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Protein

Leukocyte immunoglobulin-like receptor subfamily B member 4

Gene

LILRB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.2 Publications

GO - Molecular functioni

  • antigen binding Source: ProtInc
  • receptor activity Source: ProtInc

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • negative regulation of osteoclast differentiation Source: UniProtKB
  • negative regulation of pri-miRNA transcription from RNA polymerase II promoter Source: BHF-UCL
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily B member 4
Alternative name(s):
CD85 antigen-like family member K
Immunoglobulin-like transcript 3
Short name:
ILT-3
Leukocyte immunoglobulin-like receptor 5
Short name:
LIR-5
Monocyte inhibitory receptor HM18
CD_antigen: CD85k
Gene namesi
Name:LILRB4
Synonyms:ILT3, LIR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6608. LILRB4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 259ExtracellularSequence analysisAdd BLAST238
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Topological domaini281 – 448CytoplasmicSequence analysisAdd BLAST168

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11006.
OpenTargetsiENSG00000275730.
PharmGKBiPA30382.

Polymorphism and mutation databases

DMDMi322510117.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001482322 – 448Leukocyte immunoglobulin-like receptor subfamily B member 4Add BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 98PROSITE-ProRule annotation1 Publication
Disulfide bondi144 ↔ 195PROSITE-ProRule annotation1 Publication
Modified residuei319PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ8NHJ6.
PeptideAtlasiQ8NHJ6.
PRIDEiQ8NHJ6.

PTM databases

iPTMnetiQ8NHJ6.
PhosphoSitePlusiQ8NHJ6.

Expressioni

Tissue specificityi

Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.3 Publications

Inductioni

Upon contact with CD8+CD28- alloantigen-specific T suppressor (Ts) cells.

Gene expression databases

BgeeiENSG00000186818.
CleanExiHS_LILRB4.
ExpressionAtlasiQ8NHJ6. baseline and differential.
GenevisibleiQ8NHJ6. HS.

Organism-specific databases

HPAiHPA052807.

Interactioni

Subunit structurei

Binds PTPN6 when phosphorylated.

Protein-protein interaction databases

BioGridi116197. 13 interactors.
IntActiQ8NHJ6. 1 interactor.
STRINGi9606.ENSP00000270452.

Structurei

Secondary structure

1448
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 35Combined sources6
Beta strandi37 – 40Combined sources4
Beta strandi45 – 50Combined sources6
Beta strandi57 – 62Combined sources6
Beta strandi69 – 72Combined sources4
Beta strandi76 – 87Combined sources12
Helixi90 – 92Combined sources3
Beta strandi94 – 102Combined sources9
Beta strandi105 – 107Combined sources3
Beta strandi113 – 118Combined sources6
Beta strandi125 – 130Combined sources6
Beta strandi132 – 135Combined sources4
Beta strandi140 – 157Combined sources18
Helixi163 – 165Combined sources3
Beta strandi166 – 182Combined sources17
Helixi187 – 189Combined sources3
Beta strandi191 – 198Combined sources8
Helixi200 – 202Combined sources3
Beta strandi213 – 218Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P2TX-ray1.70A24-219[»]
ProteinModelPortaliQ8NHJ6.
SMRiQ8NHJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 118Ig-like C2-type 1Add BLAST92
Domaini124 – 218Ig-like C2-type 2Add BLAST95

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi358 – 363ITIM motif 16
Motifi410 – 415ITIM motif 26
Motifi440 – 445ITIM motif 36

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHKK. Eukaryota.
ENOG411142H. LUCA.
HOVERGENiHBG074353.
InParanoidiQ8NHJ6.
KOiK06512.
PhylomeDBiQ8NHJ6.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NHJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIPTFTALLC LGLSLGPRTH MQAGPLPKPT LWAEPGSVIS WGNSVTIWCQ
60 70 80 90 100
GTLEAREYRL DKEESPAPWD RQNPLEPKNK ARFSIPSMTE DYAGRYRCYY
110 120 130 140 150
RSPVGWSQPS DPLELVMTGA YSKPTLSALP SPLVTSGKSV TLLCQSRSPM
160 170 180 190 200
DTFLLIKERA AHPLLHLRSE HGAQQHQAEF PMSPVTSVHG GTYRCFSSHG
210 220 230 240 250
FSHYLLSHPS DPLELIVSGS LEDPRPSPTR SVSTAAGPED QPLMPTGSVP
260 270 280 290 300
HSGLRRHWEV LIGVLVVSIL LLSLLLFLLL QHWRQGKHRT LAQRQADFQR
310 320 330 340 350
PPGAAEPEPK DGGLQRRSSP AADVQGENFC AAVKNTQPED GVEMDTRQSP
360 370 380 390 400
HDEDPQAVTY AKVKHSRPRR EMASPPSPLS GEFLDTKDRQ AEEDRQMDTE
410 420 430 440
AAASEAPQDV TYAQLHSFTL RQKATEPPPS QEGASPAEPS VYATLAIH
Length:448
Mass (Da):49,356
Last modified:February 8, 2011 - v3
Checksum:iC18C21694F283FBB
GO
Isoform 2 (identifier: Q8NHJ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-348: Missing.

Note: Alternative use of an acceptor site. No experimental confirmation available.
Show »
Length:447
Mass (Da):49,228
Checksum:i5DF5A3445A3AD4FF
GO
Isoform 3 (identifier: Q8NHJ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-330: C → SG

Show »
Length:449
Mass (Da):49,397
Checksum:iBA6F3F253EF07089
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0255015F → L.1 PublicationCorresponds to variant rs28366008dbSNPEnsembl.1
Natural variantiVAR_02550218R → S.Corresponds to variant rs11574570dbSNPEnsembl.1
Natural variantiVAR_04784620H → D.1 PublicationCorresponds to variant rs11540762dbSNPEnsembl.1
Natural variantiVAR_017014223D → G.4 PublicationsCorresponds to variant rs731170dbSNPEnsembl.1
Natural variantiVAR_025503330C → Y.Corresponds to variant rs11574575dbSNPEnsembl.1
Natural variantiVAR_025504335N → D.Corresponds to variant rs11574576dbSNPEnsembl.1
Natural variantiVAR_017015362K → E.1 PublicationCorresponds to variant rs2764337dbSNPEnsembl.1
Natural variantiVAR_030939362K → T.Corresponds to variant rs11574589dbSNPEnsembl.1
Natural variantiVAR_025505414Q → R.2 PublicationsCorresponds to variant rs1048801dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035939330C → SG in isoform 3. 1 Publication1
Alternative sequenceiVSP_008460348Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91925 mRNA. Translation: AAB68665.1.
AF025532 mRNA. Translation: AAB87666.1.
AF189768 Genomic DNA. Translation: AAG02024.1.
AF283988 mRNA. Translation: AAL36992.1.
CR542048 mRNA. Translation: CAG46845.1.
CR609786 mRNA. No translation available.
AC009892 Genomic DNA. No translation available.
AC011515 Genomic DNA. No translation available.
BC026309 mRNA. Translation: AAH26309.1.
CCDSiCCDS12902.1. [Q8NHJ6-1]
CCDS42618.1. [Q8NHJ6-2]
RefSeqiNP_001265355.2. NM_001278426.3.
NP_001265356.2. NM_001278427.3.
NP_001265357.2. NM_001278428.3.
NP_001265358.2. NM_001278429.3.
NP_001265359.2. NM_001278430.3.
UniGeneiHs.67846.
Hs.731841.

Genome annotation databases

EnsembliENST00000391736; ENSP00000375616; ENSG00000186818.
ENST00000612454; ENSP00000479829; ENSG00000275730. [Q8NHJ6-1]
ENST00000614699; ENSP00000478542; ENSG00000275730. [Q8NHJ6-3]
ENST00000621693; ENSP00000482234; ENSG00000275730. [Q8NHJ6-2]
GeneIDi11006.
KEGGihsa:11006.
UCSCiuc002qgp.5. human. [Q8NHJ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91925 mRNA. Translation: AAB68665.1.
AF025532 mRNA. Translation: AAB87666.1.
AF189768 Genomic DNA. Translation: AAG02024.1.
AF283988 mRNA. Translation: AAL36992.1.
CR542048 mRNA. Translation: CAG46845.1.
CR609786 mRNA. No translation available.
AC009892 Genomic DNA. No translation available.
AC011515 Genomic DNA. No translation available.
BC026309 mRNA. Translation: AAH26309.1.
CCDSiCCDS12902.1. [Q8NHJ6-1]
CCDS42618.1. [Q8NHJ6-2]
RefSeqiNP_001265355.2. NM_001278426.3.
NP_001265356.2. NM_001278427.3.
NP_001265357.2. NM_001278428.3.
NP_001265358.2. NM_001278429.3.
NP_001265359.2. NM_001278430.3.
UniGeneiHs.67846.
Hs.731841.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P2TX-ray1.70A24-219[»]
ProteinModelPortaliQ8NHJ6.
SMRiQ8NHJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116197. 13 interactors.
IntActiQ8NHJ6. 1 interactor.
STRINGi9606.ENSP00000270452.

PTM databases

iPTMnetiQ8NHJ6.
PhosphoSitePlusiQ8NHJ6.

Polymorphism and mutation databases

DMDMi322510117.

Proteomic databases

PaxDbiQ8NHJ6.
PeptideAtlasiQ8NHJ6.
PRIDEiQ8NHJ6.

Protocols and materials databases

DNASUi11006.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391736; ENSP00000375616; ENSG00000186818.
ENST00000612454; ENSP00000479829; ENSG00000275730. [Q8NHJ6-1]
ENST00000614699; ENSP00000478542; ENSG00000275730. [Q8NHJ6-3]
ENST00000621693; ENSP00000482234; ENSG00000275730. [Q8NHJ6-2]
GeneIDi11006.
KEGGihsa:11006.
UCSCiuc002qgp.5. human. [Q8NHJ6-1]

Organism-specific databases

CTDi11006.
DisGeNETi11006.
GeneCardsiLILRB4.
H-InvDBHIX0202844.
HGNCiHGNC:6608. LILRB4.
HPAiHPA052807.
MIMi604821. gene.
neXtProtiNX_Q8NHJ6.
OpenTargetsiENSG00000275730.
PharmGKBiPA30382.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHKK. Eukaryota.
ENOG411142H. LUCA.
HOVERGENiHBG074353.
InParanoidiQ8NHJ6.
KOiK06512.
PhylomeDBiQ8NHJ6.
TreeFamiTF336644.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

ChiTaRSiLILRB4. human.
GeneWikiiLILRB4.
GenomeRNAii11006.
PROiQ8NHJ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186818.
CleanExiHS_LILRB4.
ExpressionAtlasiQ8NHJ6. baseline and differential.
GenevisibleiQ8NHJ6. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIRB4_HUMAN
AccessioniPrimary (citable) accession number: Q8NHJ6
Secondary accession number(s): A8MVL8
, O15468, O75021, Q6FGQ9, Q8N1C7, Q8NHL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: February 8, 2011
Last modified: November 2, 2016
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.