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Q8NHM4

- TRY6_HUMAN

UniProt

Q8NHM4 - TRY6_HUMAN

Protein

Putative trypsin-6

Gene

PRSS3P2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Protein uncertaini
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (19 Feb 2014)
      Previous versions | rss
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    Functioni

    May regulate cell migration.1 Publication

    Catalytic activityi

    Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei63 – 631Charge relay systemBy similarity
    Metal bindingi75 – 751CalciumBy similarity
    Metal bindingi77 – 771Calcium; via carbonyl oxygenBy similarity
    Metal bindingi80 – 801Calcium; via carbonyl oxygenBy similarity
    Metal bindingi85 – 851CalciumBy similarity
    Active sitei107 – 1071Charge relay systemBy similarity
    Sitei194 – 1941Required for specificityBy similarity
    Active sitei200 – 2001Charge relay systemBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. endothelial cell migration Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Ligandi

    Calcium, Metal-binding

    Protein family/group databases

    MEROPSiS01.298.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative trypsin-6 (EC:3.4.21.4)
    Alternative name(s):
    Serine protease 3 pseudogene 2
    Trypsinogen C
    Gene namesi
    Name:PRSS3P2
    Synonyms:T6, TRY6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:43788. PRSS3P2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 247232Putative trypsin-6PRO_0000337059Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi48 ↔ 64PROSITE-ProRule annotation
    Disulfide bondi139 ↔ 206PROSITE-ProRule annotation
    Disulfide bondi171 ↔ 185PROSITE-ProRule annotation
    Disulfide bondi196 ↔ 220PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Proteomic databases

    PRIDEiQ8NHM4.

    PTM databases

    PhosphoSiteiQ8NHM4.

    Expressioni

    Tissue specificityi

    Overexpressed in metastasing in non small cell lung tumors, leading to an enhanced cell migration.1 Publication

    Gene expression databases

    GenevestigatoriQ8NHM4.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8NHM4. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NHM4.
    SMRiQ8NHM4. Positions 24-247.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 244221Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi19 – 224Poly-Asp

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Tryptase subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8NHM4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPLLILAFV GAAVAVPFDD DDKIVGGYTC EENSVPYQVS LNSGSHFCGG    50
    SLISEQWVVS AGHCYKPHIQ VRLGEHNIEV LEGNEQFINA AKIIRHPKYN 100
    RIILNNDIML IKLSTPAVIN AHVSTISLPT APPAAGTECL ISGWGNTLSS 150
    GADYPDELQC LDAPVLTQAK CKASYPLKIT SNMFCVGFLE GGKDSCQGDS 200
    GGPVVCNGQL QGIVSWGYGC AQKRRPGVYT KVYNYVDWIK DTIAANS 247
    Length:247
    Mass (Da):26,537
    Last modified:February 19, 2014 - v2
    Checksum:i4F93CA1C93803264
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti103 – 1031I → T in AAC80208. (PubMed:8650574)Curated
    Sequence conflicti182 – 1821N → K in AAC80208. (PubMed:8650574)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC231380 Genomic DNA. No translation available.
    L36092 Genomic DNA. Translation: AAC80208.1.
    UniGeneiHs.449281.
    Hs.728780.

    Genome annotation databases

    UCSCiuc011ksq.2. human.

    Polymorphism databases

    DMDMi74760358.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC231380 Genomic DNA. No translation available.
    L36092 Genomic DNA. Translation: AAC80208.1 .
    UniGenei Hs.449281.
    Hs.728780.

    3D structure databases

    ProteinModelPortali Q8NHM4.
    SMRi Q8NHM4. Positions 24-247.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8NHM4. 1 interaction.

    Protein family/group databases

    MEROPSi S01.298.

    PTM databases

    PhosphoSitei Q8NHM4.

    Polymorphism databases

    DMDMi 74760358.

    Proteomic databases

    PRIDEi Q8NHM4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc011ksq.2. human.

    Organism-specific databases

    HGNCi HGNC:43788. PRSS3P2.
    neXtProti NX_Q8NHM4.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.

    Miscellaneous databases

    NextBioi 35541312.

    Gene expression databases

    Genevestigatori Q8NHM4.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The complete 685-kilobase DNA sequence of the human beta T cell receptor locus."
      Rowen L., Koop B.F., Hood L.
      Science 272:1755-1762(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "S100 family members and trypsinogens are predictors of distant metastasis and survival in early-stage non-small cell lung cancer."
      Diederichs S., Bulk E., Steffen B., Ji P., Tickenbrock L., Lang K., Zanker K.S., Metzger R., Schneider P.M., Gerke V., Thomas M., Berdel W.E., Serve H., Muller-Tidow C.
      Cancer Res. 64:5564-5569(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiTRY6_HUMAN
    AccessioniPrimary (citable) accession number: Q8NHM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 19, 2014
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene. However, some data suggest that it could be a protein-coding gene (PubMed:15313892).1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3