Reviewed, UniProtKB/Swiss-Prot Q8NHM5 (KDM2B_HUMAN)

Names and origin

Protein names

Recommended name:
    Lysine-specific demethylase 2B
    EC=1.14.11.27
Alternative name(s):
    JmjC domain-containing histone demethylation protein 1B
    [Histone-H3]-lysine-36 demethylase 1B
    F-box and leucine-rich repeat protein 10
    F-box/LRR-repeat protein 10
    F-box protein FBL10
    Jumonji domain-containing EMSY-interactor methyltransferase motif protein
      Short name=Protein JEMMA
    CXXC-type zinc finger protein 2
    Protein-containing CXXC domain 2

Gene names

Name:	KDM2B
Synonyms:	CXXC2, FBL10, FBXL10, JHDM1B, PCCX2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1336 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Ref.7 Ref.8
Catalytic activity	Protein N6,N(6)-dimethyl-L-lysine + 2-oxoglutarate + O2 = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO2. Ref.7 Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O2 = protein L-lysine + succinate + formaldehyde + CO2. Ref.7
Cofactor	Binds 1 Fe2+ ion per subunit By similarity.
Subunit structure	Directly interacts with SKP1A and CUL1 By similarity.
Subcellular location	Nucleus › nucleolus Ref.8.
Domain	The JmjC domain mediates demethylation activity By similarity. It is also required for repression of ribosomal RNA genes.
Sequence similarities	Belongs to the JHDM1 histone demethylase family. Contains 1 CXXC-type zinc finger. Contains 1 F-box domain. Contains 1 JmjC domain. Contains 4 LRR (leucine-rich) repeats. Contains 1 PHD-type zinc finger.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Ubl conjugation pathway
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Leucine-rich repeat Repeat Zinc-finger
Ligand	Iron Metal-binding RNA-binding Zinc rRNA-binding
Molecular function	Chromatin regulator Dioxygenase Oxidoreductase Repressor
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Non-traceable author statement. Source: UniProtKB histone demethylase activity (H3-K36 specific) Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: UniProtKB rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NHM5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NHM5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     730-730: K → KAYK
     1277-1336: DCNKVTDQCL...VEEKLLQKLS → ASLLGRVFGLQFWGICEPQARKNAGWA

Isoform 3 (identifier: Q8NHM5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     856-868: LKPGKEDKLFRKK → Q
     1204-1204: G → GPG

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1336	1336	Lysine-specific demethylase 2B		PRO_0000119853
Regions
	Domain	178 – 346	169	JmjC
	Domain	1059 – 1105	47	F-box
	Repeat	1148 – 1171	24	LRR 1
	Repeat	1217 – 1242	26	LRR 2
	Repeat	1269 – 1293	25	LRR 3
	Repeat	1294 – 1336	43	LRR 4
	Zinc finger	606 – 652	47	CXXC-type
	Zinc finger	659 – 725	67	PHD-type
	Coiled coil	943 – 971	29	Potential
	Compositional bias	409 – 430	22	Glu-rich
	Compositional bias	1014 – 1056	43	Pro-rich
Sites
	Metal binding	242	1	Iron; catalytic By similarity
	Metal binding	244	1	Iron; catalytic By similarity
	Metal binding	314	1	Iron; catalytic By similarity
	Binding site	239	1	Substrate By similarity
	Binding site	259	1	Substrate By similarity
Amino acid modifications
	Modified residue	223	1	Phosphotyrosine Ref.9
	Modified residue	474	1	Phosphoserine Ref.6 Ref.10
	Modified residue	493	1	Phosphothreonine Ref.10
	Modified residue	497	1	Phosphoserine Ref.6
	Modified residue	975	1	Phosphoserine Ref.10
	Modified residue	979	1	Phosphoserine Ref.10
Natural variations
	Alternative sequence	730	1	K → KAYK in isoform 2.		VSP_011340
	Alternative sequence	856 – 868	13	LKPGK…LFRKK → Q in isoform 3.		VSP_017475
	Alternative sequence	1204	1	G → GPG in isoform 3.		VSP_017476
	Alternative sequence	1277 – 1336	60	DCNKV…LQKLS → ASLLGRVFGLQFWGICEPQA RKNAGWA in isoform 2.		VSP_011341
Experimental info
	Sequence conflict	864	1	L → F in BAC11159. Ref.4
	Sequence conflict	1226	1	T → R in BAC11159. Ref.4
	Sequence conflict	1295	1	I → T in BAC11159. Ref.4
	Sequence conflict	1334	1	K → R in BAC11159. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 3A1A17B8EA9EA953	FASTA	1,336	152,615
	10 20 30 40 50 60 MAGPQMGGSA EDHPPRKRHA AEKQKKKTVI YTKCFEFESA TQRPIDRQRY DENEDLSDVE 70 80 90 100 110 120 EIVSVRGFSL EEKLRSQLYQ GDFVHAMEGK DFNYEYVQRE ALRVPLIFRE KDGLGIKMPD 130 140 150 160 170 180 PDFTVRDVKL LVGSRRLVDV MDVNTQKGTE MSMSQFVRYY ETPEAQRDKL YNVISLEFSH 190 200 210 220 230 240 TKLEHLVKRP TVVDLVDWVD NMWPQHLKEK QTEATNAIAE MKYPKVKKYC LMSVKGCFTD 250 260 270 280 290 300 FHIDFGGTSV WYHVFRGGKI FWLIPPTLHN LALYEEWVLS GKQSDIFLGD RVERCQRIEL 310 320 330 340 350 360 KQGYTFFIPS GWIHAVYTPV DSLVFGGNIL HSFNVPMQLR IYEIEDRTRV QPKFRYPFYY 370 380 390 400 410 420 EMCWYVLERY VYCVTQRSHL TQEYQRESML IDAPRKPSID GFSSDSWLEM EEEACDQQPQ 430 440 450 460 470 480 EEEEKDEEGE GRDRAPKPPT DGSTSPTSTP SEDQEALGKK PKAPALRFLK RTLSNESEES 490 500 510 520 530 540 VKSTTLAVDY PKTPTGSPAT EVSAKWTHLT EFELKGLKAL VEKLESLPEN KKCVPEGIED 550 560 570 580 590 600 PQALLEGVKN VLKEHADDDP SLAITGVPVV TWPKKTPKNR AVGRPKGKLG PASAVKLAAN 610 620 630 640 650 660 RTTAGARRRR TRCRKCEACL RTECGECHFC KDMKKFGGPG RMKQSCIMRQ CIAPVLPHTA 670 680 690 700 710 720 VCLVCGEAGK EDTVEEEEGK FNLMLMECSI CNEIIHPGCL KIKESEGVVN DELPNCWECP 730 740 750 760 770 780 KCNHAGKTGK QKRGPGFKYA SNLPGSLLKE QKMNRDNKEG QEPAKRRSEC EEAPRRRSDE 790 800 810 820 830 840 HSKKVPPDGL LRRKSDDVHL RKKRKYEKPQ ELSGRKRASS LQTSPGSSSH LSPRPPLGSS 850 860 870 880 890 900 LSPWWRSSLT YFQQQLKPGK EDKLFRKKRR SWKNAEDRMA LANKPLRRFK QEPEDELPEA 910 920 930 940 950 960 PPKTRESDHS RSSSPTAGPS TEGAEGPEEK KKVKMRRKRR LPNKELSREL SKELNHEIQR 970 980 990 1000 1010 1020 TENSLANENQ QPIKSEPESE GEEPKRPPGI CERPHRFSKG LNGTPRELRH QLGPSLRSPP 1030 1040 1050 1060 1070 1080 RVISRPPPSV SPPKCIQMER HVIRPPPISP PPDSLPLDDG AAHVMHREVW MAVFSYLSHQ 1090 1100 1110 1120 1130 1140 DLCVCMRVCR TWNRWCCDKR LWTRIDLNHC KSITPLMLSG IIRRQPVSLD LSWTNISKKQ 1150 1160 1170 1180 1190 1200 LSWLINRLPG LRDLVLSGCS WIAVSALCSS SCPLLRTLDV QWVEGLKDAQ MRDLLSPPTD 1210 1220 1230 1240 1250 1260 NRPGQMDNRS KLRNIVELRL AGLDITDASL RLIIRHMPLL SKLHLSYCNH VTDQSINLLT 1270 1280 1290 1300 1310 1320 AVGTTTRDSL TEINLSDCNK VTDQCLSFFK RCGNICHIDL RYCKQVTKEG CEQFIAEMSV 1330 SVQFGQVEEK LLQKLS
	Isoform 2. Checksum: 3329D5375AD25930	FASTA	1,306	149,034
	10 20 30 40 50 60 MAGPQMGGSA EDHPPRKRHA AEKQKKKTVI YTKCFEFESA TQRPIDRQRY DENEDLSDVE 70 80 90 100 110 120 EIVSVRGFSL EEKLRSQLYQ GDFVHAMEGK DFNYEYVQRE ALRVPLIFRE KDGLGIKMPD 130 140 150 160 170 180 PDFTVRDVKL LVGSRRLVDV MDVNTQKGTE MSMSQFVRYY ETPEAQRDKL YNVISLEFSH 190 200 210 220 230 240 TKLEHLVKRP TVVDLVDWVD NMWPQHLKEK QTEATNAIAE MKYPKVKKYC LMSVKGCFTD 250 260 270 280 290 300 FHIDFGGTSV WYHVFRGGKI FWLIPPTLHN LALYEEWVLS GKQSDIFLGD RVERCQRIEL 310 320 330 340 350 360 KQGYTFFIPS GWIHAVYTPV DSLVFGGNIL HSFNVPMQLR IYEIEDRTRV QPKFRYPFYY 370 380 390 400 410 420 EMCWYVLERY VYCVTQRSHL TQEYQRESML IDAPRKPSID GFSSDSWLEM EEEACDQQPQ 430 440 450 460 470 480 EEEEKDEEGE GRDRAPKPPT DGSTSPTSTP SEDQEALGKK PKAPALRFLK RTLSNESEES 490 500 510 520 530 540 VKSTTLAVDY PKTPTGSPAT EVSAKWTHLT EFELKGLKAL VEKLESLPEN KKCVPEGIED 550 560 570 580 590 600 PQALLEGVKN VLKEHADDDP SLAITGVPVV TWPKKTPKNR AVGRPKGKLG PASAVKLAAN 610 620 630 640 650 660 RTTAGARRRR TRCRKCEACL RTECGECHFC KDMKKFGGPG RMKQSCIMRQ CIAPVLPHTA 670 680 690 700 710 720 VCLVCGEAGK EDTVEEEEGK FNLMLMECSI CNEIIHPGCL KIKESEGVVN DELPNCWECP 730 740 750 760 770 780 KCNHAGKTGK AYKQKRGPGF KYASNLPGSL LKEQKMNRDN KEGQEPAKRR SECEEAPRRR 790 800 810 820 830 840 SDEHSKKVPP DGLLRRKSDD VHLRKKRKYE KPQELSGRKR ASSLQTSPGS SSHLSPRPPL 850 860 870 880 890 900 GSSLSPWWRS SLTYFQQQLK PGKEDKLFRK KRRSWKNAED RMALANKPLR RFKQEPEDEL 910 920 930 940 950 960 PEAPPKTRES DHSRSSSPTA GPSTEGAEGP EEKKKVKMRR KRRLPNKELS RELSKELNHE 970 980 990 1000 1010 1020 IQRTENSLAN ENQQPIKSEP ESEGEEPKRP PGICERPHRF SKGLNGTPRE LRHQLGPSLR 1030 1040 1050 1060 1070 1080 SPPRVISRPP PSVSPPKCIQ MERHVIRPPP ISPPPDSLPL DDGAAHVMHR EVWMAVFSYL 1090 1100 1110 1120 1130 1140 SHQDLCVCMR VCRTWNRWCC DKRLWTRIDL NHCKSITPLM LSGIIRRQPV SLDLSWTNIS 1150 1160 1170 1180 1190 1200 KKQLSWLINR LPGLRDLVLS GCSWIAVSAL CSSSCPLLRT LDVQWVEGLK DAQMRDLLSP 1210 1220 1230 1240 1250 1260 PTDNRPGQMD NRSKLRNIVE LRLAGLDITD ASLRLIIRHM PLLSKLHLSY CNHVTDQSIN 1270 1280 1290 1300 LLTAVGTTTR DSLTEINLSA SLLGRVFGLQ FWGICEPQAR KNAGWA
	Isoform 3. Checksum: BCBDAE3F675E017C	FASTA	1,326	151,328
	10 20 30 40 50 60 MAGPQMGGSA EDHPPRKRHA AEKQKKKTVI YTKCFEFESA TQRPIDRQRY DENEDLSDVE 70 80 90 100 110 120 EIVSVRGFSL EEKLRSQLYQ GDFVHAMEGK DFNYEYVQRE ALRVPLIFRE KDGLGIKMPD 130 140 150 160 170 180 PDFTVRDVKL LVGSRRLVDV MDVNTQKGTE MSMSQFVRYY ETPEAQRDKL YNVISLEFSH 190 200 210 220 230 240 TKLEHLVKRP TVVDLVDWVD NMWPQHLKEK QTEATNAIAE MKYPKVKKYC LMSVKGCFTD 250 260 270 280 290 300 FHIDFGGTSV WYHVFRGGKI FWLIPPTLHN LALYEEWVLS GKQSDIFLGD RVERCQRIEL 310 320 330 340 350 360 KQGYTFFIPS GWIHAVYTPV DSLVFGGNIL HSFNVPMQLR IYEIEDRTRV QPKFRYPFYY 370 380 390 400 410 420 EMCWYVLERY VYCVTQRSHL TQEYQRESML IDAPRKPSID GFSSDSWLEM EEEACDQQPQ 430 440 450 460 470 480 EEEEKDEEGE GRDRAPKPPT DGSTSPTSTP SEDQEALGKK PKAPALRFLK RTLSNESEES 490 500 510 520 530 540 VKSTTLAVDY PKTPTGSPAT EVSAKWTHLT EFELKGLKAL VEKLESLPEN KKCVPEGIED 550 560 570 580 590 600 PQALLEGVKN VLKEHADDDP SLAITGVPVV TWPKKTPKNR AVGRPKGKLG PASAVKLAAN 610 620 630 640 650 660 RTTAGARRRR TRCRKCEACL RTECGECHFC KDMKKFGGPG RMKQSCIMRQ CIAPVLPHTA 670 680 690 700 710 720 VCLVCGEAGK EDTVEEEEGK FNLMLMECSI CNEIIHPGCL KIKESEGVVN DELPNCWECP 730 740 750 760 770 780 KCNHAGKTGK QKRGPGFKYA SNLPGSLLKE QKMNRDNKEG QEPAKRRSEC EEAPRRRSDE 790 800 810 820 830 840 HSKKVPPDGL LRRKSDDVHL RKKRKYEKPQ ELSGRKRASS LQTSPGSSSH LSPRPPLGSS 850 860 870 880 890 900 LSPWWRSSLT YFQQQQRRSW KNAEDRMALA NKPLRRFKQE PEDELPEAPP KTRESDHSRS 910 920 930 940 950 960 SSPTAGPSTE GAEGPEEKKK VKMRRKRRLP NKELSRELSK ELNHEIQRTE NSLANENQQP 970 980 990 1000 1010 1020 IKSEPESEGE EPKRPPGICE RPHRFSKGLN GTPRELRHQL GPSLRSPPRV ISRPPPSVSP 1030 1040 1050 1060 1070 1080 PKCIQMERHV IRPPPISPPP DSLPLDDGAA HVMHREVWMA VFSYLSHQDL CVCMRVCRTW 1090 1100 1110 1120 1130 1140 NRWCCDKRLW TRIDLNHCKS ITPLMLSGII RRQPVSLDLS WTNISKKQLS WLINRLPGLR 1150 1160 1170 1180 1190 1200 DLVLSGCSWI AVSALCSSSC PLLRTLDVQW VEGLKDAQMR DLLSPPTDNR PGPGQMDNRS 1210 1220 1230 1240 1250 1260 KLRNIVELRL AGLDITDASL RLIIRHMPLL SKLHLSYCNH VTDQSINLLT AVGTTTRDSL 1270 1280 1290 1300 1310 1320 TEINLSDCNK VTDQCLSFFK RCGNICHIDL RYCKQVTKEG CEQFIAEMSV SVQFGQVEEK LLQKLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) is a novel protein which interacts with EMSY." Hughes-Davies L. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 129-1336 (ISOFORM 3). Tissue: Testis.
[3]	Fujino T., Hasegawa M., Shibata S., Kishimoto T., Imai S., Takano T. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 480-1336 (ISOFORM 2). Tissue: Fibroblast.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 504-1336 (ISOFORM 1).
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 710-1336 (ISOFORM 1). Tissue: Brain.
[6]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-474 AND SER-497, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"Histone demethylation by a family of JmjC domain-containing proteins." Tsukada Y., Fang J., Erdjument-Bromage H., Warren M.E., Borchers C.H., Tempst P., Zhang Y. Nature 439:811-816(2006) [PubMed: 16362057] [Abstract] Cited for: FUNCTION, ENZYME ACTIVITY.
[8]	"JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes." Frescas D., Guardavaccaro D., Bassermann F., Koyama-Nasu R., Pagano M. Nature 450:309-313(2007) [PubMed: 17994099] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[9]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-223, MASS SPECTROMETRY. Tissue: Epithelium.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-474; THR-493; SER-975 AND SER-979, MASS SPECTROMETRY. Tissue: T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ459424 mRNA. Translation: CAD30700.1. AL133572 mRNA. Translation: CAB63721.2. AB031230 mRNA. Translation: BAA97672.1. AK027440 mRNA. Translation: BAB55112.1. Different initiation. AK027692 mRNA. Translation: BAB55301.1. Different initiation. AK074718 mRNA. Translation: BAC11159.1. Different initiation. BC008735 mRNA. Translation: AAH08735.2. Different initiation.
IPI	IPI00185326. IPI00737594. IPI00747262.
PIR	T43477.
RefSeq	NP_115979.3.
UniGene	Hs.524800
3D structure databases
SMR	Q8NHM5. Positions 66-573, 606-662, 1066-1314.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8NHM5.
PTM databases
PhosphoSite	Q8NHM5.
Proteomic databases
PRIDE	Q8NHM5.
Genome annotation databases
Ensembl	ENST00000377071; ENSP00000366271; ENSG00000089094; Homo sapiens. [Genome view]
GeneID	84678.
UCSC	uc001uat.1. human.
Organism-specific databases
CTD	84678.
GeneCards	GC12M120329.
H-InvDB	HIX0020867.
HGNC	HGNC:13610. KDM2B.
MIM	609078. gene.
PharmGKB	PA134907116.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8NHM5.
InParanoid	Q8NHM5.
OMA	RKPSIDG.
OrthoDB	EOG9FFGM9.
Enzyme and pathway databases
BRENDA	1.14.11.27. 247.
Gene expression databases
ArrayExpress	Q8NHM5.
Bgee	Q8NHM5.
CleanEx	HS_FBXL10.
Genevestigator	Q8NHM5.
GermOnline	ENSG00000089094. Homo sapiens.
Family and domain databases
InterPro	IPR001810. F-box. IPR013129. TF_JmjC. IPR003347. TF_JmjC_AAH. IPR002857. Znf_CXXC. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. [Graphical view]
Pfam	PF00646. F-box. 1 hit. PF02373. JmjC. 1 hit. PF02008. zf-CXXC. 1 hit. [Graphical view]
SMART	SM00256. FBOX. 1 hit. SM00558. JmjC. 1 hit. SM00249. PHD. 1 hit. [Graphical view]
PROSITE	PS50181. FBOX. False negative. PS51184. JMJC. 1 hit. PS51058. ZF_CXXC. 1 hit. PS01359. ZF_PHD_1. False negative. PS50016. ZF_PHD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	74711.
SOURCE	Search...

Entry information

Entry name

KDM2B_HUMAN

Accession

Primary (citable) accession number: Q8NHM5
Secondary accession number(s): Q8NCI2 , Q96HC7, Q96SL0, Q96T03, Q9NS96, Q9UF75

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	October 1, 2002
Last modified:	January 19, 2010
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.