Q8NHH9 (ATLA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Atlastin-2
EC=3.6.5.-

Alternative name(s):
ADP-ribosylation factor-like protein 6-interacting protein 2
Short name=ARL-6-interacting protein 2
Short name=Aip-2

Gene names

Name:	ATL2
Synonyms:	ARL6IP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	583 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. Ref.7 Ref.9
Subunit structure	Interacts with REEP5 and RTN3. Ref.9
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.7.
Tissue specificity	Expressed in peripheral tissues (at protein level). Ref.7
Sequence similarities	Belongs to the GBP family. Atlastin subfamily.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Transmembrane Transmembrane helix
Ligand	GTP-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Golgi organization Inferred from mutant phenotype Ref.7. Source: UniProtKB endoplasmic reticulum organization Inferred from mutant phenotype Ref.7Ref.9. Source: UniProtKB protein homooligomerization Inferred from direct assay Ref.7. Source: UniProtKB
Cellular_component	endoplasmic reticulum Inferred from direct assay Ref.7. Source: UniProtKB endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from direct assay Ref.7. Source: UniProtKB
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Non-traceable author statement Ref.7. Source: UniProtKB identical protein binding Inferred from direct assay Ref.7. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Reep5	Q60870	2	EBI-2410430,EBI-2410304	From a different organism.
Rtn3	Q9ES97-3	2	EBI-2410430,EBI-1487798	From a different organism.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Note: Named isoforms=2.

Isoform 1 (identifier: Q8NHH9-1)

Also known as: AT2b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NHH9-2)

Also known as: AT2a;

The sequence of this isoform differs from the canonical sequence as follows:
     546-583: LKPLGDNLMEENIRQSVTNSIKAGLTDQVSHHARLKTD → FSKLFEVTRRRMVHRALSSAQRQRLSSNNNKKKN

Isoform 3 (identifier: Q8NHH9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.

Isoform 4 (identifier: Q8NHH9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: MAEGDEAARGQQPHQGLWRRRRTSDPSAAVNHVSSTTSL → MVLKKGIKFFQRLINSKSLRF
     545-583: VLKPLGDNLM...VSHHARLKTD → RSPRKVFSKL...LSSNNNKKKN

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 583	583	Atlastin-2		PRO_0000287105
Regions
	Topological domain	1 – 476	476	Cytoplasmic Ref.7
	Transmembrane	477 – 497	21	Helical; Potential
	Topological domain	498 – 499	2	Lumenal Potential
	Transmembrane	500 – 520	21	Helical; Potential
	Topological domain	521 – 583	63	Cytoplasmic Ref.7
	Nucleotide binding	101 – 108	8	GTP Potential
	Nucleotide binding	173 – 177	5	GTP Potential
	Coiled coil	256 – 284	29	Potential
Amino acid modifications
	Modified residue	24	1	Phosphoserine Ref.8 Ref.10
Natural variations
	Alternative sequence	1 – 171	171	Missing in isoform 3.		VSP_025309
	Alternative sequence	1 – 39	39	MAEGD…STTSL → MVLKKGIKFFQRLINSKSLR F in isoform 4.		VSP_041604
	Alternative sequence	545 – 583	39	VLKPL…RLKTD → RSPRKVFSKLFEVTRRRMVH RALSSAQRQRLSSNNNKKKN in isoform 4.		VSP_041605
	Alternative sequence	546 – 583	38	LKPLG…RLKTD → FSKLFEVTRRRMVHRALSSA QRQRLSSNNNKKKN in isoform 2.		VSP_025310
	Natural variant	18	1	W → R. Ref.1 Corresponds to variant rs3731847 [ dbSNP | Ensembl ].		VAR_032265
	Natural variant	272	1	N → S. Corresponds to variant rs34873284 [ dbSNP | Ensembl ].		VAR_032266
	Natural variant	420	1	D → H. Corresponds to variant rs7582826 [ dbSNP | Ensembl ].		VAR_032267
Experimental info
	Mutagenesis	107	1	K → A: Alters endoplasmic reticulum morphology. Ref.7
	Mutagenesis	244	1	R → Q: Alters endoplasmic reticulum morphogenesis. Ref.7
	Sequence conflict	509	1	G → E in BAB15598. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (AT2b) [UniParc]. Last modified May 15, 2007. Version 2. Checksum: 885738C43996DEBF	FASTA	583	66,229
	10 20 30 40 50 60 MAEGDEAARG QQPHQGLWRR RRTSDPSAAV NHVSSTTSLG ENYEDDDLVN SDEVMKKPCP 70 80 90 100 110 120 VQIVLAHEDD HNFELDEEAL EQILLQEHIR DLNIVVVSVA GAFRKGKSFL LDFMLRYMYN 130 140 150 160 170 180 KDSQSWIGGN NEPLTGFTWR GGCERETTGI QVWNEVFVID RPNGTKVAVL LMDTQGAFDS 190 200 210 220 230 240 QSTIKDCATV FALSTMTSSV QVYNLSQNIQ EDDLQHLQLF TEYGRLAMEE IYQKPFQTLM 250 260 270 280 290 300 FLIRDWSYPY EHSYGLEGGK QFLEKRLQVK QNQHEELQNV RKHIHNCFSN LGCFLLPHPG 310 320 330 340 350 360 LKVATNPSFD GRLKDIDEDF KRELRNLVPL LLAPENLVEK EISGSKVTCR DLVEYFKAYI 370 380 390 400 410 420 KIYQGEELPH PKSMLQATAE ANNLAAVAGA RDTYCKSMEQ VCGGDKPYIA PSDLERKHLD 430 440 450 460 470 480 LKEVAIKQFR SVKKMGGDEF CRRYQDQLEA EIEETYANFI KHNDGKNIFY AARTPATLFA 490 500 510 520 530 540 VMFAMYIISG LTGFIGLNSI AVLCNLVMGL ALIFLCTWAY VKYSGEFREI GTVIDQIAET 550 560 570 580 LWEQVLKPLG DNLMEENIRQ SVTNSIKAGL TDQVSHHARL KTD
	Isoform 2 (AT2a) [UniParc]. Checksum: 8C9D170C429AAA71	FASTA	579	66,087
	10 20 30 40 50 60 MAEGDEAARG QQPHQGLWRR RRTSDPSAAV NHVSSTTSLG ENYEDDDLVN SDEVMKKPCP 70 80 90 100 110 120 VQIVLAHEDD HNFELDEEAL EQILLQEHIR DLNIVVVSVA GAFRKGKSFL LDFMLRYMYN 130 140 150 160 170 180 KDSQSWIGGN NEPLTGFTWR GGCERETTGI QVWNEVFVID RPNGTKVAVL LMDTQGAFDS 190 200 210 220 230 240 QSTIKDCATV FALSTMTSSV QVYNLSQNIQ EDDLQHLQLF TEYGRLAMEE IYQKPFQTLM 250 260 270 280 290 300 FLIRDWSYPY EHSYGLEGGK QFLEKRLQVK QNQHEELQNV RKHIHNCFSN LGCFLLPHPG 310 320 330 340 350 360 LKVATNPSFD GRLKDIDEDF KRELRNLVPL LLAPENLVEK EISGSKVTCR DLVEYFKAYI 370 380 390 400 410 420 KIYQGEELPH PKSMLQATAE ANNLAAVAGA RDTYCKSMEQ VCGGDKPYIA PSDLERKHLD 430 440 450 460 470 480 LKEVAIKQFR SVKKMGGDEF CRRYQDQLEA EIEETYANFI KHNDGKNIFY AARTPATLFA 490 500 510 520 530 540 VMFAMYIISG LTGFIGLNSI AVLCNLVMGL ALIFLCTWAY VKYSGEFREI GTVIDQIAET 550 560 570 LWEQVFSKLF EVTRRRMVHR ALSSAQRQRL SSNNNKKKN
	Isoform 3 [UniParc]. Checksum: BA8D07DFDED793AF	FASTA	412	46,918
	10 20 30 40 50 60 MDTQGAFDSQ STIKDCATVF ALSTMTSSVQ VYNLSQNIQE DDLQHLQLFT EYGRLAMEEI 70 80 90 100 110 120 YQKPFQTLMF LIRDWSYPYE HSYGLEGGKQ FLEKRLQVKQ NQHEELQNVR KHIHNCFSNL 130 140 150 160 170 180 GCFLLPHPGL KVATNPSFDG RLKDIDEDFK RELRNLVPLL LAPENLVEKE ISGSKVTCRD 190 200 210 220 230 240 LVEYFKAYIK IYQGEELPHP KSMLQATAEA NNLAAVAGAR DTYCKSMEQV CGGDKPYIAP 250 260 270 280 290 300 SDLERKHLDL KEVAIKQFRS VKKMGGDEFC RRYQDQLEAE IEETYANFIK HNDGKNIFYA 310 320 330 340 350 360 ARTPATLFAV MFAMYIISGL TGFIGLNSIA VLCNLVMGLA LIFLCTWAYV KYSGEFREIG 370 380 390 400 410 TVIDQIAETL WEQVLKPLGD NLMEENIRQS VTNSIKAGLT DQVSHHARLK TD
	Isoform 4 [UniParc]. Checksum: 6D82F46C7FCB8490	FASTA	566	65,004
	10 20 30 40 50 60 MVLKKGIKFF QRLINSKSLR FGENYEDDDL VNSDEVMKKP CPVQIVLAHE DDHNFELDEE 70 80 90 100 110 120 ALEQILLQEH IRDLNIVVVS VAGAFRKGKS FLLDFMLRYM YNKDSQSWIG GNNEPLTGFT 130 140 150 160 170 180 WRGGCERETT GIQVWNEVFV IDRPNGTKVA VLLMDTQGAF DSQSTIKDCA TVFALSTMTS 190 200 210 220 230 240 SVQVYNLSQN IQEDDLQHLQ LFTEYGRLAM EEIYQKPFQT LMFLIRDWSY PYEHSYGLEG 250 260 270 280 290 300 GKQFLEKRLQ VKQNQHEELQ NVRKHIHNCF SNLGCFLLPH PGLKVATNPS FDGRLKDIDE 310 320 330 340 350 360 DFKRELRNLV PLLLAPENLV EKEISGSKVT CRDLVEYFKA YIKIYQGEEL PHPKSMLQAT 370 380 390 400 410 420 AEANNLAAVA GARDTYCKSM EQVCGGDKPY IAPSDLERKH LDLKEVAIKQ FRSVKKMGGD 430 440 450 460 470 480 EFCRRYQDQL EAEIEETYAN FIKHNDGKNI FYAARTPATL FAVMFAMYII SGLTGFIGLN 490 500 510 520 530 540 SIAVLCNLVM GLALIFLCTW AYVKYSGEFR EIGTVIDQIA ETLWEQRSPR KVFSKLFEVT 550 560 RRRMVHRALS SAQRQRLSSN NNKKKN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Physical/genetic map of the 2p22-2p21 region on chromosome 2." Gorry M.C., Zhang Y., Marks J.J., Suppe B., Hart P.S., Cortelli J.R., Pallos D., Hart T.C. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2), VARIANT ARG-18.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4). Tissue: Cerebellum.
[3]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Colon.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[6]	"Cellular localization, oligomerization, and membrane association of the hereditary spastic paraplegia 3A (SPG3A) protein atlastin." Zhu P.-P., Patterson A., Lavoie B., Stadler J., Shoeb M., Patel R., Blackstone C. J. Biol. Chem. 278:49063-49071(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[7]	"Atlastin GTPases are required for Golgi apparatus and ER morphogenesis." Rismanchi N., Soderblom C., Stadler J., Zhu P.-P., Blackstone C. Hum. Mol. Genet. 17:1591-1604(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TOPOLOGY, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-107 AND ARG-244, TISSUE SPECIFICITY.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A class of dynamin-like GTPases involved in the generation of the tubular ER network." Hu J., Shibata Y., Zhu P.-P., Voss C., Rismanchi N., Prinz W.A., Rapoport T.A., Blackstone C. Cell 138:549-561(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH REEP5 AND RTN3.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF449187 , AF449176, AF449177, AF449178, AF449179, AF449180, AF449181, AF449182, AF449183, AF449184, AF449185, AF449186 Genomic DNA. Translation: AAM97341.1. AF449187 , AF449176, AF449177, AF449178, AF449179, AF449180, AF449181, AF449182, AF449183, AF449184, AF449185, AF449186 Genomic DNA. Translation: AAM97342.1. AK294049 mRNA. Translation: BAH11658.1. AK026946 mRNA. Translation: BAB15598.1. AK225190 mRNA. No translation available. AC016995 Genomic DNA. Translation: AAX88950.1. BC053508 mRNA. Translation: AAH53508.1.
IPI	IPI00007183. IPI00169267. IPI00845387. IPI01014314.
RefSeq	NP_001129145.1. NM_001135673.1. NP_071769.2. NM_022374.2.
UniGene	Hs.727652.
3D structure databases
ProteinModelPortal	Q8NHH9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NHH9. 3 interactions.
MINT	MINT-3295758.
PTM databases
PhosphoSite	Q8NHH9.
Polymorphism databases
DMDM	147742983.
Proteomic databases
PaxDb	Q8NHH9.
PRIDE	Q8NHH9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000332337; ENSP00000333393; ENSG00000119787. ENST00000378954; ENSP00000368237; ENSG00000119787. ENST00000402054; ENSP00000384062; ENSG00000119787. ENST00000419554; ENSP00000415336; ENSG00000119787. ENST00000539122; ENSP00000446192; ENSG00000119787.
GeneID	64225.
KEGG	hsa:64225.
UCSC	uc002rqq.3. human. uc002rqs.3. human. uc010ynm.2. human.
Organism-specific databases
CTD	64225.
GeneCards	GC02M038522.
HGNC	HGNC:24047. ATL2.
HPA	HPA029108.
MIM	609368. gene.
neXtProt	NX_Q8NHH9.
PharmGKB	PA164716322.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG325148.
HOGENOM	HOG000234332.
HOVERGEN	HBG062891.
InParanoid	Q8NHH9.
OMA	QPHQGLR.
OrthoDB	EOG4255SJ.
Gene expression databases
ArrayExpress	Q8NHH9.
Bgee	Q8NHH9.
CleanEx	HS_ATL2.
Genevestigator	Q8NHH9.
Family and domain databases
InterPro	IPR003191. Guanylate-bd_C. IPR015894. Guanylate-bd_N. [Graphical view]
Pfam	PF02263. GBP. 1 hit. PF02841. GBP_C. 1 hit. [Graphical view]
SUPFAM	SSF48340. GBP. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	64225.
NextBio	66162.
SOURCE	Search...

Entry information

Entry name

ATLA2_HUMAN

Accession

Primary (citable) accession number: Q8NHH9
Secondary accession number(s): B7Z1X2 , Q4ZG30, Q7Z630, Q8NHH8, Q9H5M7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 15, 2007
Last modified:	May 1, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.