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Protein

Motile sperm domain-containing protein 2

Gene

MOSPD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes migration of primary monocytes and neutrophils, in response to various chemokines.1 Publication

GO - Biological processi

  • chemotaxis Source: UniProtKB-KW
  • neutrophil degranulation Source: Reactome
  • positive regulation of monocyte chemotaxis Source: UniProtKB
  • positive regulation of neutrophil chemotaxis Source: UniProtKB

Keywordsi

Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Motile sperm domain-containing protein 2
Gene namesi
Name:MOSPD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000130150.11.
HGNCiHGNC:28381. MOSPD2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei497 – 517HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130150.
PharmGKBiPA134898878.

Polymorphism and mutation databases

BioMutaiMOSPD2.
DMDMi67461057.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002134631 – 518Motile sperm domain-containing protein 2Add BLAST518

Proteomic databases

EPDiQ8NHP6.
MaxQBiQ8NHP6.
PaxDbiQ8NHP6.
PeptideAtlasiQ8NHP6.
PRIDEiQ8NHP6.

PTM databases

iPTMnetiQ8NHP6.
PhosphoSitePlusiQ8NHP6.

Miscellaneous databases

PMAP-CutDBiQ8NHP6.

Expressioni

Tissue specificityi

Highly expressed in CD14+ monocytes, and at lower levels in neutrophils. Does not show significant expression in B-cells or T-cells.1 Publication

Gene expression databases

BgeeiENSG00000130150.
CleanExiHS_MOSPD2.
ExpressionAtlasiQ8NHP6. baseline and differential.
GenevisibleiQ8NHP6. HS.

Organism-specific databases

HPAiHPA003334.

Interactioni

Protein-protein interaction databases

BioGridi127702. 30 interactors.
IntActiQ8NHP6. 4 interactors.
STRINGi9606.ENSP00000369860.

Structurei

3D structure databases

ProteinModelPortaliQ8NHP6.
SMRiQ8NHP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 239CRAL-TRIOPROSITE-ProRule annotationAdd BLAST158
Domaini327 – 445MSPPROSITE-ProRule annotationAdd BLAST119

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1470. Eukaryota.
ENOG410Y3Q0. LUCA.
GeneTreeiENSGT00390000016713.
HOGENOMiHOG000007082.
HOVERGENiHBG056024.
InParanoidiQ8NHP6.
OMAiGPITSED.
OrthoDBiEOG091G0614.
PhylomeDBiQ8NHP6.
TreeFamiTF351054.

Family and domain databases

CDDicd00170. SEC14. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.40.525.10. 1 hit.
InterProiView protein in InterPro
IPR001251. CRAL-TRIO_dom.
IPR036865. CRAL-TRIO_dom_sf.
IPR036273. CRAL/TRIO_N_dom_sf.
IPR013783. Ig-like_fold.
IPR000535. MSP_dom.
IPR008962. PapD-like_sf.
PfamiView protein in Pfam
PF00650. CRAL_TRIO. 1 hit.
PF00635. Motile_Sperm. 1 hit.
SMARTiView protein in SMART
SM00516. SEC14. 1 hit.
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF49354. SSF49354. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiView protein in PROSITE
PS50191. CRAL_TRIO. 1 hit.
PS50202. MSP. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NHP6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAENHAQNKA KLISETRRRF EAEYVTDKSD KYDARDVERL QQDDNWVESY
60 70 80 90 100
LSWRHNIVDE TLKMLDESFQ WRKEISVNDL NESSIPRWLL EIGVIYLHGY
110 120 130 140 150
DKEGNKLFWI RVKYHVKDQK TILDKKKLIA FWLERYAKRE NGKPVTVMFD
160 170 180 190 200
LSETGINSID MDFVRFIINC FKVYYPKYLS KIVIFDMPWL MNAAFKIVKT
210 220 230 240 250
WLGPEAVSLL KFTSKNEVQD YVSVEYLPPH MGGTDPFKYS YPPLVDDDFQ
260 270 280 290 300
TPLCENGPIT SEDETSSKED IESDGKETLE TISNEEQTPL LKKINPTEST
310 320 330 340 350
SKAEENEKVD SKVKAFKKPL SVFKGPLLHI SPAEELYFGS TESGEKKTLI
360 370 380 390 400
VLTNVTKNIV AFKVRTTAPE KYRVKPSNSS CDPGASVDIV VSPHGGLTVS
410 420 430 440 450
AQDRFLIMAA EMEQSSGTGP AELTQFWKEV PRNKVMEHRL RCHTVESSKP
460 470 480 490 500
NTLTLKDNAF NMSDKTSEDI CLQLSRLLES NRKLEDQVQR CIWFQQLLLS
510
LTMLLLAFVT SFFYLLYS
Length:518
Mass (Da):59,746
Last modified:October 1, 2002 - v1
Checksum:i6CC5920CF3B251E2
GO
Isoform 2 (identifier: Q8NHP6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.

Note: No experimental confirmation available.
Show »
Length:455
Mass (Da):52,121
Checksum:iAF10999208352E3D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034109240S → N. Corresponds to variant dbSNP:rs35164803Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0140461 – 63Missing in isoform 2. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093075 mRNA. Translation: BAC04043.1.
BC030641 mRNA. Translation: AAH30641.1.
AL834345 mRNA. Translation: CAD39011.1.
CCDSiCCDS14162.1. [Q8NHP6-1]
RefSeqiNP_001170946.1. NM_001177475.1. [Q8NHP6-2]
NP_689794.1. NM_152581.3. [Q8NHP6-1]
UniGeneiHs.744919.

Genome annotation databases

EnsembliENST00000380492; ENSP00000369860; ENSG00000130150. [Q8NHP6-1]
GeneIDi158747.
KEGGihsa:158747.
UCSCiuc004cwi.4. human. [Q8NHP6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMSPD2_HUMAN
AccessioniPrimary (citable) accession number: Q8NHP6
Secondary accession number(s): Q8N3H2, Q8NA83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2002
Last modified: November 22, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations