Reviewed,
UniProtKB/Swiss-Prot Q8NHM4 (TRY6_HUMAN)
Last modified
January 19, 2010.
Version 52.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Putative trypsin-6 EC=3.4.21.4 Alternative name(s): Trypsinogen C | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 247 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Uncertain. |
General annotation (Comments)
| Catalytic activity | Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. |
| Subcellular location | Secreted Potential. |
| Tissue specificity | Overexpressed in metastasing in non small cell lung tumors, leading to an enhanced cell migration. Ref.2 |
| Sequence similarities | Belongs to the peptidase S1 family. Tryptase subfamily. Contains 1 peptidase S1 domain. |
| Caution | Could be the product of a pseudogene. Although being similar to trypsinogen, it appears to be a transcribed pseudogene. ESTs support its transcription, but expression of its predicted protein has not been observed. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Domain | Signal |
| Ligand | Calcium Metal-binding |
| Molecular function | Hydrolase Protease Serine protease |
| PTM | Disulfide bond Zymogen |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | endothelial cell migration Ref.2 Inferred from mutant phenotype. Source: UniProtKB proteolysisInferred from electronic annotation. Source: InterPro |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 15 | 15 | Potential | ||||||||
| Chain | 16 – 247 | 232 | Putative trypsin-6 | PRO_0000337059 | |||||||
Regions | |||||||||||
| Domain | 24 – 244 | 221 | Peptidase S1 | ||||||||
| Compositional bias | 19 – 22 | 4 | Poly-Asp | ||||||||
Sites | |||||||||||
| Active site | 63 | 1 | Charge relay system By similarity | ||||||||
| Active site | 107 | 1 | Charge relay system By similarity | ||||||||
| Active site | 200 | 1 | Charge relay system By similarity | ||||||||
| Metal binding | 75 | 1 | Calcium By similarity | ||||||||
| Metal binding | 77 | 1 | Calcium; via carbonyl oxygen By similarity | ||||||||
| Metal binding | 80 | 1 | Calcium; via carbonyl oxygen By similarity | ||||||||
| Metal binding | 85 | 1 | Calcium By similarity | ||||||||
| Site | 194 | 1 | Required for specificity By similarity | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 48 ↔ 64 | By similarity | |||||||||
| Disulfide bond | 139 ↔ 206 | By similarity | |||||||||
| Disulfide bond | 171 ↔ 185 | By similarity | |||||||||
| Disulfide bond | 196 ↔ 220 | By similarity | |||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. Wilson R.K.Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "S100 family members and trypsinogens are predictors of distant metastasis and survival in early-stage non-small cell lung cancer." Diederichs S., Bulk E., Steffen B., Ji P., Tickenbrock L., Lang K., Zanker K.S., Metzger R., Schneider P.M., Gerke V., Thomas M., Berdel W.E., Serve H., Muller-Tidow C. Cancer Res. 64:5564-5569(2004) [PubMed: 15313892] [Abstract] Cited for: TISSUE SPECIFICITY. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U66061 Genomic DNA. Translation: AAC80208.1. |
| IPI | IPI00169276. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1H4W based on UniProtKB P35030. |
| SMR | Q8NHM4. Positions 24-247. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8NHM4. |
Protein family/group databases | |
| MEROPS | S01.298. |
Proteomic databases | |
| PRIDE | Q8NHM4. |
Genome annotation databases | |
| Ensembl | ENST00000290968; ENSP00000290968; ENSG00000204983; Homo sapiens. [Genome view] ENST00000361585; ENSP00000355222; ENSG00000204983; Homo sapiens. [Genome view] |
| UCSC | uc003wao.1. human. |
Organism-specific databases | |
| GeneCards | GC07P142137. GC07P142161. |
Phylogenomic databases | |
| eggNOG | prNOG16001. |
| HOVERGEN | Q8NHM4. |
Gene expression databases | |
| ArrayExpress | Q8NHM4. |
| Bgee | Q8NHM4. |
| Genevestigator | Q8NHM4. |
Family and domain databases | |
| InterPro | IPR018114. Peptidase_S1/S6_AS. IPR001254. Peptidase_S1_S6. IPR001314. Peptidase_S1A. IPR009003. Ser/Cys_Pept_Trypsin-like. [Graphical view] |
| Pfam | PF00089. Trypsin. 1 hit. [Graphical view] |
| PRINTS | PR00722. CHYMOTRYPSIN. |
| SMART | SM00020. Tryp_SPc. 1 hit. [Graphical view] |
| PROSITE | PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | TRY6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8NHM4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


