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Protein

E3 ubiquitin-protein ligase ZNRF2

Gene

ZNRF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri199 – 240RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase ZNRF2 (EC:2.3.2.27)
Alternative name(s):
Protein Ells2
RING finger protein 202
RING-type E3 ubiquitin transferase ZNRF2
Zinc/RING finger protein 2
Gene namesi
Name:ZNRF2
Synonyms:RNF202
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000180233.10
HGNCiHGNC:22316 ZNRF2
MIMi612061 gene
neXtProtiNX_Q8NHG8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Endosome, Lysosome, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180233
PharmGKBiPA134961488

Polymorphism and mutation databases

BioMutaiZNRF2
DMDMi74762595

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCurated
ChainiPRO_00002778032 – 242E3 ubiquitin-protein ligase ZNRF2Add BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei21PhosphoserineBy similarity1
Modified residuei25PhosphoserineBy similarity1
Modified residuei82PhosphoserineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei113PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei135PhosphoserineCombined sources1
Modified residuei145PhosphoserineBy similarity1
Modified residuei151PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ8NHG8
MaxQBiQ8NHG8
PaxDbiQ8NHG8
PeptideAtlasiQ8NHG8
PRIDEiQ8NHG8

PTM databases

iPTMnetiQ8NHG8
PhosphoSitePlusiQ8NHG8

Expressioni

Tissue specificityi

Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.1 Publication

Gene expression databases

BgeeiENSG00000180233
CleanExiHS_ZNRF2
ExpressionAtlasiQ8NHG8 baseline and differential
GenevisibleiQ8NHG8 HS

Interactioni

Subunit structurei

Interacts with UBE2N.1 Publication

Protein-protein interaction databases

BioGridi12882523 interactors.
IntActiQ8NHG8 4 interactors.
MINTiQ8NHG8
STRINGi9606.ENSP00000323879

Structurei

3D structure databases

ProteinModelPortaliQ8NHG8
SMRiQ8NHG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi36 – 40Poly-Gly5
Compositional biasi41 – 97Ala-richAdd BLAST57
Compositional biasi124 – 127Poly-Gly4

Domaini

The RING-type zinc finger domain is required for E3 ligase activity.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri199 – 240RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0801 Eukaryota
ENOG4111V18 LUCA
GeneTreeiENSGT00390000013068
HOGENOMiHOG000285998
HOVERGENiHBG094200
InParanoidiQ8NHG8
KOiK10694
OMAiSEEMDLH
OrthoDBiEOG091G0N7A
PhylomeDBiQ8NHG8
TreeFamiTF317681

Family and domain databases

Gene3Di3.30.40.101 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NHG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAKQSGPAA ANGRTRAYSG SDLPSSSSGG ANGTAGGGGG ARAAAAGRFP
60 70 80 90 100
AQVPSAHQPS ASGGAAAAAA APAAPAAPRS RSLGGAVGSV ASGARAAQSP
110 120 130 140 150
FSIPNSSSGP YGSQDSVHSS PEDGGGGRDR PVGGSPGGPR LVIGSLPAHL
160 170 180 190 200
SPHMFGGFKC PVCSKFVSSD EMDLHLVMCL TKPRITYNED VLSKDAGECA
210 220 230 240
ICLEELQQGD TIARLPCLCI YHKGCIDEWF EVNRSCPEHP SD
Length:242
Mass (Da):24,115
Last modified:October 1, 2002 - v1
Checksum:iD02776578A1E9E55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513707 mRNA Translation: AAQ08115.1
AF527533 mRNA Translation: AAM88868.1
CCDSiCCDS5426.1
RefSeqiNP_667339.1, NM_147128.3
UniGeneiHs.263912

Genome annotation databases

EnsembliENST00000323037; ENSP00000323879; ENSG00000180233
GeneIDi223082
KEGGihsa:223082
UCSCiuc003tat.3 human

Similar proteinsi

Entry informationi

Entry nameiZNRF2_HUMAN
AccessioniPrimary (citable) accession number: Q8NHG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 1, 2002
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome