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Protein

Tubulin polyglutamylase TTLL11

Gene

TTLL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Polyglutamase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules (PubMed:22493317). Generates long side-chains (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei385 – 3851ATPBy similarity
Binding sitei387 – 3871ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi372 – 3754ATP bindingBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin polyglutamylase TTLL11 (EC:6.-.-.-)
Alternative name(s):
Tubulin--tyrosine ligase-like protein 11
Gene namesi
Name:TTLL11
Synonyms:C9orf20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:18113. TTLL11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi578 – 5814KKKR → EEEE: Decreased binding to microtubules and polyglutamylase activity; when associated with E-416 and E-419. 1 Publication

Organism-specific databases

PharmGKBiPA25977.

Polymorphism and mutation databases

BioMutaiTTLL11.
DMDMi73920150.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 800800Tubulin polyglutamylase TTLL11PRO_0000212445Add
BLAST

Proteomic databases

PaxDbiQ8NHH1.
PeptideAtlasiQ8NHH1.
PRIDEiQ8NHH1.

PTM databases

iPTMnetiQ8NHH1.
PhosphoSiteiQ8NHH1.

Expressioni

Gene expression databases

BgeeiENSG00000175764.
CleanExiHS_TTLL11.
ExpressionAtlasiQ8NHH1. baseline and differential.
GenevisibleiQ8NHH1. HS.

Organism-specific databases

HPAiHPA021828.

Interactioni

Protein-protein interaction databases

BioGridi127650. 3 interactions.
IntActiQ8NHH1. 1 interaction.
MINTiMINT-7970579.
STRINGi9606.ENSP00000321346.

Structurei

3D structure databases

ProteinModelPortaliQ8NHH1.
SMRiQ8NHH1. Positions 220-575.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini218 – 570353TTLPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni557 – 62872c-MTBD region1 PublicationAdd
BLAST

Domaini

The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.By similarity1 Publication

Sequence similaritiesi

Belongs to the tubulin--tyrosine ligase family.Curated
Contains 1 TTL domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2158. Eukaryota.
ENOG410XNWC. LUCA.
GeneTreeiENSGT00760000118951.
HOGENOMiHOG000154710.
InParanoidiQ8NHH1.
KOiK16604.
OMAiACDIYWH.
OrthoDBiEOG091G039J.
PhylomeDBiQ8NHH1.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
[Graphical view]
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NHH1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAASVTGR VTWAASPMRS LGLGRRLSLP GPRLDAVTAA VNPSLSDHGN
60 70 80 90 100
GLGRGTRGSG CSGGSLVADW GGGAAAAAAV ALALAPALST MRRGSSESEL
110 120 130 140 150
AARWEAEAVA AAKAAAKAEA EATAETVAEQ VRVDAGAAGE PECKAGEEQP
160 170 180 190 200
KVLAPAPAQP SAAEEGNTQV LQRPPPTLPP SKPKPVQGLC PHGKPRDKGR
210 220 230 240 250
SCKRSSGHGS GENGSQRPVT VDSSKARTSL DALKISIRQL KWKEFPFGRR
260 270 280 290 300
LPCDIYWHGV SFHDNDIFSG QVNKFPGMTE MVRKITLSRA VRTMQNLFPE
310 320 330 340 350
EYNFYPRSWI LPDEFQLFVA QVQMVKDDDP SWKPTFIVKP DGGCQGDGIY
360 370 380 390 400
LIKDPSDIRL AGTLQSRPAV VQEYICKPLL IDKLKFDIRL YVLLKSLDPL
410 420 430 440 450
EIYIAKDGLS RFCTEPYQEP TPKNLHRIFM HLTNYSLNIH SGNFIHSDSA
460 470 480 490 500
STGSKRTFSS ILCRLSSKGV DIKKVWSDII SVVIKTVIAL TPELKVFYQS
510 520 530 540 550
DIPTGRPGPT CFQILGFDIL LMKNLKPILL EVNANPSMRI EHEHELSPGV
560 570 580 590 600
FENVPSLVDE EVKVAVIRDT LRLMDPLKKK RENQSQQLEK PFAGKEDALD
610 620 630 640 650
GELTSAPDCN ANPEAHLPSI CLKQVFPKYA KQFNYLRLVD RMANLFIRFL
660 670 680 690 700
GIKGTMKLGP TGFRTFIRSC KLSSSSLSMA AVDILYIDIT RRWNSMTLDQ
710 720 730 740 750
RDSGMCLQAF VEAFFFLAQR KFKMLPLHEQ VASLIDLCEY HLSLLDEKRL
760 770 780 790 800
VCGRGVPSGG RPPHRGPPQE PSPSAQPAGD NPPPRTSCAN KLSHPRHTLS
Length:800
Mass (Da):87,612
Last modified:September 16, 2015 - v2
Checksum:iDB9C75CC06124C27
GO
Isoform 2 (identifier: Q8NHH1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     514-538: ILGFDILLMKNLKPILLEVNANPSM → VTIASSQPAFPALTGLKRALWLRVG
     539-800: Missing.

Show »
Length:538
Mass (Da):58,035
Checksum:i0F23492469C2B0A7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei514 – 53825ILGFD…ANPSM → VTIASSQPAFPALTGLKRAL WLRVG in isoform 2. VSP_057853Add
BLAST
Alternative sequencei539 – 800262Missing in isoform 2. VSP_057854Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521886 mRNA. Translation: AAM81328.1.
AL162423, AL442634, AL445587 Genomic DNA. Translation: CAH73979.1.
AL442634, AL162423, AL445587 Genomic DNA. Translation: CAI39985.1.
AL445587, AL162423, AL442634 Genomic DNA. Translation: CAI40706.1.
CCDSiCCDS48012.1. [Q8NHH1-1]
CCDS6834.2. [Q8NHH1-2]
RefSeqiNP_001132914.1. NM_001139442.1. [Q8NHH1-1]
NP_919228.2. NM_194252.2. [Q8NHH1-2]
UniGeneiHs.438937.
Hs.640663.

Genome annotation databases

EnsembliENST00000321582; ENSP00000321346; ENSG00000175764. [Q8NHH1-1]
ENST00000373776; ENSP00000362881; ENSG00000175764. [Q8NHH1-2]
GeneIDi158135.
KEGGihsa:158135.
UCSCiuc004blt.2. human. [Q8NHH1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521886 mRNA. Translation: AAM81328.1.
AL162423, AL442634, AL445587 Genomic DNA. Translation: CAH73979.1.
AL442634, AL162423, AL445587 Genomic DNA. Translation: CAI39985.1.
AL445587, AL162423, AL442634 Genomic DNA. Translation: CAI40706.1.
CCDSiCCDS48012.1. [Q8NHH1-1]
CCDS6834.2. [Q8NHH1-2]
RefSeqiNP_001132914.1. NM_001139442.1. [Q8NHH1-1]
NP_919228.2. NM_194252.2. [Q8NHH1-2]
UniGeneiHs.438937.
Hs.640663.

3D structure databases

ProteinModelPortaliQ8NHH1.
SMRiQ8NHH1. Positions 220-575.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127650. 3 interactions.
IntActiQ8NHH1. 1 interaction.
MINTiMINT-7970579.
STRINGi9606.ENSP00000321346.

PTM databases

iPTMnetiQ8NHH1.
PhosphoSiteiQ8NHH1.

Polymorphism and mutation databases

BioMutaiTTLL11.
DMDMi73920150.

Proteomic databases

PaxDbiQ8NHH1.
PeptideAtlasiQ8NHH1.
PRIDEiQ8NHH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321582; ENSP00000321346; ENSG00000175764. [Q8NHH1-1]
ENST00000373776; ENSP00000362881; ENSG00000175764. [Q8NHH1-2]
GeneIDi158135.
KEGGihsa:158135.
UCSCiuc004blt.2. human. [Q8NHH1-1]

Organism-specific databases

CTDi158135.
GeneCardsiTTLL11.
HGNCiHGNC:18113. TTLL11.
HPAiHPA021828.
neXtProtiNX_Q8NHH1.
PharmGKBiPA25977.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2158. Eukaryota.
ENOG410XNWC. LUCA.
GeneTreeiENSGT00760000118951.
HOGENOMiHOG000154710.
InParanoidiQ8NHH1.
KOiK16604.
OMAiACDIYWH.
OrthoDBiEOG091G039J.
PhylomeDBiQ8NHH1.

Miscellaneous databases

GenomeRNAii158135.
PROiQ8NHH1.

Gene expression databases

BgeeiENSG00000175764.
CleanExiHS_TTLL11.
ExpressionAtlasiQ8NHH1. baseline and differential.
GenevisibleiQ8NHH1. HS.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
[Graphical view]
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTL11_HUMAN
AccessioniPrimary (citable) accession number: Q8NHH1
Secondary accession number(s): F8W6M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: September 16, 2015
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.