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Protein

Centrosomal protein of 70 kDa

Gene

CEP70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-380284. Loss of proteins required for interphase microtubule organization from the centrosome.
R-HSA-380320. Recruitment of NuMA to mitotic centrosomes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 70 kDa
Short name:
Cep70
Alternative name(s):
p10-binding protein
Gene namesi
Name:CEP70
Synonyms:BITE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114107.8.
HGNCiHGNC:29972. CEP70.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi80321.
OpenTargetsiENSG00000114107.
PharmGKBiPA128394729.

Polymorphism and mutation databases

BioMutaiCEP70.
DMDMi84028943.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894971 – 597Centrosomal protein of 70 kDaAdd BLAST597

Proteomic databases

EPDiQ8NHQ1.
PaxDbiQ8NHQ1.
PeptideAtlasiQ8NHQ1.
PRIDEiQ8NHQ1.

PTM databases

iPTMnetiQ8NHQ1.
PhosphoSitePlusiQ8NHQ1.

Expressioni

Gene expression databases

BgeeiENSG00000114107.
CleanExiHS_CEP70.
ExpressionAtlasiQ8NHQ1. baseline and differential.
GenevisibleiQ8NHQ1. HS.

Organism-specific databases

HPAiHPA036941.
HPA036942.

Interactioni

Subunit structurei

Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-739624,EBI-739624
ABT1Q9ULW35EBI-739624,EBI-2602396
AIR1P405073EBI-739624,EBI-25083From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
AKAP17AQ020405EBI-739624,EBI-1042725
AKAP17AQ02040-33EBI-739624,EBI-10222656
APL6P466823EBI-739624,EBI-2213From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
ARHGEF3Q9NR815EBI-739624,EBI-10312733
ATP5OP480475EBI-739624,EBI-355815
BARD1A0AVN23EBI-739624,EBI-9977322
BARD1Q997283EBI-739624,EBI-473181
BEX2Q9BXY85EBI-739624,EBI-745073
BIT61P470413EBI-739624,EBI-25889From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
BOL3P397243EBI-739624,EBI-2343154From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
BRD1O956964EBI-739624,EBI-714754
BRMS1Q9HCU93EBI-739624,EBI-714781
BTN2P532863EBI-739624,EBI-3796From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
BYSLQ138957EBI-739624,EBI-358049
C11orf57Q6ZUT15EBI-739624,EBI-3920396
C11orf57Q6ZUT1-23EBI-739624,EBI-10180231
C8orf33Q9H7E94EBI-739624,EBI-715389
CARD9Q9H2573EBI-739624,EBI-751319
CCDC94Q9BW855EBI-739624,EBI-10300345
CDC73Q6P1J99EBI-739624,EBI-930143
CDCA7LQ96GN55EBI-739624,EBI-5278764
CEP57L1Q8IYX83EBI-739624,EBI-1104570
CEP57L1Q8IYX8-23EBI-739624,EBI-10181988
CEP70Q8NHQ1-33EBI-739624,EBI-11526150
CFAP53Q96M913EBI-739624,EBI-742422
CLPBQ9H0783EBI-739624,EBI-2107221
COILP384323EBI-739624,EBI-945751
CSN12P471303EBI-739624,EBI-763From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
DDX41Q9UJV93EBI-739624,EBI-1046350
DDX6P261965EBI-739624,EBI-351257
DIEXFQ68CQ45EBI-739624,EBI-747711
ELOAQ142413EBI-739624,EBI-742350
EMDP504026EBI-739624,EBI-489887
EMP1P548493EBI-739624,EBI-4319440
ENKD1Q9H0I24EBI-739624,EBI-744099
ERCC3P194473EBI-739624,EBI-1183307
FAM124AQ86V423EBI-739624,EBI-744506
FAM133AQ8N9E05EBI-739624,EBI-10268158
FAM13CQ8NE313EBI-739624,EBI-751248
FAM161AQ3B8207EBI-739624,EBI-719941
FAM214BQ7L5A33EBI-739624,EBI-745689
GATAD2BQ8WXI93EBI-739624,EBI-923440
GCC1Q96CN95EBI-739624,EBI-746252
GCD7P325023EBI-739624,EBI-6260From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
GLYCTKQ8IVS84EBI-739624,EBI-748515
GPATCH2LQ9NWQ43EBI-739624,EBI-5666657
GPATCH4Q5T3I05EBI-739624,EBI-2372076
GPD2P419113EBI-739624,EBI-7791From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
GPX7Q96SL43EBI-739624,EBI-749411
HAUS1Q96CS23EBI-739624,EBI-2514791
HAUS1Q96CS2-23EBI-739624,EBI-11742270
HMGB4Q6NSH13EBI-739624,EBI-10250889
HMGB4Q8WW325EBI-739624,EBI-10277297
HSPD1P108093EBI-739624,EBI-352528
IKQ131233EBI-739624,EBI-713456
INPP5JQ157354EBI-739624,EBI-10236940
KANK2Q63ZY35EBI-739624,EBI-2556193
KANSL1Q7Z3B34EBI-739624,EBI-740244
KDM1AO603412EBI-739624,EBI-710124
KRT31Q153233EBI-739624,EBI-948001
LAMTOR5A0A0C4DGV45EBI-739624,EBI-10173304
LENG1Q96BZ85EBI-739624,EBI-726510
LENG8Q96PV63EBI-739624,EBI-739546
LIN37Q96GY33EBI-739624,EBI-748884
METTL17Q9H7H03EBI-739624,EBI-749353
MFAP1P550815EBI-739624,EBI-1048159
MMTAG2Q9BU764EBI-739624,EBI-742459
MRP4P329023EBI-739624,EBI-16248From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
NIPSNAP3AQ9UFN03EBI-739624,EBI-716291
NOL12Q9UGY13EBI-739624,EBI-716098
NOP2P460873EBI-739624,EBI-356811
NOP56Q124603EBI-739624,EBI-17148From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
NRIP1P485523EBI-739624,EBI-746484
NUSAP1Q9BXS63EBI-739624,EBI-2555618
PIBF1A0A087WUI63EBI-739624,EBI-11749468
PIMREGQ9BSJ63EBI-739624,EBI-2568609
PPIGQ134273EBI-739624,EBI-396072
PPP1R16BQ96T493EBI-739624,EBI-10293968
PRKRIP1Q9H8753EBI-739624,EBI-744488
PRP3Q033383EBI-739624,EBI-421From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
PRP4P200533EBI-739624,EBI-219From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
PRP45P280043EBI-739624,EBI-20640From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
PRPF18Q996334EBI-739624,EBI-2798416
PRPF3O433954EBI-739624,EBI-744322
PRPF31Q8WWY38EBI-739624,EBI-1567797
PSMA1P257865EBI-739624,EBI-359352
PXR1P533353EBI-739624,EBI-23652From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
RFC2P403483EBI-739624,EBI-14992From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
RPL13P263733EBI-739624,EBI-356849
RPL13Q6NZ553EBI-739624,EBI-10252046
RRD1P404543EBI-739624,EBI-25278From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
SETD5Q9C0A6-23EBI-739624,EBI-10303449
SFR1Q86XK33EBI-739624,EBI-1104535
SGD1Q061323EBI-739624,EBI-34377From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
SH2D4AQ9H788-23EBI-739624,EBI-10308083
SLU7O953913EBI-739624,EBI-750559
SMARCE1Q969G37EBI-739624,EBI-455078
SNRPD2P623163EBI-739624,EBI-297993
SPP382Q064113EBI-739624,EBI-576From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
SSX3Q999093EBI-739624,EBI-10295431
STK25O005063EBI-739624,EBI-618295
SUV39H1O434633EBI-739624,EBI-349968
SYT17Q9BSW73EBI-739624,EBI-745392
SYTL4Q96C243EBI-739624,EBI-747142
SYTL5Q8TDW53EBI-739624,EBI-2939487
TAE1P383403EBI-11526150,EBI-21116From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
TAF1DQ9H5J84EBI-739624,EBI-716128
TEAD4D3DUQ63EBI-739624,EBI-10176734
TOM20P351803EBI-739624,EBI-12522From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
TRIM29Q141344EBI-739624,EBI-702370
TRIM42Q8IWZ53EBI-739624,EBI-5235829
TRX3P253723EBI-739624,EBI-19616From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
TSFMP438973EBI-739624,EBI-1049298
TSGA10IPQ3SY005EBI-739624,EBI-10241197
TSHZ3Q63HK53EBI-739624,EBI-9053916
TTC25Q96NG33EBI-739624,EBI-1046387
TTLL10Q6ZVT03EBI-739624,EBI-7844656
TXLNBQ8N3L35EBI-739624,EBI-6116822
ULP1Q027243EBI-739624,EBI-20050From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
UTP11Q9Y3A23EBI-739624,EBI-2876697
ZBTB16Q055163EBI-739624,EBI-711925
ZBTB24O431675EBI-739624,EBI-744471
ZBTB49Q6ZSB93EBI-739624,EBI-2859943
ZCCHC10Q8TBK63EBI-739624,EBI-597063
ZFC3H1G3V1X13EBI-739624,EBI-6448783
ZGPATQ8N5A53EBI-739624,EBI-3439227
ZGPATQ8N5A5-27EBI-739624,EBI-10183064
ZNF136P527375EBI-739624,EBI-749129
ZNF148Q9UQR13EBI-739624,EBI-2688184
ZNF169Q149293EBI-739624,EBI-10234472
ZNF227Q86WZ65EBI-739624,EBI-2799529
ZNF239Q166005EBI-739624,EBI-8787052
ZNF266Q145845EBI-739624,EBI-7115319
ZNF302Q9NR113EBI-739624,EBI-3916142
ZNF329Q86UD45EBI-739624,EBI-7233259
ZNF366Q8N8955EBI-739624,EBI-2813661
ZNF408Q9H9D48EBI-739624,EBI-347633
ZNF410Q86VK43EBI-739624,EBI-720304
ZNF417Q8TAU35EBI-739624,EBI-740727
ZNF439Q8NDP43EBI-739624,EBI-747580
ZNF490Q9ULM25EBI-739624,EBI-1105370
ZNF555Q8NEP93EBI-739624,EBI-10270752
ZNF572Q7Z3I76EBI-739624,EBI-10172590
ZNF578Q3MI943EBI-739624,EBI-10241108
ZNF587Q96SQ55EBI-739624,EBI-6427977
ZNF599Q96NL34EBI-739624,EBI-8653994
ZSCAN12O433093EBI-739624,EBI-1210440

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi123234. 142 interactors.
IntActiQ8NHQ1. 263 interactors.
MINTiMINT-1446081.
STRINGi9606.ENSP00000264982.

Structurei

3D structure databases

ProteinModelPortaliQ8NHQ1.
SMRiQ8NHQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati483 – 516TPRAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili75 – 179Sequence analysisAdd BLAST105
Coiled coili254 – 326Sequence analysisAdd BLAST73

Domaini

The coiled-coil domains may be important for tubulin-gamma-binding and hence for centrosomal localization.

Keywords - Domaini

Coiled coil, TPR repeat

Phylogenomic databases

eggNOGiENOG410IFWI. Eukaryota.
ENOG4111V7R. LUCA.
GeneTreeiENSGT00390000009029.
HOGENOMiHOG000290163.
HOVERGENiHBG050899.
InParanoidiQ8NHQ1.
KOiK16802.
OMAiNVLLMMH.
OrthoDBiEOG091G08G2.
PhylomeDBiQ8NHQ1.
TreeFamiTF330986.

Family and domain databases

InterProiView protein in InterPro
IPR013026. TPR-contain_dom.
IPR019734. TPR_repeat.
PROSITEiView protein in PROSITE
PS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NHQ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFPVAPKPQD SSQPSDRLMT EKQQEEAEWE SINVLLMMHG LKPLSLVKRT
60 70 80 90 100
DLKDLIIFDK QSSQRMRQNL KLLVEETSCQ QNMIQELIET NQQLRNELQL
110 120 130 140 150
EQSRAANQEQ RANDLEQIME SVKSKIGELE DESLSRACHQ QNKIKDLQKE
160 170 180 190 200
QKTLQVKCQH YKKKRTEQEE TIASLQMEVC RLKKEEEDRI VTQNRVFAYL
210 220 230 240 250
CKRVPHTVLD RQLLCLIDYY ESKIRKIHTQ RQYKEDESQS EEENDYRNLD
260 270 280 290 300
ASPTYKGLLM SLQNQLKESK SKIDALSSEK LNLQKDLETR PTQHELRLYK
310 320 330 340 350
QQVKKLEKAL KKNVKLQELI NHKKAEDTEK KDEPSKYNQQ QALIDQRYFQ
360 370 380 390 400
VLCSINSIIH NPRAPVIIYK QTKGGVQNFN KDLVQDCGFE HLVPVIEMWA
410 420 430 440 450
DQLTSLKDLY KSLKTLSAEL VPWLNLKKQD ENEGIKVEDL LFIVDTMLEE
460 470 480 490 500
VENKEKDSNM PHFQTLQAIV SHFQKLFDVP SLNGVYPRMN EVYTRLGEMN
510 520 530 540 550
NAVRNLQELL ELDSSSSLCV LVSTVGKLCR LINEDVNEQV MQVLGPEDLQ
560 570 580 590
SIIYKLEEHE EFFPAFQAFT NDLLEILEID DLDAIVPAVK KLKVLSY
Length:597
Mass (Da):69,752
Last modified:February 1, 2005 - v2
Checksum:i345EEEB9B1F0D6C7
GO
Isoform 2 (identifier: Q8NHQ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     551-554: SIIY → RYLF
     555-597: Missing.

Show »
Length:554
Mass (Da):64,880
Checksum:i995E0945339F20CA
GO
Isoform 3 (identifier: Q8NHQ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-597: Missing.

Show »
Length:212
Mass (Da):25,034
Checksum:i5E1C436C297C8CF3
GO
Isoform 4 (identifier: Q8NHQ1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.

Note: No experimental confirmation available.
Show »
Length:579
Mass (Da):67,770
Checksum:iAE654471BDE652DF
GO
Isoform 5 (identifier: Q8NHQ1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     22-23: Missing.

Note: No experimental confirmation available.
Show »
Length:577
Mass (Da):67,513
Checksum:iF4A66BB90BB75EAE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52Missing in BAB14403 (PubMed:14702039).Curated1
Sequence conflicti293Q → L in BAH12924 (PubMed:14702039).Curated1
Sequence conflicti371Q → R in BAB14403 (PubMed:14702039).Curated1
Sequence conflicti385Q → R in BAH13584 (PubMed:14702039).Curated1
Sequence conflicti393V → A in BAH13584 (PubMed:14702039).Curated1
Sequence conflicti471S → P in AAG35616 (Ref. 1) Curated1
Sequence conflicti471S → P in AAG35791 (Ref. 1) Curated1
Sequence conflicti478D → G in AAG35616 (Ref. 1) Curated1
Sequence conflicti478D → G in AAG35791 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021177135S → N3 PublicationsCorresponds to variant dbSNP:rs1673607Ensembl.1
Natural variantiVAR_061590537N → S. Corresponds to variant dbSNP:rs35340237Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0421401 – 18Missing in isoform 4 and isoform 5. CuratedAdd BLAST18
Alternative sequenceiVSP_04214122 – 23Missing in isoform 5. Curated2
Alternative sequenceiVSP_012745213 – 597Missing in isoform 3. CuratedAdd BLAST385
Alternative sequenceiVSP_012746551 – 554SIIY → RYLF in isoform 2. 1 Publication4
Alternative sequenceiVSP_012747555 – 597Missing in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202146 mRNA. Translation: AAG35616.1.
AF289495 mRNA. Translation: AAG35791.1.
AK023098 mRNA. Translation: BAB14403.1.
AK299003 mRNA. Translation: BAH12924.1.
AK301913 mRNA. Translation: BAH13584.1.
AC020890 Genomic DNA. No translation available.
AC072045 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79062.1.
CH471052 Genomic DNA. Translation: EAW79063.1.
BC016050 mRNA. Translation: AAH16050.1.
BC030598 mRNA. Translation: AAH30598.1.
CCDSiCCDS3102.1. [Q8NHQ1-1]
CCDS75022.1. [Q8NHQ1-4]
CCDS75023.1. [Q8NHQ1-2]
CCDS82842.1. [Q8NHQ1-3]
RefSeqiNP_001275893.1. NM_001288964.1. [Q8NHQ1-4]
NP_001275894.1. NM_001288965.1. [Q8NHQ1-5]
NP_001275895.1. NM_001288966.1. [Q8NHQ1-2]
NP_001275896.1. NM_001288967.1.
NP_001307527.1. NM_001320598.1. [Q8NHQ1-1]
NP_001307529.1. NM_001320600.1. [Q8NHQ1-3]
NP_077817.2. NM_024491.3. [Q8NHQ1-1]
XP_016862764.1. XM_017007275.1. [Q8NHQ1-1]
UniGeneiHs.531962.

Genome annotation databases

EnsembliENST00000264982; ENSP00000264982; ENSG00000114107. [Q8NHQ1-1]
ENST00000464035; ENSP00000419743; ENSG00000114107. [Q8NHQ1-3]
ENST00000474781; ENSP00000419833; ENSG00000114107. [Q8NHQ1-4]
ENST00000481834; ENSP00000417465; ENSG00000114107. [Q8NHQ1-2]
ENST00000484888; ENSP00000419231; ENSG00000114107. [Q8NHQ1-1]
GeneIDi80321.
KEGGihsa:80321.
UCSCiuc003esl.5. human. [Q8NHQ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCEP70_HUMAN
AccessioniPrimary (citable) accession number: Q8NHQ1
Secondary accession number(s): B7Z5I8
, B7Z7E8, D3DNE9, F5GZX8, Q96B31, Q9H2C3, Q9H2Z1, Q9H940
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: September 27, 2017
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot