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Protein

Leukocyte immunoglobulin-like receptor subfamily B member 4

Gene

LILRB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.2 Publications

GO - Molecular functioni

  • antigen binding Source: ProtInc
  • receptor activity Source: ProtInc

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • negative regulation of osteoclast differentiation Source: UniProtKB
  • negative regulation of pri-miRNA transcription from RNA polymerase II promoter Source: BHF-UCL
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily B member 4
Alternative name(s):
CD85 antigen-like family member K
Immunoglobulin-like transcript 3
Short name:
ILT-3
Leukocyte immunoglobulin-like receptor 5
Short name:
LIR-5
Monocyte inhibitory receptor HM18
CD_antigen: CD85k
Gene namesi
Name:LILRB4
Synonyms:ILT3, LIR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6608. LILRB4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 259238ExtracellularSequence analysisAdd
BLAST
Transmembranei260 – 28021HelicalSequence analysisAdd
BLAST
Topological domaini281 – 448168CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30382.

Polymorphism and mutation databases

DMDMi322510117.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 448427Leukocyte immunoglobulin-like receptor subfamily B member 4PRO_0000014823Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 98PROSITE-ProRule annotation1 Publication
Disulfide bondi144 ↔ 195PROSITE-ProRule annotation1 Publication
Modified residuei319 – 3191PhosphoserineCombined sources

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ8NHJ6.
PRIDEiQ8NHJ6.

PTM databases

iPTMnetiQ8NHJ6.
PhosphoSiteiQ8NHJ6.

Expressioni

Tissue specificityi

Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.3 Publications

Inductioni

Upon contact with CD8+CD28- alloantigen-specific T suppressor (Ts) cells.

Gene expression databases

BgeeiQ8NHJ6.
CleanExiHS_LILRB4.
ExpressionAtlasiQ8NHJ6. baseline and differential.
GenevisibleiQ8NHJ6. HS.

Organism-specific databases

HPAiHPA052807.

Interactioni

Subunit structurei

Binds PTPN6 when phosphorylated.

Protein-protein interaction databases

BioGridi116197. 13 interactions.
IntActiQ8NHJ6. 1 interaction.
STRINGi9606.ENSP00000270452.

Structurei

Secondary structure

1
448
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 356Combined sources
Beta strandi37 – 404Combined sources
Beta strandi45 – 506Combined sources
Beta strandi57 – 626Combined sources
Beta strandi69 – 724Combined sources
Beta strandi76 – 8712Combined sources
Helixi90 – 923Combined sources
Beta strandi94 – 1029Combined sources
Beta strandi105 – 1073Combined sources
Beta strandi113 – 1186Combined sources
Beta strandi125 – 1306Combined sources
Beta strandi132 – 1354Combined sources
Beta strandi140 – 15718Combined sources
Helixi163 – 1653Combined sources
Beta strandi166 – 18217Combined sources
Helixi187 – 1893Combined sources
Beta strandi191 – 1988Combined sources
Helixi200 – 2023Combined sources
Beta strandi213 – 2186Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3P2TX-ray1.70A24-219[»]
ProteinModelPortaliQ8NHJ6.
SMRiQ8NHJ6. Positions 25-244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 11892Ig-like C2-type 1Add
BLAST
Domaini124 – 21895Ig-like C2-type 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi358 – 3636ITIM motif 1
Motifi410 – 4156ITIM motif 2
Motifi440 – 4456ITIM motif 3

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHKK. Eukaryota.
ENOG411142H. LUCA.
HOVERGENiHBG074353.
InParanoidiQ8NHJ6.
KOiK06512.
OrthoDBiEOG7R56S3.
PhylomeDBiQ8NHJ6.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NHJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIPTFTALLC LGLSLGPRTH MQAGPLPKPT LWAEPGSVIS WGNSVTIWCQ
60 70 80 90 100
GTLEAREYRL DKEESPAPWD RQNPLEPKNK ARFSIPSMTE DYAGRYRCYY
110 120 130 140 150
RSPVGWSQPS DPLELVMTGA YSKPTLSALP SPLVTSGKSV TLLCQSRSPM
160 170 180 190 200
DTFLLIKERA AHPLLHLRSE HGAQQHQAEF PMSPVTSVHG GTYRCFSSHG
210 220 230 240 250
FSHYLLSHPS DPLELIVSGS LEDPRPSPTR SVSTAAGPED QPLMPTGSVP
260 270 280 290 300
HSGLRRHWEV LIGVLVVSIL LLSLLLFLLL QHWRQGKHRT LAQRQADFQR
310 320 330 340 350
PPGAAEPEPK DGGLQRRSSP AADVQGENFC AAVKNTQPED GVEMDTRQSP
360 370 380 390 400
HDEDPQAVTY AKVKHSRPRR EMASPPSPLS GEFLDTKDRQ AEEDRQMDTE
410 420 430 440
AAASEAPQDV TYAQLHSFTL RQKATEPPPS QEGASPAEPS VYATLAIH
Length:448
Mass (Da):49,356
Last modified:February 8, 2011 - v3
Checksum:iC18C21694F283FBB
GO
Isoform 2 (identifier: Q8NHJ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-348: Missing.

Note: Alternative use of an acceptor site. No experimental confirmation available.
Show »
Length:447
Mass (Da):49,228
Checksum:i5DF5A3445A3AD4FF
GO
Isoform 3 (identifier: Q8NHJ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-330: C → SG

Show »
Length:449
Mass (Da):49,397
Checksum:iBA6F3F253EF07089
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51F → L.1 Publication
Corresponds to variant rs28366008 [ dbSNP | Ensembl ].
VAR_025501
Natural varianti18 – 181R → S.
Corresponds to variant rs11574570 [ dbSNP | Ensembl ].
VAR_025502
Natural varianti20 – 201H → D.1 Publication
Corresponds to variant rs11540762 [ dbSNP | Ensembl ].
VAR_047846
Natural varianti223 – 2231D → G.4 Publications
Corresponds to variant rs731170 [ dbSNP | Ensembl ].
VAR_017014
Natural varianti330 – 3301C → Y.
Corresponds to variant rs11574575 [ dbSNP | Ensembl ].
VAR_025503
Natural varianti335 – 3351N → D.
Corresponds to variant rs11574576 [ dbSNP | Ensembl ].
VAR_025504
Natural varianti362 – 3621K → E.1 Publication
Corresponds to variant rs2764337 [ dbSNP | Ensembl ].
VAR_017015
Natural varianti362 – 3621K → T.
Corresponds to variant rs11574589 [ dbSNP | Ensembl ].
VAR_030939
Natural varianti414 – 4141Q → R.2 Publications
Corresponds to variant rs1048801 [ dbSNP | Ensembl ].
VAR_025505

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei330 – 3301C → SG in isoform 3. 1 PublicationVSP_035939
Alternative sequencei348 – 3481Missing in isoform 2. 2 PublicationsVSP_008460

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91925 mRNA. Translation: AAB68665.1.
AF025532 mRNA. Translation: AAB87666.1.
AF189768 Genomic DNA. Translation: AAG02024.1.
AF283988 mRNA. Translation: AAL36992.1.
CR542048 mRNA. Translation: CAG46845.1.
CR609786 mRNA. No translation available.
AC009892 Genomic DNA. No translation available.
AC011515 Genomic DNA. No translation available.
BC026309 mRNA. Translation: AAH26309.1.
CCDSiCCDS12902.1. [Q8NHJ6-1]
CCDS42618.1. [Q8NHJ6-2]
RefSeqiNP_001265355.2. NM_001278426.3.
NP_001265356.2. NM_001278427.3.
NP_001265357.2. NM_001278428.3.
NP_001265358.2. NM_001278429.3.
NP_001265359.2. NM_001278430.3.
UniGeneiHs.67846.
Hs.731841.

Genome annotation databases

EnsembliENST00000391736; ENSP00000375616; ENSG00000186818.
ENST00000612454; ENSP00000479829; ENSG00000275730. [Q8NHJ6-1]
ENST00000614699; ENSP00000478542; ENSG00000275730. [Q8NHJ6-3]
ENST00000621693; ENSP00000482234; ENSG00000275730. [Q8NHJ6-2]
GeneIDi11006.
KEGGihsa:11006.
UCSCiuc002qgp.5. human. [Q8NHJ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91925 mRNA. Translation: AAB68665.1.
AF025532 mRNA. Translation: AAB87666.1.
AF189768 Genomic DNA. Translation: AAG02024.1.
AF283988 mRNA. Translation: AAL36992.1.
CR542048 mRNA. Translation: CAG46845.1.
CR609786 mRNA. No translation available.
AC009892 Genomic DNA. No translation available.
AC011515 Genomic DNA. No translation available.
BC026309 mRNA. Translation: AAH26309.1.
CCDSiCCDS12902.1. [Q8NHJ6-1]
CCDS42618.1. [Q8NHJ6-2]
RefSeqiNP_001265355.2. NM_001278426.3.
NP_001265356.2. NM_001278427.3.
NP_001265357.2. NM_001278428.3.
NP_001265358.2. NM_001278429.3.
NP_001265359.2. NM_001278430.3.
UniGeneiHs.67846.
Hs.731841.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3P2TX-ray1.70A24-219[»]
ProteinModelPortaliQ8NHJ6.
SMRiQ8NHJ6. Positions 25-244.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116197. 13 interactions.
IntActiQ8NHJ6. 1 interaction.
STRINGi9606.ENSP00000270452.

PTM databases

iPTMnetiQ8NHJ6.
PhosphoSiteiQ8NHJ6.

Polymorphism and mutation databases

DMDMi322510117.

Proteomic databases

PaxDbiQ8NHJ6.
PRIDEiQ8NHJ6.

Protocols and materials databases

DNASUi11006.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391736; ENSP00000375616; ENSG00000186818.
ENST00000612454; ENSP00000479829; ENSG00000275730. [Q8NHJ6-1]
ENST00000614699; ENSP00000478542; ENSG00000275730. [Q8NHJ6-3]
ENST00000621693; ENSP00000482234; ENSG00000275730. [Q8NHJ6-2]
GeneIDi11006.
KEGGihsa:11006.
UCSCiuc002qgp.5. human. [Q8NHJ6-1]

Organism-specific databases

CTDi11006.
GeneCardsiLILRB4.
H-InvDBHIX0202844.
HGNCiHGNC:6608. LILRB4.
HPAiHPA052807.
MIMi604821. gene.
neXtProtiNX_Q8NHJ6.
PharmGKBiPA30382.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHKK. Eukaryota.
ENOG411142H. LUCA.
HOVERGENiHBG074353.
InParanoidiQ8NHJ6.
KOiK06512.
OrthoDBiEOG7R56S3.
PhylomeDBiQ8NHJ6.
TreeFamiTF336644.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

ChiTaRSiLILRB4. human.
GeneWikiiLILRB4.
GenomeRNAii11006.
PROiQ8NHJ6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NHJ6.
CleanExiHS_LILRB4.
ExpressionAtlasiQ8NHJ6. baseline and differential.
GenevisibleiQ8NHJ6. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor."
    Arm J.P., Nwankwo C., Austen K.F.
    J. Immunol. 159:2342-2349(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT GLY-223.
    Tissue: Monocyte.
  2. "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules."
    Borges L., Hsu M.-L., Fanger N., Kubin M., Cosman D.
    J. Immunol. 159:5192-5196(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS GLY-223 AND ARG-414, TISSUE SPECIFICITY.
    Tissue: Peripheral blood leukocyte.
  3. "Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4."
    Liu W.R., Kim J., Nwankwo C., Ashworth L.K., Arm J.P.
    Immunogenetics 51:659-669(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS LEU-5; GLY-223 AND GLU-362.
  4. Canavez F.C.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Placenta.
  7. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASP-20; GLY-223 AND ARG-414.
    Tissue: Brain.
  9. "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing."
    Cella M., Doehring C., Samaridis J., Dessing M., Brockhaus M., Lanzavecchia A., Colonna M.
    J. Exp. Med. 185:1743-1751(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PTPN6, PHOSPHORYLATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  10. "Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4."
    Chang C.C., Ciubotariu R., Manavalan J.S., Yuan J., Colovai A.I., Piazza F., Lederman S., Colonna M., Cortesini R., Dalla-Favera R., Suciu-Foca N.
    Nat. Immunol. 3:237-243(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  12. "Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance."
    Cheng H., Mohammed F., Nam G., Chen Y., Qi J., Garner L.I., Allen R.L., Yan J., Willcox B.E., Gao G.F.
    J. Biol. Chem. 286:18013-18025(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 24-219, DISULFIDE BONDS.

Entry informationi

Entry nameiLIRB4_HUMAN
AccessioniPrimary (citable) accession number: Q8NHJ6
Secondary accession number(s): A8MVL8
, O15468, O75021, Q6FGQ9, Q8N1C7, Q8NHL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: February 8, 2011
Last modified: June 8, 2016
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.