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Reviewed, UniProtKB/Swiss-Prot Q8NHQ1 (CEP70_HUMAN)

Last modified December 15, 2009. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Centrosomal protein of 70 kDa
      Short name=Cep70
Alternative name(s):
    p10-binding protein
Gene names
Name: CEP70
Synonyms: BITE
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length597 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subcellular location

Cytoplasm › cytoskeleton › centrosome Ref.4.

Sequence similarities

Contains 1 TPR repeat.

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Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
TPR repeat
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcentrosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytosol

Inferred from Experiment. Source: Reactome

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

NRIP1P485522EBI-739624,EBI-746484
ZNF408Q9H9D42EBI-739624,EBI-347633

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NHQ1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8NHQ1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     551-554: SIIY → RYLF
     555-597: Missing.
Isoform 3 (identifier: Q8NHQ1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     213-597: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 597597Centrosomal protein of 70 kDa
PRO_0000089497

Regions

Repeat483 – 51634TPR
Coiled coil75 – 179105 Potential
Coiled coil254 – 32673 Potential

Natural variations

Alternative sequence213 – 597385Missing in isoform 3.
VSP_012745
Alternative sequence551 – 5544SIIY → RYLF in isoform 2.
VSP_012746
Alternative sequence555 – 59743Missing in isoform 2.
VSP_012747
Natural variant1351S → N: dbSNP rs1673607. Ref.3
VAR_021177
Natural variant5371N → S: dbSNP rs35340237.
VAR_061590

Experimental info

Sequence conflict521Missing in BAB14403. Ref.2
Sequence conflict3711Q → R in BAB14403. Ref.2
Sequence conflict4711S → P in AAG35616. Ref.1
Sequence conflict4711S → P in AAG35791. Ref.1
Sequence conflict4781D → G in AAG35616. Ref.1
Sequence conflict4781D → G in AAG35791. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 1, 2005. Version 2.
Checksum: 345EEEB9B1F0D6C7

FASTA59769,752
        10         20         30         40         50         60 
MFPVAPKPQD SSQPSDRLMT EKQQEEAEWE SINVLLMMHG LKPLSLVKRT DLKDLIIFDK 

        70         80         90        100        110        120 
QSSQRMRQNL KLLVEETSCQ QNMIQELIET NQQLRNELQL EQSRAANQEQ RANDLEQIME 

       130        140        150        160        170        180 
SVKSKIGELE DESLSRACHQ QNKIKDLQKE QKTLQVKCQH YKKKRTEQEE TIASLQMEVC 

       190        200        210        220        230        240 
RLKKEEEDRI VTQNRVFAYL CKRVPHTVLD RQLLCLIDYY ESKIRKIHTQ RQYKEDESQS 

       250        260        270        280        290        300 
EEENDYRNLD ASPTYKGLLM SLQNQLKESK SKIDALSSEK LNLQKDLETR PTQHELRLYK 

       310        320        330        340        350        360 
QQVKKLEKAL KKNVKLQELI NHKKAEDTEK KDEPSKYNQQ QALIDQRYFQ VLCSINSIIH 

       370        380        390        400        410        420 
NPRAPVIIYK QTKGGVQNFN KDLVQDCGFE HLVPVIEMWA DQLTSLKDLY KSLKTLSAEL 

       430        440        450        460        470        480 
VPWLNLKKQD ENEGIKVEDL LFIVDTMLEE VENKEKDSNM PHFQTLQAIV SHFQKLFDVP 

       490        500        510        520        530        540 
SLNGVYPRMN EVYTRLGEMN NAVRNLQELL ELDSSSSLCV LVSTVGKLCR LINEDVNEQV 

       550        560        570        580        590 
MQVLGPEDLQ SIIYKLEEHE EFFPAFQAFT NDLLEILEID DLDAIVPAVK KLKVLSY

« Hide

Isoform 2.

Checksum: 995E0945339F20CA
Show »

FASTA55464,880
Isoform 3.

Checksum: 5E1C436C297C8CF3
Show »

FASTA21225,034

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References

« Hide 'large scale' references
[1]"Cloning and characterization of BITE: a binding partner of the cell cycle inhibitor p10."
Tschan M.P., Cajot J.-F., Grob T.J., Fey M.F., Tobler A.
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tissue: Chronic myeloid leukemia cell.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1).
Tissue: Teratocarcinoma.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1 AND 3), VARIANT ASN-135.
Tissue: Skin and Testis.
[4]"Proteomic characterization of the human centrosome by protein correlation profiling."
Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.
Nature 426:570-574(2003) [PubMed: 14654843] [Abstract]
Cited for: MASS SPECTROMETRY, SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF202146 mRNA. Translation: AAG35616.1.
AF289495 mRNA. Translation: AAG35791.1.
AK023098 mRNA. Translation: BAB14403.1.
BC016050 mRNA. Translation: AAH16050.1.
BC030598 mRNA. Translation: AAH30598.1.
IPIIPI00304022.
IPI00549676.
IPI00549791.
RefSeqNP_077817.2.
UniGeneHs.531962

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ8NHQ1. 19 interactions.
STRINGQ8NHQ1.

Proteomic databases

PRIDEQ8NHQ1.

Genome annotation databases

EnsemblENST00000264982; ENSP00000264982; ENSG00000114107; Homo sapiens. [Genome view]
ENST00000484888; ENSP00000419231; ENSG00000114107; Homo sapiens. [Genome view]
GeneID80321.
KEGGhsa:80321.
NMPDRfig|9606.3.peg.23263.
UCSCuc003esl.1. human.
uc003esm.2. human.
uc003esn.2. human.

Organism-specific databases

CTD80321.
GeneCardsGC03M139696.
H-InvDBHIX0018484.
HGNCHGNC:29972. CEP70.
PharmGKBPA128394729.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHBG445369.
HOVERGENQ8NHQ1.
InParanoidQ8NHQ1.
OMAIDQRYFQ.
OrthoDBEOG9642XZ.

Enzyme and pathway databases

ReactomeREACT_152. Cell Cycle, Mitotic.

Gene expression databases

ArrayExpressQ8NHQ1.
BgeeQ8NHQ1.
CleanExHS_CEP70.
GenevestigatorQ8NHQ1.
GermOnlineENSG00000114107. Homo sapiens.

Family and domain databases

InterProIPR013026. TPR_region.
IPR019734. TPR_repeat.
[Graphical view]
PROSITEPS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio70839.

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Entry information

Entry nameCEP70_HUMAN
AccessionPrimary (citable) accession number: Q8NHQ1
Secondary accession number(s): Q96B31 expand/collapse secondary AC list , Q9H2C3, Q9H2Z1, Q9H940
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: December 15, 2009
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

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Human chromosome 3: entries, gene names and cross-references to MIM

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Recent format changes

Overview of recent format changes

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents