CC Q8NHQ1; P04179: SOD2; NbExp=3; IntAct=EBI-739624, EBI-716989; CC Q8NHQ1; Q5MJ09: SPANXN3; NbExp=3; IntAct=EBI-739624, EBI-12037215; CC Q8NHQ1; Q6ZRS2-3: SRCAP; NbExp=3; IntAct=EBI-739624, EBI-12029182; CC Q8NHQ1; Q99909: SSX3; NbExp=3; IntAct=EBI-739624, EBI-10295431; CC Q8NHQ1; O00506: STK25; NbExp=3; IntAct=EBI-739624, EBI-618295; CC Q8NHQ1; O43463: SUV39H1; NbExp=3; IntAct=EBI-739624, EBI-349968; CC Q8NHQ1; Q9BSW7: SYT17; NbExp=3; IntAct=EBI-739624, EBI-745392; CC Q8NHQ1; Q96C24: SYTL4; NbExp=4; IntAct=EBI-739624, EBI-747142; CC Q8NHQ1; Q8TDW5: SYTL5; NbExp=4; IntAct=EBI-739624, EBI-2939487; CC Q8NHQ1; Q8TDW5-2: SYTL5; NbExp=3; IntAct=EBI-739624, EBI-12243980; CC Q8NHQ1; Q9H5J8: TAF1D; NbExp=4; IntAct=EBI-739624, EBI-716128; CC Q8NHQ1; Q9NU19: TBC1D22B; NbExp=3; IntAct=EBI-739624, EBI-8787464; CC Q8NHQ1; Q9Y2I9-2: TBC1D30; NbExp=3; IntAct=EBI-739624, EBI-17455779; CC Q8NHQ1; Q9Y4C2-2: TCAF1; NbExp=3; IntAct=EBI-739624, EBI-11974855; CC Q8NHQ1; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-739624, EBI-11955057; CC Q8NHQ1; A0A0S2Z4E5: TEAD4; NbExp=3; IntAct=EBI-739624, EBI-16432288; CC Q8NHQ1; A0A0S2Z4F2: TEAD4; NbExp=3; IntAct=EBI-739624, EBI-16429215; CC Q8NHQ1; D3DUQ6: TEAD4; NbExp=3; IntAct=EBI-739624, EBI-10176734; CC Q8NHQ1; Q86UE8: TLK2; NbExp=3; IntAct=EBI-739624, EBI-1047967; CC Q8NHQ1; Q9Y228: TRAF3IP3; NbExp=3; IntAct=EBI-739624, EBI-765817; CC Q8NHQ1; Q14134: TRIM29; NbExp=5; IntAct=EBI-739624, EBI-702370; CC Q8NHQ1; O75382: TRIM3; NbExp=3; IntAct=EBI-739624, EBI-2129889; CC Q8NHQ1; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-739624, EBI-5235829; CC Q8NHQ1; P43897: TSFM; NbExp=4; IntAct=EBI-739624, EBI-1049298; CC Q8NHQ1; Q3SY00: TSGA10IP; NbExp=7; IntAct=EBI-739624, EBI-10241197; CC Q8NHQ1; Q63HK5: TSHZ3; NbExp=3; IntAct=EBI-739624, EBI-9053916; CC Q8NHQ1; Q6ZVT0: TTLL10; NbExp=3; IntAct=EBI-739624, EBI-7844656; CC Q8NHQ1; Q6ZVT0-3: TTLL10; NbExp=3; IntAct=EBI-739624, EBI-11979997; CC Q8NHQ1; Q8N3L3: TXLNB; NbExp=8; IntAct=EBI-739624, EBI-6116822; CC Q8NHQ1; Q99757: TXN2; NbExp=3; IntAct=EBI-739624, EBI-2932492; CC Q8NHQ1; O75604: USP2; NbExp=3; IntAct=EBI-739624, EBI-743272; CC Q8NHQ1; Q9Y3A2: UTP11; NbExp=3; IntAct=EBI-739624, EBI-2876697; CC Q8NHQ1; Q5TAP6: UTP14C; NbExp=3; IntAct=EBI-739624, EBI-11737646; CC Q8NHQ1; Q68CQ4: UTP25; NbExp=8; IntAct=EBI-739624, EBI-747711; CC Q8NHQ1; Q9NQZ2: UTP3; NbExp=3; IntAct=EBI-739624, EBI-714067; CC Q8NHQ1; Q8TAG6: VXN; NbExp=3; IntAct=EBI-739624, EBI-12071548; CC Q8NHQ1; Q9BW85: YJU2; NbExp=6; IntAct=EBI-739624, EBI-10300345; CC Q8NHQ1; Q05516: ZBTB16; NbExp=4; IntAct=EBI-739624, EBI-711925; CC Q8NHQ1; O43167: ZBTB24; NbExp=6; IntAct=EBI-739624, EBI-744471; CC Q8NHQ1; Q9P1Z0: ZBTB4; NbExp=3; IntAct=EBI-739624, EBI-2564133; CC Q8NHQ1; Q9UFB7: ZBTB47; NbExp=3; IntAct=EBI-739624, EBI-7781767; CC Q8NHQ1; P10074: ZBTB48; NbExp=3; IntAct=EBI-739624, EBI-744864; CC Q8NHQ1; Q6ZSB9: ZBTB49; NbExp=5; IntAct=EBI-739624, EBI-2859943; CC Q8NHQ1; Q8TBK6: ZCCHC10; NbExp=4; IntAct=EBI-739624, EBI-597063; CC Q8NHQ1; G3V1X1: ZFC3H1; NbExp=3; IntAct=EBI-739624, EBI-6448783; CC Q8NHQ1; Q15911-2: ZFHX3; NbExp=3; IntAct=EBI-739624, EBI-10237226; CC Q8NHQ1; Q6P2D0: ZFP1; NbExp=3; IntAct=EBI-739624, EBI-2555749; CC Q8NHQ1; A0A0S2Z6H0: ZGPAT; NbExp=3; IntAct=EBI-739624, EBI-16428984; CC Q8NHQ1; Q8N5A5: ZGPAT; NbExp=4; IntAct=EBI-739624, EBI-3439227; CC Q8NHQ1; Q8N5A5-2: ZGPAT; NbExp=9; IntAct=EBI-739624, EBI-10183064; CC Q8NHQ1; P52737: ZNF136; NbExp=5; IntAct=EBI-739624, EBI-749129; CC Q8NHQ1; P52738: ZNF140; NbExp=3; IntAct=EBI-739624, EBI-12069140; CC Q8NHQ1; Q9UQR1: ZNF148; NbExp=3; IntAct=EBI-739624, EBI-2688184; CC Q8NHQ1; P49910: ZNF165; NbExp=3; IntAct=EBI-739624, EBI-741694; CC Q8NHQ1; Q14929: ZNF169; NbExp=3; IntAct=EBI-739624, EBI-10234472; CC Q8NHQ1; P17021: ZNF17; NbExp=3; IntAct=EBI-739624, EBI-1105334; CC Q8NHQ1; P17024: ZNF20; NbExp=3; IntAct=EBI-739624, EBI-717634; CC Q8NHQ1; O95125: ZNF202; NbExp=3; IntAct=EBI-739624, EBI-751960; CC Q8NHQ1; Q86WZ6: ZNF227; NbExp=7; IntAct=EBI-739624, EBI-2799529; CC Q8NHQ1; Q16600: ZNF239; NbExp=6; IntAct=EBI-739624, EBI-8787052; CC Q8NHQ1; O43296: ZNF264; NbExp=4; IntAct=EBI-739624, EBI-4395808; CC Q8NHQ1; Q14584: ZNF266; NbExp=6; IntAct=EBI-739624, EBI-7115319; CC Q8NHQ1; Q9NR11: ZNF302; NbExp=4; IntAct=EBI-739624, EBI-3916142; CC Q8NHQ1; Q86UD4: ZNF329; NbExp=7; IntAct=EBI-739624, EBI-7233259; CC Q8NHQ1; P13682: ZNF35; NbExp=3; IntAct=EBI-739624, EBI-11041653; CC Q8NHQ1; Q8N895: ZNF366; NbExp=8; IntAct=EBI-739624, EBI-2813661; CC Q8NHQ1; Q9H9D4: ZNF408; NbExp=9; IntAct=EBI-739624, EBI-347633; CC Q8NHQ1; Q86VK4: ZNF410; NbExp=3; IntAct=EBI-739624, EBI-720304; CC Q8NHQ1; Q8TAU3: ZNF417; NbExp=6; IntAct=EBI-739624, EBI-740727; CC Q8NHQ1; Q8N7K0: ZNF433; NbExp=3; IntAct=EBI-739624, EBI-10267553; CC Q8NHQ1; Q8NDP4: ZNF439; NbExp=3; IntAct=EBI-739624, EBI-747580; CC Q8NHQ1; Q9ULM2: ZNF490; NbExp=7; IntAct=EBI-739624, EBI-1105370; CC Q8NHQ1; Q8N8L2: ZNF491; NbExp=3; IntAct=EBI-739624, EBI-12019860; CC Q8NHQ1; Q8NEP9: ZNF555; NbExp=3; IntAct=EBI-739624, EBI-10270752; CC Q8NHQ1; Q7Z3I7: ZNF572; NbExp=6; IntAct=EBI-739624, EBI-10172590; CC Q8NHQ1; Q6ZN55-2: ZNF574; NbExp=3; IntAct=EBI-739624, EBI-17189720; CC Q8NHQ1; Q3MI94: ZNF578; NbExp=3; IntAct=EBI-739624, EBI-10241108; CC Q8NHQ1; Q96N58: ZNF578; NbExp=3; IntAct=EBI-739624, EBI-11955189; CC Q8NHQ1; Q96SQ5: ZNF587; NbExp=6; IntAct=EBI-739624, EBI-6427977; CC Q8NHQ1; Q96NL3: ZNF599; NbExp=3; IntAct=EBI-739624, EBI-8653994; CC Q8NHQ1; Q5T619: ZNF648; NbExp=3; IntAct=EBI-739624, EBI-11985915; CC Q8NHQ1; Q96BR6: ZNF669; NbExp=3; IntAct=EBI-739624, EBI-12006574; CC Q8NHQ1; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-739624, EBI-16429014; CC Q8NHQ1; Q9H7X3: ZNF696; NbExp=3; IntAct=EBI-739624, EBI-11090299; CC Q8NHQ1; Q96BV0: ZNF775; NbExp=3; IntAct=EBI-739624, EBI-7149881; CC Q8NHQ1; Q9ULD5: ZNF777; NbExp=3; IntAct=EBI-739624, EBI-11975599; CC Q8NHQ1; A8K8V0: ZNF785; NbExp=3; IntAct=EBI-739624, EBI-3925400; CC Q8NHQ1; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-739624, EBI-5667516; CC Q8NHQ1; A6NHJ4: ZNF860; NbExp=3; IntAct=EBI-739624, EBI-17263060; CC Q8NHQ1; O43309: ZSCAN12; NbExp=3; IntAct=EBI-739624, EBI-1210440; CC Q8NHQ1; Q9Y5A6: ZSCAN21; NbExp=3; IntAct=EBI-739624, EBI-10281938; CC Q8NHQ1; Q3MJ62: ZSCAN23; NbExp=3; IntAct=EBI-739624, EBI-5667532; CC Q8NHQ1-3; P54253: ATXN1; NbExp=3; IntAct=EBI-11526150, EBI-930964; CC Q8NHQ1-3; G5E9A7: DMWD; NbExp=3; IntAct=EBI-11526150, EBI-10976677; CC Q8NHQ1-3; Q53GS7: GLE1; NbExp=3; IntAct=EBI-11526150, EBI-1955541; CC Q8NHQ1-3; P42858: HTT; NbExp=6; IntAct=EBI-11526150, EBI-466029; CC Q8NHQ1-3; D3DTS7: PMP22; NbExp=3; IntAct=EBI-11526150, EBI-25882629; CC Q8NHQ1-3; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-11526150, EBI-5235340; CC Q8NHQ1-3; Q13148: TARDBP; NbExp=6; IntAct=EBI-11526150, EBI-372899; CC Q8NHQ1-3; P54577: YARS1; NbExp=3; IntAct=EBI-11526150, EBI-1048893; CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing CC center, centrosome {ECO:0000269|PubMed:14654843, CC ECO:0000269|PubMed:21795687}. Note=Localized at the center of the CC radial microtubule array in interphase and at the spindle poles during CC various stages of mitosis. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Name=1; CC IsoId=Q8NHQ1-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8NHQ1-2; Sequence=VSP_012746, VSP_012747; CC Name=3; CC IsoId=Q8NHQ1-3; Sequence=VSP_012745; CC Name=4; CC IsoId=Q8NHQ1-4; Sequence=VSP_042140; CC Name=5; CC IsoId=Q8NHQ1-5; Sequence=VSP_042140, VSP_042141; CC -!- DOMAIN: The coiled-coil domains may be important for tubulin-gamma- CC binding and hence for centrosomal localization. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF202146; AAG35616.1; -; mRNA. DR EMBL; AF289495; AAG35791.1; -; mRNA. DR EMBL; AK023098; BAB14403.1; -; mRNA. DR EMBL; AK299003; BAH12924.1; -; mRNA. DR EMBL; AK301913; BAH13584.1; -; mRNA. DR EMBL; AC020890; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC072045; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471052; EAW79062.1; -; Genomic_DNA. DR EMBL; CH471052; EAW79063.1; -; Genomic_DNA. DR EMBL; BC016050; AAH16050.1; -; mRNA. DR EMBL; BC030598; AAH30598.1; -; mRNA. DR CCDS; CCDS3102.1; -. [Q8NHQ1-1] DR CCDS; CCDS75022.1; -. [Q8NHQ1-4] DR CCDS; CCDS75023.1; -. [Q8NHQ1-2] DR CCDS; CCDS82842.1; -. [Q8NHQ1-3] DR RefSeq; NP_001275893.1; NM_001288964.1. [Q8NHQ1-4] DR RefSeq; NP_001275894.1; NM_001288965.1. [Q8NHQ1-5] DR RefSeq; NP_001275895.1; NM_001288966.1. [Q8NHQ1-2] DR RefSeq; NP_001275896.1; NM_001288967.1. DR RefSeq; NP_001307527.1; NM_001320598.1. [Q8NHQ1-1] DR RefSeq; NP_001307529.1; NM_001320600.1. [Q8NHQ1-3] DR RefSeq; NP_077817.2; NM_024491.3. [Q8NHQ1-1] DR RefSeq; XP_016862764.1; XM_017007275.1. DR AlphaFoldDB; Q8NHQ1; -. DR SMR; Q8NHQ1; -. DR BioGRID; 123234; 277. DR IntAct; Q8NHQ1; 282. DR MINT; Q8NHQ1; -. DR STRING; 9606.ENSP00000264982; -. DR iPTMnet; Q8NHQ1; -. DR PhosphoSitePlus; Q8NHQ1; -. DR BioMuta; CEP70; -. DR DMDM; 84028943; -. DR EPD; Q8NHQ1; -. DR MassIVE; Q8NHQ1; -. DR PaxDb; 9606-ENSP00000264982; -. DR PeptideAtlas; Q8NHQ1; -. DR ProteomicsDB; 73734; -. [Q8NHQ1-1] DR ProteomicsDB; 73735; -. [Q8NHQ1-2] DR ProteomicsDB; 73736; -. [Q8NHQ1-3] DR ProteomicsDB; 73737; -. [Q8NHQ1-4] DR ProteomicsDB; 73738; -. [Q8NHQ1-5] DR Antibodypedia; 46706; 249 antibodies from 26 providers. DR DNASU; 80321; -. DR Ensembl; ENST00000264982.8; ENSP00000264982.3; ENSG00000114107.9. [Q8NHQ1-1] DR Ensembl; ENST00000464035.5; ENSP00000419743.1; ENSG00000114107.9. [Q8NHQ1-3] DR Ensembl; ENST00000474781.5; ENSP00000419833.1; ENSG00000114107.9. [Q8NHQ1-4] DR Ensembl; ENST00000481834.5; ENSP00000417465.1; ENSG00000114107.9. [Q8NHQ1-2] DR Ensembl; ENST00000484888.5; ENSP00000419231.1; ENSG00000114107.9. [Q8NHQ1-1] DR GeneID; 80321; -. DR KEGG; hsa:80321; -. DR MANE-Select; ENST00000264982.8; ENSP00000264982.3; NM_024491.4; NP_077817.2. DR UCSC; uc003esl.5; human. [Q8NHQ1-1] DR AGR; HGNC:29972; -. DR CTD; 80321; -. DR DisGeNET; 80321; -. DR GeneCards; CEP70; -. DR HGNC; HGNC:29972; CEP70. DR HPA; ENSG00000114107; Low tissue specificity. DR MIM; 614310; gene. DR neXtProt; NX_Q8NHQ1; -. DR OpenTargets; ENSG00000114107; -. DR PharmGKB; PA128394729; -. DR VEuPathDB; HostDB:ENSG00000114107; -. DR eggNOG; ENOG502QS45; Eukaryota. DR GeneTree; ENSGT00390000009029; -. DR HOGENOM; CLU_1351558_0_0_1; -. DR InParanoid; Q8NHQ1; -. DR OMA; ACQQYLQ; -. DR OrthoDB; 2910746at2759; -. DR PhylomeDB; Q8NHQ1; -. DR TreeFam; TF330986; -. DR PathwayCommons; Q8NHQ1; -. DR Reactome; R-HSA-2565942; Regulation of PLK1 Activity at G2/M Transition. DR Reactome; R-HSA-380259; Loss of Nlp from mitotic centrosomes. DR Reactome; R-HSA-380270; Recruitment of mitotic centrosome proteins and complexes. DR Reactome; R-HSA-380284; Loss of proteins required for interphase microtubule organization from the centrosome. DR Reactome; R-HSA-380320; Recruitment of NuMA to mitotic centrosomes. DR Reactome; R-HSA-5620912; Anchoring of the basal body to the plasma membrane. DR Reactome; R-HSA-8854518; AURKA Activation by TPX2. DR SignaLink; Q8NHQ1; -. DR BioGRID-ORCS; 80321; 25 hits in 1124 CRISPR screens. DR ChiTaRS; CEP70; human. DR GeneWiki; CEP70; -. DR GenomeRNAi; 80321; -. DR Pharos; Q8NHQ1; Tbio. DR PRO; PR:Q8NHQ1; -. DR Proteomes; UP000005640; Chromosome 3. DR RNAct; Q8NHQ1; Protein. DR Bgee; ENSG00000114107; Expressed in calcaneal tendon and 191 other cell types or tissues. DR ExpressionAtlas; Q8NHQ1; baseline and differential. DR GO; GO:0005813; C:centrosome; IDA:UniProtKB. DR GO; GO:0005829; C:cytosol; TAS:Reactome. DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro. DR GO; GO:0042802; F:identical protein binding; IPI:IntAct. DR GO; GO:0060271; P:cilium assembly; IEA:InterPro. DR GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:InterPro. DR InterPro; IPR037692; CEP70. DR InterPro; IPR019734; TPR_repeat. DR PANTHER; PTHR14594; CENTROSOMAL PROTEIN OF 70 KDA; 1. DR PANTHER; PTHR14594:SF1; CENTROSOMAL PROTEIN OF 70 KDA; 1. DR PROSITE; PS50005; TPR; 1. DR PROSITE; PS50293; TPR_REGION; 1. DR Genevisible; Q8NHQ1; HS. PE 1: Evidence at protein level; KW Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton; KW Reference proteome; TPR repeat. FT CHAIN 1..597 FT /note="Centrosomal protein of 70 kDa" FT /id="PRO_0000089497" FT REPEAT 483..516 FT /note="TPR" FT REGION 1..23 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 75..179 FT /evidence="ECO:0000255" FT COILED 254..326 FT /evidence="ECO:0000255" FT VAR_SEQ 1..18 FT /note="Missing (in isoform 4 and isoform 5)" FT /evidence="ECO:0000305" FT /id="VSP_042140" FT VAR_SEQ 22..23 FT /note="Missing (in isoform 5)" FT /evidence="ECO:0000305" FT /id="VSP_042141" FT VAR_SEQ 213..597 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000305" FT /id="VSP_012745" FT VAR_SEQ 551..554 FT /note="SIIY -> RYLF (in isoform 2)" FT /evidence="ECO:0000303|Ref.1" FT /id="VSP_012746" FT VAR_SEQ 555..597 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|Ref.1" FT /id="VSP_012747" FT VARIANT 135 FT /note="S -> N (in dbSNP:rs1673607)" FT /evidence="ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.4" FT /id="VAR_021177" FT VARIANT 537 FT /note="N -> S (in dbSNP:rs35340237)" FT /id="VAR_061590" FT CONFLICT 52 FT /note="Missing (in Ref. 2; BAB14403)" FT /evidence="ECO:0000305" FT CONFLICT 293 FT /note="Q -> L (in Ref. 2; BAH12924)" FT /evidence="ECO:0000305" FT CONFLICT 371 FT /note="Q -> R (in Ref. 2; BAB14403)" FT /evidence="ECO:0000305" FT CONFLICT 385 FT /note="Q -> R (in Ref. 2; BAH13584)" FT /evidence="ECO:0000305" FT CONFLICT 393 FT /note="V -> A (in Ref. 2; BAH13584)" FT /evidence="ECO:0000305" FT CONFLICT 471 FT /note="S -> P (in Ref. 1; AAG35616/AAG35791)" FT /evidence="ECO:0000305" FT CONFLICT 478 FT /note="D -> G (in Ref. 1; AAG35616/AAG35791)" FT /evidence="ECO:0000305" SQ SEQUENCE 597 AA; 69752 MW; 345EEEB9B1F0D6C7 CRC64; MFPVAPKPQD SSQPSDRLMT EKQQEEAEWE SINVLLMMHG LKPLSLVKRT DLKDLIIFDK QSSQRMRQNL KLLVEETSCQ QNMIQELIET NQQLRNELQL EQSRAANQEQ RANDLEQIME SVKSKIGELE DESLSRACHQ QNKIKDLQKE QKTLQVKCQH YKKKRTEQEE TIASLQMEVC RLKKEEEDRI VTQNRVFAYL CKRVPHTVLD RQLLCLIDYY ESKIRKIHTQ RQYKEDESQS EEENDYRNLD ASPTYKGLLM SLQNQLKESK SKIDALSSEK LNLQKDLETR PTQHELRLYK QQVKKLEKAL KKNVKLQELI NHKKAEDTEK KDEPSKYNQQ QALIDQRYFQ VLCSINSIIH NPRAPVIIYK QTKGGVQNFN KDLVQDCGFE HLVPVIEMWA DQLTSLKDLY KSLKTLSAEL VPWLNLKKQD ENEGIKVEDL LFIVDTMLEE VENKEKDSNM PHFQTLQAIV SHFQKLFDVP SLNGVYPRMN EVYTRLGEMN NAVRNLQELL ELDSSSSLCV LVSTVGKLCR LINEDVNEQV MQVLGPEDLQ SIIYKLEEHE EFFPAFQAFT NDLLEILEID DLDAIVPAVK KLKVLSY //