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Protein

Motile sperm domain-containing protein 2

Gene

MOSPD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Motile sperm domain-containing protein 2
Gene namesi
Name:MOSPD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:28381. MOSPD2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei497 – 51721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134898878.

Polymorphism and mutation databases

BioMutaiMOSPD2.
DMDMi67461057.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Motile sperm domain-containing protein 2PRO_0000213463Add
BLAST

Proteomic databases

EPDiQ8NHP6.
MaxQBiQ8NHP6.
PaxDbiQ8NHP6.
PeptideAtlasiQ8NHP6.
PRIDEiQ8NHP6.

PTM databases

iPTMnetiQ8NHP6.
PhosphoSiteiQ8NHP6.

Miscellaneous databases

PMAP-CutDBQ8NHP6.

Expressioni

Gene expression databases

BgeeiENSG00000130150.
CleanExiHS_MOSPD2.
ExpressionAtlasiQ8NHP6. baseline and differential.
GenevisibleiQ8NHP6. HS.

Organism-specific databases

HPAiHPA003334.

Interactioni

Protein-protein interaction databases

BioGridi127702. 19 interactions.
IntActiQ8NHP6. 4 interactions.
STRINGi9606.ENSP00000369860.

Structurei

3D structure databases

ProteinModelPortaliQ8NHP6.
SMRiQ8NHP6. Positions 38-240, 317-455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 239158CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST
Domaini327 – 445119MSPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
Contains 1 MSP domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1470. Eukaryota.
ENOG410Y3Q0. LUCA.
GeneTreeiENSGT00390000016713.
HOGENOMiHOG000007082.
HOVERGENiHBG056024.
InParanoidiQ8NHP6.
OMAiGPITSED.
OrthoDBiEOG091G0614.
PhylomeDBiQ8NHP6.
TreeFamiTF351054.

Family and domain databases

Gene3Di2.60.40.360. 1 hit.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR000535. MSP_dom.
IPR008962. PapD-like.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF00635. Motile_Sperm. 1 hit.
[Graphical view]
SMARTiSM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF49354. SSF49354. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50202. MSP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NHP6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAENHAQNKA KLISETRRRF EAEYVTDKSD KYDARDVERL QQDDNWVESY
60 70 80 90 100
LSWRHNIVDE TLKMLDESFQ WRKEISVNDL NESSIPRWLL EIGVIYLHGY
110 120 130 140 150
DKEGNKLFWI RVKYHVKDQK TILDKKKLIA FWLERYAKRE NGKPVTVMFD
160 170 180 190 200
LSETGINSID MDFVRFIINC FKVYYPKYLS KIVIFDMPWL MNAAFKIVKT
210 220 230 240 250
WLGPEAVSLL KFTSKNEVQD YVSVEYLPPH MGGTDPFKYS YPPLVDDDFQ
260 270 280 290 300
TPLCENGPIT SEDETSSKED IESDGKETLE TISNEEQTPL LKKINPTEST
310 320 330 340 350
SKAEENEKVD SKVKAFKKPL SVFKGPLLHI SPAEELYFGS TESGEKKTLI
360 370 380 390 400
VLTNVTKNIV AFKVRTTAPE KYRVKPSNSS CDPGASVDIV VSPHGGLTVS
410 420 430 440 450
AQDRFLIMAA EMEQSSGTGP AELTQFWKEV PRNKVMEHRL RCHTVESSKP
460 470 480 490 500
NTLTLKDNAF NMSDKTSEDI CLQLSRLLES NRKLEDQVQR CIWFQQLLLS
510
LTMLLLAFVT SFFYLLYS
Length:518
Mass (Da):59,746
Last modified:October 1, 2002 - v1
Checksum:i6CC5920CF3B251E2
GO
Isoform 2 (identifier: Q8NHP6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.

Note: No experimental confirmation available.
Show »
Length:455
Mass (Da):52,121
Checksum:iAF10999208352E3D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti240 – 2401S → N.
Corresponds to variant rs35164803 [ dbSNP | Ensembl ].
VAR_034109

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6363Missing in isoform 2. 1 PublicationVSP_014046Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093075 mRNA. Translation: BAC04043.1.
BC030641 mRNA. Translation: AAH30641.1.
AL834345 mRNA. Translation: CAD39011.1.
CCDSiCCDS14162.1. [Q8NHP6-1]
RefSeqiNP_001170946.1. NM_001177475.1. [Q8NHP6-2]
NP_689794.1. NM_152581.3. [Q8NHP6-1]
UniGeneiHs.744919.

Genome annotation databases

EnsembliENST00000380492; ENSP00000369860; ENSG00000130150. [Q8NHP6-1]
GeneIDi158747.
KEGGihsa:158747.
UCSCiuc004cwi.4. human. [Q8NHP6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093075 mRNA. Translation: BAC04043.1.
BC030641 mRNA. Translation: AAH30641.1.
AL834345 mRNA. Translation: CAD39011.1.
CCDSiCCDS14162.1. [Q8NHP6-1]
RefSeqiNP_001170946.1. NM_001177475.1. [Q8NHP6-2]
NP_689794.1. NM_152581.3. [Q8NHP6-1]
UniGeneiHs.744919.

3D structure databases

ProteinModelPortaliQ8NHP6.
SMRiQ8NHP6. Positions 38-240, 317-455.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127702. 19 interactions.
IntActiQ8NHP6. 4 interactions.
STRINGi9606.ENSP00000369860.

PTM databases

iPTMnetiQ8NHP6.
PhosphoSiteiQ8NHP6.

Polymorphism and mutation databases

BioMutaiMOSPD2.
DMDMi67461057.

Proteomic databases

EPDiQ8NHP6.
MaxQBiQ8NHP6.
PaxDbiQ8NHP6.
PeptideAtlasiQ8NHP6.
PRIDEiQ8NHP6.

Protocols and materials databases

DNASUi158747.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380492; ENSP00000369860; ENSG00000130150. [Q8NHP6-1]
GeneIDi158747.
KEGGihsa:158747.
UCSCiuc004cwi.4. human. [Q8NHP6-1]

Organism-specific databases

CTDi158747.
GeneCardsiMOSPD2.
HGNCiHGNC:28381. MOSPD2.
HPAiHPA003334.
neXtProtiNX_Q8NHP6.
PharmGKBiPA134898878.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1470. Eukaryota.
ENOG410Y3Q0. LUCA.
GeneTreeiENSGT00390000016713.
HOGENOMiHOG000007082.
HOVERGENiHBG056024.
InParanoidiQ8NHP6.
OMAiGPITSED.
OrthoDBiEOG091G0614.
PhylomeDBiQ8NHP6.
TreeFamiTF351054.

Miscellaneous databases

ChiTaRSiMOSPD2. human.
GenomeRNAii158747.
PMAP-CutDBQ8NHP6.
PROiQ8NHP6.

Gene expression databases

BgeeiENSG00000130150.
CleanExiHS_MOSPD2.
ExpressionAtlasiQ8NHP6. baseline and differential.
GenevisibleiQ8NHP6. HS.

Family and domain databases

Gene3Di2.60.40.360. 1 hit.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR000535. MSP_dom.
IPR008962. PapD-like.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF00635. Motile_Sperm. 1 hit.
[Graphical view]
SMARTiSM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF49354. SSF49354. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50202. MSP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSPD2_HUMAN
AccessioniPrimary (citable) accession number: Q8NHP6
Secondary accession number(s): Q8N3H2, Q8NA83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.