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Protein

Centrosomal protein of 70 kDa

Gene

CEP70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.
REACT_267965. Anchoring of the basal body to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 70 kDa
Short name:
Cep70
Alternative name(s):
p10-binding protein
Gene namesi
Name:CEP70
Synonyms:BITE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:29972. CEP70.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • nuclear membrane Source: HPA
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394729.

Polymorphism and mutation databases

BioMutaiCEP70.
DMDMi84028943.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 597597Centrosomal protein of 70 kDaPRO_0000089497Add
BLAST

Proteomic databases

PaxDbiQ8NHQ1.
PRIDEiQ8NHQ1.

PTM databases

PhosphoSiteiQ8NHQ1.

Expressioni

Gene expression databases

BgeeiQ8NHQ1.
CleanExiHS_CEP70.
ExpressionAtlasiQ8NHQ1. baseline and differential.
GenevisibleiQ8NHQ1. HS.

Organism-specific databases

HPAiHPA036941.
HPA036942.

Interactioni

Subunit structurei

Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ABT1Q9ULW33EBI-739624,EBI-2602396
AKAP17AQ020403EBI-739624,EBI-1042725
AKAP17AQ02040-33EBI-739624,EBI-10222656
ARHGEF3Q9NR813EBI-739624,EBI-10312733
ATP5OP480473EBI-739624,EBI-355815
BARD1A0AVN23EBI-739624,EBI-9977322
BARD1Q997283EBI-739624,EBI-473181
BEX2Q9BXY83EBI-739624,EBI-745073
BRMS1Q9HCU93EBI-739624,EBI-714781
BYSLQ138955EBI-739624,EBI-358049
C11orf57Q6ZUT13EBI-739624,EBI-3920396
C11orf57Q6ZUT1-23EBI-739624,EBI-10180231
C8orf33Q9H7E94EBI-739624,EBI-715389
CARD9Q9H2573EBI-739624,EBI-751319
CCDC94Q9BW853EBI-739624,EBI-10300345
CDC73Q6P1J94EBI-739624,EBI-930143
CDCA7LQ96GN53EBI-739624,EBI-5278764
CEP57L1Q8IYX83EBI-739624,EBI-1104570
CEP57L1Q8IYX8-23EBI-739624,EBI-10181988
CFAP53Q96M913EBI-739624,EBI-742422
CLPBQ9H0783EBI-739624,EBI-2107221
COILP384323EBI-739624,EBI-945751
DDX41Q9UJV93EBI-739624,EBI-1046350
DDX6P261963EBI-739624,EBI-351257
DIEXFQ68CQ43EBI-739624,EBI-747711
DKFZp451B226Q5HYH73EBI-739624,EBI-10173842
EMDP504023EBI-739624,EBI-489887
EMP1P548493EBI-739624,EBI-4319440
ENKD1Q9H0I24EBI-739624,EBI-744099
ERCC3P194473EBI-739624,EBI-1183307
FAM124AQ86V423EBI-739624,EBI-744506
FAM133AQ8N9E03EBI-739624,EBI-10268158
FAM13CQ8NE313EBI-739624,EBI-751248
FAM161AQ3B8203EBI-739624,EBI-719941
FAM214BQ7L5A33EBI-739624,EBI-745689
FAM64AQ9BSJ63EBI-739624,EBI-2568609
GATAD2BQ8WXI93EBI-739624,EBI-923440
GCC1Q96CN93EBI-739624,EBI-746252
GPATCH2LQ9NWQ43EBI-739624,EBI-5666657
GPATCH4Q5T3I03EBI-739624,EBI-2372076
GPX7Q96SL43EBI-739624,EBI-749411
HAUS1Q96CS23EBI-739624,EBI-2514791
HMGB4Q6NSH13EBI-739624,EBI-10250889
HMGB4Q8WW323EBI-739624,EBI-10277297
HSPD1P108093EBI-739624,EBI-352528
IKQ131233EBI-739624,EBI-713456
KANK2Q63ZY33EBI-739624,EBI-2556193
KANSL1I3L4J33EBI-739624,EBI-10178305
KDM1AO603412EBI-739624,EBI-710124
KRT31Q153233EBI-739624,EBI-948001
LENG1Q96BZ83EBI-739624,EBI-726510
LENG8Q96PV63EBI-739624,EBI-739546
LIN37Q96GY33EBI-739624,EBI-748884
METTL17Q9H7H03EBI-739624,EBI-749353
MFAP1P550813EBI-739624,EBI-1048159
NIPSNAP3AQ9UFN03EBI-739624,EBI-716291
NOL12Q9UGY13EBI-739624,EBI-716098
NOP2P460873EBI-739624,EBI-356811
NRIP1P485523EBI-739624,EBI-746484
NUSAP1Q9BXS63EBI-739624,EBI-2555618
PPIGQ134273EBI-739624,EBI-396072
PPP1R16BQ96T493EBI-739624,EBI-10293968
PRKRIP1Q9H8753EBI-739624,EBI-744488
PRPF31F1T0A53EBI-739624,EBI-10177194
PSMA1P257863EBI-739624,EBI-359352
RPL13P263733EBI-739624,EBI-356849
RPL13Q6NZ553EBI-739624,EBI-10252046
SETD5Q9C0A6-23EBI-739624,EBI-10303449
SFR1Q86XK33EBI-739624,EBI-1104535
SH2D4AQ9H788-23EBI-739624,EBI-10308083
SLU7O953913EBI-739624,EBI-750559
SMARCE1Q969G33EBI-739624,EBI-455078
SNRPD2P623163EBI-739624,EBI-297993
SSX3Q999093EBI-739624,EBI-10295431
STK25O005063EBI-739624,EBI-618295
SUV39H1O434633EBI-739624,EBI-349968
SYT17Q9BSW73EBI-739624,EBI-745392
SYTL4Q96C243EBI-739624,EBI-747142
SYTL5Q8TDW53EBI-739624,EBI-2939487
TAF1DQ9H5J84EBI-739624,EBI-716128
TCEB3Q142413EBI-739624,EBI-742350
TEAD4D3DUQ63EBI-739624,EBI-10176734
TRIM29Q141344EBI-739624,EBI-702370
TRIM42A1L4B63EBI-739624,EBI-10172216
TSGA10IPQ3SY003EBI-739624,EBI-10241197
TSHZ3A1L0U73EBI-739624,EBI-10171826
TTC25Q96NG33EBI-739624,EBI-1046387
TTLL10Q6ZVT03EBI-739624,EBI-7844656
UTP11LQ9Y3A23EBI-739624,EBI-2876697
ZBTB24O431673EBI-739624,EBI-744471
ZCCHC10Q8TBK63EBI-739624,EBI-597063
ZFC3H1G3V1X13EBI-739624,EBI-6448783
ZGPATQ8N5A53EBI-739624,EBI-3439227
ZGPATQ8N5A5-23EBI-739624,EBI-10183064
ZNF136P527375EBI-739624,EBI-749129
ZNF148Q9UQR13EBI-739624,EBI-2688184
ZNF169Q149293EBI-739624,EBI-10234472
ZNF227Q86WZ63EBI-739624,EBI-2799529
ZNF239Q166003EBI-739624,EBI-8787052
ZNF266Q145843EBI-739624,EBI-7115319
ZNF302Q9NR113EBI-739624,EBI-3916142
ZNF329Q86UD43EBI-739624,EBI-7233259
ZNF366Q8N8953EBI-739624,EBI-2813661
ZNF408Q9H9D46EBI-739624,EBI-347633
ZNF410Q86VK43EBI-739624,EBI-720304
ZNF417Q8TAU33EBI-739624,EBI-740727
ZNF439Q8NDP43EBI-739624,EBI-747580
ZNF490Q9ULM23EBI-739624,EBI-1105370
ZNF509Q32ML03EBI-739624,EBI-2859943
ZNF555Q8NEP93EBI-739624,EBI-10270752
ZNF572A1L4E93EBI-739624,EBI-10172590
ZNF572Q7Z3I73EBI-739624,EBI-10257016
ZNF578Q3MI943EBI-739624,EBI-10241108
ZNF587Q96SQ53EBI-739624,EBI-6427977
ZSCAN12O433093EBI-739624,EBI-1210440

Protein-protein interaction databases

BioGridi123234. 139 interactions.
IntActiQ8NHQ1. 144 interactions.
MINTiMINT-1446081.

Structurei

3D structure databases

ProteinModelPortaliQ8NHQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati483 – 51634TPRAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili75 – 179105Sequence AnalysisAdd
BLAST
Coiled coili254 – 32673Sequence AnalysisAdd
BLAST

Domaini

The coiled-coil domains may be important for tubulin-gamma-binding and hence for centrosomal localization.

Sequence similaritiesi

Contains 1 TPR repeat.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, TPR repeat

Phylogenomic databases

eggNOGiNOG68751.
GeneTreeiENSGT00390000009029.
HOGENOMiHOG000290163.
HOVERGENiHBG050899.
InParanoidiQ8NHQ1.
KOiK16802.
OMAiNVLLMMH.
OrthoDBiEOG70PC06.
PhylomeDBiQ8NHQ1.
TreeFamiTF330986.

Family and domain databases

InterProiIPR013026. TPR-contain_dom.
IPR019734. TPR_repeat.
[Graphical view]
PROSITEiPS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NHQ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFPVAPKPQD SSQPSDRLMT EKQQEEAEWE SINVLLMMHG LKPLSLVKRT
60 70 80 90 100
DLKDLIIFDK QSSQRMRQNL KLLVEETSCQ QNMIQELIET NQQLRNELQL
110 120 130 140 150
EQSRAANQEQ RANDLEQIME SVKSKIGELE DESLSRACHQ QNKIKDLQKE
160 170 180 190 200
QKTLQVKCQH YKKKRTEQEE TIASLQMEVC RLKKEEEDRI VTQNRVFAYL
210 220 230 240 250
CKRVPHTVLD RQLLCLIDYY ESKIRKIHTQ RQYKEDESQS EEENDYRNLD
260 270 280 290 300
ASPTYKGLLM SLQNQLKESK SKIDALSSEK LNLQKDLETR PTQHELRLYK
310 320 330 340 350
QQVKKLEKAL KKNVKLQELI NHKKAEDTEK KDEPSKYNQQ QALIDQRYFQ
360 370 380 390 400
VLCSINSIIH NPRAPVIIYK QTKGGVQNFN KDLVQDCGFE HLVPVIEMWA
410 420 430 440 450
DQLTSLKDLY KSLKTLSAEL VPWLNLKKQD ENEGIKVEDL LFIVDTMLEE
460 470 480 490 500
VENKEKDSNM PHFQTLQAIV SHFQKLFDVP SLNGVYPRMN EVYTRLGEMN
510 520 530 540 550
NAVRNLQELL ELDSSSSLCV LVSTVGKLCR LINEDVNEQV MQVLGPEDLQ
560 570 580 590
SIIYKLEEHE EFFPAFQAFT NDLLEILEID DLDAIVPAVK KLKVLSY
Length:597
Mass (Da):69,752
Last modified:February 1, 2005 - v2
Checksum:i345EEEB9B1F0D6C7
GO
Isoform 2 (identifier: Q8NHQ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     551-554: SIIY → RYLF
     555-597: Missing.

Show »
Length:554
Mass (Da):64,880
Checksum:i995E0945339F20CA
GO
Isoform 3 (identifier: Q8NHQ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-597: Missing.

Show »
Length:212
Mass (Da):25,034
Checksum:i5E1C436C297C8CF3
GO
Isoform 4 (identifier: Q8NHQ1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.

Note: No experimental confirmation available.
Show »
Length:579
Mass (Da):67,770
Checksum:iAE654471BDE652DF
GO
Isoform 5 (identifier: Q8NHQ1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     22-23: Missing.

Note: No experimental confirmation available.
Show »
Length:577
Mass (Da):67,513
Checksum:iF4A66BB90BB75EAE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521Missing in BAB14403 (PubMed:14702039).Curated
Sequence conflicti293 – 2931Q → L in BAH12924 (PubMed:14702039).Curated
Sequence conflicti371 – 3711Q → R in BAB14403 (PubMed:14702039).Curated
Sequence conflicti385 – 3851Q → R in BAH13584 (PubMed:14702039).Curated
Sequence conflicti393 – 3931V → A in BAH13584 (PubMed:14702039).Curated
Sequence conflicti471 – 4711S → P in AAG35616 (Ref. 1) Curated
Sequence conflicti471 – 4711S → P in AAG35791 (Ref. 1) Curated
Sequence conflicti478 – 4781D → G in AAG35616 (Ref. 1) Curated
Sequence conflicti478 – 4781D → G in AAG35791 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti135 – 1351S → N.3 Publications
Corresponds to variant rs1673607 [ dbSNP | Ensembl ].
VAR_021177
Natural varianti537 – 5371N → S.
Corresponds to variant rs35340237 [ dbSNP | Ensembl ].
VAR_061590

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1818Missing in isoform 4 and isoform 5. CuratedVSP_042140Add
BLAST
Alternative sequencei22 – 232Missing in isoform 5. CuratedVSP_042141
Alternative sequencei213 – 597385Missing in isoform 3. CuratedVSP_012745Add
BLAST
Alternative sequencei551 – 5544SIIY → RYLF in isoform 2. 1 PublicationVSP_012746
Alternative sequencei555 – 59743Missing in isoform 2. 1 PublicationVSP_012747Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202146 mRNA. Translation: AAG35616.1.
AF289495 mRNA. Translation: AAG35791.1.
AK023098 mRNA. Translation: BAB14403.1.
AK299003 mRNA. Translation: BAH12924.1.
AK301913 mRNA. Translation: BAH13584.1.
AC020890 Genomic DNA. No translation available.
AC072045 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79062.1.
CH471052 Genomic DNA. Translation: EAW79063.1.
BC016050 mRNA. Translation: AAH16050.1.
BC030598 mRNA. Translation: AAH30598.1.
CCDSiCCDS3102.1. [Q8NHQ1-1]
CCDS75022.1. [Q8NHQ1-4]
CCDS75023.1. [Q8NHQ1-2]
RefSeqiNP_001275893.1. NM_001288964.1. [Q8NHQ1-4]
NP_001275894.1. NM_001288965.1. [Q8NHQ1-5]
NP_001275895.1. NM_001288966.1. [Q8NHQ1-2]
NP_001275896.1. NM_001288967.1.
NP_077817.2. NM_024491.3. [Q8NHQ1-1]
XP_005247863.1. XM_005247806.2. [Q8NHQ1-1]
UniGeneiHs.531962.

Genome annotation databases

EnsembliENST00000264982; ENSP00000264982; ENSG00000114107. [Q8NHQ1-1]
ENST00000464035; ENSP00000419743; ENSG00000114107. [Q8NHQ1-3]
ENST00000474781; ENSP00000419833; ENSG00000114107. [Q8NHQ1-4]
ENST00000481834; ENSP00000417465; ENSG00000114107. [Q8NHQ1-2]
ENST00000484888; ENSP00000419231; ENSG00000114107. [Q8NHQ1-1]
GeneIDi80321.
KEGGihsa:80321.
UCSCiuc003esl.3. human. [Q8NHQ1-1]
uc003esm.3. human. [Q8NHQ1-2]
uc003esn.3. human. [Q8NHQ1-3]
uc011bmk.2. human. [Q8NHQ1-5]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202146 mRNA. Translation: AAG35616.1.
AF289495 mRNA. Translation: AAG35791.1.
AK023098 mRNA. Translation: BAB14403.1.
AK299003 mRNA. Translation: BAH12924.1.
AK301913 mRNA. Translation: BAH13584.1.
AC020890 Genomic DNA. No translation available.
AC072045 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79062.1.
CH471052 Genomic DNA. Translation: EAW79063.1.
BC016050 mRNA. Translation: AAH16050.1.
BC030598 mRNA. Translation: AAH30598.1.
CCDSiCCDS3102.1. [Q8NHQ1-1]
CCDS75022.1. [Q8NHQ1-4]
CCDS75023.1. [Q8NHQ1-2]
RefSeqiNP_001275893.1. NM_001288964.1. [Q8NHQ1-4]
NP_001275894.1. NM_001288965.1. [Q8NHQ1-5]
NP_001275895.1. NM_001288966.1. [Q8NHQ1-2]
NP_001275896.1. NM_001288967.1.
NP_077817.2. NM_024491.3. [Q8NHQ1-1]
XP_005247863.1. XM_005247806.2. [Q8NHQ1-1]
UniGeneiHs.531962.

3D structure databases

ProteinModelPortaliQ8NHQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123234. 139 interactions.
IntActiQ8NHQ1. 144 interactions.
MINTiMINT-1446081.

PTM databases

PhosphoSiteiQ8NHQ1.

Polymorphism and mutation databases

BioMutaiCEP70.
DMDMi84028943.

Proteomic databases

PaxDbiQ8NHQ1.
PRIDEiQ8NHQ1.

Protocols and materials databases

DNASUi80321.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264982; ENSP00000264982; ENSG00000114107. [Q8NHQ1-1]
ENST00000464035; ENSP00000419743; ENSG00000114107. [Q8NHQ1-3]
ENST00000474781; ENSP00000419833; ENSG00000114107. [Q8NHQ1-4]
ENST00000481834; ENSP00000417465; ENSG00000114107. [Q8NHQ1-2]
ENST00000484888; ENSP00000419231; ENSG00000114107. [Q8NHQ1-1]
GeneIDi80321.
KEGGihsa:80321.
UCSCiuc003esl.3. human. [Q8NHQ1-1]
uc003esm.3. human. [Q8NHQ1-2]
uc003esn.3. human. [Q8NHQ1-3]
uc011bmk.2. human. [Q8NHQ1-5]

Organism-specific databases

CTDi80321.
GeneCardsiGC03M138213.
H-InvDBHIX0018484.
HGNCiHGNC:29972. CEP70.
HPAiHPA036941.
HPA036942.
MIMi614310. gene.
neXtProtiNX_Q8NHQ1.
PharmGKBiPA128394729.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG68751.
GeneTreeiENSGT00390000009029.
HOGENOMiHOG000290163.
HOVERGENiHBG050899.
InParanoidiQ8NHQ1.
KOiK16802.
OMAiNVLLMMH.
OrthoDBiEOG70PC06.
PhylomeDBiQ8NHQ1.
TreeFamiTF330986.

Enzyme and pathway databases

ReactomeiREACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.
REACT_267965. Anchoring of the basal body to the plasma membrane.

Miscellaneous databases

ChiTaRSiCEP70. human.
GeneWikiiCEP70.
GenomeRNAii80321.
NextBioi70839.
PROiQ8NHQ1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NHQ1.
CleanExiHS_CEP70.
ExpressionAtlasiQ8NHQ1. baseline and differential.
GenevisibleiQ8NHQ1. HS.

Family and domain databases

InterProiIPR013026. TPR-contain_dom.
IPR019734. TPR_repeat.
[Graphical view]
PROSITEiPS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of BITE: a binding partner of the cell cycle inhibitor p10."
    Tschan M.P., Cajot J.-F., Grob T.J., Fey M.F., Tobler A.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Chronic myeloid leukemia cell.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 4 AND 5), VARIANT ASN-135.
    Tissue: Teratocarcinoma and Testis.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-135.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1 AND 3), VARIANT ASN-135.
    Tissue: Skin and Testis.
  6. "Proteomic characterization of the human centrosome by protein correlation profiling."
    Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.
    Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Lymphoblast.
  7. "CEP70 protein interacts with gamma-tubulin to localize at the centrosome and is critical for mitotic spindle assembly."
    Shi X., Sun X., Liu M., Li D., Aneja R., Zhou J.
    J. Biol. Chem. 286:33401-33408(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TUBULIN-GAMMA.

Entry informationi

Entry nameiCEP70_HUMAN
AccessioniPrimary (citable) accession number: Q8NHQ1
Secondary accession number(s): B7Z5I8
, B7Z7E8, D3DNE9, F5GZX8, Q96B31, Q9H2C3, Q9H2Z1, Q9H940
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: June 24, 2015
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.