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Protein

Small VCP/p97-interacting protein

Gene

SVIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ATPase binding Source: ParkinsonsUK-UCL
  • protein self-association Source: UniProtKB

GO - Biological processi

  • negative regulation of ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKB
  • negative regulation of protein complex assembly Source: UniProtKB
  • negative regulation of retrograde protein transport, ER to cytosol Source: ParkinsonsUK-UCL
  • negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly Source: Ensembl
  • positive regulation of autophagy Source: UniProtKB
  • positive regulation of protein lipidation Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32147-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Small VCP/p97-interacting protein
Gene namesi
Name:SVIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25238. SVIP.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: ParkinsonsUK-UCL
  • endoplasmic reticulum membrane Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB-SubCell
  • smooth endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi258010.
OpenTargetsiENSG00000198168.
PharmGKBiPA164726394.

Polymorphism and mutation databases

BioMutaiSVIP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000723372 – 77Small VCP/p97-interacting proteinAdd BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei46PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ8NHG7.
MaxQBiQ8NHG7.
PaxDbiQ8NHG7.
PeptideAtlasiQ8NHG7.
PRIDEiQ8NHG7.

PTM databases

iPTMnetiQ8NHG7.
PhosphoSitePlusiQ8NHG7.
SwissPalmiQ8NHG7.

Expressioni

Gene expression databases

BgeeiENSG00000198168.
GenevisibleiQ8NHG7. HS.

Organism-specific databases

HPAiHPA039807.

Interactioni

Subunit structurei

Interacts (via VIM motif) with VCP.1 Publication

GO - Molecular functioni

  • ATPase binding Source: ParkinsonsUK-UCL
  • protein self-association Source: UniProtKB

Protein-protein interaction databases

BioGridi129222. 21 interactors.
IntActiQ8NHG7. 2 interactors.
STRINGi9606.ENSP00000346130.

Structurei

3D structure databases

ProteinModelPortaliQ8NHG7.
SMRiQ8NHG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 33VCP/p97-interacting motif (VIM)1 PublicationAdd BLAST13

Sequence similaritiesi

Belongs to the SVIP family.Curated

Phylogenomic databases

eggNOGiENOG410J4QZ. Eukaryota.
ENOG41117ZU. LUCA.
GeneTreeiENSGT00390000007067.
HOGENOMiHOG000122415.
HOVERGENiHBG094009.
InParanoidiQ8NHG7.
KOiK14014.
OMAiGMCFPCP.
PhylomeDBiQ8NHG7.

Family and domain databases

InterProiIPR031632. SVIP.
[Graphical view]
PfamiPF15811. SVIP. 1 hit.
[Graphical view]
ProDomiPD619568. PD619568. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NHG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLCFPCPGE SAPPTPDLEE KRAKLAEAAE RRQKEAASRG ILDVQSVQEK
60 70
RKKKEKIEKQ IATSGPPPEG GLRWTVS
Length:77
Mass (Da):8,443
Last modified:October 1, 2002 - v1
Checksum:i09744BB0437F44BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527534 mRNA. Translation: AAM88869.1.
CCDSiCCDS41627.1.
RefSeqiNP_001307269.1. NM_001320340.1.
NP_001307271.1. NM_001320342.1.
NP_683691.1. NM_148893.2.
UniGeneiHs.349096.

Genome annotation databases

EnsembliENST00000354193; ENSP00000346130; ENSG00000198168.
GeneIDi258010.
KEGGihsa:258010.
UCSCiuc001mqp.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527534 mRNA. Translation: AAM88869.1.
CCDSiCCDS41627.1.
RefSeqiNP_001307269.1. NM_001320340.1.
NP_001307271.1. NM_001320342.1.
NP_683691.1. NM_148893.2.
UniGeneiHs.349096.

3D structure databases

ProteinModelPortaliQ8NHG7.
SMRiQ8NHG7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129222. 21 interactors.
IntActiQ8NHG7. 2 interactors.
STRINGi9606.ENSP00000346130.

PTM databases

iPTMnetiQ8NHG7.
PhosphoSitePlusiQ8NHG7.
SwissPalmiQ8NHG7.

Polymorphism and mutation databases

BioMutaiSVIP.

Proteomic databases

EPDiQ8NHG7.
MaxQBiQ8NHG7.
PaxDbiQ8NHG7.
PeptideAtlasiQ8NHG7.
PRIDEiQ8NHG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354193; ENSP00000346130; ENSG00000198168.
GeneIDi258010.
KEGGihsa:258010.
UCSCiuc001mqp.5. human.

Organism-specific databases

CTDi258010.
DisGeNETi258010.
GeneCardsiSVIP.
HGNCiHGNC:25238. SVIP.
HPAiHPA039807.
neXtProtiNX_Q8NHG7.
OpenTargetsiENSG00000198168.
PharmGKBiPA164726394.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4QZ. Eukaryota.
ENOG41117ZU. LUCA.
GeneTreeiENSGT00390000007067.
HOGENOMiHOG000122415.
HOVERGENiHBG094009.
InParanoidiQ8NHG7.
KOiK14014.
OMAiGMCFPCP.
PhylomeDBiQ8NHG7.

Enzyme and pathway databases

BioCyciZFISH:G66-32147-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiSVIP. human.
GenomeRNAii258010.
PROiQ8NHG7.

Gene expression databases

BgeeiENSG00000198168.
GenevisibleiQ8NHG7. HS.

Family and domain databases

InterProiIPR031632. SVIP.
[Graphical view]
PfamiPF15811. SVIP. 1 hit.
[Graphical view]
ProDomiPD619568. PD619568. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiSVIP_HUMAN
AccessioniPrimary (citable) accession number: Q8NHG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.