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Protein

Putative trypsin-6

Gene

PRSS3P2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein uncertaini

Functioni

May regulate cell migration.1 Publication

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei63 – 631Charge relay systemBy similarity
Metal bindingi75 – 751CalciumBy similarity
Metal bindingi77 – 771Calcium; via carbonyl oxygenBy similarity
Metal bindingi80 – 801Calcium; via carbonyl oxygenBy similarity
Metal bindingi85 – 851CalciumBy similarity
Active sitei107 – 1071Charge relay systemBy similarity
Sitei194 – 1941Required for specificityBy similarity
Active sitei200 – 2001Charge relay systemBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. endothelial cell migration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

MEROPSiS01.298.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative trypsin-6 (EC:3.4.21.4)
Alternative name(s):
Serine protease 3 pseudogene 2
Trypsinogen C
Gene namesi
Name:PRSS3P2
Synonyms:T6, TRY6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:43788. PRSS3P2.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence AnalysisAdd
BLAST
Chaini16 – 247232Putative trypsin-6PRO_0000337059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 64PROSITE-ProRule annotation
Disulfide bondi139 ↔ 206PROSITE-ProRule annotation
Disulfide bondi171 ↔ 185PROSITE-ProRule annotation
Disulfide bondi196 ↔ 220PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PRIDEiQ8NHM4.

PTM databases

PhosphoSiteiQ8NHM4.

Expressioni

Tissue specificityi

Overexpressed in metastasing in non small cell lung tumors, leading to an enhanced cell migration.1 Publication

Gene expression databases

GenevestigatoriQ8NHM4.

Interactioni

Protein-protein interaction databases

IntActiQ8NHM4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8NHM4.
SMRiQ8NHM4. Positions 24-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 244221Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi19 – 224Poly-Asp

Sequence similaritiesi

Belongs to the peptidase S1 family. Tryptase subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ8NHM4.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NHM4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNPLLILAFV GAAVAVPFDD DDKIVGGYTC EENSVPYQVS LNSGSHFCGG
60 70 80 90 100
SLISEQWVVS AGHCYKPHIQ VRLGEHNIEV LEGNEQFINA AKIIRHPKYN
110 120 130 140 150
RIILNNDIML IKLSTPAVIN AHVSTISLPT APPAAGTECL ISGWGNTLSS
160 170 180 190 200
GADYPDELQC LDAPVLTQAK CKASYPLKIT SNMFCVGFLE GGKDSCQGDS
210 220 230 240
GGPVVCNGQL QGIVSWGYGC AQKRRPGVYT KVYNYVDWIK DTIAANS
Length:247
Mass (Da):26,537
Last modified:February 19, 2014 - v2
Checksum:i4F93CA1C93803264
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031I → T in AAC80208. (PubMed:8650574)Curated
Sequence conflicti182 – 1821N → K in AAC80208. (PubMed:8650574)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC231380 Genomic DNA. No translation available.
L36092 Genomic DNA. Translation: AAC80208.1.
UniGeneiHs.449281.
Hs.728780.

Genome annotation databases

UCSCiuc011ksq.2. human.

Polymorphism databases

DMDMi74760358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC231380 Genomic DNA. No translation available.
L36092 Genomic DNA. Translation: AAC80208.1.
UniGeneiHs.449281.
Hs.728780.

3D structure databases

ProteinModelPortaliQ8NHM4.
SMRiQ8NHM4. Positions 24-247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8NHM4. 1 interaction.

Protein family/group databases

MEROPSiS01.298.

PTM databases

PhosphoSiteiQ8NHM4.

Polymorphism databases

DMDMi74760358.

Proteomic databases

PRIDEiQ8NHM4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc011ksq.2. human.

Organism-specific databases

GeneCardsiGC07P142809.
HGNCiHGNC:43788. PRSS3P2.
neXtProtiNX_Q8NHM4.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ8NHM4.

Miscellaneous databases

NextBioi35541312.

Gene expression databases

GenevestigatoriQ8NHM4.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The complete 685-kilobase DNA sequence of the human beta T cell receptor locus."
    Rowen L., Koop B.F., Hood L.
    Science 272:1755-1762(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "S100 family members and trypsinogens are predictors of distant metastasis and survival in early-stage non-small cell lung cancer."
    Diederichs S., Bulk E., Steffen B., Ji P., Tickenbrock L., Lang K., Zanker K.S., Metzger R., Schneider P.M., Gerke V., Thomas M., Berdel W.E., Serve H., Muller-Tidow C.
    Cancer Res. 64:5564-5569(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiTRY6_HUMAN
AccessioniPrimary (citable) accession number: Q8NHM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 19, 2014
Last modified: January 7, 2015
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. However, some data suggest that it could be a protein-coding gene (PubMed:15313892).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.